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Unstable configurations of atoms formed while a chemical reaction progresses
an activated complex represents a collection of intermediate structures in a chemical reaction when bonds are breaking and forming. The activated complex
Activated_complex
Theory describing chemical reaction rates
chemical equilibrium (quasi-equilibrium) between reactants and activated transition state complexes. TST is used primarily to understand qualitatively how chemical
Transition_state_theory
Concept in chemical kinetics
entropy of activation is symbolized ΔS‡ and equals the change in entropy when the reactants change from their initial state to the activated complex or transition
Entropy_of_activation
Chemical kinetics equation
theory, also known as activated-complex theory. If one assumes a constant enthalpy of activation and constant entropy of activation, the Eyring equation
Eyring_equation
formed complex is in an activated state. Substrate specificity of the activated complex is mainly established by the associated cyclin within the complex. Activity
Cyclin-dependent kinase complex
Cyclin-dependent_kinase_complex
Process of formation of blood clots
forming an activated complex (TF-FVIIa). TF-FVIIa activates FIX and FX. FVII is itself activated by thrombin, FXIa, FXII, and FXa. The activation of FX (to
Coagulation
Activated protein C–protein C inhibitor (APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI). It has been measured in coagulation
Activated protein C–protein C inhibitor
Activated_protein_C–protein_C_inhibitor
Slowest step of a chemical reaction
charge of the activated complex or transition state. For the NO2–CO reaction above, the rate depends on [NO2]2, so that the activated complex has composition
Rate-determining_step
Configuration of a chemical reaction when potential energy is greatest
during the SN2 reaction of bromoethane with a hydroxide anion: The activated complex of a reaction can refer to either the transition state or to other
Transition_state
Explanation for the rates of electron transfer reactions
coupled in the course of the reaction to form a structurally defined activated complex, in Marcus theory they are weakly coupled and retain their individuality
Marcus_theory
Complex formed by blood clotting factors X and V
coagulation factor X can be activated into factor Xa in two ways: either extrinsically or intrinsically. The activating complexes are together called tenase
Tenase
Any model explaining a chemical reaction
characteristics of the reaction. It also describes each reactive intermediate, activated complex, and transition state, which bonds are broken (and in what order)
Reaction_mechanism
Reaction rate equals rate of transport
they encounter each other in the right stoichiometry and form an activated complex which can form the product species. The observed rate of chemical
Diffusion-controlled_reaction
Cytokine
blood cell lineages. Activated TGF-β complexes with cell surface TGF-β receptors to form an active serine/threonine kinase complex. After binding their
Transforming growth factor beta
Transforming_growth_factor_beta
Pharmaceutical drug used to treat blood clots
thrombolytic drug. It is also known as anisoylated plasminogen streptokinase activator complex (APSAC). As a thrombolytic drug, it is used to treat blood clots in
Anistreplase
Relocation of an electron from an atom or molecule to another
"encounter complex", out of their solvent shells => precursor complex (requires work = wr) Changing bond lengths, reorganize solvent => activated complex Electron
Electron_transfer
Type of CRISPR tool
to SunTag polypeptides and activated target CXCR4 gene in K562 cell lines. Comparing with the dCas9-VP64 activation complex, they were able to increase
CRISPR_activation
Compound with a metal center bound to ligands
(ICP-MS). Wikimedia Commons has media related to Coordination compounds. Activated complex IUPAC nomenclature of inorganic chemistry Coordination cage Coordination
Coordination_complex
Formula for temperature dependence of rates of chemical reactions
the partition functions of the reactants and of the activated complex. Both the Arrhenius activation energy and the rate constant k are experimentally
Arrhenius_equation
Immune system messenger protein which induces inflammation
is activated by sTNF, then the monocyte's inflammatory response to sTNF is enhanced. If tmTNF reverse signalling occurs after a monocyte is activated by
Tumor_necrosis_factor
Speed at which a chemical reaction takes place
reaction to occur is called the activation energy and is denoted by Ea or ΔG‡. The transition state or activated complex shown on the diagram is the energy
Reaction_rate
Form of carbon with an extremely high surface area
Activated carbon, also called activated charcoal, is a form of carbon commonly used to filter contaminants from water and air, among many other uses.
