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Chemical compound
Physostigmine (also known as eserine from éséré, the West African name for the Calabar bean) is a highly toxic parasympathomimetic alkaloid, specifically
Physostigmine
Parasympathetic nervous system inhibitors
been reported after the rapid administration of physostigmine. Asystole has occurred after physostigmine administration for tricyclic antidepressant overdose
Anticholinergic
Deadly nightshade, a flowering plant
has unpredictable effects. The antidote for belladonna poisoning is physostigmine or pilocarpine, the same as for atropine. The highly toxic ripe fruit
Atropa_bella-donna
Anti-full body paralysis drug treatment
neos, meaning "new", and "-stigmine", in reference to the alkaloid, physostigmine, which inspired its design. It is available as a generic medication
Neostigmine
Species of plant
color. Calabar bean contains physostigmine, a reversible cholinesterase inhibitor alkaloid. The alkaloid physostigmine acts in effect like nerve gas
Physostigma_venenosum
Region of the human brain
nucleus of the spinal cord via reticulospinal tract.[citation needed] Physostigmine, a choline-esterase inhibitor, elevates endogenous levels of acetylcholine
Rostral_ventrolateral_medulla
Opioid analgesic compound
It is a metabolite of the acetylcholinesterase inhibitor physostigmine but unlike physostigmine, the acetylcholinesterase inhibition produced by eseroline
Eseroline
American research chemist (1899–1975)
plants. Julian was the first person to synthesize the natural product physostigmine, and a pioneer in industrial large-scale chemical synthesis of the human
Percy_Lavon_Julian
Scottish ophthalmologist (1837–1909)
January 1909) was a Scottish ophthalmologist and surgeon. He introduced physostigmine into ophthalmic practice and the Argyll Robertson pupil is named after
Douglas_Argyll_Robertson
Chemical compound
Yissum for commercial development. It is a semi-synthetic derivative of physostigmine. "Prescription medicines: registration of new generic medicines and
Rivastigmine
Drug that blocks hallucinogen effects
intravenous dose of physostigmine (0.02 mg/kg for children and 0.5 to 2 mg/ kg for adults) is recommended [159]. Physostigmine is helpful in restoring
Trip_killer
Class of alkaloids
sign of innocence, otherwise, the person was killed via the action of physostigmine, which is present in the plant and causes full body paralysis. Consumption
Indole_alkaloid
Anti-emetic and antihistamine medication
needed] An antidote that can be used for dimenhydrinate poisoning is physostigmine. Dimenhydrinate (originally known as Compound 1694) was being tested
Dimenhydrinate
Genus of venomous snakes
have been successfully treated with cholinesterase inhibitors, such as physostigmine or neostigmine, but success is variable and may be species-dependent
Bungarus
Type of organic compound or group
synthesis. Several examples exist in nature. Naturally occurring aminals Physostigmine, a highly toxic cholinesterase inhibitor found in the Calabar bean.
Aminal
Chemical compound
acetylcholinesterase inhibitor. Neostigmine Miotine T-1123 T-1152 T-1194 TL-1238 Physostigmine Chemical Warfare Agents, and Related Chemical Problems. Parts I-II.
