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Search references for BRCA2. Phrases containing BRCA2
See searches and references containing BRCA2!BRCA2
Gene known for its role in breast cancer
BRCA2 and BRCA2 (/ˌbrækəˈtuː/) are human genes and their protein products, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for
BRCA2
Gene known for its role in breast cancer
or BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer. BRCA1 and BRCA2 have
BRCA1
Medical condition
A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these
BRCA_mutation
Surgical technique
cancer, such as individuals who may have pathogenic variants of the BRCA1 or BRCA2 gene. Originally salpingectomy was used in cases of ectopic pregnancies
Prophylactic_salpingectomy
Cancer originating in or on the ovary
related to inherited genetic risk; women with mutations in the genes BRCA1 or BRCA2 have about a 50% chance of developing the disease. Some family cancer syndromes
Ovarian_cancer
Genetic disease causing anemia, birth defects, and cancers
homologous recombination. The well-known cancer susceptibility genes BRCA1 and BRCA2 are also examples of FA genes (FANCS and FANCD1 respectively), and biallelic
Fanconi_anemia
Proportion of individuals that express the trait associated with an allele
or ovaries, or sex steroid-responsive genes. Breast cancer caused by the BRCA2 mutation is an example of a disease with gender-related penetrance. The
Penetrance
Protein-coding gene in the species Homo sapiens
Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene. This gene encodes a protein that
PALB2
whole-genome sequencing (WGS)-based classifier designed to predict BRCA1 and BRCA2 deficiency based on six mutational signatures. Additionally, the classifier
HRDetect
Chemical compound
recombination repair (HRR) deficiencies as a result of mutations in BRCA1, BRCA2, PALB2, RAD51C, or RAD51D genes. "Saruparib - AstraZeneca". AdisInsight
Saruparib
Cellular mechanism
over-expression of RAD51 and BRCA2 seen in these cancers may reflect selective pressures for compensatory RAD51 or BRCA2 over-expression and increased
DNA_repair
Medical condition
new name references Mary-Claire King who identified the genes BRCA1 and BRCA2. Most hereditary breast-ovarian cancer syndromes are inherited in an autosomal
Hereditary breast–ovarian cancer syndrome
Hereditary_breast–ovarian_cancer_syndrome
International relations issue
District of New York found several of the patent claims on the BRCA1 and BRCA2 breast cancer genes held by Myriad Genetics to be invalid. The patents were
Implications of U.S. gene patent invalidation on Australia
Implications_of_U.S._gene_patent_invalidation_on_Australia
Protein involved in DNA repair
the BRCA2 complex primarily mediates orderly assembly of RAD51 on ssDNA, which is an active substrate in homologous pairing and strand invasion. BRCA2 also
RAD51
American cancer researcher and developmental biologist
in DNA strands are repaired, and for discovering the role of BRCA1 and BRCA2 in cancers. Jasin was born in 1956 in Detroit, Michigan. Her father was
Maria_Jasin
American geneticist (born 1955)
awarded the University of Pennsylvania's Basser Global Prize for BRCA1 and BRCA2-related research and an Ellis Island Medal of Honor for his national professional
Kenneth_Offit
Group of diseases involving cell growth
these syndromes include: certain inherited mutations in the genes BRCA1 and BRCA2 with a more than 75% risk of breast cancer and ovarian cancer, and hereditary
Cancer
genetics of cancer. In 1994, he assembled a research group that localised BRCA2, a major breast cancer susceptibility gene that repairs chromosomal damage
Michael_Stratton
Chemical compound (cancer therapy drug)
DNA repair. It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which include some ovarian, breast, and prostate cancers. In
Olaparib
American scientist and businessman (born 1946)
breast cancer susceptibility gene, BRCA1; found the full-length sequence of BRCA2. Connecting Demography with Genetics: According to Skolnick, "the first
Mark_Skolnick
Complete set of nucleic acid sequences for humans
Breast/Ovarian cancer (susceptibility) ~5% of cases of these cancer types BRCA1, BRCA2 FAP (hereditary nonpolyposis coli) 1:3500 APC Lynch syndrome 5–10% of all
Human_genome
Cancer that originates in mammary glands
cancer, such as p53, BRCA1 and BRCA2, occur in mechanisms to correct errors in DNA. The inherited mutation in BRCA1 or BRCA2 genes can interfere with the
Breast_cancer
Public research institute in London, England
