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Quaternary ammonium cation
Berberine is an organic compound classified as benzylisoquinoline alkaloid. Chemically, it is a quaternary ammonium compound. Its name is derived from
Berberine
Enzyme
Berberine reductase (EC 1.5.1.31) is an enzyme that catalyzes the chemical reaction (R)-canadine + 2 NADP+ 2 H+ 2 H+ berberine + 2 NADPH The
Berberine_reductase
Species of flowering plant
and berberine concentrations of at least 2.5%. The requirements in Europe are that hydrastine concentrations be at least 2.5% and that berberine concentrations
Goldenseal
Class of naturally occurring chemical compounds
antibacterial (e.g. chelerythrine), and antihyperglycemic activities (e.g. berberine). Many have found use in traditional or modern medicine, or as starting
Alkaloid
Genus of flowering plants representing the barberry family
alkaloids, especially berberine. A full list of phytochemicals was compiled and published in 2014. The safety of using berberine for any condition is not
Berberis
Herb in Chinese medicine
PMID 2816389. Liu, WZ; Peng, WB; Yang, CH (1991). "Berberine-electrochemical detector for the determination of berberine-type alkaloids in various Chinese patent
Huang_Bai
Genus of flowering plants
Florida and west to Ohio and eastern Texas. It contains the alkaloid berberine, which has a number of traditional and contemporary uses for dyeing and
Xanthorhiza
Species of flowering plant
chinensis) The rhizomes of Coptis chinensis contain the isoquinoline alkaloids berberine, palmatine, and coptisine among others. Coptis chinensis is one of the
Coptis_chinensis
Antifungal medication
arrhythmia if used concurrently with other drugs that prolong the QT interval. Berberine has been shown to exert synergistic effects with fluconazole even in drug-resistant
Fluconazole
Species of flowering plant
Asia it is grown for medicinal purposes, with the main alkaloid being berberine. Rhizomes partly prepared for herbal medicines "Coptis japonica (Thunb
Coptis_japonica
Berberine bridge enzyme-like (BBE-like enzymes) form a subgroup of the superfamily of FAD-linked oxidases (SCOPe d.58.32), structurally characterized
BBE-like_enzymes
Species of tree
isoquinoline alkaloids, palmatine, jatrorrhizine, phellodendorine with berberine found within the leaves. The indole alkaloid has also been found in the
Phellodendron_amurense
Chemical compound
(S)-reticuline through the action of berberine bridge enzyme. It is a precursor of other BIAs, notably berberine, noscapine, (S)-tetrahydropalmatine,
Scoulerine
contains berberine, which also occurs in other plant families, such as the Berberidaceae. An example of the Berberidaceae with the ingredient berberine is Berberis
Isoquinoline_alkaloids
Genus of flowering plants belonging to the barberry family
ripened fruits are acidic with a very sharp flavor. The plants contain berberine, a compound found in many Berberis and Mahonia species which in high doses
Mahonia
Species of flowering plant
Northwest Plateau use Oregon grape for indigestion. The plant contains berberine and reportedly has antimicrobial properties similar to those of goldenseal
Berberis_aquifolium
Chemical compound
following compounds: papaverine, noscapine, codeine, morphine, apomorphine, berberine, tubocurarine. (S)-Norcoclaurine (higenamine) has been identified as the
Benzylisoquinoline
Species of shrub
with opium and lime-juice. The root bark contains the bitter alkaloid berberine, which has been studied for its potential pharmacological properties.
