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ERITORAN

Eritoran

Chemical compound

Eritoran is a synthetic lipid that inhibits the receptor TLR4. It was developed as a potential treatment for severe sepsis, an excessive inflammatory response

Eritoran

Sepsis

Life-threatening response to infection

mortality. It was removed from sale in 2011. Another medication known as eritoran also has not shown benefit. In those with high blood sugar levels, insulin

Sepsis

Lipid A

Lipid component of lipopolysaccharide endotoxins of gram-negative bacteria

by Gram-negative bacteria, and synthetic versions of these inhibitors (Eritoran) were in clinical trials for the prevention of harmful effects caused by

Lipid A

Lipid_A

Toll-like receptor 4

Cell surface receptor found in humans

antagonists approved as drugs. Amitriptyline Cyclobenzaprine CyRL-QN15 Eritoran Ketotifen Imipramine Mianserin Ibudilast Pinocembrin Resatorvid M62812

Toll-like receptor 4

Toll-like_receptor_4

List of drugs: Eq–Es

ergotamine (INN) eribaxaban (USAN, INN) eribulin (INN) ericolol (INN) eritoran tetrasodium (USAN) Erivedge erizepine (INN) erlizumab (INN) erlotinib hydrochloride

List of drugs: Eq–Es

List_of_drugs:_Eq–Es

Lymphocyte antigen 96

Protein-coding gene in the species Homo sapiens

"Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran". Cell. 130 (5): 906–17. doi:10.1016/j.cell.2007.08.002. PMID 17803912

Lymphocyte antigen 96

Lymphocyte_antigen_96

Kim Ho Min

South Korean biologist

"Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran". Cell. 130 (5). Cell Press: 906–917. doi:10.1016/j.cell.2007.08.002. PMID 17803912

Kim Ho Min

Kim_Ho_Min

(+)-Naloxone

Drug

result in unwanted side effects or drug interactions. Dextromethorphan Eritoran Methylnaltrexone Iijima I, Minamikawa J, Jacobson AE, Brossi A, Rice KC

(+)-Naloxone