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Nuclear protein
Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular
Wee1
Increase of the total mass of a cell
balance of Wee1 and Cdc25 activity with changes in cell size is coordinated by the mitotic entry control system. It has been shown in Wee1 mutants, cells
Cell_growth
Protein-coding gene in the species Homo sapiens
WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene. This gene encodes a nuclear protein, which is a
Wee1-like_protein_kinase
Third subphase of interphase
employ such a mechanism, via Cdr2-mediated spatial regulation of Wee1 activity. Though Wee1 is a fairly conserved negative regulator of mitotic entry, no
G2_phase
Cell cycle checkpoint in eukaryotic organisms
CyclinB-Cdc2 inhibitors, Wee1 and Myt1. Cdc25 activates the complex through the removal of phosphates from the active site while Wee1 inactivates the complex
G2-M_DNA_damage_checkpoint
Chemical compound
anti-cancer drug candidate. It is a small molecule inhibitor of the kinase enzyme WEE1. It is being developed by AstraZeneca. It is being investigated as a treatment
Adavosertib
Biological factor
phase, the CDK1 subunit of MPF is inactive due to an inhibitory enzyme, Wee1. Wee1 phosphorylates the Tyr-15 residue of CDK1, rendering MPF inactive. During
Maturation_promoting_factor
Dependence of the state of a system on its history
active CDK1 promotes the activation of more CDK1 molecules by inhibiting Wee1 (an inhibitor) and activating Cdc25 (a phosphatase that activates CDK1).
Hysteresis
Control mechanism in the eukaryotic cell cycle
and reaches the G2/M transition, the kinase Plk1 phosphorylates Wee1, which targets Wee1 for degradation via the SCF ubiquitin ligase complex. An additional
Cell_cycle_checkpoint
Drug typically used in cancer treatment
based on early studies on TKIs aiming at VEGF receptors. Adavosertib is a Wee1 kinase inhibitor that is undergoing numerous clinical trials in the treatment
Tyrosine_kinase_inhibitor
Pharmaceutical compound
treatment of advanced solid tumors. It is an orally administered inhibitor of WEE1 kinase, a key regulator of cell cycle checkpoints. "IMP 7068". AdisInsight
Potrasertib
Species of yeast
Pom1 inhibits Cdr2, preventing Cdr2 and Cdr1 from inhibiting Wee1, and allowing Wee1 to phosphorylate Cdk1, thus inactivating cyclin-dependent kinase
Schizosaccharomyces_pombe
Class of enzymes
phosphorylation state of CDKs is controlled by kinases and phosphatases such as WEE1 kinases, Myt1 kinases, and Cdc25c phosphatases for CDK1. Inhibitory phosphorylation
Cyclin-dependent_kinase
non-essential. Cdr2 regulates mitotic entry through direct inhibition of Wee1, which is then unable to continue to Cdk1 and subsequently start mitosis
Mitosis inducer protein kinase cdr2
Mitosis_inducer_protein_kinase_cdr2
Protein-coding gene in the species Homo sapiens
that in humans is encoded by the PKMYT1 gene. Myt 1 is an enzyme in the Wee1 family and found in vertebrates. The Wee 1 family includes a variety of
PKMYT1
Cell division producing haploid gametes
phosphorylation of CDK1 at amino acid residues Thr-14 and Tyr-15 by MYT1 and WEE1 as well as regulation of cyclin B levels facilitated by the anaphase-promoting
Meiosis
Events leading to cell division
Retinoblastoma protein Synchronous culture – synchronization of cell cultures Wee1 Although in some cases Cdk inhibitor proteins or phosphorylation introduce
Cell_cycle
Class of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Extracellular signal-regulated kinases
Extracellular_signal-regulated_kinases
Mammalian protein found in Homo sapiens
to stabilization of this phosphorylation, preventing mitotic progression. Wee1, conserved among all eukaryotes phosphorylates Tyr15, whereas members of
Cyclin-dependent_kinase_1
then phosphorylates and inhibits Wee1, also recruited to the medial node by the presence of Cdr2. The phosphorylated Wee1 allows Cdc25 to dephosphorylate
Pom1
Investigational drug
drug that is being evaluated for the treatment of solid tumors. It is a WEE1 kinase inhibitor. "Debio 0123". AdisInsight. Springer Nature Switzerland
Zedoresertib
Protein-coding gene in the species Homo sapiens
(2000). "The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts". Genetics. 153 (4): 1561–72
PTGES3
Largest known protein in human muscles
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Titin
Wee1 has an ultrasensitive response to Cdk1, and this likely arises because of substrate competition among the various phosphorylation sites on Wee1.
