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Protein domain
A bromodomain is an approximately 110 amino acid protein domain that recognizes acetylated lysine residues, such as those on the N-terminal tails of histones
Bromodomain
Drug class
BET inhibitors are a class of drugs that reversibly bind the bromodomains of Bromodomain and Extra-Terminal motif (BET) proteins BRD2, BRD3, BRD4, and
BET_inhibitor
Protein-coding gene in the species Homo sapiens
Bromodomain-containing protein 4 is a protein that in humans is encoded by the BRD4 gene. BRD4 is a member of the BET (bromodomain and extra terminal domain)
BRD4
Mammalian protein found in Homo sapiens
Bromodomain-containing protein 9 is a protein that in humans is encoded by the BRD9 gene. BRD9 contains a bromodomain. It is closely related to BRD7.
BRD9
Protein-coding gene in the species Homo sapiens
Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET)
BRD2
Protein-coding gene in the species Mus musculus
Peregrin also known as bromodomain and PHD finger-containing protein 1 is a protein that in humans is encoded by the BRPF1 gene located on 3p26-p25. Peregrin
BRPF1
Protein-coding gene in humans
Bromodomain testis-specific protein is a protein that in humans is encoded by the BRDT gene. It is a member of the Bromodomain and Extra-terminal motif
BRDT
Chemical compound
thienotriazolodiazepine and a potent inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein
JQ1
Enzymes that catalyze acyl group transfer from acetyl-CoA to histones
protein–protein interaction domains, such as the acetyllysine-binding bromodomain[citation needed]. Histone acetyltransferases can also acetylate non-histone
Histone_acetyltransferase
Biological processes used in gene regulation
include HAT domains approximately 160 residues in length and a conserved bromodomain that has been found to be an acetyl-lysine targeting motif. Gcn5 has
Histone acetylation and deacetylation
Histone_acetylation_and_deacetylation
Protein-coding gene in the species Homo sapiens
Bromodomain adjacent to zinc finger domain, 1B (BAZ1B) is an enzyme that in humans is encoded by the BAZ1B gene. This gene encodes a member of the bromodomain
BAZ1B
Protein-coding gene in the species Homo sapiens
Bromodomain-containing protein 3 (BRD3) also known as RING3-like protein (RING3L) is a protein that in humans is encoded by the BRD3 gene. This gene was
Bromodomain-containing protein 3
Bromodomain-containing_protein_3
Protein-coding gene in the species Homo sapiens
WD repeat-containing protein 11 (WDR11) also known as bromodomain and WD repeat-containing protein 2 (BRWD2) is a protein that in humans is encoded by
WD repeat-containing protein 11
WD_repeat-containing_protein_11
Chemical compound
are bromodomain and extra terminal domain (BET) proteins, and in particular the BET family member BRD4. BET proteins, which contain two bromodomains, interact
Apabetalone
Protein family
occurs together with other domains, such as the chromodomain and the bromodomain. The PHD finger, approximately 50-80 amino acids in length, is found
PHD_finger
Investigational oral small-molecule drug
PELA) is an investigational oral small-molecule drug designed to inhibit bromodomain and extra-terminal domain (BET)-mediated gene transcription involved
Pelabresib
Protein-coding gene in the species Homo sapiens
Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene. BRD7 has been shown to interact with IRF2 and HNRPUL1. BRD7
BRD7
Chemical compound
Switzerland AG. Braun T, Gardin C (July 2017). "Investigational BET bromodomain protein inhibitors in early stage clinical trials for acute myelogenous
Birabresib
Nuclear protein that binds to CREB
others bind via allosteric cooperation as in the case of MLL and Myb. Bromodomains (BRD) consist of approximately 110 amino acids, that function to recognize
