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Complement control proteins are proteins that interact with components of the complement system. The complement system is tightly regulated by a network
Complement_control_protein
Part of the immune system that enhances the ability of antibodies and phagocytic cells
membrane attack complex. About 50 proteins and protein fragments make up the complement system, including plasma proteins, and cell membrane receptors. They
Complement_system
Protein found in humans
regulators of complement activation (RCA) family. It functions as a complement control protein and plays a critical role in regulating the complement system
Factor_H
Protein found in humans
Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1
Complement_receptor_1
Mammalian protein found in humans
C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentration rises in response to inflammation
C-reactive_protein
Biological term
complement activation through its binding to a complement control protein, factor H. As a result, complement recognition of infected cells is reduced, and
Viral_protein
Topics referred to by the same term
(SCR) or complement control protein (CCP) repeat Signal Corps Radio or Set, Complete, Radio, U.S. Army Signal Corps designation Silicon controlled rectifier
SCR
Topics referred to by the same term
Familial hypercholesterolemia, a genetic disorder Factor H, a complement control protein Family history FH, a gene that encodes the enzyme fumarase Ferrihydrite
FH
Protein family
1988). "Antiphagocytic activity of streptococcal M protein: Selective binding of complement control protein Factor H". Proceedings of the National Academy
M_protein_(Streptococcus)
Topics referred to by the same term
events that takes place in a cell Complement control protein, proteins that interact with components of the complement system Context change potential,
CCP_(disambiguation)
Type of cascade reaction of the complement system
pathway is one of three complement pathways that opsonize and kill pathogens. The pathway is triggered when the C3b protein directly binds a microbe
Alternative complement pathway
Alternative_complement_pathway
Class of serine proteases
at the site of complement activation. After cleavage and binding to cell surface, the C3b fragment is ready to bind a plasma protein called Factor B
C3-convertase
Protein involved in the immune system
Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system
Complement_component_4
Technology used to validate protein interactions
Bimolecular fluorescence complementation (also known as BiFC) is a technology typically used to validate protein interactions. It is based on the association
Bimolecular fluorescence complementation
Bimolecular_fluorescence_complementation
Protein domain
Sushi domain is an evolutionarily conserved protein domain. It is also known as complement control protein (CCP) modules or short consensus repeats (SCR)
Sushi_domain
Biomolecule consisting of chains of amino acid residues
into proteins, using modified tRNAs, and may allow the rational design of new proteins with novel properties. The total complement of proteins present
Protein
Aspect of the immune system
and death. The classical complement pathway can also be activated by apoptotic cells, necrotic cells, and acute phase proteins. The classical pathway is
Classical_complement_pathway
Mammalian protein found in Homo sapiens
membrane protein that attaches to the cell membrane via a glycophosphatidylinositol (GPI) anchor. DAF contains four complement control protein (CCP) repeats
Decay-accelerating_factor
Class of proteins involved in inflammation
destroy or inhibit growth of microbes, e.g., C-reactive protein, mannose-binding protein, complement factors, ferritin, ceruloplasmin, serum amyloid A and
Acute-phase_protein
Topics referred to by the same term
Hoiberg, Iowa State University men's basketball coach Complement Factor H, a complement control protein NHS Connecting for Health, The UK Agency delivering
CFH
Genetic disease causing anemia, birth defects, and cancers
be phosphorylated by protein complex ATM/ATR activated by double-strand DNA breaks and takes part in S-phase checkpoint control. This pathway was proven
Fanconi_anemia
Extracellular matrix protein
proteins, including an amino-terminal NIDO domain, several calcium binding EGF-like domains (EGF_CA), a Sushi domain also known as complement control
SNED1
Large group of transport proteins
membrane attack complex (MAC) proteins of the complement system (C6, C7, C8α, C8β and C9) and perforin (PF). Members of this protein family are pore-forming
MACPF
Proteins present in blood serum
activity and functioning of the immune system. Other blood proteins act as enzymes, complement, components, protease inhibitors or kinin precursors. Contrary
Plasma_protein
Type of cascade reaction in the complement system
C4 and C2 to produce activated complement proteins further down the cascade. In contrast to the classical complement pathway, the lectin pathway does