Activated_carbon
Influence of a solvent on chemical reactivity, stability, etc.
accelerates the rates of reactions where a charge is developed in the activated complex from neutral or slightly charged reactant An increase in solvent polarity
Solvent_effects
Function describing the energy of a physical system in terms of certain parameters
repulsive by comparing the extensions of the bond lengths in the activated complex relative to those of the reactants and products. For a reaction of
Potential_energy_surface
Dioxygen complexes are coordination compounds that contain O2 as a ligand. The study of these compounds is inspired by oxygen-carrying proteins such as
Transition metal dioxygen complex
Transition_metal_dioxygen_complex
Aspect of cell metabolism
sufficient, mTORC1 will be activated. The lysosomal membrane is the main area in which mTORC1 is activated. However, some activation can occur in the Golgi
Ragulator-Rag_complex
Medication
It is given by slow injection into a vein. Another product, activated prothrombin complex concentrate or FEIBA (Factor Eight Inhibitor Bypassing Agent)
Prothrombin complex concentrate
Prothrombin_complex_concentrate
Branch of chemistry
study of the dynamical systems associated to reactive chemicals, the activated complex and their corresponding differential equations. Cheminformatics (also
Theoretical_chemistry
Protein complex
of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-6-7 complex. The C5b-6-7 complex binds to C8, which is
Complement membrane attack complex
Complement_membrane_attack_complex
Type of chemical reaction
molecule of the alcohol gives an activated complex Protonation of one of the hydroxy groups of the activated complex gives a new oxonium ion. Loss of
Fischer–Speier_esterification
Part of the immune system that enhances the ability of antibodies and phagocytic cells
requires antigen-antibody complexes for activation (specific immune response), whereas the alternative pathway can be activated by spontaneous complement
Complement_system
Complex that catalyzes conversion of prothrombin to thrombin
prothrombinase complex alters the sequence of prothrombin bond cleavage. Factor Va is inactivated following cleavage by activated protein C. Activated protein
Prothrombinase
1,3-dipolar cycloaddition
the spectator ligands undergo displacement reaction to produce an activated complex which is converted, through oxidative coupling of an alkyne and an
Azide-alkyne Huisgen cycloaddition
Azide-alkyne_Huisgen_cycloaddition
Complex of blood coagulation factors
Prothrombin activator is a complex of a dozen blood coagulation factors that functions in catalyzing prothrombin into thrombin. Prothrombin activator is released
Prothrombin_activator
Metal carbon dioxide complexes are coordination complexes that contain carbon dioxide ligands. Aside from the fundamental interest in the coordination
Metal_carbon_dioxide_complex
Protein complex
antigen-antibody complex. When C1q binds antigen-antibody complexes, the C1 complex becomes activated. Activation of the C1 complex initiates the classical
Complement_component_1q
British-born Canadian chemist (1916–2003)
Physical Chemistry, A pioneer in the field of chemical kinetics and activated-complex theory The science.ca team, GCS Research Society (2001 and 2015).
