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through the blocking of the coinhibitory molecule CTLA-4. The blocking antibody does not directly target tumor cells, but rather blocks the regulatory
Blocking_antibody
Immunologic phenomenon occurring in high antigen or antibody levels
where blocking antibodies can interfere with other antibodies involved in hypersensitivity and thus improve allergy treatment. Blocking antibody Schiettecatte
Hook_effect
Antibodies targeted against the thyroid
activating, blocking and neutral antibodies, depending on their effect on the TSH receptor. Anti-sodium/iodide (Anti–Na+/I−) symporter antibodies are a more
Antithyroid_autoantibodies
Combination medication
It contains pembrolizumab, a programmed death receptor-1 (PD-1) blocking antibody; and berahyaluronidase alfa, a variant of hyaluronidase. It is given
Pembrolizumab/berahyaluronidase alfa
Pembrolizumab/berahyaluronidase_alfa
Type of antibody
Neutralizing antibodies can inhibit infectivity by binding to the pathogen and blocking the molecules needed for cell entry. This can be due to the antibodies statically
Neutralizing_antibody
Combination drug
programmed death receptor-1 (PD-1) blocking antibody, and relatlimab, a lymphocyte activation gene-3 (LAG-3) blocking antibody. It is given by intravenous infusion
Nivolumab/relatlimab
Type of antibody
two antibodies.) Heterophile antibodies may thus give false positives (by bridging the capture and signal antibody) or false negatives (by blocking one
Heterophile_antibody
Antibodies rarely making an infection worse instead of better
Antibody-dependent enhancement (ADE), sometimes less precisely called immune enhancement or disease enhancement, is a phenomenon in which binding of a
Antibody-dependent enhancement
Antibody-dependent_enhancement
Medication
human immunoglobulin G1 (IgG1) programmed death ligand-1 (PD-L1) blocking antibody. The most common adverse reactions include fatigue, musculoskeletal
Cosibelimab
Protein(s) forming a major part of an organism's immune system
directly (for example, by blocking a part of a virus that is essential for its ability to invade a host cell). Antibodies may be borne on the surface
Antibody
Artificial stimulation of the immune system to treat cancer
checkpoint blockade (specifically CTLA-4 blocking antibodies), or a combination of check-point blocking antibodies, are at high risk of having immune-related
Cancer_immunotherapy
Medical condition
also involve other muscle groups (generalized MG). Although these blocking antibodies may be confined to one of the larger muscles responsible for moving
Ocular_myasthenia
Artificial protein
A bispecific monoclonal antibody (BsMAb, BsAb) is an artificial protein that can simultaneously bind to two different types of antigen or two different
Bispecific monoclonal antibody
Bispecific_monoclonal_antibody
Life-threatening allergic reaction
binding to the allergen (i.e., it is a blocking antibody) and its immune complexes (lattices of antigen and antibody, or in this case, allergen and IgG)
Anaphylaxis
Medication
other parts of the body) melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor with or without
Lifileucel
Medication
contains nivolumab, a programmed death receptor-1 (PD-1)–blocking monoclonal antibody; and hyaluronidase, an endoglycosidase. It is given by subcutaneous
Nivolumab/hyaluronidase
Infection following vaccine administration
improper administration or storage of vaccines, mutations in viruses, blocking antibody formation, and other factors. For these reasons, vaccines are rarely
Breakthrough_infection
Analytical technique used in molecular biology
the proteins are blocked with milk (or other blocking agents) to prevent non-specific antibody binding, and then stained with antibodies specific to the
Western_blot
Group of signal transduction pathways involved in embryonic development
PMID 24492943. Gao W, Xu Y, Liu J, Ho M (May 2016). "Epitope mapping by a Wnt-blocking antibody: evidence of the Wnt binding domain in heparan sulfate". Scientific
Wnt_signaling_pathway
Common application of immunostaining
secondary antibody was produced, the background staining can be reduced. It is also possible to use commercially available universal blocking buffers.
