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BMPR2

  • BMPR2

    • Protein-coding gene in the species Homo sapiens

    morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase encoded by the BMPR2 gene. It binds bone morphogenetic proteins

    BMPR2

    BMPR2

    BMPR2

  • Pulmonary hypertension

    • Increased blood pressure in lung arteries

    the lung Idiopathic in most cases (heritable in some cases) Heritable (BMPR2, ALK1, SMAD9, caveolin 1, KCNK3 mutations) Drug- and toxin-induced (e.g

    Pulmonary hypertension

    Pulmonary hypertension

    Pulmonary_hypertension

  • Pulmonary arterial hypertension

    • High blood pressure in the pulmonary arteries

    receptor 2 (BMPR2) account for approximately 75-80% of cases of heritable PAH. BMPR2 mutations are also seen in 20% of idiopathic PAH. BMPR2 is a protein

    Pulmonary arterial hypertension

    Pulmonary arterial hypertension

    Pulmonary_arterial_hypertension

  • Monocrotaline

    • Chemical compound

    Initial stress factors are released intracellular upon binding of MCT to BMPR2 receptors and elevated MAPK phosphorylation levels are induced, which can

    Monocrotaline

    Monocrotaline

    Monocrotaline

  • TGF beta signaling pathway

    • Signaling pathway involving transforming growth factor beta proteins

    factors. The BMPs bind to the bone morphogenetic protein receptor type-2 (BMPR2). They are involved in a multitude of cellular functions including osteogenesis

    TGF beta signaling pathway

    TGF_beta_signaling_pathway

  • Chromosome 2

    • Human chromosome

    3-N-acetylglucosaminyltransferase 7 BCS1L: GRACILE (Finnish heritage disease) related gene BMPR2: bone morphogenetic protein receptor, type II (serine/threonine kinase)

    Chromosome 2

    Chromosome 2

    Chromosome_2

  • Growth differentiation factor 9

    • Protein-coding gene in the species Homo sapiens

    generates a signal is the bone morphogenetic protein type II receptor (BMPR2). GRCh38: Ensembl release 89: ENSG00000164404 – Ensembl, May 2017 GRCm38:

    Growth differentiation factor 9

    Growth differentiation factor 9

    Growth_differentiation_factor_9

  • Bone morphogenetic protein 4

    • Human protein and coding gene

    bind to BMPR2 without BMPR1 however, the affinity significantly increases in the presence of both receptors. BMPR1 is transphosphorylated via BMPR2 which

    Bone morphogenetic protein 4

    Bone morphogenetic protein 4

    Bone_morphogenetic_protein_4

  • GDF15

    • Protein-coding gene in humans

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    GDF15

    GDF15

    GDF15

  • Activin and inhibin

    • Regulators of feedback on FSH-production

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Activin and inhibin

    Activin and inhibin

    Activin_and_inhibin

  • Repulsive guidance molecule A

    • Protein-coding gene in the species Homo sapiens

    molecule family. Together with BMPR1A and BMPR1B, as well as ACVR2A and BMPR2, it binds BMPs thereby activating the intracellular SMAD1/5/8 signalling

    Repulsive guidance molecule A

    Repulsive guidance molecule A

    Repulsive_guidance_molecule_A

  • ACVR1

    • Protein-coding gene

    ACVR1 transduces signals of BMPs. BMPs bind either ACVR2A/ACVR2B or a BMPR2 and then form a complex with ACVR1. These go on to recruit the R-SMADs SMAD1

    ACVR1

    ACVR1

    ACVR1

  • Paracrine signaling

    • Form of localized cell signaling

    homeostasis. The BMPs bind to the bone morphogenetic protein receptor type II (BMPR2). Some of the proteins of the BMP family are BMP4 and BMP7. BMP4 promotes

    Paracrine signaling

    Paracrine signaling

    Paracrine_signaling

  • Transforming growth factor beta

    • Cytokine

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Transforming growth factor beta

    Transforming growth factor beta

    Transforming_growth_factor_beta

  • Titin

    • Largest known protein in human muscles

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Titin

    Titin

    Titin

  • Myostatin

    • Mammalian and avian protein

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Myostatin

    Myostatin

    Myostatin

  • Protein kinase C

    • Family of enzymes

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Protein kinase C

    Protein_kinase_C

  • List of human protein-coding genes 1

    • Q8N8U9 1599 BMPR1A HGNC:1076; P36894 1600 BMPR1B HGNC:1077; O00238 1601 BMPR2 HGNC:1078; Q13873 1602 BMS1 HGNC:23505; Q14692 1603 BMX HGNC:1079; P51813

