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Protein
Suppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene. This gene encodes a member of the STAT-induced
SOCS3
Biological signaling pathway h
each other. The SH2 domains of SOCS2, SOCS3 and CIS bind directly to receptors themselves. Also, SOCS1 and SOCS3 can prevent JAK-STAT signalling by binding
JAK-STAT_signaling_pathway
Family of genes
involved in inhibiting the JAK-STAT signaling pathway. CISH SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SOCS6 SOCS7 All SOCS have certain structures in common. This
Suppressor of cytokine signalling
Suppressor_of_cytokine_signalling
Chinese-American neuroscientist
pathways involved in neural repair. He discovered that the PTEN/mTOR and SOCS3/STAT3 signaling pathways are key regulators of the intrinsic growth capabilities
Zhigang_He
Protein that stimulates red blood cell production
differentiation, survival and proliferation of the erythroid cell. SOCS1, SOCS3 and CIS are also expressed which act as negative regulators of the cytokine
Erythropoietin
Non-receptor tyrosine kinase and coding gene in humans
GHR IRS1 IL12RB2 IL5RA PIK3R1 PPP2R4 PTK2 PTPN11 PTPN6 PRMT5 SH2B1 SHC1 SOCS3 STAT5A STAT5B STAM SOCS1 TEC TNFRSF1A VAV1 YES1 Prolactin signals through
Janus_kinase_2
Protein family
expression of target genes including suppressor of cytokine signaling 3 (SOCS3), a strong inhibitor of insulin signaling. Research has demonstrated that
Receptor for retinol uptake STRA6
Receptor_for_retinol_uptake_STRA6
Group of proteins
et al. showed that another molecule, SOCS3, plays an important role in IL-17 production. In the absence of SOCS3, IL-23-induced STAT3 phosphorylation
Interleukin_17
Protein domain
SH2D6; SH3BP2; SHB; SHC1; SHC3; SHC4; SHD; SHE SLA; SLA2 SOCS1; SOCS2; SOCS3; SOCS4; SOCS5; SOCS6; SOCS7 SRC; SRMS STAT1; STAT2; STAT3; STAT4; STAT5A;
SH2_domain
Field of study
accounting 24% of variance. Lastly, in a study conducted in 2018, the gene SOCS3, a cytokine signaling suppressor, was found to be upregulated in obesity
Epigenetics of physical exercise
Epigenetics_of_physical_exercise
Medical condition
increase of suppressor of cytokine signaling 3 (SOCS3) in a large number of STAT GOF patients. SOCS3 negatively regulates STAT3 and inhibits other STAT
STAT3_GOF
Mammalian protein found in Homo sapiens
HER2/neu, Janus kinase 1 Leukemia inhibitory factor receptor, PTPN11, SHC1, SOCS3, and TLE1. GRCh38: Ensembl release 89: ENSG00000134352 – Ensembl, May 2017
Glycoprotein_130
RNA family
SOCS3 is not repressed by miR-203. In contrast, Wei et al. (2010) validated SOCS3 as a target for miR-203. In their study, they introduced the SOCS3 3'UTR
MiR-203
Imaki, Toshihiro; Minami, Shiro (2004-04-01). "Human growth hormone induces SOCS3 and CIS mRNA increase in the hypothalamic neurons of hypophysectomized rats"
Periventricular_nucleus
Protein-coding gene in the species Homo sapiens
the total level of transcription of the STAT3 target genes, Bcl-XL and SOCS3. Likewise, expression of wild-type PTPrho decreases the ability of STAT3
PTPRT
Cell receptor protein found in humans
Mdm2, NEDD4, PIK3R3, PTPN11, RAS p21 protein activator 1, SHC1 SOCS2, SOCS3, and YWHAE. There is evidence to suggest that IGF1R is negatively regulated
Insulin-like growth factor 1 receptor
Insulin-like_growth_factor_1_receptor
Protein-coding gene in the species Homo sapiens
PAP-1 and TRAF2 / SNX6), and regulation of the JAK/STAT pathway (SOCS1 and SOCS3). Furthermore, Pim-1 has been shown to be a cofactor for c-Myc, a transcription
PIM1
Mammalian protein found in Homo sapiens
Sobota RM, Hortner M, Friederichs K, et al. (January 2003). "SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through
Janus_kinase_1
Regulation Changes activity by an unknown mechanism (may be direct or indirect) SOCS3 has a positive "Regulation" relationship with diabetes mellitus Direct Regulation
EMBiology
Protein-coding gene in humans
Janus kinase 2, LAIR1, LRP1, PDGFRB, PI3K → Akt PLCG2, PTK2B, Ras SLAMF1, SOCS3, SOS1, STAT3, STAT5A, and STAT5B. Inhibitors Batoprotafib SHP099 Sitneprotafib
PTPN11