CREB-binding_protein
Proteine
member of the SWI/SNF family, possessing a SANT domain instead of the bromodomain. The protein ISWI can interact with several proteins giving three different
Imitation_SWI
Protein-coding gene in the species Homo sapiens
Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene. The protein encoded by this gene interacts with thyroid hormone
BRD8
Field of study
and temozolamide in patients with brain cancer. Proteins containing bromodomains recognize and bind acetylated lysine residues in histones, causing chromatin
Pharmacoepigenetics
Protein-coding gene in humans
Bromodomain and WD repeat-containing protein 1 (BRWD1) also known as WD repeat-containing protein 9 (WDR9) is a protein that in humans is encoded by the
Bromodomain and WD repeat-containing protein 1
Bromodomain_and_WD_repeat-containing_protein_1
Type of breast cancer lacking certain gene expressions
(LAS17) shows encouraging results in a pre-clinical study. Recently, BET (Bromodomain and Extra-Terminal Domain Proteins) inhibitors have shown anti-tumor
Triple-negative_breast_cancer
Protein-coding gene in humans
Bromodomain and WD repeat-containing protein 3 is a protein that in humans is encoded by the BRWD3 gene. The protein encoded by this gene contains a bromodomain
Bromodomain and WD repeat-containing protein 3
Bromodomain_and_WD_repeat-containing_protein_3
Topics referred to by the same term
behaviour of propellers Bromo- and Extra-Terminal domain (BET) family of Bromodomain-containing proteins Bet (letter), the second letter in many Semitic alphabets
Bet
Chinese-American scientist
his major contributions to science are the Zhou Lab's discovery of the bromodomain as the acetyl-lysine binding domain ('chromatin reader') in gene transcription
Ming-Ming_Zhou
Study of DNA modifications that do not change its sequence
remodeler can then cause changes to the state of the chromatin. Indeed, a bromodomain – a protein domain that specifically binds acetyl-lysine – is found in
Epigenetics
Pharmaceutical compound
drug that has been evaluated for the treatment of cancer. It inhibits Bromodomain and Extra-Terminal domain (BET) proteins, with potential antineoplastic
Ezobresib
Small molecule (PROTAC)
(August 2015). "Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4". ACS Chemical Biology. 10 (8): 1770–1777. doi:10.1021/acschembio
Proteolysis_targeting_chimera
Protein-coding gene in the species Homo sapiens
Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene. The protein encoded by this gene belongs
BAZ1A
Protein-coding gene in humans
Bromodomain adjacent to zinc finger domain protein 2A is a protein that in humans is encoded by the BAZ2A gene. GRCh38: Ensembl release 89: ENSG00000076108
BAZ2A
Pregnancy prevention methods used by men
MN, Faver JC, et al. (March 2021). "Discovery and characterization of bromodomain 2-specific inhibitors of BRDT". Proceedings of the National Academy of
Male_contraceptive
Protein-coding gene in the species Homo sapiens
"Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein". Mol. Cell. Biol. 23 (15): 5354–65. doi:10.1128/MCB
HIST2H4A
Family of regulator genes
(June 2014). "The mechanisms behind the therapeutic activity of BET bromodomain inhibition". Molecular Cell. 54 (5): 728–36. doi:10.1016/j.molcel.2014
Myc
Protein-coding gene in the species Homo sapiens
much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation
BPTF
Mechanism of transmission of gene expression programs through cell division
Maruyama, T; Sciortino, S; Lippincott-Schwartz, J; Ozato, K (2000). "A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M
Bookmarking
Protein-coding gene in the species Homo sapiens
