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Protein-coding gene in the species Homo sapiens
receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene. This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim
ARNT2
Semitic-speaking ethnic group in Ethiopia
involvement in high-altitude adaptation in Ethiopia, including CBARA1, VAV3, ARNT2 and THRB. Although most of these genes have not been identified in previous
Amhara_people
Semitic-speaking ethnic group in Ethiopia
under positive selection in northern highlanders include CBARA1, VAV3, ARNT2, and THRB, all of which are associated with HIF‑1 pathways. Interestingly
Tigrayans
Protein-coding gene in the species Homo sapiens
proteins in the superfamily. It functions as an heterodimer by binding ARNT2, another member of the bHLH-PAS superfamily. NPAS3 harbors the largest cluster
NPAS3
adaptation of Ethiopians, including CBARA1, VAV3, ARNT2 and THRB. Two of these genes (THRB and ARNT2) are known to play a role in the HIF-1 pathway, a
High-altitude adaptation in humans
High-altitude_adaptation_in_humans
Protein structural motif
for C or T, R is A or G, M is A or C and K is G or T. AHR; AHRR; ARNT; ARNT2; ARNTL; ARNTL2; ASCL1; ASCL2; ASCL3; ASCL4; ATOH1; ATOH7; ATOH8; BHLHB2;
Basic_helix–loop–helix
Protein that responds to low oxygen
aryl-hydrocarbon receptor nuclear translocator 2 Identifiers Symbol ARNT2 Alt. symbols HIF2B, KIAA0307, bHLHe1 NCBI gene 9915 HGNC 16876 OMIM 606036 RefSeq
Hypoxia-inducible_factor
Known motif – from protein with 100% identical DBD – in vitro [31] KCACGTGM ARNT2 ENSG00000172379 bHLH Known motif – High-throughput in vitro [32] RDCACGTGM
List of human transcription factors
List_of_human_transcription_factors
Protein-coding gene in the species Homo sapiens
helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function". PLOS ONE. 9 (1) e85768. Bibcode:2014PLoSO...985768B.
Neuronal_PAS_domain_protein_4
Organisms capable of living at high altitudes
other genes appear to be involved in Ethiopians, including CBARA1, VAV3, ARNT2 and THRB, which are known to play a role in HIF genetic functions. The EPAS1
Organisms_at_high_altitude
HGNC:19846; Q86TY3 1064 ARMS2 HGNC:32685; P0C7Q2 1065 ARNT HGNC:700; P27540 1066 ARNT2 HGNC:16876; Q9HBZ2 1067 ARPC1A HGNC:703; Q92747 1068 ARPC1B HGNC:704; O15143
List of human protein-coding genes 1
List_of_human_protein-coding_genes_1
American immunologist and geneticist
Russell, Jamie; Beutler, Bruce (December 18, 2018). "A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis". Disease
Bruce_Beutler
American geneticist (born 1965)
different gene candidates underlying adaptation to high altitude (CBARA1, VAV3, ARNT2, and THRB). This study demonstrates another example of convergent evolution
Sarah_Tishkoff
ARNT2
ARNT2
ARNT2
ARNT2
Female
French
French and German form of Irish Gaelic BrÃghid, BRIGITTE means "exalted one."
Boy/Male
Indian, Sanskrit
Virtuous; Divine; To be Pure; Flawless; Happiest
Boy/Male
Hebrew
Lion of God.
Boy/Male
Muslim
Support, Prop
Girl/Female
English
and Kayla, meaning: keeper of the keys; pure.
Boy/Male
Arabic, Muslim
Servant of the Most Generous
Surname or Lastname
English
English : variant spelling of Leaf.Dutch (de Lief) : nickname from lief, ‘dear’, ‘beloved’, with the definite article de.Jewish : unexplained, possibly from the Netherlands, with the same etymology as 2.
Girl/Female
Muslim
Angel
Girl/Female
Muslim
Success
Boy/Male
Muslim
Popularity
ARNT2
ARNT2
ARNT2
ARNT2
ARNT2