Berberis_aristata
Species of shrub
isoquinoline and protoberberine alkaloids; the primary constituents include berberine, oxyacanthine, palmatine, berberrubine, lambertine, obamegine, aromoline
Berberis_vulgaris
Nonsteroidal anti-inflammatory drug
14-prostaglandin J2 15-HETE 15-HpETE Aleglitazar Arachidonic acid Balaglitazone Berberine Bezafibrate Cannabidiol Cevoglitazar Chiglitazar Ciglitazone Daidzein
Ibuprofen
Tricyclic antidepressant
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Amitriptyline
Research into causes and treatment of cancer
prevention or treatment, with candidate substances including apigenin, berberine, jiaogulan, and rhodiola rosea. Cancer research is funded by government
Cancer_research
Group of nuclear receptor proteins
perfluorononanoic acid activates both PPARα and PPARγ. [citation needed] Berberine reduces the mRNA and protein levels of PPARγ. Other natural compounds
Peroxisome proliferator-activated receptor
Peroxisome_proliferator-activated_receptor
Chemical compound
it is used in Chinese herbal medicine along with the related compound berberine for digestive disorders caused by bacterial infections. Coptisine is produced
Coptisine
Herbal tea made out of poppy straw or poppy seeds
but may contain non-narcotic alkaloids like protopine, sanguinarine or berberine. Side effects increase with dosage, and include drowsiness, mild stomach
Poppy_tea
Chemical compound
precursor of berberine, which is produced through the action of the enzyme tetrahydroberberine oxidase. (S)-canadine + H+ 2 O2 2 H2O2 berberine It is
Canadine
Psychoactive substance found in plants in the family Apocynaceae
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Ibogaine
Enzyme blocker and diabetes treatment drug
(HSK- 7653; compound 2) Fotagliptin Prusogliptin Cetagliptin (CGT 8012) Berberine, an alkaloid found in plants of the genus Berberis (the "barberry"), inhibits
Dipeptidyl peptidase-4 inhibitor
Dipeptidyl_peptidase-4_inhibitor
Remedy in Traditional Chinese medicine
in powder and pill form. It contains, among other things, quercetin, berberine, and achyranthine. It contains the same ingredients as Sān miào wán ("Three
Sì_miào_wán
Genus of flowering plants in the poppy family Papaveraceae
amounts found in leaves and flowers. Related compounds in the plant are berberine and protopine, among other minor alkaloids. Bloodroot produces benzylisoquinoline
Sanguinaria
Fat reducing drug
associated with a very modest increase in LDL (~5%). Choline Pycnogenol Berberine Red yeast rice is the natural source from which statins were discovered
Lipid-lowering_agent
Functional group
methoxy group. Examples of products formed by this process are canadine and berberine. Similarly, ortho-demethylenation can be carried out by other members
Methylenedioxy
Mammalian protein found in humans
ligand 10 (CXCL10). Development of dipeptidyl peptidase-4 inhibitors Berberine GRCh38: Ensembl release 89: ENSG00000197635 – Ensembl, May 2017 GRCm38:
Dipeptidyl_peptidase-4
Dissociative hallucinogenic drug, mostly used recreationally
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Phencyclidine
Organic chemical
made up of four rings, two of which contain nitrogen. It is related to berberine but without its methylenedioxy group. Columbamine is also called dehydroisocorypalmine
Columbamine
Family of flowering plants
fenestratum, a local Thai remedy for stomach ailments (which contains berberine and related alkaloids) was recently implicated in mass harvesting operations
Menispermaceae
Chemical compound
and 5-positions. The name is derived from berberine. Berberonic acid is obtained in the oxidation of berberine with nitric acid. It can also be derived
Berberonic_acid
Species of plant
used in Indonesian traditional medicine, primarily because it contains berberine, an isoquinoline alkaloid under preliminary research to identify its possible
Fibraurea_tinctoria
Study of phytochemicals, which are chemicals derived from plants
scopolamine, and hyoscyamine (all from nightshade), the traditional medicine berberine (from plants such as Berberis and Mahonia), caffeine (Coffea), cocaine
Phytochemistry
Species of flowering plant and state flower of California
(californidine), and other similar (Papaveraceae) alkaloids, as well as berberine. The California poppy has been used through two methods: fresh petals
Eschscholzia_californica
Typical antipsychotic medication
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Haloperidol
Psychedelic drug
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Dimethyltryptamine
Chemical compound
TMATooltip 3,4,5-Trimethoxyamphetamine UMB-23 UMB-82 W-18 Unsorted Agonists: Berberine Ethylketazocine Fourphit Metaphit Naluzotan Tapentadol Tenocyclidine Antagonists:
Dipropyltryptamine
Film of microorganisms on a surface
X, Zhu Z, Tang T, Dai K, Sadovskaya I, et al. (July 2009). "Effect of berberine on Staphylococcus epidermidis biofilm formation". International Journal
Biofilm
Class of cell surface receptors
