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Protein-coding gene in the species Homo sapiens
ERCC4 is a protein designated as DNA repair endonuclease XPF that in humans is encoded by the ERCC4 gene. Together with ERCC1, ERCC4 forms the ERCC1-XPF
ERCC4
Protein-coding gene in the species Homo sapiens
image, panel A). DNA repair, involving high expression of PMS2, ERCC1 and ERCC4 (XPF) proteins, appears to be very active in colon crypts in normal, non-neoplastic
Mismatch repair endonuclease PMS2
Mismatch_repair_endonuclease_PMS2
DNA repair mechanism
their corresponding proteins include ERCC1(ERCC1), ERCC2(XPD), ERCC3(XPB), ERCC4(XPF), ERCC5 (XPG), ERCC6(CSB) and ERCC8(CSA). DNA repair-deficient ERCC1
Nucleotide_excision_repair
researchers isolated the ERCC4 gene independently through two different methods: the first approach discovered that ERCC1 worked with ERCC4 in the same complex
Excision repair cross-complementing
Excision_repair_cross-complementing
Topics referred to by the same term
Polynesia, New Caledonia and Wallis and Futuna ERCC4, an enzyme that in humans is encoded by the ERCC4 gene The Extended Control Program Facility (XPF)
XPF
Medical condition multisystem disorder
ubiquitinnated by these complexes include proteins employed in DNA repair. The XPF (ERCC4) protein together with the ERCC1 protein forms a complex usually designated
Xeroderma_pigmentosum
Protein-coding gene in humans
is a protein that in humans is encoded by the ERCC1 gene. Together with ERCC4, ERCC1 forms the ERCC1-XPF enzyme complex that participates in DNA repair
ERCC1
Range of genetic disorders which cause a person to appear to grow older faster
XP can be caused by mutations in any of these genes: DDB2, ERCC2, ERCC3, ERCC4, ERCC5, XPA, XPC. These genes are all involved in the NER repair pathway
Progeroid_syndromes
syndrome 4p16.3 dominant, often de novo 1:50,000 Xeroderma pigmentosum 15 ERCC4 recessive X-linked intellectual disability and macroorchidism (fragile X
List_of_genetic_disorders
Protein
endodeoxyribonuclease activity oxidized DNA binding Cellular component nucleoplasm ERCC4-ERCC1 complex nucleus nucleolus Biological process single strand break repair
XRCC1
Protein involved in DNA repair
endonuclease activity 3'-flap endonuclease activity Cellular component ERCC4-ERCC1 complex nucleoplasm cell junction Holliday junction resolvase complex
SLX4
Protein-coding gene in the species Homo sapiens
A (May 1994). "Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins". Proceedings of the National Academy of Sciences
XPA
Protein-coding gene in the species Homo sapiens
damage theory of aging.) FANCA has been shown to interact with: BRCA1, CHUK, ERCC4, FANCE, FANCF, FANCG, FANCC, IKK2, SMARCA4 SNX5 SPTAN1 and HES1 GRCh38:
FANCA
Formation of cancer
frequently have epigenetic defects in two or three DNA repair proteins (ERCC1, ERCC4 (XPF) and/or PMS2) in the entire area of the field defect. When expression
Carcinogenesis
Hypothesis that aging is caused by accumulated DNA damage
ERCC4 (XPF) Nucleotide excision repair, Interstrand cross link repair, Single-strand annealing, Microhomology-mediated end joining mutations in ERCC4
DNA_damage_theory_of_aging
Protein-coding gene in the species Homo sapiens
somatic cells, MUS81 and another structure specific DNA endonuclease, XPF (ERCC4), play overlapping and essential roles in completion of homologous recombination
MUS81
Medical condition
ERCC4 (XPF) Nucleotide excision repair, Interstrand cross link repair, Single-strand annealing, Microhomology-mediated end joining mutations in ERCC4
DNA repair-deficiency disorder
DNA_repair-deficiency_disorder
Giant virus
DNA as it is suggested by the presence of the sequences of MutS7 and an ERCC4-type DNA repair nuclease (which are involved in DNA repair). This last enzyme
Chrysochromulina ericina virus
Chrysochromulina_ericina_virus
Mammalian protein found in Homo sapiens
evaluated, 13 DNA repair genes, MGMT, NTHL1, OGG1, SMUG1, ERCC1, ERCC2, ERCC3, ERCC4, MLH1, MLH3, RAD50, XRCC4 and XRCC5 were all significantly down-regulated
Methylated-DNA–protein-cysteine methyltransferase
Methylated-DNA–protein-cysteine_methyltransferase
278760; ERCC4 Xeroderma pigmentosum group G; 278780; ERCC5 Xeroderma pigmentosum, variant type; 278750; POLH XFE progeroid syndrome; 610965; ERCC4 X-inactivation
List_of_OMIM_disorder_codes
HGNC:3433; P07992 5057 ERCC2 HGNC:3434; P18074 5058 ERCC3 HGNC:3435; P19447 5059 ERCC4 HGNC:3436; Q92889 5060 ERCC5 HGNC:3437; P28715 5061 ERCC6 HGNC:3438; P0DP91
List of human protein-coding genes 3
List_of_human_protein-coding_genes_3
Protein-coding gene in humans
repair genes, MLH1, MLH3, MGMT, NTHL1, OGG1, SMUG1, ERCC1, ERCC2, ERCC3, ERCC4, RAD50, XRCC4 and XRCC5 were all significantly down-regulated in all three
MLH1
Field of study in cancer research
ATR (miR-185), Wip1 (miR-16), MLH1, MSH2 and MSH6 (miR-155), ERCC3 and ERCC4 (miR-192) and UNG2 (mir-16, miR-34c and miR-199a). Of these miRNAs, miR-16
Cancer_epigenetics
ERCC4
ERCC4
ERCC4
ERCC4
Boy/Male
Bengali, Hindu, Indian
Prasadam of Lord Krishna
Boy/Male
Muslim
Visible
Male
Native American
Native American Cheyenne name OTOAHHASTIS means "tall bull."
Boy/Male
Hindu
Five eyed, Lord Shiva, Couch of Krishna
Girl/Female
Tamil
Smiles
Female
Welsh
Variant spelling of Welsh Branwen, BRANWENN means "fair raven."
Boy/Male
Celtic
Marksman.
Boy/Male
Hindu
Lord of Sabari hill, Lord Ayyappa
Girl/Female
Muslim/Islamic
Destiny
Boy/Male
Hindu, Indian
Ones with Happiness; Prosperous
ERCC4
ERCC4
ERCC4
ERCC4
ERCC4