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Chemotherapy and immunosuppressant medication
Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases, and
Methotrexate
Derivative of folic acid used in cancer treatment
as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil
Folinic_acid
Type of autoimmune arthritis
Disease-modifying antirheumatic drugs (DMARDs), such as hydroxychloroquine and methotrexate, may be used to try to slow the progression of disease. Biological DMARDs
Rheumatoid_arthritis
Autoimmune diseases of the skin
vitamin D3 cream, ultraviolet light, immunosuppressive drugs, such as methotrexate, and biologic therapies targeting specific immunologic pathways. About
Psoriasis
Treatment of cancer using drugs that inhibit cell division or kill cells
deoxynucleoside analogues and thiopurines. The anti-folates include methotrexate and pemetrexed. Methotrexate inhibits dihydrofolate reductase (DHFR), an enzyme that
Chemotherapy
Female reproductive system health issue
or to remove the fallopian tube altogether. The use of the medication methotrexate works as well as surgery in some cases. Specifically, it works well when
Ectopic_pregnancy
Biopharmaceutical drug
(DMARDs). Upadacitinib may be used as monotherapy or in combination with methotrexate or other nonbiologic DMARDs. Upadacitinib was approved in January 2022
Upadacitinib
Chemotherapy regimen
Cyclophosphamide Methotrexate Fluorouracil (CMF) is a commonly used regimen of breast cancer chemotherapy that combines three anti-cancer agents: cyclophosphamide
CMF_(chemotherapy)
Abnormal formation of clumps of inflammatory cells (granulomata)
problems, steroids such as prednisone are indicated. Medications such as methotrexate, chloroquine, or azathioprine may occasionally be used in an effort to
Sarcoidosis
Indian-American biochemist (1895–1948)
adenosine triphosphate (ATP) as an energy source in the cell, developed methotrexate for the treatment of cancer, and led the department at Lederle laboratories
Yellapragada_Subbarow
Group of autoimmune diseases resulting in abnormal growth of connective tissue
treatment may improve symptoms. Medications used include corticosteroids, methotrexate, and non-steroidal anti-inflammatory drugs (NSAIDs). Outcome depends
Scleroderma
Category of drugs
tsDMARDs, respectively) csDMARDs are the traditional drugs (such as methotrexate, sulfasalazine, leflunomide, hydroxychloroquine, gold salts) tsDMARDs
Disease-modifying antirheumatic drug
Disease-modifying_antirheumatic_drug
Pharmaceutical drug
(Voraxaze) is a medication used for the treatment of elevated levels of methotrexate (defined as 1 micromol/L) during treatment of cancer patients who have
Glucarpidase
Vitamin B9; nutrient essential for DNA synthesis
with folate metabolism are used to treat cancer. The antifolate drug methotrexate is often used to treat cancer because it inhibits the production of the
Folate
Autoimmune disease of skin and muscle
dermatomyositis relies on immunosuppressive agents such as corticosteroids, methotrexate, mycophenolate mofetil, azathioprine, tacrolimus, and cyclosporine, with
Dermatomyositis
Laboratories. These analogues — first aminopterin and then amethopterin (now methotrexate) were antagonistic to folic acid, and blocked the function of folate-requiring
History of cancer chemotherapy
History_of_cancer_chemotherapy
Medical condition
symptoms were improved with methotrexate and infliximab. However, in another patient with Dercum's disease, the effect of methotrexate was discreet. The mechanism
Dercum's_disease
Chemical compound
(DMARDs). Filgotinib may be used as monotherapy or in combination with methotrexate (MTX). Filgotinib is a Janus kinase inhibitor with selectivity for subtype
Filgotinib
Hearing loss caused by an inner ear or vestibulocochlear nerve defect
progressing sensorineural hearing loss, usually without vestibular symptoms. Methotrexate, a chemotherapy agent, is also known to cause hearing loss. In most cases
Sensorineural_hearing_loss
Medical condition
Methotrexate-induced papular eruption appears in patients being treated with methotrexate, such as those with rheumatic disease, presenting with erythematous
Methotrexate-induced papular eruption
Methotrexate-induced_papular_eruption
Molecule that blocks enzyme activity