fission yeast gene mapping close to suc1 encodes a protein containing two bromodomains". Molecular & General Genetics. 248 (4): 491–8. doi:10.1007/BF02191650
SMARCA2
Protein complex regulating transcription in eukaryotes
cyclin T1, T2, and K. P-TEFb associates with other factors including the bromodomain protein BRD4, and is found associated with a large complex of proteins
P-TEFb
Family of viruses
origin of replication. E2 also utilizes a cellular protein known as Bromodomain-4 (Brd4) to tether the viral genome to cellular chromosomes. This tethering
Papillomaviridae
Protein family
linked to additional domains associated with chromatin, such as the bromodomain, the AT hook motif, the SET domain, or the PHD finger. MBD-containing
Methyl-CpG-binding_domain
Region of a genome which regulates expression of genes related to cell identity
Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K (August 2005). "The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates
Super-enhancer
Protein found in humans
associated with SET domain (AWS), a SET domain, a post-set domain, a bromodomain, a bromo-adjacent homology domain, and a plant homeodomain finger (PHD
ASH1L
Categories of protein tertiary structure
few isolated β-sheets on the periphery. Common examples include the bromodomain, the globin fold and the homeobox. All-β proteins are a class of structural
Protein_fold_class
Field of study
place. Acetyl groups on histone proteins can act as binding sites for bromodomain-containing proteins and other chromatin-remodeling proteins that promote
Epigenetics of bipolar disorder
Epigenetics_of_bipolar_disorder
British chemist
His group reported inhibitors of the BET-bromodomain-containing proteins, the CREBBP and P300 bromodomains, and developed hypoxia-targeted pro-drugs
Stuart_Conway
Protein-coding gene in the species Homo sapiens
possesses a domain that interacts with heterochromatin protein 1 (HP1) and a bromodomain capable of recognizing acetylated lysine residues in other proteins.
TRIM28
Protein-coding gene in the species Homo sapiens
(March 1998). "Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein
KAT2A
Compounds that inhibit histone deacetylases
treatment with the pan-HDAC inhibitor LBH589 (panobinostat) and the BET bromodomain JQ1 compound. Trichostatin A (TSA) and others are being investigated
Histone_deacetylase_inhibitor
Muscular degenerative disease of the face, shoulder blades, and upper arms
van der Maarel SM, Tapscott SJ, Sverdrup FM (4 September 2017). "BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified
Facioscapulohumeral muscular dystrophy
Facioscapulohumeral_muscular_dystrophy
Protein-coding gene in the species Homo sapiens
Sciortino S, Shuman J, Hurwitz J, Ozato K (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression
RFC3
domains, either in association or alone PHD domain associated with a bromodomain MATH domain (in e.g., TRIM37) ARF domain (in e.g., TRIM23) EXOIII domain
Tripartite_motif_family
Type of skeletal muscle tumor
2017). "PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability". Cancer Discovery. 7 (8): 884–899. doi:10.1158/2159-8290
Alveolar_rhabdomyosarcoma
Protein-coding gene in the species Homo sapiens
Sciortino S, Shuman J, Hurwitz J, Ozato K (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression
RFC4
Shilatifard, Ali (2017). "Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas". Nature Medicine. 23 (4):
Ali_Shilatifard
Protein-coding gene in the species Homo sapiens
PMC 139241. PMID 12477932. Farina A, Hattori M, Qin J, et al. (2004). "Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity
SIPA1
; Ward, T. R.; Schönbrunn, E.; Georg, G. I.; Pomerantz, W. C. K. BET Bromodomain Inhibitors with One-step Synthesis Discovered from a Virtual Screen.