Lectin_pathway
C3a is one of the proteins formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue anaphylatoxin that binds to the C3a
C3a_(complement)
Mammalian protein found in humans
to the serpin superfamily. Its main function is the inhibition of the complement system (C1r, C1s) to prevent spontaneous activation but also as the major
C1-inhibitor
Mammalian protein found in Homo sapiens
to activate the complement system when MBL binds to its target (for example, mannose on the surface of a bacterium), the MASP protein functions to cleave
Mannan-binding_lectin
Protein-coding gene in the species Homo sapiens
of the complement system and is responsible for activating MASP-2 and MASP-3. It is also involved in the process of cleaving complement proteins, C4 and
MASP1
Protein
Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. Complement factor I (factor I) is a protein
Complement_factor_I
British protein biochemist, immunologist, and academic
Simon J. Clark is a British protein biochemist, immunologist, and academic, most known for the study of the complement system. He is the holder of the
Simon_J._Clark
Medical condition
instigates activation of the entire complement pathway. Consequently, levels of all complement proteins become low. The complement pathway is composed of several
Urticarial_vasculitis
Key component of arthropod innate immune system
gambiae mosquitoes. TEP1 is an antimicrobial protein which acts in a system reminiscent of the human complement pathway, which damages the cell membranes
Thioester-containing protein 1
Thioester-containing_protein_1
Protein-coding gene in humans
analogy to other proteins that contain Sushi domains, it is believed that the gene product of CSMD1 functions as a Complement control protein. It is a potential
CSMD1
resemble cytokines, growth factors, or complement regulators; the term viroceptor is sometimes used if the proteins resemble cellular receptors. A third
Virokine
Sequence of DNA that determines traits in an organism
during protein translation between codons and amino acids. The genetic code is nearly the same for all known organisms. The total complement of genes
Gene
Serine protease that plays key role in innate immunity
participates in the complement system ending with cell death. There are four different C5 convertases able to specifically convert the protein C5 to C5a and
C5-convertase
Topics referred to by the same term
dictionary. C4S may refer to: C4S (gene), a gene variant for encoding the protein complement component 4 Clips4Sale, adult video site SAP Cloud for Services (C4S)
C4S
Protein-coding gene in the species Homo sapiens
Gamma-aminobutyric acid B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene. GABAB1 is a receptor for Gamma-aminobutyric
GABBR1
Protein found in humans
Complement component 6 is a protein that in humans is encoded by the C6 gene. Complement component 6 is a protein involved in the complement system. It
Complement_component_6
Immunity strategy in living beings
epithelial barrier, soluble plasma proteins called complement proteins become activated (proteins C1-C9). These complement proteins trigger a cascade of reactions
Innate_immune_system
Protein-coding gene in the species Homo sapiens
The complement component 1, q subcomponent-like 1 (or C1QL1) is encoded by a gene located at chromosome 17q21.31. It is a secreted protein and is 258 amino
C1QL1
Species of bacterium that can cause meningitis
H binding protein (fHbp) that is exhibited in N. meningitidis and some commensal species is the main inhibitor of the alternative complement pathway. fHbp
Neisseria_meningitidis
Enzyme that cleaves other proteins into smaller peptides
of complement and kinins. This group includes the calpains. Basic proteases (or alkaline proteases) Proteases are involved in digesting long protein chains
Protease
Change of a linear protein chain to a 3D structure
Protein folding is the physical process by which a protein, after synthesis by a ribosome as a linear chain of amino acids, changes from an unstable random
Protein_folding
Medical condition
and physical inactivity. Protein S circulates in human plasma in two forms: approximately 60 percent is bound to complement component C4b β-chain while
Protein_S_deficiency
Enzyme that adds phosphate groups to other proteins
A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases
Protein_kinase
Physical interactions and constructions between multiple proteins
Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical
Protein–protein_interaction
Biochemical process
the first crystal structure of a protein containing this type of glycosylation was determined—that of human complement component 8. Currently it is established
Glycosylation
Vision loss due to damage to the macula of the eye
Complement factor B/complement component 2 (CFB/CC2) on chromosome 6 at 6p21.3[citation needed] Polymorphisms in genes for complement system proteins:
Macular_degeneration