Keith_J._Laidler
Process of breaking bonds between carbon atoms
construction of complex organic molecules. However, C–C bond activation is challenging mainly for the following reasons: (1) C-H bond activation is a competitive
Carbon-carbon_bond_activation
Organic reaction
Cp2WH2 complex) in a benzene C–H bond and George M. Whitesides in 1979 was the first to carry out an intramolecular aliphatic C–H activation In 1977
Carbon–hydrogen bond activation
Carbon–hydrogen_bond_activation
Two related parameters used in description of the kinetics of electrochemical reactions
{\displaystyle \nu } : stoichiometric number, i.e., the number of activated complexes formed and destroyed in the overall reaction (with n electrons) R
Charge_transfer_coefficient
Ion, and compounds containing the ion
cations such as Fe2+ in solution is due to the difficulty to form an activated complex facilitating the electron transfer and the exchange of oxo groups
Perchlorate
Protein-coding gene in humans
CUL4A in the DNA damage binding protein 2 (DDB2) complex is activated by NEDD8, and this activated complex allows GGR-NER to proceed to remove the damage
NAE1
Benzylic activation in tricarbonyl(arene)chromium complexes refers to the reactions at the benzylic position of aromatic rings complexed to chromium(0)
Benzylic activation in tricarbonyl(arene)chromium complexes
Benzylic_activation_in_tricarbonyl(arene)chromium_complexes
Control mechanism in the eukaryotic cell cycle
specific cyclin-CDK complexes being formed and activated at different phases of the cell cycle. Those complexes, in turn, activate different downstream
Cell_cycle_checkpoint
Molecular entity formed as an elementary step in a multi-step chemical reaction
that the reaction required the formation of a reaction intermediate. Activated complex Transition state Moore, John W. (2015). Chemistry : the molecular
Reaction_intermediate
Protein-coding gene in the species Homo sapiens
Activating signal cointegrator 1 complex subunit 1 (ASCC1) is a protein that in humans is encoded by the ASCC1 gene. GRCh38: Ensembl release 89: ENSG00000138303
ASCC1
Protein complex
converge at the translation initiation complex on the 5' end of mRNA, and thus activate translation. Activated mTORC1 will phosphorylate translation repressor
MTORC1
Cellular process inhibiting another gene's expression
Receptor-Activated Gene Expression Shows Potency and Efficacy Changes and Predicts Squelching Due to Competition for Transcription Co-Activators". PLOS
Squelching
Molecules which increase enzyme activity
where G6P acts as a feedback inhibitor. At low G6P concentration, HK-I is activated; at high G6P concentration, the HK-I is inhibited. Glucokinase (GK) is
Enzyme_activator
Protein complex on the surface of T cells that recognizes antigens
are integrated. Only if both signals are present, PLCγ is activated. Once PLCγ is activated by phosphorylation. It hydrolyses PIP2 into two secondary
T-cell_receptor
Protein complex
C1 complex is ~790 kDa and is composed of 1 molecule of C1q, 2 molecules of C1r and 2 molecules of C1s, or C1qr2s2. Activation of the C1 complex initiates
C1_complex
Protein complex and T cell co-receptor
(cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells)
CD3_(immunology)
Mammalian protein found in humans
stress. mTOR Complex 2 (mTORC2) is composed of mTOR, rapamycin-insensitive companion of mTOR (RICTOR), MLST8, and mammalian stress-activated protein kinase
MTOR
Protein involved in the breakdown of blood clots
JF, Herz J (August 1992). "Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized
Tissue-type plasminogen activator
Tissue-type_plasminogen_activator
Protein domain
Caspase activating multiprotein complex called the Apoptosome. Once activated, initiator caspases such as Caspase 9 will cleave and activate other executioner
Caspase
Protein that increases transcription of a gene or set of genes
usually more than one activator assembles at the binding-site, forming a complex that acts to promote transcription. These activators bind cooperatively
Transcriptional_activator
Indian chemist
where the reaction between the starting reactants happens in Eyring activated complex. He demonstrated that carbon dioxide molecule does bind to magnesium
Sabyasachi_Sarkar
Chemical kinetics model
functions of the reactants, and Q‡ is the partition function of the activated complex. In Ref., the significance of the parameter d and an explicit procedure
Aquilanti–Mundim deformed Arrhenius model
Aquilanti–Mundim_deformed_Arrhenius_model
Component of blood aiding in coagulation
granules. Activated platelets secrete the contents of these granules through their canalicular systems to the exterior. Bound and activated platelets
Platelet
Electrocardiogram waveform representing ventricular contraction in the heart
The QRS complex is the combination of three of the graphical deflections seen on a typical electrocardiogram (ECG or EKG). It is usually the central and
QRS_complex
transition state and form AD+. The activated complex with strict steric requirements is referred to as a "tight complex" whereas the transition state without
Unimolecular ion decomposition
Unimolecular_ion_decomposition
British chemist
1931, 109 (762), 308, doi:10.1098/rspb.1931.0083 H. Eyring, "The activated complex in chemical reactions", J. Chem. Phys., 1935, 3, 107-115, doi:10.1063/1
Meredith_Gwynne_Evans
Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)
TA, Baldwin DT, Stewart TA (November 1999). "RIP2 is a Raf1-activated mitogen-activated protein kinase kinase". The Journal of Biological Chemistry.
