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HAP2

Membrane fusion protein

Class of proteins

strongly favor an interpretation where HAP2/GCS1 is acquired from a virus, but the grouping of Fsx1 with HAP2/GCS1 has allowed the possibility of a much

Membrane fusion protein

Membrane_fusion_protein

HAP2

Protein family

HAP2 (hapless 2), also known as GCS1 (generative cell-specific protein 1), is a family of membrane fusion proteins found in the sperm cell of diverse eukaryotes

HAP2

Flagellum

Cellular appendage functioning as locomotive or sensory organelle

Vonderviszt, Ferenc (18 June 2004). "Stabilization of flagellar filaments by HAP2 capping". FEBS Letters. 568 (1–3): 105–109. Bibcode:2004FEBSL.568..105D.

Flagellum

Cell–cell fusogens

Protein family

process. As of late, another protein has been classified as a gamete fusogen (HAP2 or GCS1). Like the previous example, this protein is present in plants, protists

Cell–cell fusogens

Cell–cell_fusogens

Huntingtin-associated protein 1

Protein-coding gene in the species Homo sapiens

HAP1 Identifiers Aliases HAP1, HAP2, HIP5, HLP, hHLP1, huntingtin-associated protein 1, huntingtin associated protein 1 External IDs OMIM: 600947; MGI:

Huntingtin-associated protein 1

Huntingtin-associated_protein_1

GCS1

Protein-coding gene in the species Homo sapiens

reticulum. GCS1 may also refer to "generative cell specific 1", also called HAP2 (hapless2), a gene of lower eukaryotes which is thought to be responsible

GCS1

List of sequenced animal genomes

14 February 2025. "Branchiostoma lanceolatum genome assembly klBraLanc5.hap2". NCBI. Retrieved 21 February 2025. Seo HC, Kube M, Edvardsen RB, Jensen

List of sequenced animal genomes

List_of_sequenced_animal_genomes

Protein structural phylogenetics

Field of molecular evolution

Podbilewicz, B (2022). "Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins". Nat Commun. 13 (1): 3880. Bibcode:2022NatCo

Protein structural phylogenetics

Protein_structural_phylogenetics

NFYA

Protein-coding gene in the species Homo sapiens

PDBe RCSB List of PDB id codes 4AWL Identifiers Aliases NFYA, CBF-A, CBF-B, HAP2, NF-YA, nuclear transcription factor Y subunit alpha External IDs OMIM: 189903;

NFYA

Leishmania tropica

Species of protozoan parasite

hybridization in vitro marked by expression of the ancestral gamete fusogen HAP2 as revealed by single-cell RNA-seq". eLife. 11. doi:10.7554/eLife.73488.

Leishmania tropica