Gunda_Georg
Protein-coding gene in the species Homo sapiens
ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem. J. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281
HIST1H2AL
Human chromosome
5-azacytidine-induced protein 2 BRK1: SCAR/WAVE actin nucleating complex subunit BRPF1: bromodomain and PHD finger containing 1 BTD: biotinidase C3orf14-Chromosome 3 open
Chromosome_3
Protein-coding gene in the species Homo sapiens
"Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID". Proceedings of the National Academy of Sciences
ASF1A
Human chromosome
transcription factor transcription regulator protein BACH1 BRWD1: encoding bromodomain and WD repeat-containing protein 1 BTG3: encoding protein BTG3 C21orf58:
Chromosome_21
Protein-coding gene in the species Homo sapiens
Wijnen AJ (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory
IRF2
Topics referred to by the same term
type in the EAGLE design automation software BRD2, BRD3, BRD4 and BRDT, bromodomain families Business requirements document Bycatch reduction device, see
BRD
Rare genetic condition
proteins, prototypical members of the p300-CBP coactivator family, have a bromodomain and a histone acetyltransferase domain and are able to bind to various
Rubinstein–Taybi_syndrome
DNA changes that regulate human traits
using the bromodomain with the assistance of the acetylated K5 on H4. BRD4 is a member of the BET protein family, which includes other bromodomain-containing
Epigenetics of human development
Epigenetics_of_human_development
Protein-coding gene in the species Homo sapiens
binding specifically to phosphorylated CREB protein. p300 HAT contains a bromodomain which is involved in IL6 signaling. This gene has also been identified
EP300
Protein-coding gene in humans
Cheng Y, Billin AN, Hardison RC, Mackay JP, Blobel GA (May 2011). "Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin
GATA1
Mammalian protein found in Homo sapiens
Harel-Bellan A (August 2001). "Interaction between acetylated MyoD and the bromodomain of CBP and/or p300". Mol. Cell. Biol. 21 (16): 5312–20. doi:10.1128/MCB
MyoD
Protein-coding gene in humans
separate acetyltransferase and E3 ubiquitin ligase domains as well as a bromodomain for interaction with other proteins. PCAF also possesses sites for its
PCAF
Human protein-coding gene
GC-Box factors SP1/GC 359 375 - HSF Heat shock factors 240 264 - BPTF Bromodomain and PHD domain transcription factors 423 433 + ZNF35 Zinc finger protein
C7orf25
Protein-coding gene in the species Homo sapiens
Sciortino S, Shuman J, Hurwitz J, Ozato K (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression
RFC2
Protein-coding gene in the species Homo sapiens
Sciortino S, Shuman J, Hurwitz J, Ozato K (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression
RFC5
Serbian-American chemical biologist
on virus-host interactions in response to SARS-CoV-2. She showed that bromodomain and extraterminal (BET) proteins were involved in the body's response
Danica_Galonić_Fujimori
Tool in chemical genetics
concentrations. The BET (Bromodomains and Extra Terminal) family of proteins contain conserved motifs known as bromodomains (BDs) responsible for recognizing
Bump_and_hole
Spiliotopoulos, Dimitrios; Caflisch, Amedeo (2014-06-01). "Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking". Bioorganic & Medicinal
LeDock
a prime target for cancer therapies. BRD4 BRD4, a member of the BET (Bromodomain and Extra-Terminal) family of proteins, plays a crucial role in transcriptional
Transcriptional addiction in cancer
Transcriptional_addiction_in_cancer
Chromatin remodeling complex
expression. Moreover, the unique composition of the ncBAF complex (i.e. Bromodomain-containing protein 9 -BRD9- subunit) makes it an attractive target for
Mammalian SWI/SNF (BAF) complex
Mammalian_SWI/SNF_(BAF)_complex
Protein-coding gene in the species Homo sapiens
are often acetylated to open DNA for transcription. TAF1 contains two bromodomains, which each can bind one of two acetyllysine residues at position 5 and
TAF1
Protein family
acetylating histones and other proteins. These proteins also contain a bromodomain that can recognize the acetylated lysines and a PHD finger domain; therefore
P300-CBP_coactivator_family
Protein encoding gene in mammals
transcription factor binding sites, with a fork head domain factor (V$FKHD), a bromodomain and PHD domain transcription factor (V$BPTF), and a sex/testes determining
C2orf74
