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PENDRIN

Pendrin

Anion exchange protein

Pendrin is an anion exchange protein that in humans is encoded by the SLC26A4 gene (solute carrier family 26, member 4). Pendrin was initially identified

Pendrin

Collecting duct system

Kidney system

Kirsten M.; Nielsen, Søren (2002-10-01). "Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney". American Journal

Collecting duct system

Collecting_duct_system

Thyroid

Endocrine gland in the neck

then travels from within the cell into the lumen, through the action of pendrin, an iodide-chloride antiporter. In the follicular lumen, the iodide is

Thyroid

Α-Ketoglutaric acid

Chemical compound

α-ketoglutarate's binding to, and thereby inhibits its activation of OXGR1. The pendrin protein promotes the electroneutral exchange of tissue chloride (Cl−) for

Α-Ketoglutaric acid

Α-Ketoglutaric_acid

Pendred syndrome

Medical condition

It has been linked to mutations in the PDS gene, which codes for the pendrin protein (solute carrier family 26, member 4, SLC26A4). The gene is located

Pendred syndrome

Pendred_syndrome

Thyroid hormones

Hormones produced by the thyroid gland

is moved across the apical membrane into the colloid of the follicle by pendrin. Hydrogen peroxide is also introduced into the follicle by the action of

Thyroid hormones

Thyroid_hormones

Loop diuretic

Diuretics that act along the loop of Henle in the kidneys

tubule, epithelial sodium channels, and chloride-bicarbonate exchanger pendrin. This will promote sodium reabsorption and fluid retention, causing diuretic

Loop diuretic

Loop_diuretic

Thiocyanate

Chemical compound

Resting and IL-4-Stimulated Human Bronchial Epithelial Cells: Role of Pendrin and Anion Channels". Journal of Immunology. 178 (8): 5144–5153. doi:10

Thiocyanate

Thyroid peroxidase

Enzyme expressed mainly in the thyroid gland

side, iodide is shuttled across the apical membrane into the colloid via pendrin after which thyroid peroxidase oxidizes iodide to atomic iodine (I) or

Thyroid peroxidase

Thyroid_peroxidase

Chromosome 7

Human chromosome

2025-12-25. Grimaldi R, Capuano P, Miranda N, Wagner C, Capasso G (2007). "[Pendrin: physiology, molecular biology and clinical importance]". Giornale Italiano

Chromosome 7

Chromosome_7

Thyroid follicular cell

Hormone-producing cell in the thyroid gland

iodide is secreted into the colloid by the chloride/iodide transporter pendrin. Thyroid diverticulum List of human cell types derived from the germ layers

Thyroid follicular cell

Thyroid_follicular_cell

Contraction alkalosis

Increase in blood pH resulting from fluid loss

attributable entirely to chloride depletion, which leads to a failure of pendrin, a chloride/bicarbonate exchanger in the collecting duct. Diagnosis of

Contraction alkalosis

Contraction_alkalosis

Renal physiology

Study of the physiology of the kidney

reabsorption (thick ascending) – reabsorption (intercalated cells, via band 3 and pendrin) Protons Uses vacuolar H+ATPase – – – secretion (intercalated cells) Potassium

Renal physiology

Renal_physiology

Department of Pharmacology, University of Oxford

Academic department in the UK

Alan W.; Fong, Peying; Gray, Michael A. (2011-11-25). "Novel Role for Pendrin in Orchestrating Bicarbonate Secretion in Cystic Fibrosis Transmembrane

Department of Pharmacology, University of Oxford

Department_of_Pharmacology,_University_of_Oxford

Hypothiocyanite

Chemical compound

resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels". J. Immunol. 178 (8): 5144–53. doi:10.4049/jimmunol

Hypothiocyanite

Anion exchange protein 2

Protein found in humans

Greeley T, Petrovic S, Wang Z, Amlal H, Kopp P, Burnham CE (February 2001). "Pendrin: an apical Cl−/OH−/HCO3− exchanger in the kidney cortex". American Journal

Anion exchange protein 2

Anion_exchange_protein_2

Anion exchange protein 3

Protein-coding gene in the species Homo sapiens

M, Greeley T, Petrovic S, Wang Z, Amlal H, Kopp P, et al. (Feb 2001). "Pendrin: an apical Cl−/OH−/HCO3− exchanger in the kidney cortex". American Journal

Anion exchange protein 3

Anion_exchange_protein_3

TRPV6

Protein-coding gene in the species Homo sapiens

caused by mutations in which compromise the function of the encoded protein pendrin - an anion Cl−/HCO3 − exchanger expressed in the inner ear. The loss of

TRPV6