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Complement control proteins are proteins that interact with components of the complement system. The complement system is tightly regulated by a network
Complement_control_protein
Part of the immune system that enhances the ability of antibodies and phagocytic cells
membrane attack complex. About 50 proteins and protein fragments make up the complement system, including plasma proteins, and cell membrane receptors. They
Complement_system
Protein found in humans
regulators of complement activation (RCA) family. It functions as a complement control protein and plays a critical role in regulating the complement system
Factor_H
Extracellular matrix protein
proteins, including an amino-terminal NIDO domain, several calcium binding EGF-like domains (EGF_CA), a Sushi domain also known as complement control
SNED1
Mammalian protein found in humans
C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentration rises in response to inflammation
C-reactive_protein
Topics referred to by the same term
Familial hypercholesterolemia, a genetic disorder Factor H, a complement control protein Family history FH, a gene that encodes the enzyme fumarase Ferrihydrite
FH
Topics referred to by the same term
(SCR) or complement control protein (CCP) repeat Signal Corps Radio or Set, Complete, Radio, U.S. Army Signal Corps designation Silicon controlled rectifier
SCR
Protein domain
Sushi domain is an evolutionarily conserved protein domain. It is also known as complement control protein (CCP) modules or short consensus repeats (SCR)
Sushi_domain
Protein found in humans
Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1
Complement_receptor_1
Topics referred to by the same term
events that takes place in a cell Complement control protein, proteins that interact with components of the complement system Context change potential,
CCP_(disambiguation)
Type of cascade reaction of the complement system
pathway is one of three complement pathways that opsonize and kill pathogens. The pathway is triggered when the C3b protein directly binds a microbe
Alternative complement pathway
Alternative_complement_pathway
Class of serine proteases
at the site of complement activation. After cleavage and binding to cell surface, the C3b fragment is ready to bind a plasma protein called Factor B
C3-convertase
Protein family
1988). "Antiphagocytic activity of streptococcal M protein: Selective binding of complement control protein Factor H". Proceedings of the National Academy
M_protein_(Streptococcus)
Topics referred to by the same term
Hoiberg, Iowa State University men's basketball coach Complement Factor H, a complement control protein NHS Connecting for Health, The UK Agency delivering
CFH
Biological term
complement activation through its binding to a complement control protein, factor H. As a result, complement recognition of infected cells is reduced, and
Viral_protein
Aspect of the immune system
and death. The classical complement pathway can also be activated by apoptotic cells, necrotic cells, and acute phase proteins. The classical pathway is
Classical_complement_pathway
Mammalian protein found in humans
membrane protein that attaches to the cell membrane via a glycophosphatidylinositol (GPI) anchor. DAF contains four complement control protein (CCP) repeats
Decay-accelerating_factor
Genetic disease causing anemia, birth defects, and cancers
be phosphorylated by protein complex ATM/ATR activated by double-strand DNA breaks and takes part in S-phase checkpoint control. This pathway was proven
Fanconi_anemia
Proteins present in blood serum
activity and functioning of the immune system. Other blood proteins act as enzymes, complement, components, protease inhibitors or kinin precursors. Contrary
Plasma_protein
Class of proteins involved in inflammation
destroy or inhibit growth of microbes, e.g., C-reactive protein, mannose-binding protein, complement factors, ferritin, ceruloplasmin, serum amyloid A and
Acute-phase_protein
Technology used to validate protein interactions
Bimolecular fluorescence complementation (also known as BiFC) is a technology typically used to validate protein interactions. It is based on the association
Bimolecular fluorescence complementation
Bimolecular_fluorescence_complementation
Protein-coding gene in the species Homo sapiens
of the complement system and is responsible for activating MASP-2 and MASP-3. It is also involved in the process of cleaving complement proteins, C4 and
MASP1
Protein involved in the immune system
Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system
Complement_component_4
C3a is one of the proteins formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue anaphylatoxin that binds to the C3a
C3a_(complement)
