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Genetically modified mouse used in gene research
A knockout mouse, or knock-out mouse, is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or "knocked out", an existing
Knockout_mouse
Small long-tailed rodent
A knockout mouse is a genetically modified mouse that has had one or more of its genes made inoperable through a gene knockout. Experimental mouse model
Mouse
Genetic technique
create knockout mice. With the aid of gene targeting, numerous mouse genes have been shut down, leading to the creation of hundreds of distinct mouse models
Gene_knockout
Scientific project organization
The International Knockout Mouse Consortium (IKMC) is a scientific endeavour to produce a collection of mouse embryonic stem cell lines that together
International Knockout Mouse Consortium
International_Knockout_Mouse_Consortium
American pharmaceutical company
Bradley's postdoctoral fellow Arthur T Sands. The company has used its mouse gene knockout technology and in vivo screening capabilities to study nearly 5,000
Lexicon_Pharmaceuticals
William; Rosen, Barry; et al. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10
Conditional_gene_knockout
Variety of genetically modified laboratory mice
they will not sell the woolly mouse, and that they will remain private for further de-extinction research. Knockout mouse Oncomouse Davis, Nicola (March
Woolly_mouse
Genetically engineered variety of rose
Eucalyptus Mustard Animals Mammals Mouse Knockout mouse Oncomouse Woolly mouse Gene-edited human Enviropig Herman the Bull Knockout rat Rabbit Ruppy Wolves Other
Blue_rose
Mouse with altered genomes
A genetically modified mouse, genetically engineered mouse model (GEMM) or transgenic mouse is a mouse (Mus musculus) that has had its genome altered
Genetically_modified_mouse
Type of genetically engineered rat
that are unavailable in the mouse. Knockout rat models can also complement existing transgenic mouse models. Comparing mouse and rat mutants can facilitate
Knockout_rat
Species of mammal
a model organism, a great deal is known about mouse genetics, with a major tool being the knockout mouse technique. House mice usually live less than one
House_mouse
Congenital extreme form of developmental delay and neoteny
disorder. A mutation in one gene (TMEM63B) was identified in a large knockout mouse study as likely to result in disease in humans. In two patients, a small
Neotenic_complex_syndrome
International Mouse Phenotyping Consortium (IMPC) is an international scientific endeavour to create and characterize the phenotype of 20,000 knockout mouse strains
International Mouse Phenotyping Consortium
International_Mouse_Phenotyping_Consortium
Acquired allergy resulting from tick bites
in the context of tick bites has been confirmed using an alpha-gal knockout mouse model. Tick larvae, nymphs, and adults can cause AGS. Tick larvae are
Alpha-gal_syndrome
British biologist
Capecchi and Oliver Smithies, for his work in the development of the knockout mouse and the related technology of gene targeting, a method of using embryonic
Martin_Evans
Mouse carrying functioning human genes, cells, etc.
Nude mouse SCID mouse NOG mouse NSG mouse Mouse model of colorectal and intestinal cancer Mouse models of breast cancer metastasis Knockout mouse Chuprin
Humanized_mouse
Biomedical research institution
modeling. The National Institutes of Health (NIH) funds phase 2 of the Knockout Mouse Production and Phenotyping Project (KOMP2). Researchers link mutations
Jackson_Laboratory
American biotechnology company
Eucalyptus Mustard Animals Mammals Mouse Knockout mouse Oncomouse Woolly mouse Gene-edited human Enviropig Herman the Bull Knockout rat Rabbit Ruppy Wolves Other
AquaBounty_Technologies
Chemical compound
hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse". American Journal of Physiology. Endocrinology and Metabolism. 291
CJC-1295
Topics referred to by the same term
KOMP 104.9 Radio Compa, an album by Akwid Knockout Mouse Program (KOMP), part of the International Knockout Mouse Consortium Comp (disambiguation) This disambiguation
Komp
Protein-coding gene in humans
