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AFADIN

Afadin

Protein found in humans

Afadin is a protein that in humans is encoded by the AFDN gene. Afadin is a Ras (see HRAS; MIM 190020) target that regulates cell–cell adhesions downstream

Afadin

Poliovirus receptor-related 1

Protein-coding gene in the species Homo sapiens

synapse of neurons. The cytoplasmic tail of PVRL1 can bind the protein afadin which is a scaffolding protein that binds actin. In the chemical synapse

Poliovirus receptor-related 1

Poliovirus_receptor-related_1

SSX2IP

Protein-coding gene in the species Homo sapiens

Afadin- and alpha-actinin-binding protein is a protein that in humans is encoded by the SSX2IP gene. It has been shown that it functions together with

SSX2IP

Poliovirus receptor-related 2

Protein-coding gene in the species Homo sapiens

Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein". J. Cell Biol. 145 (3): 539–49. doi:10

Poliovirus receptor-related 2

Poliovirus_receptor-related_2

PLEKHA7

Protein-coding gene in the species Homo sapiens

Nezha (CAMSAP3) (residues 680-821), paracingulin (residues 620-769) and Afadin (residues 120-374). The protein PDZD11 was identified as a protein interacting

PLEKHA7

SORBS1

Protein-coding gene in the species Homo sapiens

Satoh K, Nishioka H, Mizoguchi A, Takai Y (Mar 1999). "Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens

SORBS1

Parkin (protein)

Mammalian protein found in humans

formation. Similarly, chromosomal breaks in PARK2 suppressed expression of afadin scaffold protein in breast cancer, thereby comprising epithelial integrity

Parkin (protein)

Parkin_(protein)

Nectin-3

Mammalian protein found in Homo sapiens

assosicated adaptor protein afadin which plays role in the formation of variety of cell-cell junctions. Nectin-3γ in not able to bind afadin due to lacking C-terminal

Nectin-3

Vinculin

Mammalian protein found in humans

K, Nishioka H, Mizoguchi A, Takai Y (March 1999). "Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens

Vinculin

Rosselli–Gulienetti syndrome

Medical condition

in keratinocytes and that mutations in PVRL1 may abrogate NAP (nectin, afadin, ponsin)-dependent cell-cell adhesion. It is thought that the genetic transmission

Rosselli–Gulienetti syndrome

Rosselli–Gulienetti_syndrome

Synaptic stabilization

Modifying synaptic strength via cell adhesion molecules

intracellular domain of all nectins directly bind to a protein called L-Afadin. L-Afadin is an actin binding protein that binds to the F-actin of the actin

Synaptic stabilization

Synaptic_stabilization

Actin-binding protein

Class of proteins

Actophorin Acumentin (= L-plastin) Adducin ADF/Cofilin Adseverin (scinderin) Afadin AFAP-110 Affixin Aginactin AIP1 Aldolase Angiogenin Anillin Annexins Aplyronine

Actin-binding protein

Actin-binding_protein

Nectin

Family of cellular adhesion molecules

all nectins the intracellular domain can bind a scaffold protein named afadin (the product of the MLLT4 gene). All nectins and Necls can form homo-cis

Nectin

Alpha-actinin-1

Protein-coding gene in the species Homo sapiens

Yamada A, Ikeda W, Takeuchi M, Takai Y (February 2003). "ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions"

Alpha-actinin-1

Α-Catenin

Primary protein link between cadherins and the actin cytoskeleton

can interact with many different actin-binding proteins (α-actinin, ZO-1, afadin) to remodel cytoskeletal structure. This catenin has also been shown to

Α-Catenin

RASSF9

Protein-coding gene in the species Homo sapiens

RalGDS-RBD through their C-terminal Ras-binding domains (RBD). Such outliers as afadin/AF-6 and Rin1 were found to inhibit the binding of Raf to Ras. Adenylyl

RASSF9