Immunohistochemistry
Type of antibody response
which has made transfusion possible and safer. Agglutination-PCR Blocking antibody Coagulation Immune system Macrophage Mannan oligosaccharides (MOS)
Agglutination_(biology)
Antibody found in humans
anti-mouse antibody or human anti-murine antibody (HAMA) is an antibody found in humans which reacts to immunoglobins found in mice. Antibody treatment
Human_anti-mouse_antibody
Monoclonal antibody medication
(March 2005). "Omalizumab: a recombinant humanized monoclonal IgE-blocking antibody". Dermatology Online Journal. 11 (1): 2. doi:10.5070/D30MC9C9TW. PMID 15748543
Omalizumab
Antibodies from clones of the same blood cell
A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent
Monoclonal_antibody
Skin cancer originating in melanocytes
PMID 24912947. "U.S. Food and Drug Administration Approves First LAG-3-Blocking Antibody Combination, Opdualag (nivolumab and relatlimab-rmbw), as Treatment
Melanoma
Autoantibody that binds to contents of the cell nucleus
anti-Ro antibodies, anti-La antibodies, anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies
Antinuclear_antibody
American pharmaceutical company
(megestrol acetate) Opdivo (nivolumab) is a programmed death receptor blocking antibody used for the treatment of unresectable or metastatic melanoma and
Bristol_Myers_Squibb
British pharmaceutical and biotechnology company
formulation of dostarlimab, a programmed death receptor-1 (PD-1) blocking antibody. In February 2026, GlaxoSmithKline announced an agreement to acquire
GSK_plc
Combination of the Oncolytic Immunotherapy Pexa-Vec With the PD-1 Receptor Blocking Antibody Nivolumab in the First-line Treatment of Advanced Hepatocellular Carcinoma
SillaJen
Antibody isotype
(IgG) is a type of antibody. Representing approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found in blood circulation
Immunoglobulin_G
Measure of virus or bacteria concentration
other than virus-specific antibodies can inhibit agglutination between virus and RBCs, as well as potentially blocking antibody from binding to virus. Receptor-destroying
Hemagglutination_assay
Antibodies sensitive to cold temperature
Cold sensitive antibodies (CSA) are antibodies sensitive to cold temperature. Some cold sensitive antibodies are pathological and can lead to blood disorder
Cold_sensitive_antibodies
Form of immunotherapy
Monoclonal antibodies (mAbs) have varied therapeutic uses. It is possible to create a mAb that binds specifically to almost any extracellular target, such
Monoclonal_antibody_therapy
Class of biopharmaceutical drugs
Antibody–drug conjugates or ADCs are a class of bioconjugates and immunoconjugates. ADCs are composed of an antibody linked to a cytotoxic (anticancer)
Antibody–drug_conjugate
Form of cancer immunotherapy
check-point blockade (specifically CTLA-4 blocking antibodies), or a combination of check-point blocking antibodies, are at high risk of suffering from immune-related
Checkpoint_inhibitor
all influenza subtypes. The FI6 antibody makes extensive contact with conserved parts of the stalk, thereby blocking HA from harpooning a sticky fusion
FI6_(antibody)
Antibody fragment
antibody (sdAb), also known as a Nanobody, is an antibody fragment consisting of a single monomeric variable antibody domain. Like a whole antibody,
Single-domain_antibody
Macromolecule
PMID 24492943. Gao W, Xu Y, Liu J, Ho M (May 2016). "Epitope mapping by a Wnt-blocking antibody: evidence of the Wnt binding domain in heparan sulfate". Scientific
Heparan_sulfate
Autoimmune endocrine disease
The exact cause of the disease is unclear, but symptoms are a result of antibodies binding to receptors on the thyroid, causing over-expression of thyroid
Graves'_disease
Aspect of immunity
aspect of immunity that is mediated by macromolecules—including secreted antibodies, complement proteins, and certain antimicrobial peptides—located in extracellular
Humoral_immunity
Healthcare test
competitive blocking profile is created for each antibody relative to the others in the library. Closely related binning profiles indicate that the antibodies have