    List of human protein-coding genes 1

    List_of_human_protein-coding_genes_1

  • Phosphorylase kinase

    • Enzyme involved in glycogenolysis

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Phosphorylase kinase

    Phosphorylase kinase

    Phosphorylase_kinase

  • STK11

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    STK11

    STK11

    STK11

  • TGF-beta receptor family

    • Family of proteins involved in a TGF signaling pathway

    (BMPR1A) ALK4 (ACVR1B) ALK5 (TGFβR1) ALK6 (BMPR1B) ALK7 (ACVR1C) TGFβR2 BMPR2 ACVR2A ACVR2B AMHR2 (AMHR) Unlike the Type I and II receptors which are

    TGF-beta receptor family

    TGF-beta_receptor_family

  • Cyclin-dependent kinase 2

    • Protein found in humans

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Cyclin-dependent kinase 2

    Cyclin-dependent kinase 2

    Cyclin-dependent_kinase_2

  • Anti-Müllerian hormone

    • Mammalian protein found in humans

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Anti-Müllerian hormone

    Anti-Müllerian hormone

    Anti-Müllerian_hormone

  • PRKACA

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    PRKACA

    PRKACA

    PRKACA

  • Activin receptor

    • Protein domain

    receptors ACVR1; ACVR1B; ACVR1C; ACVR2A; ACVR2B; ACVRL1; BMPR1A; BMPR1B; BMPR2; TGFBR1; Wrana JL, Attisano L (1996). "Signal transduction by members of

    Activin receptor

    Activin_receptor

  • Serine/threonine-specific protein kinase

    • Class of protein kinase enzymes

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Serine/threonine-specific protein kinase

    Serine/threonine-specific protein kinase

    Serine/threonine-specific_protein_kinase

  • MTOR

    • Mammalian protein found in humans

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    MTOR

    MTOR

    MTOR

  • PKC alpha

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    PKC alpha

    PKC alpha

    PKC_alpha

  • Metelimumab

    • Chemical compound

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Metelimumab

    Metelimumab

  • SMAD9

    • Homolog protein

    is most commonly associated with mutations in the BMP type II receptor (BMPR2),  this finding was unexpected; researchers believed that the loss of a

    SMAD9

    SMAD9

  • MTORC1

    • Protein complex

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    MTORC1

    MTORC1

    MTORC1

  • CASK

    • Protein-coding gene in humans

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    CASK

    CASK

    CASK

  • RAF kinase

    • (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    RAF kinase

    RAF kinase

    RAF_kinase

  • Phototropin

    • Class of photoreceptor proteins in plants

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Phototropin

    Phototropin

  • VRK1

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    VRK1

    VRK1

    VRK1

  • Protein kinase A

    • Family of enzymes

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Protein kinase A

    Protein kinase A

    Protein_kinase_A

  • AMP-activated protein kinase

    • Class of enzymes

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    AMP-activated protein kinase

    AMP-activated protein kinase

    AMP-activated_protein_kinase

  • Phosphoinositide-dependent kinase-1

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Phosphoinositide-dependent kinase-1

    Phosphoinositide-dependent kinase-1

    Phosphoinositide-dependent_kinase-1

  • G protein-coupled receptor kinase 2

    • Enzyme

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    G protein-coupled receptor kinase 2

    G protein-coupled receptor kinase 2

    G_protein-coupled_receptor_kinase_2

  • GDF11

    • Protein-coding gene in humans

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    GDF11

    GDF11

    GDF11

  • MAP2K1

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    MAP2K1

    MAP2K1

    MAP2K1

  • EEF2K

    • Protein-coding gene in humans

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    EEF2K

    EEF2K

    EEF2K

  • Extracellular signal-regulated kinases

    • Class of enzymes

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Extracellular signal-regulated kinases

    Extracellular_signal-regulated_kinases

  • MAP3K4

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    MAP3K4

    MAP3K4

    MAP3K4

  • CAMK1

    • Protein-coding gene in humans

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    CAMK1

    CAMK1

    CAMK1

  • Nodal signaling pathway

    • Cellular process in embryonic development

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Nodal signaling pathway

    Nodal_signaling_pathway

  • Casein kinase 1

    • Family of protein kinases

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Casein kinase 1

    Casein_kinase_1

  • PRKCE

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    PRKCE

    PRKCE

    PRKCE

  • BCKDHB

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    BCKDHB

    BCKDHB

    BCKDHB

  • TGF beta 1

    • Protein-coding gene in the species Homo sapiens

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    TGF beta 1

    TGF beta 1

    TGF_beta_1

  • Phosphatidylinositol 3-kinase-related kinase

    • Protein family

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Phosphatidylinositol 3-kinase-related kinase