opipramol, PCP, fluvoxamine, methamphetamine, dextromethorphan, and berberine.[citation needed] However, the exact role of σ-receptors is difficult
Sigma_receptor
Medication mainly used for depression and smoking cessation
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Bupropion
Index of plants with the same common name
plants native to Eastern North America. These plants contain the compound berberine, which gives the roots a yellow color, and have been employed in herbal
Yellowroot
State of active attention by high sensory awareness such as being watchful
breakfast (modifiable as well, for example via choice of food and with berberine) The baseline level of daily alertness is related to the quality of sleep
Alertness
partly (40-50%) homologous to several other oxidoreductases, such as berberine bridge enzyme in Eschscholzia californica and Nectarin V in Nicotiana
Cannabidiolic_acid_synthase
Mammalian protein found in humans
free cholesterol, phospholipids, and triglycerides. The plant alkaloid berberine inhibits the transcription of the PCSK9 gene in immortalized human hepatocytes
PCSK9
Species of shrub
skin melanoma. Several species of Berberis contain alkaloids such as berberine, canadine, columbamine, corypalmine, jatrorrhizine, and palmatine. These
Berberis_koreana
Chemical compound
responsible for nine of the eleven remaining chemical transformations. First, berberine bridge enzyme (BBE), an enzyme not encoded by the cluster, forms the fused
Noscapine
Species of plant
secrete a pale yellow latex when cut open. This argemone resin contains berberine and protopine. The seeds resemble the seeds of Brassica nigra (mustard)
Argemone_mexicana
Agent that alters the strength of muscular contractions
Examples of positive inotropic agents include:[citation needed] Digoxin Berberine Calcium Calcium sensitisers Levosimendan Catecholamines Dopamine Dobutamine
Inotrope
Insertion of molecules between DNA
good nucleic acid stains. Intensively studied DNA intercalators include berberine, ethidium bromide, proflavine, daunomycin, doxorubicin, and thalidomide
Intercalation_(biochemistry)
Cough suppressant and dissociative drug
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Dextromethorphan
SSRI antidepressant
TMATooltip 3,4,5-Trimethoxyamphetamine UMB-23 UMB-82 W-18 Unsorted Agonists: Berberine Ethylketazocine Fourphit Metaphit Naluzotan Tapentadol Tenocyclidine Antagonists:
Escitalopram
Metabolic pathway for transport of energy into and removal of ammonia from muscles
They proceeded by treating the metabolically reprogrammed HCC cells with Berberine, a naturally occurring inhibitor of GPT1; the observed affect was to curb
Cahill_cycle
Spice made from crocus flowers
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Saffron
Mammalian protein found in humans
prevalences, degrees of association and strength of effect on type 2 diabetes. Berberine, an isoquinoline alkaloid, has been shown to increase adiponectin expression
Adiponectin
Species of flowering plant in the poppy family
protopine, cryptopine, hemochelidonine, homochelidonine, norchelidonine, berberine, chelidonine, sanguinarine, chelerythrine and 8-hydroxydihydrosanguinarine
Chelidonium_majus
Beta blocker drug
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Propranolol
Central nervous system stimulant
TMATooltip 3,4,5-Trimethoxyamphetamine UMB-23 UMB-82 W-18 Unsorted Agonists: Berberine Ethylketazocine Fourphit Metaphit Naluzotan Tapentadol Tenocyclidine Antagonists:
Methamphetamine
Species of flowering plant
inflammatory or musculoskeletal conditions. The plant contains the alkaloid berberine, which has been studied for antimicrobial and metabolic effects in laboratory
Berberis_nervosa
Species of flowering plant in the poppy family
Wang YM, Zhao LB, Lin SL, Dong SS, An DK (1989). "[Determination of berberine and palmatine in cortex phellodendron and Chinese patent medicines by
Corydalis_yanhusuo
SSRI antidepressant
TMATooltip 3,4,5-Trimethoxyamphetamine UMB-23 UMB-82 W-18 Unsorted Agonists: Berberine Ethylketazocine Fourphit Metaphit Naluzotan Tapentadol Tenocyclidine Antagonists:
Sertraline
Psychoactive drug, often called ecstasy
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MDMA
Chemical compound
Kutchan TM, Dittrich H (1995). "Characterization and mechanism of the berberine bridge enzyme, a covalently flavinylated oxidase of benzophenanthridine
Reticuline
Class of antidepressant medication
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Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Mammalian protein found in humans
compounds, including epigallocatechin gallate (EGCG), caffeine, curcumin, berberine, quercetin, resveratrol and pterostilbene, have been reported to inhibit
MTOR
Class of organic molecules
penetrating properties. The cations with the well-known medical properties — berberine and palmatine were also tested. SkQBerb and SkQPalm – SkQ derivatives
SkQ
(methylene-bridge-forming). Other names in common use include BBE, berberine bridge enzyme, berberine-bridge-forming enzyme, and tetrahydroprotoberberine synthase