body). In 1994 an ICR team led by Michael Stratton discovered the gene BRCA2, which has been linked to breast cancer, prostate cancer and ovarian cancer
Institute_of_Cancer_Research
Pharmaceutical compound
DNA damage response (DDR) pathways, particularly those with ATM or BRCA1/BRCA2 mutations. It is currently in Phase 2 clinical trials both as a monotherapy
Camonsertib
Protein-coding gene in the species Homo sapiens
BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in humans. This gene product was isolated based on its interaction
BCCIP
English musical artist (born 1979)
The Bahamas in July 2010. In 2012, Heaton was diagnosed with a mutated BRCA2 gene and then found out that she had an 80% chance of developing breast
Michelle_Heaton
Fungal plant disease on maize and teosinte
proteins, and is a streamlined version of the mammalian Breast Cancer 2 (BRCA2) protein. When any of these proteins is inactivated, sensitivity of M. maydis
Corn_smut
Nigerian physician (born 1957)
performed extensive clinical work surrounding the role of the BRCA1 and BRCA2 genes in the incidence of breast cancer in women of African descent. She
Olufunmilayo_Olopade
Hormone therapy used to treat symptoms of menopause
safer options than combined systemic therapy. In women who are BRCA1 or BRCA2 mutation carriers, HRT does not appear to impact breast cancer risk. The
Hormone_replacement_therapy
Alleles responsible for death of an organism
result in a severe subtype of Fanconi anemia (FA-S for BRCA1, FA-D1 for BRCA2), itself an extremely rare medical condition. Another example of a recessive
Lethal_allele
Surgical removal of the ovary or ovaries
benefit but increases risks and adverse effects. For women with high-risk BRCA2 mutations, oophorectomy around age 40 has a relatively modest benefit for
Oophorectomy
Removal of an ovary and its fallopian tube
statistically lower negative impact, in those of the tumour suppressing BRCA2 gene, which can increase the risk of developing ovarian cancer to as high
Salpingo-oophorectomy
Species of parasitic protist
infantum BRCA2 protein is approximately three times smaller (125 kD) than its human counterpart. Furthermore, analyses revealed that LiBRCA2 possesses
Leishmania_infantum
Mammalian protein found in Homo sapiens
both BRCA1 and BRCA2. Many breast cancers have defects in the BRCA1/BRCA2 HR repair pathway due to mutations in either BRCA1 or BRCA2, or other essential
PARP1
Type of endocrine gland cancer
autosomal recessive ATM and autosomal dominantly inherited mutations in the BRCA2 and PALB2 genes; hereditary non-polyposis colon cancer (Lynch syndrome);
Pancreatic_cancer
Male reproductive organ cancer
cancer, particularly those who inherit cancer-associated variants of the BRCA2 gene. Each year, 1.2 million cases of prostate cancer are diagnosed, and
Prostate_cancer
Pharmacological enzyme inhibitors of poly (ADP-ribose) polymerases
single-strand breaks generated by the radiotherapy in tumor tissue with BRCA1/BRCA2 mutations. This combination could therefore lead to either more powerful
PARP_inhibitor
Genetic recombination between identical or highly similar strands of genetic material
known function of BRCA2 is to help initiate homologous recombination, researchers have speculated that more detailed knowledge of BRCA2's role in homologous
Homologous_recombination
British cancer researcher
cancer gene, BRCA2, and related proteins cause genome instability to trigger carcinogenesis. His work has helped to explain why carriers of BRCA2 mutations
Ashok_Venkitaraman
Protein-coding gene in the species Homo sapiens
group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. Fanconi anemia is a genetically
FANCE
Mutation that shifts codon alignment
Frequency of mutations on BRCA2 gene on chromosome 13
Frameshift_mutation
Icelandic neurologist (born 1949)
75% of women with a BRCA2 risk mutation will develop breast cancer before the age of 80. On the poorer prognosis of carriers of BRCA2 variants with prostate
Kári_Stefánsson
Control mechanism in the eukaryotic cell cycle
damage. BRCA2 is believed to be involved in homologous recombination and regulating the S-phase checkpoint, and mutations of deficiencies in BRCA2 are strongly
Cell_cycle_checkpoint
Medical condition of a man whose semen contains no sperm
breast cancer susceptibility gene 2 (BRCA2) is employed in DNA repair. A common single nucleotide polymorphism in BRCA2 is associated with idiopathic male
Azoospermia
Medical term