ultimately lead to cancer due to the loss of function as a sensor. Runx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and
RUNX3
Genome engineering tools
enable complete functional annotation of the mouse genome (coordinated by the International Knockout-Mouse Consortium, IKMC) with the ultimate goal to
Site-specific recombinase technology
Site-specific_recombinase_technology
Lipid-containing residue associated with aging
this holds in vivo over longer time periods is not clear. The ABCR -/- knockout mouse has delayed dark adaptation but normal final rod threshold relative
Lipofuscin
Medication
a major role in social reward in animals and the μ-opioid receptor knockout mouse is an animal model of autism. Studies on whether naltrexone can decrease
Naltrexone
Sequence of DNA that determines traits in an organism
Bradley A, Bucan M, Capecchi M, Collins FS, et al. (September 2004). "The knockout mouse project". Nature Genetics. 36 (9): 921–4. Bibcode:2004NaGen..36..921
Gene
Biological process in primates
with a high GH secretion. An animal model of Laron syndrome, the GHR knockout mouse, shows severely impaired ductal outgrowth at 11 weeks of age. However
Breast_development
Class of chemical compounds
HG; Gonzalez, FJ; Nebert, DW (2006). "Oral Benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required
Benzopyrene
Critical protein in embryonic development
Additionally, a double (SHH-/- ) knockout mouse model exhibited poor lung development. The lungs of the SHH double knockout failed to undergo lobation and
Sonic_hedgehog_protein
Glycoprotein found in humans
lacritin promotes tearing in rabbit preclinical studies. In the Aire knockout mouse model of dry eye (considered similar to human Sjogren's syndrome), topical
Lacritin
One of five Nobel Prizes established in 1895 by Alfred Nobel
mice, employing embryonic stem cells through the development of the knockout mouse. In 2009, the Nobel Prize was awarded to Elizabeth Blackburn, Carol
Nobel Prize in Physiology or Medicine
Nobel_Prize_in_Physiology_or_Medicine
Common strain of laboratory mouse
therefore it is used even more. In 1993 the first C57BL/6 gene targeted knockout mouse was published by a group at Hoffmann-La Roche in Switzerland. In 2013
C57BL/6
Exocrine gland in humans and other mammals
Broadus, A. E. (1998). "Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for
Mammary_gland
X-linked dominant genetic disorder
(2002). "Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse". Hippocampus. 12 (1): 39–46. doi:10.1002/hipo.10005. ISSN 1050-9631
Fragile_X_syndrome
Ramberg Capecchi (born 1937), and Oliver Smithies (1925–2017), U.S. – Knockout mouse, Gene targeting Ole Evinrude (1877–1934), Norway – outboard motor Charles
List_of_inventors
Uncontrolled gene flow into wild populations
Eucalyptus Mustard Animals Mammals Mouse Knockout mouse Oncomouse Woolly mouse Gene-edited human Enviropig Herman the Bull Knockout rat Rabbit Ruppy Wolves Other
Genetic_pollution
mutant genes. The EUCOMM consortium is a member of the International Knockout Mouse Consortium, (an organisation including the EUCOMM, KOMP, NorCOMM and
EUCOMM
Human protein
phenotype. Foxp3 expression is not affected by loss of CD83 in a CD83 knockout mouse. In contrast, CD83 seems important for peripheral Treg cell induction
CD83
Protein-coding gene in the species Homo sapiens
jellyfish, anemones) with a conserved protein domain composition. Using knockout mouse models of TNFAIP3 and its transcriptional repressor (i.e. KCHIP3), TNFAIP3
TNFAIP3
Long projection on a neuron that conducts signals to other neurons
K, Surendran S, Tyring SK (2006). "Canavan Disease: Studies on the Knockout Mouse". N-Acetylaspartate. Advances in Experimental Medicine and Biology.
Axon
Genetic technique that uses homologous recombination to change an endogenous gene
mice, the DNA is inserted into mouse embryonic stem cells in culture. Cells with the insertion can contribute to a mouse's tissue via embryo injection.
Gene_targeting
Fatty substance insulating nerve cell axons
K, Surendran S, Tyring SK (2006). "Canavan disease: studies on the knockout mouse". N-Acetylaspartate. Advances in Experimental Medicine and Biology.