AP-1_transcription_factor
Molecule formed binding antigens to antibodies
these receptors and immune complex binding to these receptors induces apoptosis, or cell death. After B cells are activated, they differentiate into plasma
Immune_complex
RNA polymerase II to the pre-initiation complex. Once initiated, RNA polymerase II is released from the complex and transcription begins. The property
Upstream_activating_sequence
Type of strength training
Complex training, also known as contrast training or post-activation potentiation training, involves the integration of strength training and plyometrics
Complex_training
Immune cell found in connective tissue
signaling cascade. An important adaptor protein activated by the Syk phosphorylation step is the linker for activation of T cells (LAT). LAT can be modified by
Mast_cell
Regulatory protein in bacteria
RNAP-promoter closed complex and isomerizes the RNAP-promoter complex to the open conformation. Busby S, Ebright RH (1999). "Transcription activation by catabolite
CAMP_receptor_protein
Genetic disease causing anemia, birth defects, and cancers
repair DNA. The FA core complex of 8 proteins is normally activated when DNA stops replicating because of damage. The core complex adds ubiquitin, a small
Fanconi_anemia
Protein-coding gene in the species Homo sapiens
mediating the association of the AMPK complex. PRKAB1 has been shown to interact with PRKAG2 and PRKAG1. The 5'-AMP-activated protein kinase beta subunit interaction
PRKAB1
Protein found in humans
Proteasome activator complex subunit 4 is a protein that in humans is encoded by the PSME4 gene. GRCh38: Ensembl release 89: ENSG00000068878 – Ensembl
PSME4
Part of the innate immune system
inflammatory by macrophage chemokine production. SP-A and SP-D can suppress activated T-lymphocytes and IL-2 (interleukin-2) production. SP-D increases bacterial
Collectin
P; Peter, ME (May 15, 1997). "FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)". The EMBO Journal. 16 (10): 2794–2804
Death-inducing signaling complex
Death-inducing_signaling_complex
Cell cycle checkpoint in eukaryotic organisms
defining biochemical feature of this checkpoint is the activation of M-phase cyclin-CDK complexes, which phosphorylate proteins that promote spindle assembly
G2-M_DNA_damage_checkpoint
Chemical reaction in organic chemistry
bond begins to break, as does the carbon–hydrogen bond that is being activated. Compared to other possible processes such as oxidative addition of the
Concerted metalation deprotonation
Concerted_metalation_deprotonation
Family of transcription factor protein complexes
factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription of DNA
NF-κB
Signaling within the same cell
Another example occurs in activated T cell lymphocytes, i.e., when a T cell is induced to mature by binding to a peptide:MHC complex on a professional antigen-presenting
Autocrine_signaling
P38 mitogen-activated protein kinases
(Feb 2011). "Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
Cell-cycle regulatory complex
of the entire complex via different mechanisms at different sites. In further drosophila studies, Cdk16 and cdk23 appear to be activated via phosphorylation
Anaphase-promoting_complex
applied to music demonstrates that listening to or playing music activates complex brain areas, including the auditory, motor, and emotional systems
Melomania
Cell signaling pathway
When the GRB2-SOS complex docks to phosphorylated EGFR, SOS becomes activated. Activated SOS then promotes the removal of GDP from a member of the Ras subfamily
MAPK/ERK_pathway
Protein complex
Mre11 endonuclease activity has been implicated in ATM activation by the MRN complex. The MRN complex has been mainly studied in eukaryotes. However, recent
MRN_complex
Thrombin–antithrombin complex (TAT) is a protein complex of thrombin and antithrombin. It is a marker of net activation of coagulation. TAT is formed
Thrombin–antithrombin_complex
Human protein and coding gene
context-dependent NLRP3 activation. In the absence of an activating signal, some studies have suggested that NLRP3 is kept in an inactive state complexed with HSP90
NLRP3
Protein-coding gene in the species Homo sapiens
caspase-9, become activated through the formation of large protein complexes, which promote dimerization and self-cleavage. Once activated, they initiate