TP53, WT1, Ki67, Topo-II, BRCA1, BRCA2 Cervical cancer Ki67, MYC, p16INK4a, PTEN, Bm-3a Breast cancer BRCA1, BRCA2, HER-2, TP53, EGFR Prostate cancer
Prognosis_marker
Model of DNA repair in biology
such as RAD51 (searches for homology and mediates strand invasion) and BRCA2 (the well studied RAD51 localizer) are critical in support of DNA replication
Double-strand break repair model
Double-strand_break_repair_model
Genetic variant of unknown significance
commonly associated with hereditary breast and ovarian cancers; ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2 and TP53, found 15,311 DNA sequence variants in only
Variant of uncertain significance
Variant_of_uncertain_significance
Use of low-energy X-rays to examine the human breast
recommendations for screening. These include those who: Have a known BRCA1 or BRCA2 gene mutation. Have a 1st-degree relative (parent, brother, sister, or child)
Mammography
Type of breast cancer lacking certain gene expressions
for cancers of the breast, ovaries, pancreas, and prostate, the BRCA1 and BRCA2 genes were identified as high risk for triple-negative. Changes or mutations
Triple-negative_breast_cancer
Facility that sells gasoline and diesel
"Health survey and assessment of the polymorphismsBRCA1/P871L,BRCA1/Q356R, andBRCA2/N372H in female gas station workers in Rio de Janeiro". Environmental and
Filling_station
Surgical removal of the breasts to reduce breast cancer risk
preventive operation pertains to women with these characteristics: BRCA1 or BRCA2 mutation carriers; this is the main indication for bilateral prophylactic
Preventive_mastectomy
Autosomal recessive conditions that affect ethnic Jews more frequently
1/100 Breast cancer and ovarian cancer Oncology Autosomal dominant BRCA1 or BRCA2 1/100 and 1/75, respectively Canavan disease Endocrinology, neurology Autosomal
Medical_genetics_of_Jews
British molecular biologist
cancer risk. He was a key part of the team that in 1995 discovered the BRCA2 gene, which is linked to an increased risk of some types of cancers/ which
Alan_Ashworth
Inherited genetic condition that predisposes a person to cancer
FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM, FANCN, FANCO, FANCP and BRCA2 (previously known as FANCD1). Inheritance of this syndrome is primarily
Hereditary_cancer_syndrome
Protein-coding gene in the species Homo sapiens
interferes with the association of the HMG20B and BRCA2 proteins. HMG20B has been shown to interact with: BRCA2, HDAC1, HDAC2, KIF4A, PHF21A, and RCOR1. GRCh38:
HMG20B
Variable associated with an increased risk of disease or infection
(2003). "Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined
Risk_factor
Overview article
hereditary BRCA1 or BRCA2 gene mutation is about two-fold higher than those women without a familial history. Commercial testing for BRCA1 and BRCA2 gene mutations
Risk factors for breast cancer
Risk_factors_for_breast_cancer
Decade of the Gregorian calendar (1990–1999)
2003). "Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined
1990s
Surgical removal of one or both breasts
women who have tested positive for a deleterious mutation on the BRCA1 or BRCA2 gene and opt for a preventive mastectomy since they are at high risk for
Mastectomy
American biotechnology company
cancer and ovarian cancer. Two of the company's patents on the BRCA1 and BRCA2 genes, which are inherited gene mutations that link to around half of the
Myriad_Genetics
Bikeway in England, connecting Harlow, Essex to King's Lynn, Norfolk
10,257 lines of four colours representing the nucleotide sequence of the BRCA2 gene. This gene, implicated in early-onset breast cancer, was discovered
National_Cycle_Route_11
American physician (1928–2019)
specific genes responsible for these familial cancers, such as BRCA1 and BRCA2. In 1984 he established the Hereditary Cancer Prevention Clinic at Creighton
Henry_T._Lynch
Biological phenomenon whereby tumor growth is uninhibited or underinhibited
must decrease its expression of tumor suppressor genes such as p53, BRCA1, BRCA2, RB1, or the fas receptor. A tumor suppressor would trigger an apoptotic
Tumor_promotion
Tumor or other abnormal growth of tissue
Oostrom CT, Ross GM, van Steeg H, Ashworth A (March 2002). "Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing
Neoplasm
Medical condition
gene 2 (BRCA2) is employed in homologous recombinational repair of DNA damages during meiosis. A common single-nucleotide polymorphism of BRCA2 is associated
Oligospermia
Probabilities of the presence of a condition