Myelin
Blood proteins made in the liver and secreted into the bloodstream
drastically exacerbated when the fetuin-A knockout was combined with the genetic background DBA/2. The mouse strain DBA/2 is known for its proneness to
Fetuin
Class of animals with milk-producing glands
mice and rats, are used in experiments each year. A knockout mouse is a genetically modified mouse with an inactivated gene, replaced or disrupted with
Mammal
Opioid used to treat pain and opioid use disorder
activation by beta-endorphin in pons/medulla of the mu-opioid receptor knockout mouse". Neuroscience. 115 (3): 715–721. doi:10.1016/s0306-4522(02)00486-4
Buprenorphine
Sanger Institute, the project uses knockout mice most of which were generated by the International Knockout Mouse Consortium. For each mutant line, groups
Mouse_Genetics_Project
Medical condition
G.; Carlson, M.; Lockridge, O. (2007). "The Butyrylcholinesterase Knockout Mouse as a Model for Human Butyrylcholinesterase Deficiency". Journal of Pharmacology
Butyrylcholinesterase deficiency
Butyrylcholinesterase_deficiency
Central nervous system stimulant
alertness. Caffeine is an antagonist of adenosine A2A receptors, and knockout mouse studies have specifically implicated antagonism of the A2A receptor
Caffeine
Popular model for studying Duchenne muscular dystrophy
the mouse model and human disease. To overcome these limitations, researchers have developed improved models such as the mdx/utrophin double knockout mouse
Mdx_mouse
Italian-American molecular geneticist (born 1937)
sister. Capecchi was awarded the Nobel prize for creating a knockout mouse. This is a mouse, created by genetic engineering and in vitro fertilization
Mario_Capecchi
Iron and oxygen-binding protein
Laussmann T, Flögel U, et al. (Apr 2004). "Adaptation of the myoglobin knockout mouse to hypoxic stress". American Journal of Physiology. Regulatory, Integrative
Myoglobin
American scientist
"Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model". Molecular Autism. 6 (1): 1. doi:10.1186/2040-2392-6-1. ISSN 2040-2392
Robert_K._Naviaux
Protein that initiates male sex determination in therian mammals
Yamashita S, Tamano M, Miura K, et al. (November 2013). "Production of Sry knockout mouse using TALEN via oocyte injection". Scientific Reports. 3 (1) 3136. Bibcode:2013NatSR
Sex-determining region Y protein
Sex-determining_region_Y_protein
Protein-coding gene in the species Homo sapiens
is largely unknown due to unidentified direct binding partners. Many knockout mouse models with tendon phenotypes have helped in understanding which upstream
Tenomodulin
Genetically modified mouse for cancer research
of Virginia. Animal testing Biobreeding rat Biological patent Knockout mouse Woolly mouse European Patent Register entry for European patent no. 0169672
Oncomouse
Lab mouse strain lacking immunity and fur
A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune
Nude_mouse
Protein found in humans
Stargardt's disease and macular degeneration. An animal study using ABCA4 knockout mouse proved that reduction in serum RBP4 level could inhibit lipofuscin without
Retinol_binding_protein_4
Medical condition
"Schneckenbecken dysplasia". In 2007, Hiraoka et al. created an SLC35D1-knockout mouse model, said experiment revealed that while mice heterozygous for the
Schneckenbecken_dysplasia
Chemical compound
tested and found to be non-carcinogenic when using the established p53 knockout mouse model. The technology is currently in routine use in certain European
Psoralen
Organic compound, a stimulant in humans
Borowsky B, Seeman P, et al. (October 2007). "The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia". Genes Brain Behav
Phenethylamine
Protein-coding gene in the species Homo sapiens
been investigated using Eid1-knockout mouse models. In one transcriptomic study, RNA sequencing of the Eid1-knockout mouse brain identified 2,531 genes
EID1
Group of enzymes
through which environmental toxicants contribute to PD pathogenesis." Knockout mouse models further confirm the involvement of ALDH family in neurodegeneration
Aldehyde_dehydrogenase
Protein-coding gene in the species Homo sapiens
"Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology
HSD17B4
Transcription factor
cell fate. Cell lineage analysis of Nkx 2.9 and Nkx 2.2 double knockout (deficient) mouse embryos shows that cranial nerve alterations are a result of changes
NKX_2-9
Medical condition
citrate diet delays progression of renal insufficiency in the ClC-5 knockout mouse model of Dent's disease". Kidney Int. 68 (2): 642–52. doi:10.1111/j
Dent's_disease
Behavioral measure in animals
Branchek T, Gerald CP (October 2007). "The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia". Genes Brain Behav
Locomotor_activity
Protein-coding gene in the species Homo sapiens
organisms have been used in the study of TREM1 function. A conditional knockout mouse line called Trem1tm1(KOMP)Vlcg was generated at the Wellcome Trust Sanger
TREM1
Egyptian-American medical researcher
and to use molecular imaging for drug screening. His group created a knockout mouse of death receptor 5 (DR5) that shows reduced apoptosis in vivo after
Wafik_El-Deiry
Free radical toxicity
"Alpha-tocopherol protects against oxidative stress in the fragile X knockout mouse: an experimental therapeutic approach for the Fmr1 deficiency".