PIDD1
Medical condition affecting newborn infants
of action in which, once bound to a glucocorticoid receptor, the activated complex moves into the nucleus and inhibits transcription of mRNA. Ultimately
Meconium_aspiration_syndrome
Set of biological processes
1:1 complex with a protein called colipase (also a constituent of pancreatic juice), which is necessary for its activity. The activated complex can work
Fatty_acid_metabolism
Supermolecular coordination-based assembly methodology
the catalyst is activated. As the reaction proceeds, more acetate is generated, which leads to the formation of more activated complex and progressively
Weak-Link_Approach
activated by their ligands, they allow for the dissociation of the G protein into its individual α-subunit and βγ-complex so it can in turn activate the
G_protein-gated_ion_channel
Protein found in humans
Proteasome activator complex subunit 3 is a protein encoded by the PSME3 gene in humans. The 26S proteasome is a multicatalytic proteinase complex with a
PSME3
Protein molecule receiving signals for a cell
are activated. Affinity is a measure of the tendency of a ligand to bind to its receptor. Efficacy is the measure of the bound ligand to activate its
Receptor_(biochemistry)
Topics referred to by the same term
may refer to: Anistreplase (anisoylated plasminogen streptokinase activator complex) Army Public School and College (Pakistan) This disambiguation page
APSAC
1989). "Role of botrocetin in platelet agglutination: formation of an activated complex of botrocetin and von Willebrand factor". Blood. 74 (3): 1031–5. PMID 2473809
Cerastocytin
Surface glycoproteins involved in hemostasis
complex activation) is prevented by aggregin, which disables their contact necessary for the complex activation. The complex can be activated by ADP.
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Protein-coding gene in the species Homo sapiens
An activated complex of GAB2, SHC, and SHP2 is required for binding of Phospholipase C gamma 2 (PLCG2) through its SH2 domain, which activates PIP3
GAB2
Chemical compound
formation of an inner sphere complex giving rise to a possible reorganisation of the activated complex. The resulting high activation energy prohibits a thermodynamically
Iron(II)_perchlorate
Class of chemical compounds
GmbH US 5244594, T.L.F. Favre et al., "Bleach activation multinuclear manganese-based coordination complexes", issued 1993-09-14, assigned to Lever Brothers
Bleach_activator
Cluster of interneurons in the medulla oblongata
current and calcium-activated nonspecific currents (ICAN). When a neuron becomes depolarized, voltage gated calcium channels become activated and calcium is
Pre-Bötzinger_complex
Overreaction of the immune system to an antigen
myasthenia gravis). Activation of the complement system via the classical pathway, causing formation of the membrane attack complex, anaphylatoxin production
Hypersensitivity
cluster formation early in the 19th century. Henry Eyring developed the activated-complex theory describing kinetics of reactions. Interest in studying the
Infrared photodissociation spectroscopy
Infrared_photodissociation_spectroscopy
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ACTIVATED COMPLEX
ACTIVATED COMPLEX
Surname or Lastname
English
English : variant of Grice.French (Grisé) : variant spelling of Griset, a nickname for someone with gray hair, a gray complexion, or perhaps one who habitually wore gray, from Old French gris ‘gray’.
Boy/Male
Tamil
Panduranga | பாநà¯à®¤à¯à®°à®‚கா
A deity, One with pale white complexion, Lord Vishnu
Panduranga | பாநà¯à®¤à¯à®°à®‚கா
Surname or Lastname
English
English : nickname for someone with a complexion that was as ‘white as a lily’ (Middle English lilie).
Boy/Male
Tamil
Pandurangan | பநà¯à®¤à¯à®°à®‚கந
A deity, One with pale white complexion, Lord Vishnu
Pandurangan | பநà¯à®¤à¯à®°à®‚கந
Surname or Lastname
Irish
Irish : reduced Anglicized form of Gaelic Ó Duinn, Ó Doinn ‘descendant of Donn’, a byname meaning ‘brown-haired’ or ‘chieftain’.English : nickname for a man with dark hair or a swarthy complexion, from Middle English dunn ‘dark-colored’.Scottish : habitational name from Dun in Angus, named with Gaelic dùn ‘fort’.Scottish : nickname from Gaelic donn ‘brown’. Compare 1.