woman with a BRCA2 mutation would have a risk of approximately 6%. However, in the rather improbable situation of having both a BRCA1 and a BRCA2 mutation
Pre- and post-test probability
Pre-_and_post-test_probability
Gene that inhibits tumorigenic phenotype
tumor suppressors include pVHL, APC, CD95, ST5, YPEL3, ST7, and ST14, p16, BRCA2. Anticancer gene Metastasis suppressor Adenomatosis polyposis coli Oncogene
Tumor_suppressor_gene
Medical condition
in the cell DNA (2) to interact with FANCD2 that can activate the BRCA1/BRCA2 pathway of DNA repair. This explains why mutations in the NBS1 gene lead
Nijmegen_breakage_syndrome
Protein-coding gene in the species Homo sapiens
however, BRCA2 primarily mediates orderly assembly of RAD51 on ssDNA, the form that is active for homologous pairing and strand invasion. BRCA2 also redirects
RAD52
Protein-coding gene in the species Homo sapiens
deficient in expression of BRCA1 and BRCA2 proteins. Cancers that often have defective expression of BRCA1 or BRCA2 include breast cancer and ovarian cancer
Flap structure-specific endonuclease 1
Flap_structure-specific_endonuclease_1
Macromolecular complex containing protein and RNA molecules
the cell is impaired. Additionally, BRCA1 and BRCA2 levels fall when hnRNP C is lost. BRCA1 and BRCA2 are crucial tumor-suppressor genes which are strongly
Heterogeneous ribonucleoprotein particle
Heterogeneous_ribonucleoprotein_particle
Effect in population genetics
C. A.; Torres, D. (2016). "Founder and Recurrent Mutations in BRCA1 and BRCA2 Genes in Latin American Countries: State of the Art and Literature Review"
Founder_effect
Any type of epithelial lung cancer other than small-cell lung carcinoma
"Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer". Clinical Cancer Research. 13
Non-small-cell_lung_cancer
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List_of_MeSH_codes_(D12.776)
American actor (born 1977)
Art Student Episode: "Portraits" 2000 Strong Medicine Traylor Episode: "BRCA2" 2000 Gilmore Girls Kid #4 Episode: "Rory's Birthday Parties" 2001 Grounded
Greg_Rikaart
Substance or process that is indicative of the presence of cancer in the body
including, AFP (liver cancer), BCR-ABL (chronic myeloid leukemia), BRCA1 / BRCA2 (breast/ovarian cancer), BRAF V600E (melanoma/colorectal cancer), CA-125
Cancer_biomarker
Mammalian protein found in Homo sapiens
"M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex". The Journal of Biological
PLK1
inheritance Blunt-end ligation Bookmarking Brachydactyly Branch migration BRCA1 BRCA2 Bud Buoyant density Burkitt lymphoma Cancer Candidate gene Capillary array
Index_of_genetics_articles
Familial syndrome causing hamartomas and cancers
JH, Schaapveld M, de Vries EG (April 2002). "Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility". Journal of Medical Genetics.
Cowden_syndrome
American comedy film directed by Amy Poehler
she also has problems, as she is waiting on the results of a BRCA1 and BRCA2 test. She then storms out of the restaurant. After Rebecca tells Abby that
Wine_Country_(film)
Loss of the copy of a gene from one parent in a diploid organism
development of this retinal cancer in the young child. The genes BRCA1 and BRCA2 show loss of heterozygosity in samplings of tumors from patients who have
Loss_of_heterozygosity
Medical condition
HGSC. A mutation in BRCA1 or BRCA2 can confer a lifetime ovarian cancer risk of 40-50% and 10-20% respectively, with BRCA2 mutations strongly associated
High-grade_serous_carcinoma
Medical model that tailors medical practices to the individual patient
women are already being genotyped for certain mutations in the BRCA1 and BRCA2 gene if they are predisposed because of a family history of breast cancer
Personalized_medicine
Protein-coding gene in humans
also been drawn to certain brain tumors and osteosarcoma. Unlike BRCA1 and BRCA2 mutations, CHEK2 mutations do not appear to cause an elevated risk for ovarian
CHEK2
limited to "men aged 45 to 61 who have a pathogenic (able to cause disease) BRCA2 variant and a family history of breast, ovarian, pancreatic, or prostate
UK National Screening Committee
UK_National_Screening_Committee
English actress (b. 1983)
after testing positive to being a carrier of the BRCA mutation BRCA1 and BRCA2 genes. In a post on social media site Instagram, she stated, "There is a
Kara_Tointon
2013 United States Supreme Court case
collaboration with University of Utah, isolated and sequenced the BRCA2 gene, and the first BRCA2 patent was filed in the U.S. by the University of Utah and
Association for Molecular Pathology v. Myriad Genetics, Inc.