a pathogen such as a virus, bacterium or parasite. Examples include methotrexate (used in chemotherapy and in treating rheumatic arthritis) and the protease
Enzyme_inhibitor
Drug that inhibits activity of immune system
synthesis of nucleic acids. These include: folic acid analogues, such as methotrexate purine analogues, such as azathioprine and mercaptopurine pyrimidine
Immunosuppressive_drug
Medical condition
methotrexate even at low doses. In contrast to intravenous methotrexate for cancer patients, leukoencephalopathy induced by orally taken methotrexate
Toxic_leukoencephalopathy
Class of antimetabolite medications
dihydrofolate reductase (DHFR), i.e. are dihydrofolate reductase inhibitors. Methotrexate Pemetrexed Raltitrexed Pralatrexate Many are primarily DHFR inhibitors
Antifolate
Drug class
As such, it will help to reduce the side effects of methotrexate. Contraindications of methotrexate include: Patient with active infection Ascites Immunodeficiency
Antiarthritics
Autoimmune disease with chronic blood vessel inflammation
corticosteroids to control the symptoms of the disease, and azathioprine, methotrexate, or rituximab to keep the disease under control. Plasma exchange is also
Granulomatosis with polyangiitis
Granulomatosis_with_polyangiitis
1976 film by Ralph Nelson
the subject's cells age uncontrollably, so Holliston uses the drug methotrexate to counter the effect. It works, and the embryo grows into an 22 year-old
Embryo_(film)
1968, an adjuvant methotrexate study for head and neck cancer. The methotrexate study employed combinations of radiation, methotrexate and surgery in the
Radiation Therapy Oncology Group
Radiation_Therapy_Oncology_Group
Monoclonal antibody pharmaceutical drug
use alone, or with methotrexate or similar medicines, in the United States since 2002. It has a similar effectiveness as methotrexate and, in combination
Adalimumab
Medical speciality of inflammatory diseases
such as infliximab and adalimumab, the TNF inhibitor etanercept, and methotrexate for moderate to severe rheumatoid arthritis. The biologic agent rituximab
Rheumatology
its trade name, Adriamycin), and dexamethasone. Course B consists of methotrexate and cytarabine. The protocol was originally developed to treat leukemia
Hyper-CVAD
Chemical compound
has also been used to prevent methotrexate-induced kidney damage by alkalinizing the urine, hence speeding up methotrexate excretion by increasing its solubility
Acetazolamide
Use of pharmaceuticals for conditions different from that for which they were approved
is commonly used to good effect by healthcare providers. For example, methotrexate is commonly used off-label because its immunomodulatory effects relieve
Off-label_use
Medical condition
addition of IV methotrexate and folinic acid (leucovorin) may extend survival to a median of 3.5 years. If radiation is added to methotrexate, median survival
Primary central nervous system lymphoma
Primary_central_nervous_system_lymphoma
Accumulation of mutations
resistance came from studies of methotrexate. Methotrexate inhibits the dihydrofolate reductase (DHFR) gene. However, methotrexate therapy appears to select
Somatic_evolution_in_cancer
Human monoclonal antibody medication
has been suspended after the drug failed to show clinical benefit over methotrexate in a phase II trial. Sarilumab is used for the treatment of moderately
Sarilumab
Medical condition
have been found to be associated with long-standing alopecia totalis. Methotrexate and corticosteroids are proposed treatments. Scalp cooling has specifically
Alopecia_totalis
Monoclonal antibody
severe rheumatoid arthritis in combination with methotrexate who have an inadequate response to methotrexate or tumor necrosis factor inhibitor (TNFi) therapy
Olokizumab
Chemical compound
pharmaceuticals such as malaria treatments, the cytostatic agents aminopterin and methotrexate, as well as the diuretic triamterene. In 1905, Wilhelm Traube reported
2,4,6-Triaminopyrimidine
Medical condition
include: Leaving the placenta in the uterus and curettage of uterus. Methotrexate has been used in this case. Intrauterine balloon catheterization to compress
Placenta_accreta_spectrum
Medical treatment in addition to a primary treatment to maximise effectiveness