Oxidative_stress
Scientific endeavours to determine the complete genome sequence of an organism
Project 100K Pathogen Genome Project International Mouse Phenotyping Consortium IMPC Knockout Mouse Phenotyping Project KOMP2 Giant Sequoia, Sequoiadendron
Genome_project
Protein found in humans
adrenocortical carcinoma patients. Mouse models where the Jag1 gene is turned off in certain tissues (conditional knockout mouse models) have been used to study
JAG1
Oil spill involving two Russian oil tankers
HG; Gonzalez, FJ; Nebert, DW (2006). "Oral Benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required
2024_Black_Sea_oil_spill
Class of compounds
(in TAAR1-DAT cells or wild-type mouse striatal synaptosomes) than in its absence (in DAT cells or TAAR1 knockout mouse striatal synaptosomes), and it was
Monoamine_releasing_agent
Protein found in humans
involved in cell adhesion, its biological function is not known. A knockout mouse line that lacks mesothelin reproduces and develops normally. Mesothelin
Mesothelin
Protein-coding gene in the species Homo sapiens
also is a crucial surfactant in saliva. When the gene is silenced in a knockout mouse, the saliva exhibits the surface tension of water. Further, without
BPIFA2
(born 1937), Italian-born US molecular geneticist, co-invented the knockout mouse, Nobel Prize in Medicine, 2007 Elof Axel Carlson (1931–2025), US geneticist
List_of_geneticists
American biochemist and academic
J. A., Lust, R. M., & Clemens, S. (2013). The dopamine D3 receptor knockout mouse mimics aging-related changes in autonomic function and cardiac fibrosis
Tracy_L._Johnson
Protein-coding gene in the species Homo sapiens
suggesting that THOC5 may be involved in cancer development. Recent THOC5 knockout mouse data reveal that THOC5 is an essential element in the maintenance of
THOC5
Type of genetically modified mouse
efficacy. Immunology Knockout mouse Hughes, Christopher C. W.; Mestas, Javier (2004-03-01). "Of Mice and Not Men: Differences between Mouse and Human Immunology"
Humouse
Small-molecule oxytocin receptor agonist
LIT-001 reduces social deficits in a mouse model of autism, specifically the μ-opioid receptor knockout mouse model. It was the first small-molecule
LIT-001
Species of virus
Fever (CCHF) infections in suckling mice and in the interferon receptor knockout mouse model This indicates that Hazara orthonairovirus could represent a valid
Hazara_virus
Protein-coding gene in the species Homo sapiens
developing mouse embryo, CYP26B1 is expressed in the distal tip of the forming limb bud with an abundance in the apical ectodermal ridge. In a knockout mouse model
CYP26B1
Protein-coding gene in the species Homo sapiens
single-stranded DNA with a 5’ to 3’ directionality. Using an SNM1B/Apollo knockout mouse model, evidence was obtained that SNM1B/Apollo protein is required to
DCLRE1B
mice and rats, are used in experiments each year. A knockout mouse is a genetically modified mouse with an inactivated gene, replaced or disrupted with
Human_uses_of_mammals
Organism altered by genetic engineering
predisposing them to developing cancer. Mice with genes removed (termed a knockout mouse) were created in 1989. The first transgenic livestock were produced
Genetically_modified_organism
Mammalian protein found in Homo sapiens
stability of sperm chromatin, yet both knockout mouse models (for mGPX4 and nGPX4) were fully viable. Surprisingly, knockout of GPX4 heterozygously in mice (GPX4+/−)
Glutathione_peroxidase_4
the production of a knockout mouse. This is accomplished through the administration of one or more transgenes into a fertilized mouse oocyte’s pronucleus
Genetic_ablation
Small non-coding ribonucleic acid molecule
aneurysms. High throughput whole transcriptome profiling of the FoxD1-Dicer knockout mouse model revealed ectopic upregulation of pro-apoptotic gene, Bcl2L11 (Bim)
MicroRNA
Class of immune system proteins
fever in humans. TLR11 deficient knockout mice, on the other hand, are efficiently infected. As a result, this knockout mouse can act as a disease model of
Toll-like_receptor
American molecular biologist and Nobel laureate
