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Search references for NLRC4. Phrases containing NLRC4
See searches and references containing NLRC4!NLRC4
Protein-coding gene in the species Homo sapiens
domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene. The NLRC4 protein is highly conserved across mammalian species. It bears homology
NLRC4
Cytosolic multiprotein complex that mediates the activation of Caspase 1
of which are also driven by NLRs—NLRP3 (NLR family PYD-containing 3) and NLRC4 (NLR family CARD-containing 4). The physiological relevance of the inflammasome
Inflammasome
Frequently fatal immune reaction
juvenile idiopathic arthritis–associated macrophage activation syndrome, NLRC4 macrophage activation syndrome, cytokine release syndrome and sepsis. The
Cytokine_storm
Blue dye also used as a medication
electron acceptor), and decreases the activation of inflammasomes NLRP3 and NLRC4. As a result, it's been considered potentially useful in neuropsychiatric
Methylene_blue
Type of programmed cell death
DAMPs are recognised by certain endogenous PRRs. For example, NLR proteins NLRC4 can recognise flagellin and type III secretion system components. NLRP3
Pyroptosis
Chinese American biochemist
the first oligomeric disc structure of an inflammasome, that of the NAIP-NLRC4 inflammasome. Since 2019, she revealed detailed step-by-step analysis of
Hao_Wu_(biochemist)
Group of innate immune system disorders
(nucleotide-binding oligomerization domain (NOD)-like receptors), pyrin, or NLRC4 (NOD-like receptors (NLR) Family CARD Domain Containing 4). Inflammasomes
Autoinflammatory_diseases
Class of proteins
domain): CIITA NLRB (B for BIRs): NAIP NLRC (C for CARD): NOD1, NOD2, NLRC3, NLRC4, NLRC5 NLRP (P for PYD): NLRP1, NLRP2, NLRP3, NLRP4, NLRP5, NLRP6, NLRP7
NOD-like_receptor
Protein found in humans
canonical pathway and is activated by canonical inflammasomes such as NLRP3 and NLRC4 inflammasomes, which are multi-protein complexes that are formed upon recognition
GSDMD
Kenyan molecular biologist
unequivocal genetic evidence by identifying the NOD-like receptors NLRP3 and NLRC4 as proximal components of inflammasomes responsible for caspase-1 activation
Vishva_Dixit
Infection caused by Salmonella bacteria
infection. Resident macrophages can also recognize flagellin and activate NLRC4 inflammasome complex to activate caspase-1 and IL-1β and IL-18 release.
Salmonellosis
Enzyme found in humans
(ASC) and Nod-like receptor (NLR) family CARD domain–containing protein 4 (NLRC4) through CARD–CARD interactions in the formation of inflammasomes. Caspase-1
Caspase_1
Chemical compound
flagellin or the dsDNA analog Poly(dA:dT) to activate inflammasomes such as NLRC4 and AIM 2 respectively. When Dapansutrile was added they found no difference
Dapansutrile
Protein domain
family. Human proteins containing this domain include: CIITA NAIP NLRC3, NLRC4, NLRC5 NLRP1, NLRP2, NLRP3, NLRP4, NLRP5, NLRP6, NLRP7, NLRP8, NLRP9, NLRP10
NACHT_domain
British veterinarian and pharmacologist
C. E. (6 May 2014). "Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex". Proceedings of the National
Clare_Bryant
Family of cell surface receptors
monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation". Nature Communications. 6 6931. Bibcode:2015NatCo
Pattern_recognition_receptor
Overview of and topical guide to immunology
Inhibitor of apoptosis domain) NAIP NLRC (C for CARD domain) NOD1 NOD2 NLRC3 NLRC4 (IPAF) NLRC5 NLRP (P for Pyrin domain) NLRP1 NLRP2 NLRP3 NLRP4 NLRP5 NLRP6
Outline_of_immunology
Any type of cell death eliciting an immune response
PRRs that are known to induce inflammasome formation are NLRP3, NLRP1, NLRC4, AIM2 and Pyrin. These proteins contain oligomerization NACHT domains, CARD
Immunogenic_cell_death
Interaction motifs found in a wide array of proteins
protease-activating factor, also known as NLR family, card domain containing 4 (NLRC4), CARD, LRR, and NACHT-containing protein (CLAN) and Caspase recruitment
CARD_(domain)
Protein-coding gene in humans
PD-1/PD-L1 immune checkpoint blockade. NOD2 has been shown to interact with NLRC4. NOD2 has also been shown to bind to MAVS in response to ssRNA or viral
NOD2
Q9UBE8 10587 NLN HGNC:16058; Q9BYT8 10588 NLRC3 HGNC:29889; Q7RTR2 10589 NLRC4 HGNC:16412; Q9NPP4 10590 NLRC5 HGNC:29933; Q86WI3 10591 NLRP1 HGNC:14374;
List of human protein-coding genes 5
List_of_human_protein-coding_genes_5
Indian immunologist
Neale, Geoffrey (3 May 2018). "IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation". Cell. 173 (4): 920–933.e13. doi:10.1016/j.cell
Thirumala-Devi_Kanneganti
American immunologist
Philip, N.H., Ayres, J.S., Brodsky, I.E., Gronert, K., Vance, R.E. NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid
Janelle_Ayres
Italian-American neurologist
"Discovery and characterization of small molecule inhibitors of NLRP3 and NLRC4 inflammasomes". Journal of Biological Chemistry. 296 100597. doi:10.1016/j
Giulio_Maria_Pasinetti
Human protein
Gabriel; Syvänen, Ann-Christine; Wallentin, Lars; Siegbahn, Agneta (2015). "NLRC4 Inflammasome Is an Important Regulator of Interleukin-18 Levels in Patients
MROH6
NLRC4
NLRC4
NLRC4
NLRC4
Girl/Female
Tamil
Vivikta | விவிகதா
Distinguished, Pure, Deep, Logically intelligent
Boy/Male
Indian, Sanskrit
Sun of Happiness
Girl/Female
Assamese, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Sindhi, Telugu
Goddess of Birth and Death
Boy/Male
Muslim
Young one in Arabic
Boy/Male
Indian, Punjabi, Sikh
Light of Wealth
Surname or Lastname
English
English : from the medieval personal name Wiot, Wyot, Gyot, which derives from the Old English personal name Wīgheard, composed of the elements wīg ‘war’ + heard ‘hardy’, ‘brave’, ‘strong’. Under Norman influence it was also adopted as a diminutive of both Guy 1 and William.
Girl/Female
Muslim
Property, Treasure
Boy/Male
Hindu
The three worlds heaven, Earth, Hell
Boy/Male
Latin
Youthful.
Boy/Male
Hindu
Prosperity or awakening or high quality, Advancement - to rise
NLRC4
NLRC4
NLRC4
NLRC4
NLRC4