TL-599
British physician
was a Scottish physician who first demonstrated the effectiveness of physostigmine in the treatment of the condition myasthenia gravis, a disease relating
Mary_Broadfoot_Walker
Agent which mimics choline
the elderly. The memory impairments were reversed when treated with physostigmine, a cholinergic agonist. However, reversing memory impairments in AD
Cholinergic
Species of mushroom
the muscarinic acetylcholine receptor site, and therefore atropine or physostigmine as an antidote is not recommended. If a patient is delirious or agitated
Amanita_muscaria
Group of chemical substances used as poison
acetylcholinesterase (AChE) inhibitor (anti-cholinesterase), such as physostigmine or neostigmine. By blocking ACh degradation, AChE inhibitors raise the
Curare
Chemical compound
back to physostigmine, an alkaloid found in the seeds of an African plant Calabar bean. Due to its ability to inhibit cholinesterase, physostigmine was among
Buntanetap
oxychloride Phosphorus pentachloride Phosphorus trichloride Physostigmine Physostigmine, salicylate (1:1) Picrotoxin Piperidine Pirimifos-ethyl Plutonium
EPA list of extremely hazardous substances
EPA_list_of_extremely_hazardous_substances
Genus of poisonous, potentially psychoactive plants
reduce the stomach's absorption of the ingested material, and the drug physostigmine is used to reverse the effect of the poisons. Benzodiazepines can be
Datura
Benzodiazepine sedative
or soman (or other organophosphate poisons), lindane, chloroquine, physostigmine, or pyrethroids. Diazepam is sometimes used intermittently for the prevention
Diazepam
Group of stereoisomers
brought to medical attention, where reversal can be attempted with physostigmine administered intravenously or subcutaneously. Procyclidine is an anticholinergic
Procyclidine
Class of organophosphates; classified as weapons of mass destruction
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Nerve_agent
Medication used for dementia
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Donepezil
Medical condition
ventilation until the crisis resolves on its own.[citation needed] Physostigmine Edrophonium Asensio JA, Trunkey DD (Apr 20, 2015). Current Therapy of
Cholinergic_crisis
Dryness of the mouth
lozenges. Physostigmine Gel: A study by Knosravini in 2009 showed a reduction in the oral dryness and a 5 times increase in saliva following physostigmine treatment
Xerostomia
Chemical compound
2006). "Best evidence topic report. Gammahydroxybutyrate overdose and physostigmine". Emergency Medicine Journal. 23 (4): 300–01. doi:10.1136/emj.2006.035139
Γ-Hydroxybutyric_acid
Antihistamine medication
toxicity is known, but the anticholinergic syndrome has been treated with physostigmine for severe delirium or tachycardia. Benzodiazepines may be administered
Diphenhydramine
Type of substances designed to affect the nervous system
the dose can cause side effects like nausea, diarrhea and headache. Physostigmine is an anticholinesterase drug and it is used in treating glaucoma. For
Autonomic_drug
Chemical group (>N–C(=O)–O–)
oxamyl, and methomyl. They are synthetic analogues of the toxic alkaloid physostigmine, the study of which led to this class of insecticides. An estimated
Carbamate
Peptide hormone that stimulates growth
"Association of a nicotinic receptor mutation with reduced height and blunted physostigmine-stimulated growth hormone release". The Journal of Clinical Endocrinology
Growth_hormone
Organic chemical and neurotransmitter
that competitively inhibit acetylcholinesterase (e.g., neostigmine, physostigmine, or primarily pyridostigmine) are effective in treating the symptoms
Acetylcholine
Tropane alkaloid & anticholinergic drug
Blurred vision Mydriasis (dilated pupils) Drowsiness Dizziness Somnolence Physostigmine, a cholinergic drug that readily crosses the blood–brain barrier, has
Scopolamine
Chemical compound used as antidote for nerve agent poisoning
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Pralidoxime
Psychoactive component of cannabis
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Tetrahydrocannabinol
Neurological impairment of voluntary muscle movement
ataxia include: 5-hydroxytryptophan (5-HTP), idebenone, amantadine, physostigmine, L-carnitine or derivatives, trimethoprim/sulfamethoxazole, vigabatrin
Ataxia
Insect killing chemical, organophosphate
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Dichlorvos
Species of flowering plant in the nightshade family
weeks. As with other cases of anticholinergic poisoning, intravenous physostigmine can be administered in severe cases as an antidote. These chemical production