Biomolecule consisting of chains of amino acid residues
into proteins, using modified tRNAs, and may allow the rational design of new proteins with novel properties. The total complement of proteins present
Protein
Type of cascade reaction in the complement system
C4 and C2 to produce activated complement proteins further down the cascade. In contrast to the classical complement pathway, the lectin pathway does
Lectin_pathway
Medical condition
instigates activation of the entire complement pathway. Consequently, levels of all complement proteins become low. The complement pathway is composed of several
Urticarial_vasculitis
British protein biochemist, immunologist, and academic
Simon J. Clark is a British protein biochemist, immunologist, and academic, most known for the study of the complement system. He is the holder of the
Simon_J._Clark
Topics referred to by the same term
dictionary. C4S may refer to: C4S (gene), a gene variant for encoding the protein complement component 4 Clips4Sale, adult video site SAP Cloud for Services (C4S)
C4S
Key component of arthropod innate immune system
gambiae mosquitoes. TEP1 is an antimicrobial protein which acts in a system reminiscent of the human complement pathway, which damages the cell membranes
Thioester-containing protein 1
Thioester-containing_protein_1
resemble cytokines, growth factors, or complement regulators; the term viroceptor is sometimes used if the proteins resemble cellular receptors. A third
Virokine
Serine protease that plays key role in innate immunity
participates in the complement system ending with cell death. There are four different C5 convertases able to specifically convert the protein C5 to C5a and
C5-convertase
Mammalian protein found in humans
to the serpin superfamily. Its main function is the inhibition of the complement system (C1r, C1s) to prevent spontaneous activation but also as the major
C1-inhibitor
Protein-coding gene in the species Homo sapiens
Gamma-aminobutyric acid B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene. GABAB1 is a receptor for Gamma-aminobutyric
GABBR1
Protein
Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. Complement factor I (factor I) is a protein
Complement_factor_I
Mammalian protein found in Homo sapiens
to activate the complement system when MBL binds to its target (for example, mannose on the surface of a bacterium), the MASP protein functions to cleave
Mannan-binding_lectin
Protein found in humans
Complement component 6 is a protein that in humans is encoded by the C6 gene. Complement component 6 is a protein involved in the complement system. It
Complement_component_6
Protein-coding gene in humans
analogy to other proteins that contain Sushi domains, it is believed that the gene product of CSMD1 functions as a Complement control protein. It is a potential
CSMD1
Enzyme that adds phosphate groups to other proteins
A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases
Protein_kinase
Protein-coding gene in the species Homo sapiens
The complement component 1, q subcomponent-like 1 (or C1QL1) is encoded by a gene located at chromosome 17q21.31. It is a secreted protein and is 258 amino
C1QL1
Change of a linear protein chain to a 3D structure
Protein folding is the physical process by which a protein, after synthesis by a ribosome as a linear chain of amino acids, changes from an unstable random
Protein_folding
Immunity strategy in living beings
epithelial barrier, soluble plasma proteins called complement proteins become activated (proteins C1-C9). These complement proteins trigger a cascade of reactions
Innate_immune_system
Nanoparticle technology
A protein corona is a dynamic coating of biomolecules, usually proteins, around the surface of a nanoparticle that forms spontaneously in colloidal nanomaterials
Protein_corona
Biochemical process
the first crystal structure of a protein containing this type of glycosylation was determined—that of human complement component 8. Currently it is established
Glycosylation
Life-threatening immune-related blood disease
The complement system activation may be due to mutations in the complement regulatory proteins (factor H, factor I, or membrane cofactor protein (CD46))
Atypical hemolytic uremic syndrome
Atypical_hemolytic_uremic_syndrome
Sequence of DNA that determines traits in an organism
during protein translation between codons and amino acids. The genetic code is nearly the same for all known organisms. The total complement of genes
Gene
Medical condition
and physical inactivity. Protein S circulates in human plasma in two forms: approximately 60 percent is bound to complement component C4b β-chain while
Protein_S_deficiency
Mammalian protein found in Homo sapiens
C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a.