Biochemical switches in the cell cycle
Biochemical_switches_in_the_cell_cycle
Protein-coding gene in humans
through phosphorylating Nek11. WEE1 kinase and PLK1 are also targeted by Chk1 to induce cell cycle arrest. Phosphorylation of WEE1 kinase inhibits cdk1 which
CHEK1
Class of protein kinase enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Serine/threonine-specific protein kinase
Serine/threonine-specific_protein_kinase
Enzyme type
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
CAMK
Class of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Ca2+/calmodulin-dependent protein kinase II
Ca2+/calmodulin-dependent_protein_kinase_II
Protein complex
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
MTORC1
P38 mitogen-activated protein kinases
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
Protein-coding gene in the species Homo sapiens
whereas in G2, βTrCP contributes to CDK1 activation by targeting the kinase WEE1 for degradation. In early mitosis, βTrCP mediates the degradation of EMI1
FBXW11
Protein-coding gene in the species Homo sapiens
EPB41L3, HDAC4 KCNK3, MAPK7, PTPN3, PRKCZ, RPS6KA1, TESK1, TNFAIP3, and WEE1. 14-3-3 proteins GRCh38: Ensembl release 89: ENSG00000166913 – Ensembl, May
YWHAB
Protein family
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Phosphatidylinositol 3-kinase-related kinase
Phosphatidylinositol_3-kinase-related_kinase
Class of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
AMP-activated_protein_kinase
Protein-coding gene
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
ACVR1
Protein-coding gene in the species Homo sapiens
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Myotonin-protein_kinase
RNA family
of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts". The Journal of Biological Chemistry. 284
Let-7_microRNA_family
Family of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Protein_kinase_A
Protein-coding gene in humans
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
BRAF_(gene)
American pediatric oncologist
January 2013, Maris co-authored Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma which was a combination
John_M._Maris
Swiss biopharmaceutical company
bacterial skin and skin structure infections. Zedoresertib (Debio 0123), a WEE1 inhibitor for the treatment of glioblastoma. Debio 1562M, a second-generation
Debiopharm
Mammalian protein found in humans
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
MTOR
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
RIP_kinase
Kinase enzyme
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Mitogen-activated protein kinase kinase
Mitogen-activated_protein_kinase_kinase
Family of proteins
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
MAP kinase kinase kinase kinase
MAP_kinase_kinase_kinase_kinase
Family of protein kinases
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Ribosomal_s6_kinase
Putative drug class for treating cancer
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Aurora_inhibitor
Class of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Acetate_kinase
Enzymes that block actions of protein kinases
Name Target Company Class FDA approval Adavosertib WEE1 AstraZeneca Small molecule Afatinib EGFR/ErbB2 Boehringer Ingelheim Small molecule 2013 Non-small
Protein_kinase_inhibitor
Protein complex
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
MTORC2
Protein
Sarott, Roman C.; Fischer, Eric S. (2024-11-20). "Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library". Journal
Ubiquitin_ligase
Family of protein kinases
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
G protein-coupled receptor kinase
G_protein-coupled_receptor_kinase
Enzyme involved in glycogenolysis
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Phosphorylase_kinase
Enzyme
by M-Cdk (a complex of Cdk1 and cyclin B) activates Cdc25. Together with Wee1, M-Cdk activation is switch-like. The switch-like behavior forces entry into
Cdc25
Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)
v t e Regulome Activates cAMP, IL-2, CREB, WEE1, OPN, RD, MMP, calpain-2, G1-Cyclin–dependent Kinases, BMP-4, H1 receptor, cyclin D1, GC-A, TGF-b, NOTCH4
AP-1_transcription_factor
Protein family
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Rho-associated_protein_kinase
Class of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
GSK-3
Family of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Protein_kinase_C
Protein-coding gene in the species Homo sapiens
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
GAK_(protein)
Class of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
(Pyruvate, phosphate dikinase) kinase
(Pyruvate,_phosphate_dikinase)_kinase
Protein-coding gene in the species Homo sapiens