Protein found in humans
a protein that in humans is encoded by the CLU gene on chromosome 8. CLU is an extracellular molecular chaperone which binds to misfolded proteins in
Clusterin
Life-threatening immune-related blood disease
The complement system activation may be due to mutations in the complement regulatory proteins (factor H, factor I, or membrane cofactor protein (CD46))
Atypical hemolytic uremic syndrome
Atypical_hemolytic_uremic_syndrome
Biological system protecting an organism against disease
sequential proteolytic activation of complement molecules, which are also proteases. After complement proteins initially bind to the microbe, they activate
Immune_system
Blood disease in which red blood cells are attacked by the immune system
complement system, a part of the body's innate immune system. This destructive process occurs due to deficiency of the red blood cell surface protein
Paroxysmal nocturnal hemoglobinuria
Paroxysmal_nocturnal_hemoglobinuria
Protein-coding gene in the species Homo sapiens
DNA repair protein complementing XP-A cells (or XPA) is a protein that in humans is encoded by the XPA gene. Nucleotide excision repair (NER) is a major
XPA
Species of bacteria
least seven plasminogen binding proteins for interference of factor H at the activation level. This is part of a complement system evasion strategy that
Borrelia_burgdorferi
Mammalian protein found in Homo sapiens
C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a.
C5a_receptor
Family of enzymes
; Martinez, R.; Hunter, T.; Sudarsanam, S. (2002-12-06). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–1934. Bibcode:2002Sci
Protein_kinase_A
Protein that exhibits bright green fluorescence when exposed to ultraviolet light
The green fluorescent protein (GFP) is a protein that exhibits green fluorescence when exposed to light in the blue to ultraviolet range. The label GFP
Green_fluorescent_protein
Explanation of the flow of genetic information within a biological system
transcribed to RNA, its complement is paired to it. DNA codes are transferred to RNA codes in a complementary fashion. The encoding of proteins is done in groups
Central dogma of molecular biology
Central_dogma_of_molecular_biology
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors
G_protein-coupled_receptor
Class of enzymes
Protein phosphorylation is one of the most common forms of reversible protein posttranslational modification (PTM), with up to 30% of all proteins being
Protein_phosphatase
Protein domain
prototypical modular protein-protein interaction domain, in that it allows for the transmission of signals controlling a variety of intracellular functions
SH2_domain
Mammalian protein found in Homo sapiens
ten, and eleven cysteine-rich complement-type repeats, respectively. These repeats bind extracellular matrix proteins, growth factors, proteases, protease
LRP1
Database on Schizosaccharomyces pombe
regarding when specific genes are expressed Complementation data for where there is functional complementation between a fission yeast gene and a gene from
PomBase
P38 mitogen-activated protein kinases
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
Medical condition
role of C1-INH is to regulate and control the activities of the complement cascade, such that complement proteins remain in check and do not lead to
Acquired C1 esterase inhibitor deficiency
Acquired_C1_esterase_inhibitor_deficiency
Protein-coding gene in the species Homo sapiens
region. The protein encoded by this gene is a nuclear protein. It has been implicated in the control of apoptosis and regulating heat shock protein. There
Large proline-rich protein BAG6
Large_proline-rich_protein_BAG6
Species of flavivirus causing West Nile fever
(2006-12-12). "West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H". Proceedings of the National
West_Nile_virus
Species of virus
two proteins (p33 and p92), a capsid protein (called CP or p41), and two additional proteins, the RNA silencing suppressor p19 and movement protein p22
Tomato_bushy_stunt_virus
Mammalian protein found in humans
(August 2004). "Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals"
MTOR
Autoimmune vascular inflammatory disease
demonstrates IgA and C3 (a protein of the complement system) in the blood vessel wall. However, overall serum complement levels are normal. On the basis
Henoch–Schönlein_purpura
Topics referred to by the same term
cdc25 Cdc42, cell-division cycle protein Cholesterol-dependent cytolysin, exotoxins secreted by bacteria Complement-dependent cytotoxicity Conventional
CDC_(disambiguation)
Breakdown of proteins into smaller polypeptides or amino acids
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Protein degradation is a major regulatory mechanism of gene expression
Proteolysis
Autoimmune disease in which the immune system attacks healthy tissue
complement component 4 genes, C4A and C4B. (The C4A and C4B genes code, respectively, for complement component A and complement component B proteins.