C5a_receptor
Enzyme that cleaves other proteins into smaller peptides
of complement and kinins. This group includes the calpains. Basic proteases (or alkaline proteases) Proteases are involved in digesting long protein chains
Protease
Large group of transport proteins
membrane attack complex (MAC) proteins of the complement system (C6, C7, C8α, C8β and C9) and perforin (PF). Members of this protein family are pore-forming
MACPF
Protein-coding gene in the species Homo sapiens
DNA repair protein complementing XP-A cells (or XPA) is a protein that in humans is encoded by the XPA gene. Nucleotide excision repair (NER) is a major
XPA
Protein-coding gene in the species Homo sapiens
Fanconi anemia group A protein (FANCA), also known as Fanconi anaemia, complementation group A (FAA, FACA), is a protein which in humans is encoded by
Fanconi anemia group A protein
Fanconi_anemia_group_A_protein
Species of virus
two proteins (p33 and p92), a capsid protein (called CP or p41), and two additional proteins, the RNA silencing suppressor p19 and movement protein p22
Tomato_bushy_stunt_virus
Extracellular serine protease
regulation of the complement system and of neutrophil-derived proteases. Glutamyl endopeptidase is indicated to participate in control and dissemination
Glutamyl_endopeptidase_GluV8
Protein that exhibits bright green fluorescence when exposed to ultraviolet light
The green fluorescent protein (GFP) is a protein that exhibits green fluorescence when exposed to light in the blue to ultraviolet range. The label GFP
Green_fluorescent_protein
Blood disease in which red blood cells are attacked by the immune system
complement system, a part of the body's innate immune system. This destructive process occurs due to deficiency of the red blood cell surface protein
Paroxysmal nocturnal hemoglobinuria
Paroxysmal_nocturnal_hemoglobinuria
Topics referred to by the same term
cdc25 Cdc42, cell-division cycle protein Cholesterol-dependent cytolysin, exotoxins secreted by bacteria Complement-dependent cytotoxicity Conventional
CDC_(disambiguation)
Species of bacterium that can cause meningitis
H binding protein (fHbp) that is exhibited in N. meningitidis and some commensal species is the main inhibitor of the alternative complement pathway. fHbp
Neisseria_meningitidis
Protein domain
prototypical modular protein-protein interaction domain, in that it allows for the transmission of signals controlling a variety of intracellular functions
SH2_domain
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors
G_protein-coupled_receptor
Physical interactions and constructions between multiple proteins
Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical
Protein–protein_interaction
Chemical compound
a urine protein-to-creatinine ratio ≥1.5 g/g; for the treatment of adults with complement 3 glomerulopathy, to reduce proteinuria. Complement 3 glomerulopathy
Iptacopan
Merging of two or more mitochondria within a cell to form a single compartment
are understood by the way in which these proteins regulate and bind to each other. These GTPases in control of mitochondrial fusion are well conserved
Mitochondrial_fusion
RNA family
of the mRNA. sbi protein interferes with the host's innate immune response by binding Factor H, Complement component 3 and IgG. Protein A SprX Chabelskaya
SprD
Vision loss due to damage to the macula of the eye
Complement factor B/complement component 2 (CFB/CC2) on chromosome 6 at 6p21.3[citation needed] Polymorphisms in genes for complement system proteins:
Macular_degeneration
Protein found in humans
subunit 2 X-ray repair complementing defective repair in Chinese hamster cells 5 X-ray repair cross-complementing 5 (XRCC5) The protein expression level of
Ku80
Protein found in humans
a protein that in humans is encoded by the CLU gene on chromosome 8. CLU is an extracellular molecular chaperone which binds to misfolded proteins in
Clusterin
Protein family
the resistance against attack by the human complement system a Bacteriophage lambda outer membrane protein, Lom OspA/B are lipoproteins from Borrelia
Virulence-related outer membrane protein family
Virulence-related_outer_membrane_protein_family
Medical condition
role of C1-INH is to regulate and control the activities of the complement cascade, such that complement proteins remain in check and do not lead to
Acquired C1 esterase inhibitor deficiency
Acquired_C1_esterase_inhibitor_deficiency
Protein-coding gene in the species Homo sapiens
Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene
Fanconi anemia group I protein
Fanconi_anemia_group_I_protein
Medical condition
pharynx or the skin, given the time required to raise antibodies and complement proteins. The infection causes blood vessels in the kidneys to develop inflammation
Acute proliferative glomerulonephritis
Acute_proliferative_glomerulonephritis
Diet in which people decrease their intake of protein
quality, protein only needs to come from a wide variety of foods; there is neither a need to mix animal and plant food together nor a need to complement specific
Low-protein_diet
Set genes encoding proteins and enzymes for lactose metabolism
transcriptional level, by controlling transcription of DNA. Bacterial operons are polycistronic transcripts that are able to produce multiple proteins from one mRNA
Lac_operon
Explanation of the flow of genetic information within a biological system
transcribed to RNA, its complement is paired to it. DNA codes are transferred to RNA codes in a complementary fashion. The encoding of proteins is done in groups