Datura_stramonium
Drug that block acetylcholine in synapses of cholinergic nervous system
ingestion. Physostigmine is given only if presenting both peripheral and central signs and symptoms of anticholinergic poisoning. Physostigmine is a central
Cholinergic_blocking_drug
Central nervous system stimulant
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Caffeine
Chemical compound and chemical warfare nerve agent
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
VX_(nerve_agent)
Chemical compound and chemical warfare nerve agent
such as Sevin, and the medicines pyridostigmine, neostigmine, and physostigmine. Controlled studies in healthy men have shown that a nontoxic 0.43 mg
Sarin
Protagonist of the TV series House
undergoes a blood transfusion to assist with a diagnosis, and overdoses on physostigmine to improve his memory after sustaining head injuries, subsequently causing
Gregory_House
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
A-234_(nerve_agent)
Class of acetylcholinesterase inhibitors
disease and Parkinson's disease. The name "stigmine" is derived from physostigmine, a naturally occurring acetylcholinesterase inhibitor isolated from
Stigmine
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Diisopropyl_fluorophosphate
Acetylcholinesterase inhibitor
acetylcholinesterase inhibitor. Its structure is related to that of physostigmine, another acetylcholinesterase (AChE) inhibitor. Quilostigmine displays
Quilostigmine
Autoimmune disease resulting in skeletal muscle weakness
Jolly, a German physician. Mary Walker treated a person with MG with physostigmine in 1934. Simpson and Nastuck detailed the autoimmune nature of the condition
Myasthenia_gravis
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Lycorine
Substance that mimics stimulation of cholinergic receptors
Reversible cholinesterase inhibitors Donepezil Edrophonium Neostigmine Physostigmine Pyridostigmine Rivastigmine Tacrine Caffeine (non-competitive) Huperzine
Parasympathomimetic_drug
Chemical compound and essential nutrient
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Choline
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Methomyl
Primary cholinesterase in the body
that hydrolyze in hours and have been used for medical purposes (e.g., physostigmine for the treatment of glaucoma). Reversible inhibitors occupy the esteratic
Acetylcholinesterase
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Parathion_S
Chemical compound
pronounced anti-acetylcholine, anti-tremorine-induced tremor, anti-physostigmine-induced death, anti-haloperidol-induced parkinsonism and anti EEG arousal
Mazaticol
Model of enzyme kinetics
1137/1031091. Eadie, G. S. (1942). "The inhibition of cholinesterase by physostigmine and prostigmine". J. Biol. Chem. 146 (1): 85–93. Bibcode:1942JBiCh.146
Michaelis–Menten_kinetics
Series of nerve agents developed by the Soviet Union
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Novichok
Chemical compound
Cymserine is a drug related to physostigmine, which acts as a reversible cholinesterase inhibitor, with moderate selectivity (15 times) for the plasma
Cymserine
Pharmaceutical drug classification
V03AB17 Methylthioninium chloride V03AB18 Potassium permanganate V03AB19 Physostigmine V03AB20 Copper sulfate V03AB21 Potassium iodide V03AB22 Amyl nitrite
ATC_code_V03
Investigational restless legs syndrome drugs
lamotrigine, levetiracetam, orphenadrine, oxcarbazepine, perampanel, physostigmine, rasagiline, rifaximin, selegiline, topiramate, valproic acid) List
List of investigational restless legs syndrome drugs
List_of_investigational_restless_legs_syndrome_drugs
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Miotine
Mammalian protein found in humans
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Butyrylcholinesterase
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Butocarboxim
Chemical compound
Two research groups were independently trying to synthesize the drug physostigmine. One group, led by Percy Julian at Howard University aimed to create
Eserethole
Class of psychoactive drugs
Thomas J (1998). "Treatment of acute anticholinergic poisoning with physostigmine". The American Journal of Emergency Medicine. 16 (5): 505–507. doi:10
Deliriant
Type of paralyzing anesthetic including lepto- and pachycurares
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Neuromuscular-blocking_drug
Anticholinergic medication used as antidote for nerve agent poisoning
(by mouth) with a probit slope of 1.8. The antidote to atropine is physostigmine or pilocarpine.[medical citation needed] A common mnemonic used to describe