kinase 14), ERK5 (extracellular regulated kinase 5), or the checkpoint kinase Wee1. Cystic fibrosis (CF, mucoviscidosis) is a genetic disease with increased
HSP90AB1
Protein-coding gene in the species Homo sapiens
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
SMG1
switch Wee1/Cdc25. Wee1 activity is high in early prophase I and the accumulation of Cdc25 activates M-Cdk by direct phosphorylation and marking Wee1 to be
Meiotic recombination checkpoint
Meiotic_recombination_checkpoint
Class of kinase enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Myosin_light-chain_kinase
Protein-coding gene in humans
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
AKT1
Protein-coding gene in the species Homo sapiens
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
SGK2
Protein-coding gene in the species Homo sapiens
pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413
YWHAG
Class of pharmaceutical drugs
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
MTOR_inhibitors
Protein-coding gene in humans
pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413
PPP2R5D
Set of three serine threonine-specific protein kinases
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Protein_kinase_B
Mammalian protein found in Homo sapiens
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
ATM_serine/threonine_kinase
loops through Cdc25 and Wee1, and delayed activation by MPF of the APC, but includes additional reactions such as that of Wee1 and Cdc25. The result is
Novak–Tyson_model
Chemical compounds
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
C-Jun_N-terminal_kinases
Enzyme found in humans
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
RPS6KC1
Protein-coding gene in the species Homo sapiens
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
WNK4
Class of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Tau-protein_kinase
Protein family
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
P38 mitogen-activated protein kinases
P38_mitogen-activated_protein_kinases
Protein
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Casein_kinase_2
Class of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
(tyrosine 3-monooxygenase) kinase
(tyrosine_3-monooxygenase)_kinase
Class of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Receptor protein serine/threonine kinase
Receptor_protein_serine/threonine_kinase
Enzyme found in humans
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Cyclin-dependent_kinase_19
Enzyme found in humans
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Casein_kinase_1,_alpha_1
Protein family
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
TGF_beta_receptor
Class of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Pyruvate_dehydrogenase_kinase
Protein
was inspired by a similar study in Schizosaccharomyces pombe, in which the Wee1 gene was identified as an inhibitor of cell cycle progression that maintained
Cln3
Class of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Dephospho-(reductase kinase) kinase
Dephospho-(reductase_kinase)_kinase
Protein found in humans
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
DNA-PKcs
Protein serine/threonine kinase that is induced by interferon
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
EIF-2_kinase
Quality of a system having two stable equilibrium states
its activator Cdc25 while at the same time inactivating its inactivator, Wee1, thus allowing for progression of a cell into mitosis. Without this double
Bistability
Protein-coding gene in the species Homo sapiens
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
TRIO_(gene)
Protein-coding gene in the species Homo sapiens
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
DAPK3
Protein family
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
SGK
Class of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
MAP_kinase_kinase_kinase
Class of enzymes
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
IkappaB_kinase
Protein-coding gene in humans
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
PRKAB2
Human gene encoding the IKAP protein
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
IKBKAP
Protein kinase that detects DNA damage and halts cell division
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Ataxia telangiectasia and Rad3 related
Ataxia_telangiectasia_and_Rad3_related
Protein-coding gene in the species Homo sapiens
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
MAP2K2
Protein
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
Aurora_kinase_B
Protein-coding gene in the species Homo sapiens
Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase (EC 2.7.11.2) PDK1 PDK2 PDK3 PDK4 Dephospho-(reductase
BRSK2
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WEE1
WEE1
WEE1
WEE1
WEE1
WEE1
WEE1
WEE1
WEE1
travel, tourism, insurance