Epitope_binning
Primary and secondary antibodies are two groups of antibodies that are classified based on whether they bind to antigens or proteins directly or target
Primary and secondary antibodies
Primary_and_secondary_antibodies
Cytokine protein
by exercise in human adults can be reversed by the IL-6 receptor blocking antibody tocilizumab. Together with the findings that IL-6 prevents obesity
Interleukin_6
Overreaction of the immune system to an antigen
monoclonal antibodies lower free IgE and down-regulate FcεRI on mast cells and basophils, decreasing effector cell sensitivity. Alternatively, blocking key type
Hypersensitivity
Protein-coding gene in humans
astrocytoma cells but not normal astrocytes. Additionally, CD47 blocking antibodies inhibit proliferation of unstimulated astrocytoma cells but not normal
CD47
Protein that detects other antibodies
Anti-immunoglobulin antibodies are defined as a protein that detects other antibodies from an organism. Specifically, anti-immunoglobulin antibodies are created
Anti-immunoglobulin
Hypothesis in the treatment of metastatic cancer
throughout the 20th century, the clinical use of immune checkpoint blocking antibodies such as ipilimumab or pembrolizumab has greatly increased the number
Abscopal_effect
Hospital in Florida, United States
unresectable or metastatic melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor with or without
H. Lee Moffitt Cancer Center & Research Institute
H._Lee_Moffitt_Cancer_Center_&_Research_Institute
Inflammation of the pituitary gland due to autoimmune dysfunction
cases of isolated attacks as a result of drug reactions (i.e., use of blocking antibody ipilimumab) or idiopathic events that have presented symptoms which
Autoimmune_hypophysitis
Method to detect an antigen using an antibody and enzyme
matching antibody is applied over the surface so it can bind the antigen. This antibody is linked to an enzyme, and then any unbound antibodies are removed
ELISA
Topics referred to by the same term
Look up blocking in Wiktionary, the free dictionary. Blocking may refer to: Blacklist (computing) Blocking (computing), holding up a task until an event
Blocking
Protein found in humans
rheumatoid arthritis and atherosclerosis. Administration of anti-CCL2 antibodies in a model of glomerulonephritis reduces infiltration of macrophages and
CCL2
Medical condition
largely due to severe insulin resistance, which can be secondary to blocking antibodies against the insulin receptor or genetically absent/reduced insulin
HAIR-AN_syndrome
German biochemist
effective anticoagulant in mice. Building on this, a therapeutic FXIIa-blocking antibody (Garadacimab, CSL Behring) was developed, which has been approved
Bernhard_Nieswandt
Protein-coding gene in the species Homo sapiens
hydrophobic groove that interacts with Wnt3a. Blocking the Wnt binding domain on GPC3 using the HN3 single domain antibody can inhibit Wnt activation. Wnt also
Glypican_3
Therapeutic, diagnostic and preventive monoclonal antibodies are clones of a single parent cell. When used as drugs, the International Nonproprietary Names
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Organ central to the nervous system
the blood–brain barrier, which blocks the passage of many toxins and pathogens (though at the same time blocking antibodies and some drugs, thereby presenting
Brain
Monoclonal antibody
S2CID 245407697. "U.S. Food and Drug Administration Approves First LAG-3-Blocking Antibody Combination, Opdualag (nivolumab and relatlimab-rmbw), as Treatment
Relatlimab
therapy Autophagy Beta-2 microglobulin Binding antibody Biological response modifiers Blocking antibody Blotto (biology) BNAber Body odor Bone marrow-derived
Index_of_immunology_articles
Protein-coding gene in the species Homo sapiens
ISBN 978-0-387-89519-2. PMID 19760066. "Development of a first in class APRIL fully blocking antibody BION-1301 for the treatment of multiple myeloma". AACR 2017 Proceedings
APRIL_(protein)