Lupus
Protein-coding gene in humans
CD5 antigen-like is a protein (also known as AIM, for apoptosis inhibitor of macrophage) that in humans is encoded by the CD5L gene. It is expressed by
CD5L
Diet in which people decrease their intake of protein
quality, protein only needs to come from a wide variety of foods; there is neither a need to mix animal and plant food together nor a need to complement specific
Low-protein_diet
RNA family
of the mRNA. sbi protein interferes with the host's innate immune response by binding Factor H, Complement component 3 and IgG. Protein A SprX Chabelskaya
SprD
Protein tag
splitFAST (2019), a complementation system for protein-protein interaction monitoring, and CATCHFIRE (2023), a self-reporting protein dimerizing system
Fluorescence-activating and absorption-shifting tag
Fluorescence-activating_and_absorption-shifting_tag
Genome regions affecting protein levels
Protein quantitative trait loci (pQTL) are regions in the genome associated with variation in protein expression levels. Since proteins are the primary
Protein quantitative trait loci
Protein_quantitative_trait_loci
Protein family
the resistance against attack by the human complement system a Bacteriophage lambda outer membrane protein, Lom OspA/B are lipoproteins from Borrelia
Virulence-related outer membrane protein family
Virulence-related_outer_membrane_protein_family
Species of bacterium
inhibits opsonization by the alternative complement pathway by binding to host complement regulators. The M protein found on some serotypes is also able to
Streptococcus_pyogenes
Protein-coding gene in the species Homo sapiens
Fanconi anaemia, complementation group A, also known as FAA, FACA and FANCA, is a protein which in humans is encoded by the FANCA gene. It belongs to the
FANCA
Virus of the herpes family
membrane, allowing EBV to enter the B cell. Human CD35, also known as complement receptor 1 (CR1), is an additional attachment factor for gp350 / 220,
Epstein–Barr_virus
Chemical compound
a urine protein-to-creatinine ratio ≥1.5 g/g; for the treatment of adults with complement 3 glomerulopathy, to reduce proteinuria. Complement 3 glomerulopathy
Iptacopan
Medical condition
gastrointestinal manifestation. It is caused by a deficit of the complement protein, C5; however, case reports have described it in relation to deficits
Leiner's_disease
Causes of tick-borne disease
on such a role for the protein. OspC attaches to the tick salivary protein Salp15, which protects the spirochete from complement and impairs the function
Microbiology_of_Lyme_disease
Biological process
adenosine diphosphate (ADP), and the levels of protein DnaA. All these control the binding of initiator proteins to the origin sequences. Because E. coli methylates
DNA_replication
Cellular process of protein synthesis
sequence of the encoded protein on paper. First, convert each template DNA base to its RNA complement (note that the complement of A is now U), as shown
Translation_(biology)
Mammalian protein found in Homo sapiens
CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in
Cyclin-dependent_kinase_1
Cell surface proteins, part of the acquired immune system
Class III molecules include several secreted proteins with immune functions: components of the complement system (such as C2, C4, and B factor), cytokines
Major histocompatibility complex
Major_histocompatibility_complex
Protein found in humans
subunit 2 X-ray repair complementing defective repair in Chinese hamster cells 5 X-ray repair cross-complementing 5 (XRCC5) The protein expression level of
Ku80
Antibody isotype
itself; IgG activates the classical pathway of the complement system, a cascade of immune protein production that results in pathogen elimination; IgG
Immunoglobulin_G
(HP1 Holin) Family (TC# 1.E.7 ) is a member of the Holin Superfamily II. Proteins in this family are typically found to contain two transmembrane segments
HP1_holin_family
Disease of blood and kidneys after bacterial infection
genes for several complement regulatory proteins. Later, mutations in complement factor H, complement factor I, membrane cofactor protein, factor B, C3,
Hemolytic–uremic_syndrome
Merging of two or more mitochondria within a cell to form a single compartment
are understood by the way in which these proteins regulate and bind to each other. These GTPases in control of mitochondrial fusion are well conserved
Mitochondrial_fusion
Protein domain
Ku is a dimeric protein complex that binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair
Ku_(protein)
Variant surface glycoprotein (VSG) is a ~60kDa protein which densely packs the cell surface of protozoan parasites belonging to the genus Trypanosoma
Variant_surface_glycoprotein
Protein
DnaA is a protein that activates initiation of DNA replication in bacteria. Based on the Replicon Model, a positively active initiator molecule contacts
DnaA
Protein found in humans
DNA repair protein XRCC4 (hXRCC4) also known as X-ray repair cross-complementing protein 4 is a protein that in humans is encoded by the XRCC4 gene. XRCC4
DNA_repair_protein_XRCC4
COMPLEMENT CONTROL-PROTEIN
COMPLEMENT CONTROL-PROTEIN
Boy/Male
Hindu, Indian
Control
Boy/Male
Hindu
Check, Control
Boy/Male
Gujarati, Hindu, Indian
Self Control
Boy/Male
Indian, Sanskrit
Control of the Senses; Self-control
Boy/Male
Indian
Control; Patient
Boy/Male
Muslim
Compliments, Happiness
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Anglo Saxon
Competent.