favorable survival outcomes that accompanied use of cyclophosphamide methotrexate fluorouracil (CMF) after the initial mastectomy. In 1976, shortly after
Adjuvant_therapy
Immunosuppressive drug
moderate to severe rheumatoid arthritis, applied in combination with methotrexate, if other drugs like disease-modifying antirheumatic drugs (DMARDs) and
Tocilizumab
Abnormally low level of folate (vitamin B9) in the body
deficiency. When methotrexate is prescribed, folic acid supplements are sometimes given with the methotrexate. The therapeutic effects of methotrexate are due
Folate_deficiency
Autoimmune disease in which the immune system attacks healthy tissue
NSAIDs, corticosteroids, immunosuppressants, hydroxychloroquine, and methotrexate. Although corticosteroids are rapidly effective, long-term use results
Lupus
Antibiotic derived from Penicillin
Flucloxacillin can reduce the excretion of methotrexate, potentially resulting in a risk of methotrexate toxicity. The level of flucloxacillin in the
Flucloxacillin
Medical condition
immunosuppression through immunosuppressive drugs (with case reports of methotrexate and azathioprine), infections such as HIV or chronic viral hepatitis
Lymphomatoid_granulomatosis
Medical condition
psoriatic erythroderma include immunosuppressive medications such as methotrexate, acitretin, or ciclosporin. Psoriatic erythroderma displays generalized
Psoriatic_erythroderma
Using drugs to bring about an abortion
combination for uterine pregnancies is methotrexate-misoprostol, which is typically reserved for ectopic pregnancies. Methotrexate is given either orally or intramuscularly
Medical_abortion
Autoimmune disease
such as methotrexate, may be helpful. Hydroxychloroquine (Plaquenil) is another option and is generally considered safer than methotrexate. However,
Sjögren's_disease
Malignant cancer, usually of the placenta
single-agent methotrexate or actinomycin-D is recommended for low-risk disease, while intense combination regimens including EMACO (etoposide, methotrexate, actinomycin
Choriocarcinoma
Chemical compound
ulcerative colitis. For acute lymphocytic leukemia it is generally used with methotrexate. It is taken orally. Common side effects include bone marrow suppression
Mercaptopurine
Type of inflammatory bowel disease
improve symptoms rapidly, alongside another medication such as either methotrexate or a thiopurine to prevent recurrence. Cessation of smoking is recommended
Crohn's_disease
Time taken for a drug to halve its concentration in blood plasma
2021. Flurazepam Monograph. Accessed 15 April 2021. "Trexall, Otrexup (methotrexate) dosing, indications, interactions, adverse effects, and more". reference
Biological_half-life
Form of scleroderma involving isolated patches of hardened skin
hydroxychloroquine or chloroquine have been used. Other immunomodulators such as methotrexate, topical tacrolimus, and penicillamine have been tried. Children and
Morphea
Medication to induce abortion and treat ulcers
For abortions it is typically used in conjunction with mifepristone or methotrexate, but can be used alone. By itself, effectiveness for abortion is between
Misoprostol
Biopharmaceutical drug
United States, it has been FDA approved for use in combination with methotrexate for reducing signs and symptoms in adult patients with moderately to
Rituximab
Medical condition
unrelated donor transplants has a reduced incidence and severity of GvHD. Methotrexate, cyclosporin and tacrolimus are common drugs used for GvHD prophylaxis
Graft-versus-host_disease
Relative measure of dispersion expressed as the ratio of standard deviation to the mean
oral versus subcutaneous methotrexate in patients with rheumatoid arthritis: drug-exposure limitations of oral methotrexate at doses >=15 mg may be overcome
Coefficient_of_variation
Chemical compound
therapy leflunomide plus methotrexate.[clarification needed] However, some studies have shown that the combination of methotrexate and leflunomide in patients
Leflunomide
Catholic term for medical procedure that results in abortion as a secondary effect
seen with consensus to be indirect while some claim salpingostomy and methotrexate to be indirect. Of the other 7-10% of ectopic pregnancies, there are
Indirect_abortion
American scientist
folate analogue aminopterin (later replaced by another folate analogue methotrexate) had increased levels of the dihydrofolate reductase enzyme (DHFR), a