Reticuline_oxidase
German pharmacologist
credited with isolating salicin from willow bark (1828) and the discovery of berberine (from the root bark of Berberis vulgaris). Vollständiger Inbegriff der
Johann_Andreas_Buchner
Chemical compound
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BD1063
Protein-coding gene in the species Homo sapiens
TMATooltip 3,4,5-Trimethoxyamphetamine UMB-23 UMB-82 W-18 Unsorted Agonists: Berberine Ethylketazocine Fourphit Metaphit Naluzotan Tapentadol Tenocyclidine Antagonists:
Sigma-2_receptor
with minoxidil hair solution). Black Pepper leaf extract (Piper nigrum) Berberine β-Sitosterol, one of many phytosterols. Chinese knotweed (Reynoutria multiflora
List of 5α-reductase inhibitors
List_of_5α-reductase_inhibitors
Genus of flowering plants in the buttercup family
as magnoflorine, hernandezine, and the structurally related alkaloid berberine.[citation needed] Thalictrum alpinum – alpine meadow-rue Thalictrum aquilegiifolium
Thalictrum
Class of medications
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Tricyclic_antidepressant
F-15063 ITI-007 tetracyclic quinoxaline Lu AF35700 RP5063 Stepholidine berberine Development abandoned Amperozide Diphenylbutylpiperazine QN05AX90 Bifeprunox
List_of_antipsychotics
Medication
14-prostaglandin J2 15-HETE 15-HpETE Aleglitazar Arachidonic acid Balaglitazone Berberine Bezafibrate Cannabidiol Cevoglitazar Chiglitazar Ciglitazone Daidzein
Gemfibrozil
SNRI antidepressant
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Venlafaxine
Chemical compound
morphine. For sanguinarine, (S)-reticuline is converted to scoulerine via berberine bridge enzyme (BBE), which is the commitment step in the sanguinarine
Sanguinarine
Drug of the fibrate class, mainly used to reduce cholesterol levels
14-prostaglandin J2 15-HETE 15-HpETE Aleglitazar Arachidonic acid Balaglitazone Berberine Bezafibrate Cannabidiol Cevoglitazar Chiglitazar Ciglitazone Daidzein
Fenofibrate
Dissociative anesthetic and anti-depressant
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Ketamine
Enzyme that metabolizes substances by oxidation
grapefruit juice), cyclosporine, donedarone, fluvoxamine, imatinib, valerian. berberine (an alkaloid found in plants such as berberis or goldenseal), buprenorphine
CYP3A4
Antidepressant
TMATooltip 3,4,5-Trimethoxyamphetamine UMB-23 UMB-82 W-18 Unsorted Agonists: Berberine Ethylketazocine Fourphit Metaphit Naluzotan Tapentadol Tenocyclidine Antagonists:
Imipramine
Species of flowering plant
are often reported to contain protoanemonin. The plant also contains berberine. All parts of the plant contain an irritant oil that is most concentrated
Actaea_rubra
SSRI antidepressant
TMATooltip 3,4,5-Trimethoxyamphetamine UMB-23 UMB-82 W-18 Unsorted Agonists: Berberine Ethylketazocine Fourphit Metaphit Naluzotan Tapentadol Tenocyclidine Antagonists:
Fluoxetine
Protein-coding gene in the species Homo sapiens
downstream proteins such as CYP2D6, in vitro and in vivo. The alkaloid berberine upregulates HNF4A expression. This gene plays a pivotal role in the expression
Hepatocyte nuclear factor 4 alpha
Hepatocyte_nuclear_factor_4_alpha
Pharmaceutical compound
14-prostaglandin J2 15-HETE 15-HpETE Aleglitazar Arachidonic acid Balaglitazone Berberine Bezafibrate Cannabidiol Cevoglitazar Chiglitazar Ciglitazone Daidzein
Estianeptine
Combination medication
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Dextromethorphan/bupropion
Plants used to treat medical conditions
scopolamine, and hyoscyamine (all from nightshade), the traditional medicine berberine (from plants such as Berberis and Mahonia), caffeine (Coffea), cocaine
Medicinal_plants
Polyatomic ion of the form >C=N< and charge +1
Micol; Guamán Ortiz, Luis M.; Lombardi, Paolo; Scovassi, A. Ivana (2012). "Berberine: New perspectives for old remedies". Biochemical Pharmacology. 84 (10):
Iminium
Tricyclic antidepressant
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Clomipramine
Blood pressure medication
14-prostaglandin J2 15-HETE 15-HpETE Aleglitazar Arachidonic acid Balaglitazone Berberine Bezafibrate Cannabidiol Cevoglitazar Chiglitazar Ciglitazone Daidzein
Telmisartan
Sedating antihistamine
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Promethazine
Opioid receptor antagonist
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Naloxone
Chemical compound
14-prostaglandin J2 15-HETE 15-HpETE Aleglitazar Arachidonic acid Balaglitazone Berberine Bezafibrate Cannabidiol Cevoglitazar Chiglitazar Ciglitazone Daidzein
15-Hydroxyeicosatetraenoic acid
15-Hydroxyeicosatetraenoic_acid
Chemical compound
dehydrogenation reactions. The quinolizinium core is represented in the berberine family of natural products. It is formally derived from the elusive quinolizines
Quinolizinium
Tropane alkaloid and stimulant drug
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Cocaine
travel, tourism, insurance
BERBERINE
BERBERINE
BERBERINE
BERBERINE
BERBERINE
BERBERINE
BERBERINE
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BERBERINE
travel, tourism, insurance