Chemical compound
attachment structure to the antibody. Monomethyl auristatin F is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin
Monomethyl_auristatin_F
Broadly neutralizing HIV-1 antibodies (bNAbs) are neutralizing antibodies which neutralize multiple HIV-1 viral strains. bNAbs are unique in that they
Broadly neutralizing HIV-1 antibodies
Broadly_neutralizing_HIV-1_antibodies
Immunoglobulin E (IgE) Antibody
Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isoform") that has been found only in mammals. IgE is synthesised by plasma cells
Immunoglobulin_E
Protein-coding gene in the species Homo sapiens
expansion in vivo. Treatment of PTPN22-deficient mice with an anti-GITR-L blocking antibody suppresses the expansion of Treg cells. PTPN22 deficiency does not
PTPN22
Antibody directed against an autogenic protein
An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins
Autoantibody
Monoclonal antibody
"Inhibition of plasma kallikrein by a highly specific active site blocking antibody". The Journal of Biological Chemistry. 289 (34): 23596–23608. doi:10
Lanadelumab
of determining the efficacy of the programmed cell death-ligand 1 blocking antibody, durvalumab, with and following concurrent chemoradiotherapy versus
Bradley_J._Monk
Type of anti-nuclear autoantibodies
Sjögren's disease. In clinical tests for autoimmune disease, Anti-Ro antibodies are some of the most consistently and frequently detected among autoantibodies
Anti-SSA/Ro_autoantibodies
Monoclonal antibody
European Union in January 2022. Eptinezumab is a fully human monoclonal antibody, blocking the calcitonin gene-related peptide (CGRP) from binding its receptor
Eptinezumab
Afucosylated monoclonal antibodies are monoclonal antibodies engineered so that the oligosaccharides in the Fc region of the antibody do not have any fucose
Afucosylated monoclonal antibodies
Afucosylated_monoclonal_antibodies
Monoclonal antibody
under the brand name Darzalex among others, is an anti-cancer monoclonal antibody medication. It binds to CD38, which is overexpressed in multiple myeloma
Daratumumab
Medical condition
of B-cell epitopes from the allergen Hev b 6.02 revealed by using blocking antibodies". Molecular Immunology. 46 (4): 668–76. doi:10.1016/j.molimm.2008
Latex_allergy
Autoimmune disease resulting in skeletal muscle weakness
autoimmune disease of the neuromuscular junction which results from antibodies that block or destroy nicotinic acetylcholine receptors (AChR) at the junction
Myasthenia_gravis
Chemical compound
agent which inhibits cell division by blocking the polymerisation of tubulin. The linker to the monoclonal antibody is stable in extracellular fluid, but
Monomethyl_auristatin_E
Medication for endometrial cancer treatment
monoclonal antibody used as an anti-cancer medication for the treatment of endometrial cancer. Dostarlimab is a programmed death receptor-1 (PD-1)–blocking monoclonal
Dostarlimab
Human and animal disease
another drawback. False-negative SAT may be caused by the presence of blocking antibodies (the prozone phenomenon) in the α2-globulin (IgA) and in the α-globulin
Brucellosis
Type of immunoglobulin molecule
Polyclonal antibodies (pAbs) are antibodies that are secreted by different B cell lineages within the body (whereas monoclonal antibodies come from a single
Polyclonal_antibodies
Class of drugs
inflammation, pain, and swelling in the case of migraine. Several monoclonal antibodies that bind to the CGRP receptor or peptide have been approved for prevention
Calcitonin gene-related peptide receptor antagonist
Calcitonin_gene-related_peptide_receptor_antagonist
Combination of the Oncolytic Immunotherapy Pexa-Vec With the PD-1 Receptor Blocking Antibody Nivolumab in the First-line Treatment of Advanced Hepatocellular Carcinoma"
Pexastimogene_devacirepvec
Chemical compound
Imaavy, is a monoclonal antibody used for the treatment of generalized myasthenia gravis. It is a neonatal Fc receptor blocker. It is a high affinity,
Nipocalimab
Medication used for the treatment of gastro-intestinal diseases
