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Chemical compound
AM-679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl
AM-679_(FLAP_inhibitor)
Topics referred to by the same term
code number AM-679, invented by teams led by Alexandros Makriyannis and Alla Musiyenko respectively. AM-679 (cannabinoid) AM-679 (FLAP inhibitor) This disambiguation
AM-679
Medication class that inhibits leukotriene synthesis and/or activity
activating protein (FLAP) inhibit functioning of 5-lipoxygenase and may help in treating atherosclerosis. Examples of 5-LOX inhibitors include drugs, such
Antileukotriene
Protein-coding gene in the species Homo sapiens
focused experiments to probe the cell biology of FLAP and its role in leukotriene biosynthesis. AM-679 MK-886 Veliflapon (BAY X1005) GRCm38: Ensembl release
5-lipoxygenase-activating protein
5-lipoxygenase-activating_protein
Chemical compound
leukotriene inhibition with some cases. Originally MK-886 was made as a FLAP inhibitor which has some interference with the leukotriene pathway. This is done
MK-886
Chemical compound
arachidonate 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTC4 synthase (LTC4S), which couples glutathione to an LTA4 intermediate
Leukotriene_C4
Class of inflammation mediator molecules
donated by the 5-lipoxygenase-activating protein (FLAP) to 5-lipoxygenase. 5-Lipoxygenase (5-LO) uses FLAP to convert arachidonic acid into 5-hydroperoxyeicosatetraenoic
Leukotriene
Class of enzymes
inhibiting ALOX5. Indirubin-3'-monoxime, a derivative of the naturally occurring alkaloid, indirubin, is also described as selective ALOX5 inhibitor effective
Arachidonate_5-lipoxygenase
Mammalian protein found in Homo sapiens
Cyclin-dependent kinase 4 Cyclin-dependent kinase inhibitor 1C DNMT1 EP300 Establishment of Sister Chromatid Cohesion 2 Flap structure-specific endonuclease 1 GADD45A
Proliferating cell nuclear antigen
Proliferating_cell_nuclear_antigen
Digestive system in humans
teeth clean by breaking down any lodged food particles. The epiglottis is a flap of elastic cartilage attached to the entrance of the larynx. It is covered
Human_digestive_system
Upper airway closure disrupting sleep
temporary airway obstruction. Following pharyngeal flap surgery, depending on size and position, the flap itself may have an "obturator" or obstructive effect
Obstructive_sleep_apnea
Chemical compound
the enzyme 5-lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) in the presence of ATP and calcium ions. The resulting 5-HPETE yields the
Leukotriene_A4
Cancer arises in the head or neck region
some anatomy with tissue from other areas of the body (soft tissue or bone flap reconstruction). This can lead to changes in sensation and function of this
Head_and_neck_cancer
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AM 679-FLAP-INHIBITOR
AM 679-FLAP-INHIBITOR
AM 679-FLAP-INHIBITOR
AM 679-FLAP-INHIBITOR
AM 679-FLAP-INHIBITOR
AM 679-FLAP-INHIBITOR
AM 679-FLAP-INHIBITOR
AM 679-FLAP-INHIBITOR
AM 679-FLAP-INHIBITOR
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