    Phosphatidylinositol_3-kinase-related_kinase

  • ACVR2A

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    ACVR2A

    ACVR2A

    ACVR2A

  • Biochemical cascade

    • Series of chemical reactions resulting in a cell response

    the development of both. GDF9 and BMP15 produced by the oocyte bind to BMPR2 receptors on follicular cells activating SMADs 2/3, ensuring follicular

    Biochemical cascade

    Biochemical_cascade

  • Growth differentiation factor

    • Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Growth differentiation factor

    Growth differentiation factor

    Growth_differentiation_factor

  • (Pyruvate, phosphate dikinase) kinase

    • Class of enzymes

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    (Pyruvate, phosphate dikinase) kinase

    (Pyruvate,_phosphate_dikinase)_kinase

  • MKNK1

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    MKNK1

    MKNK1

    MKNK1

  • SMG1

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    SMG1

    SMG1

    SMG1

  • Transforming growth factor

    • Biomarker indicative of breast cancer patients' prognosis

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Transforming growth factor

    Transforming_growth_factor

  • CHEK2

    • Protein-coding gene in humans

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    CHEK2

    CHEK2

    CHEK2

  • Mitogen-activated protein kinase

    • P38 mitogen-activated protein kinases

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Mitogen-activated protein kinase

    Mitogen-activated_protein_kinase

  • Myosin light-chain kinase

    • Class of kinase enzymes

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Myosin light-chain kinase

    Myosin light-chain kinase

    Myosin_light-chain_kinase

  • Transforming growth factor beta superfamily

    • Protein family

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Transforming growth factor beta superfamily

    Transforming growth factor beta superfamily

    Transforming_growth_factor_beta_superfamily

  • PRKCB1

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    PRKCB1

    PRKCB1

    PRKCB1

  • KIAA0999

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    KIAA0999

    KIAA0999

    KIAA0999

  • Cyclin-dependent kinase 4

    • Human protein

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Cyclin-dependent kinase 4

    Cyclin-dependent kinase 4

    Cyclin-dependent_kinase_4

  • Follistatin

    • Mammalian protein found in Homo sapiens

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Follistatin

    Follistatin

    Follistatin

  • PKMYT1

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    PKMYT1

    PKMYT1

    PKMYT1

  • Protein kinase B

    • Set of three serine threonine-specific protein kinases

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Protein kinase B

    Protein kinase B

    Protein_kinase_B

  • Bone morphogenetic protein

    • Group of growth factor proteins

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Bone morphogenetic protein

    Bone_morphogenetic_protein

  • P70-S6 Kinase 1

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    P70-S6 Kinase 1

    P70-S6 Kinase 1

    P70-S6_Kinase_1

  • C-Jun N-terminal kinases

    • Chemical compounds

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    C-Jun N-terminal kinases

    C-Jun N-terminal kinases

    C-Jun_N-terminal_kinases

  • Aurora inhibitor

    • Putative drug class for treating cancer

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Aurora inhibitor

    Aurora inhibitor

    Aurora_inhibitor

  • Cyclin-dependent kinase

    • Class of enzymes

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Cyclin-dependent kinase

    Cyclin-dependent kinase

    Cyclin-dependent_kinase

  • RIP kinase

    • (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    RIP kinase

    RIP_kinase

  • IkappaB kinase

    • Class of enzymes

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    IkappaB kinase

    IkappaB_kinase

  • Decorin

    • Protein-coding gene in humans

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Decorin

    Decorin

    Decorin

  • MASTL

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    MASTL

    MASTL

    MASTL

  • Mitogen-activated protein kinase kinase

    • Kinase enzyme

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Mitogen-activated protein kinase kinase

    Mitogen-activated_protein_kinase_kinase

  • Beta-adrenergic-receptor kinase

    • Enzyme

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Beta-adrenergic-receptor kinase

    Beta-adrenergic-receptor_kinase

  • BMPR1A

    • Bone morphogenetic protein receptor

    type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1

    BMPR1A

    BMPR1A

    BMPR1A

  • Ca2+/calmodulin-dependent protein kinase II

    • Class of enzymes

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Ca2+/calmodulin-dependent protein kinase II