Central dogma of molecular biology
Central_dogma_of_molecular_biology
Protein domain
Ku is a dimeric protein complex that binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair
Ku_(protein)
Species of flavivirus causing West Nile fever
(2006-12-12). "West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H". Proceedings of the National
West_Nile_virus
Mammalian protein found in humans
complex is able to control the functioning of many different genes in the body and the XPD protein acts as a stabilizer. XPB is another protein in the general
ERCC2
Topics referred to by the same term
vertebral column C04, oral cancer ICD-10 code Complement component 4, a protein involved in the intricate complement system, encoded by C4A or C4B gene in humans
C4
Class of enzymes
Protein phosphorylation is one of the most common forms of reversible protein posttranslational modification (PTM), with up to 30% of all proteins being
Protein_phosphatase
Family of enzymes
; Martinez, R.; Hunter, T.; Sudarsanam, S. (2002-12-06). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–1934. Bibcode:2002Sci
Protein_kinase_A
Breakdown of proteins into smaller polypeptides or amino acids
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Protein degradation is a major regulatory mechanism of gene expression
Proteolysis
Cellular process of protein synthesis
sequence of the encoded protein on paper. First, convert each template DNA base to its RNA complement (note that the complement of A is now U), as shown
Translation_(biology)
PTX3 binds with high affinity to the complement component C1q, the extracellular matrix component TNFα induced protein 6 (TNFAIP6; also called TNF-stimulated
PTX3
Variant surface glycoprotein (VSG) is a ~60kDa protein which densely packs the cell surface of protozoan parasites belonging to the genus Trypanosoma
Variant_surface_glycoprotein
Mammalian protein found in Homo sapiens
residues in the protein sequence. This modification event is performed by a vitamin K-dependent microsomal carboxylase. The full complement of Gla is required
Protein_C
Protein tag
splitFAST (2019), a complementation system for protein-protein interaction monitoring, and CATCHFIRE (2023), a self-reporting protein dimerizing system
Fluorescence-activating and absorption-shifting tag
Fluorescence-activating_and_absorption-shifting_tag
Set of all protein kinases encoded in a genome
Phosphatome Protein phosphatase Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human
Kinome
Autoimmune disease in which the immune system attacks healthy tissue
complement component 4 genes, C4A and C4B. (The C4A and C4B genes code, respectively, for complement component A and complement component B proteins.
Lupus
Autoimmune vascular inflammatory disease
demonstrates IgA and C3 (a protein of the complement system) in the blood vessel wall. However, overall serum complement levels are normal. On the basis
Henoch–Schönlein_purpura
Use of related sequences to construct an ancestral-like gene
must be complemented with extensive controls (usually alternate ASR experiments) to mitigate algorithmic error. Not all studied ASR proteins exhibit this
Ancestral sequence reconstruction
Ancestral_sequence_reconstruction
RNA that facilitates the addition of amino acids to a new protein
"Regulation of RNA polymerases I and III by the retinoblastoma protein: a mechanism for growth control?". Trends in Biochemical Sciences. 22 (3): 77–80. doi:10
Transfer_RNA
Mammalian protein found in humans
(August 2004). "Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals"
MTOR
Protein-coding gene in the species Homo sapiens
region. The protein encoded by this gene is a nuclear protein. It has been implicated in the control of apoptosis and regulating heat shock protein. There
Large proline-rich protein BAG6
Large_proline-rich_protein_BAG6
Protein-coding gene in the species Homo sapiens
anemia proteins, including FANCD2, are an emerging therapeutic target in cancer This gene encodes the Fanconi anemia complementation group D2 protein (FANCD2)
Fanconi anemia group D2 protein
Fanconi_anemia_group_D2_protein
Parasitic disease that results in diarrhea
They are targeting: recombinant proteins, DNA vaccines, variant-specific surface proteins (VSP), cyst wall proteins (CWP), giadins, and enzymes. Researchers
Giardiasis
Physical effects resulting from activation of the immune system
systems—consisting of preformed plasma proteins—act in parallel to initiate and propagate the inflammatory response. These include the complement system activated by bacteria
Inflammation
Mammalian protein found in Homo sapiens
ten, and eleven cysteine-rich complement-type repeats, respectively. These repeats bind extracellular matrix proteins, growth factors, proteases, protease
LRP1
Molecular biology technique
protein-fragment complementation assay. Pioneered by Stanley Fields and Ok-Kyu Song in 1989, the technique was originally designed to detect protein–protein
Two-hybrid_screening
Antibody isotype
itself; IgG activates the classical pathway of the complement system, a cascade of immune protein production that results in pathogen elimination; IgG
Immunoglobulin_G
Medical condition
gastrointestinal manifestation. It is caused by a deficit of the complement protein, C5; however, case reports have described it in relation to deficits
Leiner's_disease
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