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FCGR2A

FCGR2A

Mammalian protein found in Homo sapiens

region receptor II-a is a protein that in humans is encoded by the FCGR2A gene. FCGR2A has been shown to interact with PIK3R1 and Syk. CD32 GRCh38: Ensembl

FCGR2A

Takayasu's arteritis

Medical condition

association was identified and confirmed between Takayasu's arteritis and the FCGR2A/FCGR3A locus on chromosome 1 (rs10919543, OR = 1.81, p = 5.89 × 10-12).

Takayasu's arteritis

Takayasu's_arteritis

Kawasaki disease

Disease found in young children

different ethnic groups, both with Asian and non-Asian backgrounds. SNPs in FCGR2A, CASP3, BLK, ITPKC, CD40 and ORAI1 have all been linked to susceptibility

Kawasaki disease

Kawasaki_disease

List of human clusters of differentiation

the Fc (constant) region of immunoglobulin G (IgG). Of the related pair FCGR2A and FCGR2B (CD32B), the 'A' type is considered the activating isoform. CD32B**

List of human clusters of differentiation

List_of_human_clusters_of_differentiation

Immunoglobulin domain

Protein domain

CNTN4 CNTN5 CNTN6 CSF1R DSCAM DSCAML1 EMB F11R FAIM3 FCAR FCER1A FCGR1A FCGR2A FCGR2B FCGR2C FCGR3A FCGR3B FCRH1 FCRH3 FCRH4 FCRL1 FCRL2 FCRL3 FCRL4 FCRL5

Immunoglobulin domain

Immunoglobulin_domain

Tyrosine-protein kinase SYK

Enzyme

invade and metastasize. Syk has been shown to interact with: Cbl gene CRKL, FCGR2A, FYN, Grb2, Lck, LYN, PTK2, PTPN6, and VAV1. GRCh38: Ensembl release 89:

Tyrosine-protein kinase SYK

Tyrosine-protein_kinase_SYK

CD32

Surface receptor glycoprotein

have linked CD32C to augmentation of pathological inflammatory responses. FCGR2A FCGR2B FCGR2C Fc-gamma receptors PDB: 2FCB; Sondermann P, Huber R, Jacob

CD32

PIK3R1

Protein-coding gene in the species Homo sapiens

ADAM12, BCAR1, CBLB, CD117, CD28, CD7, CENTG1, CBL, EPHA2, EPOR, ERBB3, EZR, FCGR2A, GAB1, GAB2, Grb2, HRAS, IRS1 IRS2, IL1R1, JAK2, KHDRBS1, LTK, LAT, LCP2

PIK3R1

FCGR2C

Protein-coding gene in the species Homo sapiens

variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B". Hum. Mutat. 30 (5): E640–50. doi:10.1002/humu.20997. PMID 19309690

FCGR2C

List of human protein-coding genes 3

Q9Y324 5571 FCGBP HGNC:13572; Q9Y6R7 5572 FCGR1A HGNC:3613; P12314 5573 FCGR2A HGNC:3616; P12318 5574 FCGR2B HGNC:3618; P31994 5575 FCGR2C HGNC:15626;

List of human protein-coding genes 3

List_of_human_protein-coding_genes_3

FCGR2B

Antibody fragment receptor in humoral immunity

regions. The extracellular domains are 95% identical to the domains of FCGR2A and almost completely identical to the FCGR2C (the other members of CD32

FCGR2B