June_Biedler
Biopharmaceutical drug for autoimmune disorders
known to reduce the efficacy of the drug. Combination treatment with methotrexate (an antifolate drug which suppresses the immune system) has been shown
Infliximab
Heightened sense of smell
due to the destruction of dopaminergic neurons in the olfactory bulb. Methotrexate, administered in the treatment of psoriasis, has been known to cause
Hyperosmia
American politician (born 1988)
life-threatening ectopic pregnancy in 2024. Treatment (intramuscular methotrexate) was initially delayed due to confusion about Florida's abortion ban
Kat_Cammack
remission in a patient with leukaemia with the antifolate drug aminopterin (methotrexate) 1949 – US FDA approves mechlorethamine, a nitrogen mustard compound
Timeline of cancer treatment development
Timeline_of_cancer_treatment_development
Medication
(S phase) Folic acid Dihydrofolate reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed
Tretinoin
Medication
response to, or who are intolerant of, methotrexate". In the European Union, in combination with methotrexate, tofacitinib citrate is indicated for the
Tofacitinib
NSAID analgesic medication
cases. Lornoxicam can also increase the adverse effects of lithium, methotrexate and digoxin and its derivatives. The effect of diuretics, ACE inhibitors
Lornoxicam
Group of disorders
doxorubicin, and high-dose methotrexate alternating with ifosfamide, etoposide, and cytarabine plus intrathecal methotrexate and cytarabine) give event-free
Epstein–Barr virus–associated lymphoproliferative diseases
Epstein–Barr_virus–associated_lymphoproliferative_diseases
Chemical substances that can terminate a pregnancy
abortifacient agents are taken with the intention to end a pregnancy. Methotrexate, a drug often used for management of rheumatoid arthritis, can induce
Abortifacient
Medication used to treat cancer
(S phase) Folic acid Dihydrofolate reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed
Carboplatin
Pregnancy-related tumours
(intravenous) methotrexate. The treatment for invasive mole or choriocarcinoma generally is the same. Both are usually treated with chemotherapy. Methotrexate and
Gestational trophoblastic disease
Gestational_trophoblastic_disease
Type of enzyme inhibition by forming an irreversible complex with the substrate
no thymine to create more DNA. This is often used in combination with methotrexate, a potent inhibitor of dihydrofolate reductase enzyme. O6-Benzylguanine
Suicide_inhibition
Instillation Menstrual extraction Medical abortion Abortifacient drugs Methotrexate Mifepristone Misoprostol Oxytocin Self-induced abortion Unsafe abortion
Abortion statistics in the United States
Abortion_statistics_in_the_United_States
Chemical compound
(S phase) Folic acid Dihydrofolate reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed
Navitoclax
List of drugs given to treat leukemia
ozogamicin Idarubicin Imatinib mesylate Interferon-α Interleukin-2 Melphalan Methotrexate Mitoxantrone Nelarabine Nilotinib Oblimersen Pegaspargase Pentostatin
List_of_antileukemic_drugs
Human colon cancer cell line
features of mature colonic epithelial cells. Methotrexate (MTX) Selection: Treatment with methotrexate selects a mucus-secreting subpopulation known
HT-29
Medical condition
interfering with DNA synthesis (such as certain immunosuppressants like methotrexate and azathioprine), bone marrow disease, pregnancy, as well as autoimmune
Macrocytic_anemia
Cancer drug
(S phase) Folic acid Dihydrofolate reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed
Protein-bound_paclitaxel
Medical condition
skin. Drugs such as antibiotics, antifungals, corticosteroids, dapsone, methotrexate, thalidomide, etretinate, cyclosporine and, most recently, intramuscular
Hailey–Hailey_disease
therapeutic effect of penicillin. When methotrexate is administered with penicillin, toxicity may occur related to methotrexate. Animals are often treated with
Side_effects_of_penicillin
Inflammation of the uvea of the eye
antirheumatic drugs (DMARDs) methotrexate, mycophenolate, cyclosporine, azathioprine, and tacrolimus. In comparing various studies, methotrexate is more efficacious
Uveitis
Chronic disease of the liver, characterized by fibrosis