Association_for_Molecular_Pathology_v._Myriad_Genetics,_Inc.
Chromatin remodeling complex
Harikrishna (5 January 2024). "Signaling Pathway Alterations Driven by BRCA1 and BRCA2 Germline Mutations are Sufficient to Initiate Breast Tumorigenesis by the
Mammalian SWI/SNF (BAF) complex
Mammalian_SWI/SNF_(BAF)_complex
American radiologist
"Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2" published in the journal Science in 2003 detailing the clinical effect
Thomas_Kolb
Later, Dana's mother discloses that she herself has breast cancer. 11 11 "BRCA2" Steve DeJarnatt Richard Alexander October 15, 2000 (2000-10-15) 111 Dana
List of Strong Medicine episodes
List_of_Strong_Medicine_episodes
Protein-coding gene in humans
Chang F, Guo H, Wei Q (2015). "Expression characteristics of FHIT, p53, BRCA2 and MLH1 in families with a history of oesophageal cancer in a region with
MLH1
American actress
2000 Secret Cutting Dawn Cottrell film 2000 Strong Medicine Penny Pointer "BRCA2" 2000 Baywatch Liv Larson "Ties That Bind" 2001 The Young and the Restless
Kimberlee_Peterson
Medical specialty
low-grade subtypes of the cancer. Genetic mutations such as the BRCA1 and BRCA2 have been strongly linked to the development of ovarian cancer. The BRCA1
Gynecologic_oncology
Accumulation of mutations
mutations. Deficiency of DNA repair proteins PMS2, MLH1, MSH2, MSH3, MSH6 or BRCA2 can cause up to 100-fold increases in mutation frequency Epigenetic deficiencies
Somatic_evolution_in_cancer
Genetic characteristic
groups. The first group consists of high-penetrance genes, such as BRCA1, BRCA2, and TP53. Mutations in these genes are inherited and significantly increase
Genetic_predisposition
Protein-coding gene in humans
"M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex". J. Biol. Chem. 278 (38):
PCAF
Medical condition
to females, is unclear. However, breast cancers associated with BRCA1 or BRCA2 gene mutations (see below section on "Gene mutations") are widely considered
Male_breast_cancer
Surgical clipping, removal or blocking of the fallopian tubes
increase the risk of ovarian and fallopian tube cancer, such as BRCA1 and BRCA2. While the procedure for these patients still results in sterilization,
Tubal_ligation
British biochemist
shown at left in David Goodsell's drawing, nerve growth factor, the RAD51-BRCA2 DNA recombination complex, and the DNA ligase shown at right. His group
Tom_Blundell
Italian academic
in clinical applications. Additionally, his meta-analysis of BRCA1 and BRCA2 penetrance provided cancer risk estimates, clarifying risks for germline
Giovanni_Parmigiani
BRCA2
BRCA2
BRCA2
BRCA2
Surname or Lastname
English
English : variant spelling of Tomlinson.
Boy/Male
Hindu, Indian
Friend
Boy/Male
Indian, Sanskrit
Full of Vies
Biblical
same as Peniel
Boy/Male
Tamil
Cowherd
Girl/Female
American, Australian, Chinese, Danish, French, Greek
Shining Light; Light; Similar to Helen
Boy/Male
Tamil
Bal Gopal | பாலகோபால
Baby Krishna, Infant Krishna
Boy/Male
Indian, Sanskrit
Offering Oblations
Boy/Male
Welsh
From the sea fortress.
Boy/Male
Hindu
Smart, Good looking
BRCA2
BRCA2
BRCA2
BRCA2
BRCA2