Vedolizumab, sold under the brand name Entyvio, is a monoclonal antibody medication developed by Takeda Oncology for the treatment of ulcerative colitis
Vedolizumab
Monoclonal antibody
humanized monoclonal antibody used for the treatment of prurigo nodularis and atopic dermatitis. It is a monoclonal antibody that blocks the interleukin-31
Nemolizumab
Protein family
Liu, Jian; Ho, Mitchell (May 17, 2016). "Epitope mapping by a Wnt-blocking antibody: evidence of the Wnt binding domain in heparan sulfate". Scientific
Glypican
Drugs to suppress IL-6 signalling
first approved medication in this class, tocilizumab (Actemra), is an antibody directed against the IL6-receptor. The second, siltuximab (Sylvant), is
Anti-interleukin-6
Antibodies that react to self-gangliosides
Antiganglioside antibodies that react to self-gangliosides are found in autoimmune neuropathies. These antibodies were first found to react with cerebellar
Antiganglioside_antibodies
Protein family
numerous ion channel-blocking peptides. In 1995, a group led by Olga Castaneda and Evert Karlsson isolated ShK, a potassium channel-blocking 35-residue peptide
Stichodactyla_toxin
Medication for macular degeneration
under the brand name Vabysmo (/vəˈbaɪzmoʊ/ və-BYEZ-mow), is a monoclonal antibody used for the treatment of neovascular age-related macular degeneration
Faricimab
Monoclonal antibody medication
is a monoclonal antibody used for the treatment of myasthenia gravis. Rozanolixizumab is a humanized and chimeric monoclonal antibody; and is a neonatal
Rozanolixizumab
Surface protein important to the immune system
cytotoxic cells to destroy microbes, or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity. Some viruses such
Fc_receptor
Medication
Sugemalimab, sold under the brand name Cejemly among others, is a monoclonal antibody used for the treatment of metastatic non-small cell lung cancer (NSCLC)
Sugemalimab
Medication
is a monoclonal antibody conjugate medication used to treat large B-cell lymphoma and high-grade B-cell lymphoma. It is an antibody-drug conjugate (ADC)
Loncastuximab_tesirine
Pharmaceutical drug
disease. It is a chimeric (made from human and mouse proteins) monoclonal antibody that binds to interleukin-6. It is an interleukin-6 (IL-6) antagonist.
Siltuximab
Mammalian protein found in humans
expression in T cells, NK cells, and macrophages. PD-L1 blockade (using blocking antibodies) resulted in increased mortality for infected mice. Blockade reduced
PD-L1
Cells that ingest harmful matter within the body
proteins to block engulfment. Some proteins hinder opsonin-related ingestion; Staphylococcus aureus produces Protein A to block antibody receptors, which
Phagocyte
framework region is a subdivision of the variable region (Fab) of the antibody. The variable region is composed of seven amino acid regions, four of which
Framework_region
Monoclonal antibody
Galcanezumab, sold under the brand name Emgality, is a humanized monoclonal antibody used for the prevention of migraine. It is also used for the treatment
Galcanezumab
Monoclonal antibody
is a monoclonal antibody, which is being developed for the treatment of type 1 diabetes and other autoimmune diseases. The antibody is being developed
Otelixizumab
Antibody-based immunotherapy
Oligoclonal antibodies are an emerging immunological treatment relying on the combinatory use of several monoclonal antibodies (mAb) in one single drug
Oligoclonal_antibody
Medication
carcinoma. Retifanlimab is a programmed death receptor-1 (PD-1)–blocking monoclonal antibody. It was approved for medical use in the United States in March
Retifanlimab
Experimental antibody treatment for COVID-19
respiratory tract of monkeys. The Blocking Viral Attachment and Cell Entry with SARS-CoV-2 Neutralizing Antibodies (BLAZE-1) trial was sponsored by the
Bamlanivimab
BLOCKING ANTIBODY
BLOCKING ANTIBODY
Surname or Lastname
English (chiefly Devon)
English (chiefly Devon) : from a Middle English pet form of the Old English personal name Hocca.Dutch : patronymic from Hock 4.