collaboration with Ronald A. DePinho, produced the first telomerase knockout mouse, showing that although telomerase is dispensable for life, increasingly
Carol_W._Greider
American biologist
characterization of the world's longest lived laboratory mouse, the growth hormone receptor knockout mouse. Dr. Kopchick has an h-index of 80, has advised more
John_Kopchick
Protein-coding gene in the species Homo sapiens
et al. (2002). "Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux"
CTRL_(gene)
cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models. Oncogene. 2002 Dec 5;21(55):8486-97. PMID 12466968. Pledger
Warren_Jackson_Pledger
Protein found in humans
Flemming A, Huang QQ, Jin JP, Jumaa H, Herzog S (2015). "A Conditional Knockout Mouse Model Reveals That Calponin-3 Is Dispensable for Early B Cell Development"
Calponin_3,_acidic
Free-radical aging theory
(2009). "The mitochondrial theory of aging: Insight from transgenic and knockout mouse models". Experimental Gerontology. 44 (4): 256–60. doi:10.1016/j.exger
Free-radical_theory_of_aging
Rare autosomal dominant cancer syndrome
removed without taking the whole kidney, in a partial nephrectomy. Knockout mouse studies have shown that administration of rapamycin may mitigate the
Birt–Hogg–Dubé_syndrome
Genetic engineering technique
James J. (2012-04-01). "The Construction of Transgenic and Gene Knockout/Knockin Mouse Models of Human Disease". Transgenic Research. 21 (2): 327–349.
Gene_knock-in
Protein-coding gene in the species Homo sapiens
methylmalonyl-CoA, feeding back into the pathway. According to an Acsf3 knockout mouse model, threonine catabolism was identified as the major contributor
ACSF3
Life science research institute in Hyderabad, India
people among Indians Developed the first genetically engineered, gene knockout mouse in India Demonstrated the first artificial insemination in spotted deer
Centre for Cellular and Molecular Biology
Centre_for_Cellular_and_Molecular_Biology
British pharmacologist and Professor
working on an endothelial mediator that required the generation of a knockout mouse, and, to maximise efficiency, used female as well as male mice in her
Amrita_Ahluwalia
Dutch behavioral neurogeneticist
Crawley, Jacqueline (2007). What's Wrong with My Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice. John Wiley & Sons. p. 138. ISBN 9780470119044
Wim_Crusio
KNOCKOUT MOUSE
KNOCKOUT MOUSE
Boy/Male
Hindu, Indian
Mouse
Boy/Male
Hindu
One who has mouse as charioteer
Boy/Male
Tamil
One who has mouse as his charioteer
Surname or Lastname
English
English : habitational name from either of the places in Leicestershire and North Yorkshire so named, from Old English mūs ‘mouse’ + tūn ‘enclosure’, ‘settlement’. The Yorkshire Muston may alternatively have been called ‘Músi’s farmstead’, from an Old Scandinavian personal name + tūn.
Boy/Male
Australian, British, English
Of Cornish Hen Mouse and Luster; Moon
Male
Native American
Native American Algonquin name ABUKCHEECH means "mouse."
Girl/Female
Biblical
A house for a mouse.
Surname or Lastname
English (Cumbria)
English (Cumbria) : habitational name from either of two villages in Cumbria, named in Old English with mÅ«s ‘mouse’ (perhaps a byname) + grÄf ‘grove’ (see Grove 1). The Norman surname de Mucegros, established in Herefordshire and elsewhere in the 12th and 13th centuries, is unrelated and has died out.
Male
Italian
Italian form of Hebrew Moshe (Greek Mouses), MOSÈ means "drawn out."
Surname or Lastname
English
English : habitational name from Muscott, a minor place in Northamptonshire, or Muscoates in North Yorkshire, both named from Old English mūs ‘mouse’ + cot ‘hut’, ‘small dwelling’, ‘shelter’.
Male
Greek
Variant spelling of Greek Moyses, MOUSES means "drawn out." In the bible, this is the name of the leader who brought the Israelites out of bondage and led them to the promised land.Â
Male
English
Anglicized form of Hebrew Moshe and Greek Mouses, MOSES means "drawn out." In the bible, this is the name of the leader who brought the Israelites out of bondage and led them to the promised land.Â
Boy/Male
Native American
Mouse.