Atropine
Medical condition
due to increased risk of respiratory depression. There is no role for physostigmine in the treatment of tricyclic toxicity as it may increase cardiac toxicity
Tricyclic antidepressant overdose
Tricyclic_antidepressant_overdose
Nerve agent
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Chinese_VX
Chemical agents that inhibit Cholinesterase
Some organophosphates not listed under "Irreversible" below Carbamates Physostigmine Neostigmine Pyridostigmine Ambenonium Demecarium Rivastigmine Phenanthrene
Cholinesterase_inhibitor
Chemical compound found in a variety of plants
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Rosmarinic_acid
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Oxydemeton-methyl
Active region of an enzyme
inhibit it so no new mature viral particle can be made. Insecticides Physostigmine In the animal nervous system, Acetylcholinesterase is required to break
Active_site
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Chlorpyrifos
Group of stereoisomers
respiratory depression and cardiac arrest. A specific antagonist is physostigmine which combines a peripheral and a central action. Carbachol can be used
Biperiden
Species of bacterium
produces azinomycin A, azinomycin B, bundlin A, bundlin B, moldicidin A, physostigmine, fungichromin and pentamycin. List of Streptomyces species LPSN bacterio
Streptomyces_griseofuscus
Military incapacitating agent
effects of BZ within minutes. Some military references suggest the use of physostigmine to temporarily increase synaptic acetylcholine concentrations. BZ was
3-Quinuclidinyl_benzilate
Neurotoxin produced by Clostridium botulinum
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Botulinum_toxin
Graph of enzyme kinetics
S2CID 4162570. Eadie GS (1942). "The Inhibition of Cholinesterase by Physostigmine and Prostigmine". Journal of Biological Chemistry. 146: 85–93. doi:10
Eadie–Hofstee_diagram
Class of naturally occurring chemical compounds
β-carboline Harman, harmine, harmaline, eleagnine Pyrroloindole alkaloids Physostigmine (eserine), etheramine, physovenine, eptastigmine Semiterpenoid indole
Alkaloid
drugs from plants. He was the first to synthesize the natural product physostigmine, and a pioneer in the industrial large-scale chemical synthesis of the
List of African-American inventors and scientists
List_of_African-American_inventors_and_scientists
British toxicologist and physician (1797–1882)
experiments on himself such as taking large doses of calabar bean (physostigmine). In 1827, he was appointed physician-in-ordinary to the Royal Infirmary
Robert_Christison
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
A-232
Medication used to treat myasthenia gravis
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Pyridostigmine
Class of drugs
Thomas J (1998). "Treatment of acute anticholinergic poisoning with physostigmine". The American Journal of Emergency Medicine. 16 (5): 505–507. doi:10
Hallucinogen
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
VR-56_(nerve_agent)
Therapeutics. London: P. Blakiston's. p. 53. the antidote for belladonna is physostigmine or pilocarpine the same as for atropine. North Carolina State University
List_of_poisonous_plants
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Ungiminorine
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Ladostigil
Interruption of a chemical pathway
Biochemistry (5th ed.). Eadie SG (1942). "The Inhibition of Cholinesterase by Physostigmine and Prostigmine". Journal of Biological Chemistry. 146: 85–93. doi:10
Competitive_inhibition
Nerve agent
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
4-686-293-01
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
VG_(nerve_agent)
Chemical compound
; Reinert, M. (1931). "Pharmacological action of some analogues of physostigmine". Journal of Pharmacology and Experimental Therapeutics. 43 (3): 413–444
Dimethylcarbamoyl_chloride
German pharmacologist and toxicologist
the university. He is remembered for his pharmacological studies of physostigmine and apomorphine. He was the son of theologian Theodosius Harnack and
Erich_Harnack
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Carbaryl
Chemical compound (nerve agent)
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Soman
Chemical compound
Eptastigmine Ganstigmine Neostigmine +glycopyrronium bromide Phenserine Physostigmine Pyridostigmine Quilostigmine Rivastigmine Terestigmine Tolserine; Others:
Ro_3-0412
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