fibrosis Hepatotoxic drugs or toxins, such as acetaminophen (paracetamol), methotrexate, or amiodarone The liver plays a vital role in many metabolic processes
Cirrhosis
Collection of human autoimmune diseases
(e.g., hydroxychloroquine and corticosteroids). A second-line drug is methotrexate in its low-dose schedule. In 2011, the U.S. Food and Drug Administration
Lupus_erythematosus
Topics referred to by the same term
three drug treatments used in Management of HIV/AIDS the combination of methotrexate, sulfasalazine, and hydroxychloroquine used to treat rheumatoid arthritis
Triple_therapy
Systemic necrotizing inflammation of medium-sized muscular arteries
hepatitis B virus infection should be immediately treated. In some cases, methotrexate or leflunomide may be helpful. Some patients have entered a remission
Polyarteritis_nodosa
Antagonist of the histamine H4 receptor
efficacy against rheumatoid arthritis in patients who were nonresponsive to methotrexate. As the H4 receptor is widely implicated in the regulation of inflammatory
Toreforant
Cellular enzyme inhibitor
thymine, this effect may be used to therapeutic advantage. For example, methotrexate is used as cancer chemotherapy because it can prevent neoplastic cells
Dihydrofolate reductase inhibitor
Dihydrofolate_reductase_inhibitor
Drugs that are useful against cancer
Doxifluridine Fludarabine Fluorouracil Gemcitabine Hydroxyurea Mercaptopurine Methotrexate Nelarabine Pemetrexed Tioguanine (formerly Thioguanine) Actinomycin Bleomycin
List of chemotherapeutic agents
List_of_chemotherapeutic_agents
Instillation Menstrual extraction Medical abortion Abortifacient drugs Methotrexate Mifepristone Misoprostol Oxytocin Self-induced abortion Unsafe abortion
Abortion in the Republic of the Congo
Abortion_in_the_Republic_of_the_Congo
Pharmaceutical compound
Propolis Quercetin Tisopurine Topiroxostat Others Aminopterin Azathioprine Methotrexate Mycophenolic acid Pemetrexed Pralatrexate Many others Others Precursors:
Ciforadenant
Photopharmacological agent
is a photoisomerizable structural analogue of the chemotherapy agent methotrexate. It is also an example of "azologization". Pharmacological effects of
Phototrexate
Propolis Quercetin Tisopurine Topiroxostat Others Aminopterin Azathioprine Methotrexate Mycophenolic acid Pemetrexed Pralatrexate Many others Others Precursors:
Adenosinergic
Instillation Menstrual extraction Medical abortion Abortifacient drugs Methotrexate Mifepristone Misoprostol Oxytocin Self-induced abortion Unsafe abortion
Abortion_in_Zambia
Medical intervention
may, however, be counter-productive for patients who are also taking methotrexate, which is a folic acid inhibitor. Folic acid might also be counter-productive
Management of ulcerative colitis
Management_of_ulcerative_colitis
Instillation Menstrual extraction Medical abortion Abortifacient drugs Methotrexate Mifepristone Misoprostol Oxytocin Self-induced abortion Unsafe abortion
Abortion in the United Arab Emirates
Abortion_in_the_United_Arab_Emirates
American cancer researcher
potential drugs on cancer cells. She also pioneered the use of the drug methotrexate to treat breast cancer and skin cancer (mycosis fungoids). Wright's family
Jane_C._Wright
Instillation Menstrual extraction Medical abortion Abortifacient drugs Methotrexate Mifepristone Misoprostol Oxytocin Self-induced abortion Unsafe abortion
Abortion_in_Guinea
Pharmaceutical drug
develop resistance to the medication over time. Co-administration of methotrexate increases the response rate approximately two-fold. In individuals with
Pegloticase
Combination of two antibiotic drugs
phenytoin is increased Antifolates like pyrimethamine, proguanil and methotrexate increase the risk of associated side effects like bone marrow toxicity
Trimethoprim/sulfamethoxazole
METHOTREXATE
METHOTREXATE
METHOTREXATE
METHOTREXATE
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Pet form of Hungarian Vilmos, VILI means "will-helmet."
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Variant spelling of Welsh unisex Bryn, BRYNN means "hill."
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Bengali, Indian
Good Promise
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American, British, English
Lives at the Cave Slope
METHOTREXATE
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