Protein-coding gene in the species Homo sapiens
promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. IntAct, STRING, NextProt
Multiple epidermal growth factor-like domains 8
Multiple_epidermal_growth_factor-like_domains_8
Class of kinase enzymes
Johnston JA, Yoshimura A (June 1999). "Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase
Non-receptor_tyrosine_kinase
Protein-coding gene in the species Homo sapiens
CRKL, Erythropoietin, Grb2, Janus kinase 2, LYN, PIK3R1, PTPN6, SOCS2, SOCS3, and STAT5A. GRCh38: Ensembl release 89: ENSG00000187266 – Ensembl, May
Erythropoietin_receptor
efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway". Frontiers in Immunology. 15 1455771. doi:10.3389/fimmu
Ozone_and_biology
Indian pharmacologist
Clouthier, S G; Malik, F; Paulson, A K; D'Angelo, R C (17 February 2014). "SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated
Fayaz_A._Malik
Biological process
hair cell regeneration has been demonstrated in the inner ear. The Stat3/SOCS3 pathway has been identified as key in promoting hair cell regeneration through
Inner_ear_regeneration
Protein-coding gene in humans
mice negatively affects the expression of tumor suppressor genes TNFAIP3, SOCS3, and TNFRSF14. Conversely, KMT2D deficiency in several breast and colon
KMT2D
A7XYQ1 15500 SOCS1 HGNC:19383; O15524 15501 SOCS2 HGNC:19382; O14508 15502 SOCS3 HGNC:19391; O14543 15503 SOCS4 HGNC:19392; Q8WXH5 15504 SOCS5 HGNC:16852;
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
Protein-coding gene in the species Homo sapiens
EPHB2, EPHB3, GNB2L1 HCK, HRAS, HTT, IGF1R, KHDRBS1, NCK1, PDGFRB, PTK2B, SOCS3, and Src. The mRNA can interact with Mir-132 microRNA; this process is linked
RAS_p21_protein_activator_1
Australian pathologist (born 1937)
STAT3 proteins in their bone cells. Cortical bone maturation depends on SOCS3-mediated suppression of interleukin-6 cytokine-induced STAT3 phosphorylation
Thomas_Martin_(pathologist)
Protein-coding gene in the species Homo sapiens
attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3". FEBS Letters. 480 (2–3): 132–136. doi:10.1016/S0014-5793(00)01905-0. PMID 11034314
SOCS2
Cassandra; Zadjali, Fahad; Yoshimura, Akihiko; Karlsson, Mikael (2021-03-18). "SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development"
Thymus_stromal_cells
American physician
attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3". Nature Medicine. 10 (7): 734–8. doi:10.1038/nm1072. PMID 15220914. S2CID 8086930
Jeffrey_Flier
Australian-American immunologist and biochemist
Jörg; Ihle, James N.; Rutschman, Robert; Murray, Peter J. (June 2003). "SOCS3 regulates the plasticity of gp130 signaling". Nature Immunology. 4 (6):
Peter_Murray_(immunologist)
Sub-field of nutritional genomics
vivo studies, to be regulated by epigenetic mechanisms include leptin, SOCS3, glucose transporter (GLUT)-4, POMC, 11-β-hydroxysteroid dehydrogenase type
Nutriepigenomics
RNA family
microRNA-122 enhances interferon-α signaling in the liver through regulating SOCS3 promoter methylation". Scientific Reports. 2 637. Bibcode:2012NatSR...2
MiR-122
SOCS3
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Girl/Female
Tamil
Hanvitha | ஹநà¯à®µà¯€à®¤à®¾
Happy
Girl/Female
Muslim
Capable one
Girl/Female
Australian, Hebrew
Devoted to God
Girl/Female
Hindu, Indian
Light
Girl/Female
British, English
The Long Field
Girl/Female
Hindu
The Moon
Boy/Male
Hindu
Shailastha resident of Gandhamadhana
Surname or Lastname
Irish
Irish : adopted as an English equivalent of Gaelic Ó Maoil Fhábhail ‘descendant of Maolfhábhail’, a personal name meaning ‘fond of movement or travel’.English : from the common French place name Laval, from Old French val ‘valley’. This is also a Huguenot name (with the same etymology), taken to England by Etienne-Abel Laval, a minister of the French church in Castle Street, London, around 1730.French : habitational name from Lavelle in Puy-de-Dôme or various other, smaller places so named.
Boy/Male
Portuguese Spanish
Form of Justus 'just; upright; righteous.
Boy/Male
Muslim
Vision, Propitious, Auspicious, Prudent, Bringer of glad tidings
SOCS3
SOCS3
SOCS3
SOCS3
SOCS3