    Ca2+/calmodulin-dependent protein kinase II

    Ca2+/calmodulin-dependent_protein_kinase_II

  • Protein kinase domain

    • Protein domain

    ANKK1 ; ARAF ; AURKA ; AURKB ; AURKC ; AXL ; BLK ; BMP2K ; BMPR1A ; BMPR1B ; BMPR2 ; BMX ; BRAF ; BRSK1 ; BRSK2 ; BTK ; BUB1 ; BUB1B ; CAMK1 ; CAMK1D ; CAMK1G ;

    Protein kinase domain

    Protein kinase domain

    Protein_kinase_domain

  • Endoglin

    • Protein-coding gene in the species Homo sapiens

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Endoglin

    Endoglin

    Endoglin

  • Rho-associated protein kinase

    • Protein family

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Rho-associated protein kinase

    Rho-associated protein kinase

    Rho-associated_protein_kinase

  • Casein kinase 1, alpha 1

    • Enzyme found in humans

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Casein kinase 1, alpha 1

    Casein kinase 1, alpha 1

    Casein_kinase_1,_alpha_1

  • ATM serine/threonine kinase

    • Mammalian protein found in Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    ATM serine/threonine kinase

    ATM serine/threonine kinase

    ATM_serine/threonine_kinase

  • NLK

    • Mammalian protein found in Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    NLK

    NLK

    NLK

  • Calcium/calmodulin-dependent protein kinase type II subunit alpha

    • Protein found in humans

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Calcium/calmodulin-dependent protein kinase type II subunit alpha

    Calcium/calmodulin-dependent protein kinase type II subunit alpha

    Calcium/calmodulin-dependent_protein_kinase_type_II_subunit_alpha

  • P38 mitogen-activated protein kinases

    • Protein family

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    P38 mitogen-activated protein kinases

    P38_mitogen-activated_protein_kinases

  • GAK (protein)

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    GAK (protein)

    GAK (protein)

    GAK_(protein)

  • Cyclin-dependent kinase 1

    • Mammalian protein found in Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Cyclin-dependent kinase 1

    Cyclin-dependent kinase 1

    Cyclin-dependent_kinase_1

  • VRK2

    • Protein-coding gene in the species Homo sapiens

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    VRK2

    VRK2

    VRK2

  • Activin type 1 receptors

    • Human biological material

    Kristine; Katagiri, Takenobu; Knaus, Petra; Holien, Toril (11 June 2018). "BMPR2 inhibits activin and BMP signaling via wild-type ALK2". journals.biologists

    Activin type 1 receptors

    Activin_type_1_receptors

  • CAMK

    • Enzyme type

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    CAMK

    CAMK

  • ACVR2B

    • Protein-coding gene in humans

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    ACVR2B

    ACVR2B

    ACVR2B

  • Gremlin (protein)

    • Inhibitor protein in the TGF beta signaling pathway

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Gremlin (protein)

    Gremlin_(protein)

  • CDKL5

    • Protein-coding gene in humans

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    CDKL5

    CDKL5

    CDKL5

  • IDH2

    • Protein-coding gene in humans

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    IDH2

    IDH2

    IDH2

  • Stamulumab

    • Monoclonal antibody

    Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: DMH-2 LY-364947 BMPR2 Agonists: BMP (2, 4, 6, 7, 10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9)

    Stamulumab

    Stamulumab

  • Wee1

    • Nuclear protein

    (EC 2.7.11.30) Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

    Wee1

    Wee1

    Wee1

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Online names & meanings

  • Saharsha

    • Girl/Female

    Hindu, Indian

    Saharsha

    Sun; Dawn; Morning; Bewitch

  • Vaneet

    • Girl/Female

    Assamese, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu

    Vaneet

    Slender; Intelligent; Loving Beauty

  • Mae

    • Surname or Lastname

    Japanese

    Mae

    Japanese : ‘front’ or ‘before’; not common in Japan. Some occurrences in America could be shortened versions of longer names beginning with this element.Hawaiian : unexplained.English : variant of May.

  • Yashus

    • Boy/Male

    Hindu

    Yashus

    Glory

  • Nidhi | நிதி

    • Girl/Female

    Tamil

    Nidhi | நிதி

    Treasure

  • Otta

    • Girl/Female

    Australian, Danish, Swedish

    Otta

    Thin

  • Ekaja | ஏகஜ஼ா

    • Girl/Female

    Tamil

    Ekaja | ஏகஜ஼ா

    The only child

  • Umapati | உமாபதி

    • Boy/Male

    Tamil

    Umapati | உமாபதி

    Consort of Uma

  • Agalya | அகல்யா 

    • Girl/Female

    Tamil

    Agalya | அகல்யா 

    Beauty, Splendor

  • Cedro

    • Boy/Male

    Spanish

    Cedro

    Abbreviation of Isadoro 'strong gift.

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