Girl/Female
Gujarati, Hindu, Indian
Blooming
Surname or Lastname
English
English : variant of Brookins. This is the most frequent form of the surname in the British Isles.
Boy/Male
Indian
Blooming
Surname or Lastname
English
English : from Old English LÄ“ofecing, a patronymic from LÄ“ofeca (see Levick 2), or possibly, as Reaney suggests, a late derivative of Lovekin (see Lucken).
Girl/Female
Latin Spanish Italian
Blooming.
Girl/Female
Gujarati, Hindu, Indian
Blooming
Girl/Female
Latin
Blooming.
Boy/Male
Spanish
Blooming.
Boy/Male
Muslim
Blooming
Girl/Female
Latin
Blooming.
Surname or Lastname
English
English : from a diminutive of Middle English cok ‘cock’ (see Cocke).
Boy/Male
Hindu
Blooming
Boy/Male
Spanish
Blooming.
Boy/Male
Tamil
Blooming
Girl/Female
Spanish
Blooming.
Surname or Lastname
English
English : topographic name from Middle English stocking ‘ground cleared of stumps’.South German : habitational name from any of several places in Bavaria and Styria named Stocking.
Boy/Male
Tamil
Blooming
Girl/Female
Latin Italian
Blooming.
Girl/Female
Latin
Blooming.
BLOCKING ANTIBODY
BLOCKING ANTIBODY
Boy/Male
American, Australian, British, English
Cheerful
Girl/Female
Greek Russian
Rainbow.
Boy/Male
French
Gray-haired.
Girl/Female
English American
Bright wood; bright meadow; from the white meadow. Famous Bearers: child star Shirley Temple.
Boy/Male
German
Dominant Ruler
Boy/Male
Arabic
Generous
Boy/Male
Hindu, Indian
Knowledge of Veda's
Girl/Female
Indian, Punjabi, Sikh
Immovable
Female
English
Latin form of Severn, the name of a river in England where a Celtic goddess dwelt. The Old Welsh form of Severn is Habren. The name is of uncertain origin, possibly from Hebrew Sabra, the name for a native-born Israeli, SABRINA means "thorny cactus."Â
Girl/Female
Gujarati, Hindu, Indian
Goddess
BLOCKING ANTIBODY
BLOCKING ANTIBODY
BLOCKING ANTIBODY
BLOCKING ANTIBODY
BLOCKING ANTIBODY
n.
The act or process of making black.
n.
A mirror made of glass on which has been placed a backing of some reflecting substance, as quicksilver.
n.
Blotting paper.
p. pr. & vb. n.
of Black
n.
A projection on the bolt, which passes through the tumbler gates in locking and unlocking.
n.
The act of obstructing, supporting, shaping, or stamping with a block or blocks.
n.
Blocks used to support (a building, etc.) temporarily.
p. pr. & vb. n.
of Flock
a.
Having a certain look or appearance; -- often compounded with adjectives; as, good-looking, grand-looking, etc.
a.
Hateful; shocking.
a.
Having a swaying, rolling, or back-and-forth movement; used for rocking.
p. pr. & vb. n.
of Block
n.
Any preparation for making things black; esp. one for giving a black luster to boots and shoes, or to stoves.
a.
Looking on or forward.
a.
Blooming in the night.
n.
A coarse woolen fabric, used for floor cloths, to cover carpets, etc.; -- so called from the town of Bocking, in England, where it was first made.
v. t.
Looking behind; looking backward watchfully.