Boy/Male
Hindi
Competent.
Boy/Male
Tamil
Check, Control
Boy/Male
Indian, Sanskrit
Competent
Boy/Male
Muslim
Competent
Girl/Female
Indian
Competent.
Boy/Male
Italian Spanish
Mountain. Abbreviation of Montague and Montgomery.
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Hindu, Indian, Sanskrit
Under Control
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Hindu, Indian, Sanskrit
Agree; Control
Girl/Female
Indian
Competent
COMPLEMENT CONTROL-PROTEIN
COMPLEMENT CONTROL-PROTEIN
Girl/Female
Hindu
Goddess Laxmi, Consort of Lord Krishna
Girl/Female
Muslim/Islamic
Sweet joy, fortunate
Boy/Male
Arabic, German, Muslim
Shining
Biblical
Hardness; soreness
Boy/Male
Tamil
God of Yoga (Lord Shiva), One who practices Yoga
Boy/Male
Native American
Setting sun.
Girl/Female
Indian
Moon's Light
Surname or Lastname
English
English : patronymic from the personal name Dodde (see Dodd).
Girl/Female
Arabic, Muslim, Sindhi
Well-built; Attractive
Boy/Male
Muslim
Awf guest, Fragrance, Lion
COMPLEMENT CONTROL-PROTEIN
COMPLEMENT CONTROL-PROTEIN
COMPLEMENT CONTROL-PROTEIN
COMPLEMENT CONTROL-PROTEIN
COMPLEMENT CONTROL-PROTEIN
imp. & p. p.
of Control
n.
Control of one's self; restraint exercised over one's self; self-command.
v. t.
To praise, flatter, or gratify, by expressions of approbation, respect, or congratulation; to make or pay a compliment to.
v. t.
A compliment.
n.
Rule; dominion; control.
p. pr. & vb. n.
of Control
v. t.
To exercise restraining or governing influence over; to check; to counteract; to restrain; to regulate; to govern; to overpower.
n.
That which serves to check, restrain, or hinder; restraint.
n.
Control over one's own feelings, temper, etc.; self-control.
a.
Self-satisfied; contented; kindly; as, a complacent temper; a complacent smile.
n. & v.
See Control.
v. t.
To compliment.
v. t.
The interval wanting to complete the octave; -- the fourth is the complement of the fifth, the sixth of the third.
n.
A duplicate book, register, or account, kept to correct or check another account or register; a counter register.
n.
Power or authority to check or restrain; restraining or regulating influence; superintendence; government; as, children should be under parental control.
v. t.
To provide with an implement or implements; to cause to be fulfilled, satisfied, or carried out, by means of an implement or implements.
v. t.
To check by a counter register or duplicate account; to prove by counter statements; to confute.
v. i.
To pass compliments; to use conventional expressions of respect.
n.
Authority; jurisdiction; control.
n.
An expression, by word or act, of approbation, regard, confidence, civility, or admiration; a flattering speech or attention; a ceremonious greeting; as, to send one's compliments to a friend.