Surname or Lastname
English
English : nickname from Middle English mūs ‘mouse’ + ēage ‘eye’.Possibly an altered spelling of French Musset (see Mussett 1).
Boy/Male
Tamil
Musikvahana | à®®à¯à®¸à¯€à®•à¯à®µà®¾à®¹à®¾à®¨à®¾Â
One who has mouse as charioteer
Musikvahana | à®®à¯à®¸à¯€à®•à¯à®µà®¾à®¹à®¾à®¨à®¾Â
Surname or Lastname
English (chiefly southern Yorkshire and Lancashire)
English (chiefly southern Yorkshire and Lancashire) : habitational name from any of several places called Mos(e)ley in central, western, and northwestern England. The obvious derivation is from Old English mos ‘peat bog’ + lēah ‘woodland clearing’, but the one in southern Birmingham (Museleie in Domesday Book) had as its first element Old English mūs ‘mouse’, while one in Staffordshire (Molesleie in Domesday Book) had the genitive case of the Old English byname Moll.
Girl/Female
Egyptian Latin Russian
Mouse.
Surname or Lastname
English (Hertfordshire)
English (Hertfordshire) : nickname from titmose ‘tit(mouse)’, applied to someone thought to resemble the bird.
Male
Welsh
Welsh form of Hebrew Moshe and Greek Mouses, MOESEN means "drawn out."
Boy/Male
Hindu, Indian, Kannada, Telugu
One who has Mouse as his Charioteer
KNOCKOUT MOUSE
KNOCKOUT MOUSE
Girl/Female
French American English
Fairy. Also a, meaning: Confidence; trust; belief.
Girl/Female
Hindu
Light
Girl/Female
Indian
Pure, Clean
Boy/Male
Italian
strong warrior'.
Boy/Male
Arabic, Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Muslim, Telugu
Beautiful
Girl/Female
Tamil
Sravanthi | ஸà¯à®°à®µà®¨à®¤à¯€
Flowing river
Male
Danish
, war.
Boy/Male
Assamese, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Sikh, Telugu
Remembrance; Memory
Boy/Male
American, Australian, British, English, German, Greek
Gift of God; Wealthy Defender
Surname or Lastname
Irish
Irish : variant spelling of Keane.English : variant spelling of Keen.
KNOCKOUT MOUSE
KNOCKOUT MOUSE
KNOCKOUT MOUSE
KNOCKOUT MOUSE
KNOCKOUT MOUSE
n.
A little mouse.
n.
The act of coming forth; a leaving of houses, shops, etc.; esp., a quitting of employment for the purpose of forcing increase of wages; a strike; -- opposed to lockout.
n.
Any flying marsupial of the genera Petaurus, Phalangista, Acrobata, and allied genera. See Flying mouse, under Flying, and Phalangister.
imp. & p. p.
of Mouse
n.
A genus of plants. See Mouse-ear.
n.
One who pries about on the lookout for something.
v. t.
To furnish with a mouse; to secure by means of a mousing. See Mouse, n., 2.
n.
A small nocturnal and arboreal Australian marsupial (Tarsipes rostratus) about the size of a mouse. It has a long muzzle, a long tongue, and very few teeth, and feeds upon honey and insects. Called also noolbenger.
n.
A genus of ranunculaceous plants (Myosurus), in which the prolonged receptacle is covered with imbricating achenes, and so resembles the tail of a mouse.
a.
Pertaining to a family of rodents (Muridae), of which the mouse is the type.
n.
Diminutive for Mouse.
n.
Any one of numerous species of small rodents belonging to the genus Mus and various related genera of the family Muridae. The common house mouse (Mus musculus) is found in nearly all countries. The American white-footed, or deer, mouse (Hesperomys leucopus) sometimes lives in houses. See Dormouse, Meadow mouse, under Meadow, and Harvest mouse, under Harvest.
n.
One of a tribe of rodents, of which the mouse is the type.
n.
The closing of a factory or workshop by an employer, usually in order to bring the workmen to satisfactory terms by a suspension of wages.
v. t.
To tear, as a cat devours a mouse.
n.
A genus of small rodents, including the common mouse and rat.
n.
A hole made by a mouse, for passage or abode, as in a wall; hence, a very small hole like that gnawed by a mouse.