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Protein-coding gene in the species Homo sapiens
of nonsense transcripts 2 is a protein that in humans is encoded by the UPF2 gene. This gene encodes a protein that is part of a post-splicing multiprotein
UPF2
Elimination of mRNA with premature stop codons in eukaryotes
Saccharomyces cerevisiae (brewer's yeast), the pathway has three main factors: UPF1, UPF2, and UPF3 (UPF3A and UPF3B in humans), which make up the conserved core of
Nonsense-mediated_decay
Protein complex assembled on mRNA
for UPF3, which acts as a bridge between UPF2 and UPF1 forming a trimeric complex. Within this complex, UPF2 and UPF3 act cooperatively to promote ATPase
Exon_junction_complex
Eukaryotic protein complex that removes the 5' cap on mRNA
helicase Dhh1, the exonuclease Xrn1, nonsense mediated decay factors Upf1, Upf2, and Upf3, the LSm complex, Pat1, and various other proteins. These proteins
Decapping_complex
Intracellular mechanisms
A surveillance complex consisting of various proteins (eRF1, eRF3, Upf1, Upf2 and Upf3) is assembled and scans the mRNA for premature stop codons. The
MRNA_surveillance
Protein-coding gene in the species Homo sapiens
sites has been noted for this gene. UPF1 interacts with: DCP1A, DCP2, SMG1, UPF2, UPF3A, and UPF3B. GRCh38: Ensembl release 89: ENSG00000005007 – Ensembl
UPF1
Formation on 5' ends of mRNAs
mRNA decapping enzyme DCP2. A host of proteins accompany it including UPF1, UPF2, UPF3A, Dcp1, Dhh1, XRN1, and others. The decapping enzyme removes the 5'
Cap_binding_complex
Protein-coding gene in the species Homo sapiens
isoforms have been found for this gene. UPF3B has been shown to interact with UPF2 and UPF1. GRCh38: Ensembl release 89: ENSG00000125351 – Ensembl, May 2017
UPF3B
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
Autophagy Activating Kinase 2 UPF1 UPF1 UPF1, RNA Helicase and ATPase yes UPF2 UPF2 UPF2, RNA Helicase and ATPase UPF3B UPF3B UPF3B, Regulator of Nonsense Mediated
Stress_granule
Protein-coding gene in the species Homo sapiens
been shown that STAU1 binding to UPF2 is a more stable interaction than with UPF1, which indicates that the STAU1/UPF2 complex is responsible for recruiting
STAU1
Protein-coding gene in the species Homo sapiens
variants encoding different isoforms exist. UPF3A interacts with RBM8A, UPF2 and UPF1. GRCm38: Ensembl release 89: ENSMUSG00000038398 – Ensembl, May 2017
UPF3A
Protein-coding gene in the species Homo sapiens
The SURF complex then associates with a downstream complex composed of Upf2, Upf3, and EJC to create a new complex: Decay-Inducing Complex (DECID). Upon
Eukaryotic translation termination factor 1
Eukaryotic_translation_termination_factor_1
Protein-coding gene in the species Homo sapiens
This structure is based upon the crystal structure of the complex between 2 human nonsense mediated decay factors, upf1 and upf2, orthorhombic form.
Protein_ZGRF1
mRNA surveillance roles of conserved NMD pathway proteins including UPF1, UPF2, UPF3, and DCP2. To study the relationship between translation and NMD, Jacobson
Allan_Jacobson
Protein product of a maternally expressed gene
when Staufen protein binds to an mRNA and recruits SMD factors (i.e. UPF1, UPF2) that degrade the RNA molecule bound to Staufen. SMD potently affects metabolism
Staufen_(protein)
Chinese-American reproductive biologist
Johannes; Tang, Chong; Ge, Ying; Porse, Bo T.; Yan, Wei (5 May 2016). "UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis
Wei_Yan_(biologist)
Q9H9P5 17909 UPB1 HGNC:16297; Q9UBR1 17910 UPF1 HGNC:9962; Q92900 17911 UPF2 HGNC:17854; Q9HAU5 17912 UPF3A HGNC:20332; Q9H1J1 17913 UPF3B HGNC:20439;
List of human protein-coding genes 8
List_of_human_protein-coding_genes_8
UPF2
UPF2
UPF2
UPF2
Girl/Female
Welsh
Wretched.
Boy/Male
Australian, Finnish
Earth- Worker; Farmer
Boy/Male
Latin
Faithful.
Boy/Male
Hindu, Indian
Covered with Hides; Protected; Sheltered
Male
Italian
Italian form of Latin Mauricius, MAURO means "dark-skinned; Moor."
Boy/Male
Muslim
Greenery
Male
Japanese
(法男) Japanese name NORIO means "man of law."
Male
Welsh
Welsh form of Roman Latin Ovid, OFYDD means "sheep herder."
Girl/Female
Arabic, Hindu, Indian, Muslim
Forgiver; One who Forgives
Boy/Male
Indian, Tamil
Sweet Like a Mango
UPF2
UPF2
UPF2
UPF2
UPF2