Girl/Female
Tamil
Gourangi | கௌராஂகீ
Giver of happiness, One name of radhas name, Lord krishnas beloved, Fair complexioned
Gourangi | கௌராஂகீ
Surname or Lastname
English
English : from Old English dūst ‘dust’, applied as a nickname, possibly for someone with a dusty complexion or hair (as, for example, a miller), or for a worthless person.North German : possibly a Westphalian habitational name from a farm named with dost ‘bush’, ‘brush’. However, the word also means ‘fine dust’, ‘flour’ and may have been applied as an occupational nickname for a miller. Compare 1.
Girl/Female
Tamil
Dheekshit | தீகà¯à®·à®¿à®¤
Fair complexioned
Dheekshit | தீகà¯à®·à®¿à®¤
Girl/Female
Tamil
Fair complexioned
Surname or Lastname
English (Midlands)
English (Midlands) : nickname for a dark-complexioned man, from Old English earp ‘swarthy’.Americanized spelling of German Erp.
Surname or Lastname
German
German : nickname from the small medieval coin known as the häller or heller because it was first minted (in 1208) at the Swabian town of (Schwäbisch) Hall. Compare Hall.Jewish (Ashkenazic) : habitational name for someone from Schwäbisch Hall.German : topographic name for someone living by a field named as ‘hell’ (see Helle 3).English : topographic name for someone living on a hill, from southeastern Middle English hell + the habitational suffix -er.Dutch : from a Germanic personal name composed of the elements hild ‘strife’ + hari, heri ‘army’.Jewish (Ashkenazic) : nickname for a person with fair hair or a light complexion, from an inflected form, used before a male personal name, of German hell ‘light’, ‘bright’, Yiddish hel.
Boy/Male
Tamil
Pandurang | பாஂடà¯à®°à®‚க
A deity, One with pale white complexion, Lord Vishnu
Pandurang | பாஂடà¯à®°à®‚க
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Motivated; The Inspired One
Girl/Female
Arabic, Muslim
Fascinated; Charmed; Captivated; Enamoured
Surname or Lastname
English
English : nickname from Middle English gulle ‘gull’ or gul(le) (Old Norse gulr) ‘yellow’, ‘pale’ (of hair or complexion).Swiss German : nickname for an irascible or unreliable person, from an Alemannic form of Latin gallus ‘rooster’. See also Guell.
Girl/Female
Tamil
Gaurangi | கௌராஂகீ
Giver of happiness, One name of radhas name, Lord krishnas beloved, Fair complexioned
Gaurangi | கௌராஂகீ
Surname or Lastname
English
English : from the popular medieval personal name Hudde, which is of complex origin. It is usually explained as a pet form of Hugh, but there was a pre-existing Old English personal name, Hūda, underlying place names such as Huddington, Worcestershire. This personal name may well still have been in use at the time of the Norman Conquest. If so, it was absorbed by the Norman Hugh and its many diminutives. Reaney adduces evidence that Hudde was also regarded as a pet form of Richard.German : from a short form of a Germanic compound personal name formed with hut ‘guard’ as the first element.Variant spelling of German Hütt (see Huett).Jewish (Ashkenazic) : metonymic occupational name from Yiddish hut, German Hut ‘hat’ (see Huth).
Girl/Female
Tamil
Anekavarna | அநேகவாரநா
One who has many complexions
Anekavarna | அநேகவாரநா
Surname or Lastname
English
English : nickname for a person with a ruddy complexion, from an adjective derivative of Middle English mad(d)er ‘madder’, the dye plant (see Mader 1), here used in a transferred sense.
Girl/Female
Tamil
Dheekshitha | தீகà¯à®·à¯€à®¤à®¾Â
Fair complexioned
ACTIVATED COMPLEX
ACTIVATED COMPLEX
ACTIVATED COMPLEX
ACTIVATED COMPLEX
ACTIVATED COMPLEX
ACTIVATED COMPLEX
ACTIVATED COMPLEX
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