American cancer scientist
Chiang, Cheng-Ming; Grundhoff, Adam; Johnsen, Steven A. (2014-07-24). "Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation
Steven_A._Johnsen
American biochemist (born 1954)
chromatin sites. Kingston also discovered that DIGIT interacts with the Bromodomain-containing protein 3 (BRD3) to regulate endoderm differentiation transcriptionally
Robert_E._Kingston
Protein-coding gene in the species Homo sapiens
association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. 16 (8): 1727–37. doi:10.1210/me.2001-0353
E2F2
Gene regulation in autoimmune diseases
(TATA-box binding protein associated factor 1) which contains a double bromodomain and can detect very low levels of histone acetylation. TAF1 detects acetylation
Epigenetics of autoimmune disorders
Epigenetics_of_autoimmune_disorders
extra-terminal domain. It is thought that this domain is related to bromodomain proteins, and this domain is used for protein binding. N-linked glycosylation
FAM199X
Protein found in humans
(March 1998). "Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein
Ku70
Protein-coding gene in humans
Bonventre JV (2001). "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1"
TFDP1
1,132-amino acid
immature-appearing cells containing a BRD4-NUTM1 fusion gene. BRD4 is the bromodomain-containing protein 4 gene. A fusion gene is an abnormal gene consisting
Nuclear protein in testis gene
Nuclear_protein_in_testis_gene
Protein-coding gene in humans
response to growth factors, RUNX3 is acetylated by p300 to complex with bromodomain-containing protein 2 (BRD2; a member of the BET family of transcription
RUNX3
Italian British biochemist
which Ciulli and colleagues designed an engineered mutant variant of BET bromodomains able to accommodate selectively its binding ligand, enabling the individual
Alessio_Ciulli
Protein found in humans
(March 1998). "Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein
Ku80
Human gene
complex plays roles in cell proliferation and differentiation. BPTF bromodomain PHD finger transcription factor a complex which catalyzes ATP-dependent
C17orf58
Protein-coding gene in the species Homo sapiens
(Mar 1998). "Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein
TADA2L
Artificial peptide attached to protein for marking purpose
streptavidin BromoTag, a "bump-and-hole" mutated version of the second bromodomain of Brd4, Brd4-BD2 L387A, that can be highly selectively bound by tag-specific
Protein_tag
Chemical compound
"The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains". ACS Chemical Biology. 9 (2): 495–502. doi:10.1021/cb400789e. PMID 24533473
LY294002
Protein-coding gene in the species Homo sapiens
T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator
ZMYND8
Form of dynamic modification
recruited to such histone modifications and bind via specific domains, e.g., bromodomain, chromodomain. These triple action of 'writing', 'reading' and 'erasing'
Chromatin_remodeling
Mammalian protein found in Homo sapiens
Cheong J, Bermudez VP, Tamura T, et al. (September 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression
Proliferating cell nuclear antigen
Proliferating_cell_nuclear_antigen
Cancer originating in precursors to muscle cells
(2017-08-01). "PAX3–FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability". Cancer Discovery. 7 (8): 884–899. doi:10.1158/2159-8290
Rhabdomyosarcoma
Field of study
serve as binding sites for certain transcription factors due to their bromodomains and chromodomains, and also prevent the binding of such factors by hiding
Epigenetics of physical exercise
Epigenetics_of_physical_exercise
BROMODOMAIN
BROMODOMAIN
BROMODOMAIN
BROMODOMAIN
Boy/Male
Tamil
Lord Krishna
Girl/Female
German, Italian, Swedish, Swiss
Foreign Woman
Girl/Female
Hindu, Indian, Kannada, Malayalam, Marathi, Sindhi, Tamil, Telugu
One who Lived in Malva
Girl/Female
Indian
A songbird
Girl/Female
Tamil
Friend, See also ervin
Boy/Male
Indian, Punjabi, Sikh
Light of Remembrance of God
Boy/Male
Hindu
The scriptures, Vedic method of self realization, Knower of the Vedas, One who knows all, Hindu philosophy or ultimate wisdom, King of all
Girl/Female
American, Australian, French, German, Latin
Woman from Rome; Of Rome; Citizen of Rome; Female Version of Roman
Female
English
Feminine form of English Kenneth, KENINA means both "comely; finely made" and "born of fire."Â
Boy/Male
Indian
Divine of Power
BROMODOMAIN
BROMODOMAIN
BROMODOMAIN
BROMODOMAIN
BROMODOMAIN