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One of the main bile acids
Chenodeoxycholic acid (CDCA; also known as chenodesoxycholic acid, chenocholic acid and 3α,7α-dihydroxy-5β-cholan-24-oic acid) is a bile acid. Salts of
Chenodeoxycholic_acid
Steroid acid in the bile of animals
cholic acid) and taurochenodeoxycholic acid and glycochenodeoxycholic acid (derivatives of chenodeoxycholic acid) are the major bile salts. The salts of
Bile_acid
Main bile acid
substance. Salts of cholic acid are called cholates. Cholic acid, along with chenodeoxycholic acid, is one of the two major bile acids produced by the liver
Cholic_acid
Bile acid
bile acids secreted by the liver are cholic acid and chenodeoxycholic acid. Bacteria metabolize chenodeoxycholic acid into the secondary bile acid lithocholic
Deoxycholic_acid
Medication and metabolite of cholesterol
which is less frequent than with chenodeoxycholic acid therapy. Bacterial conversion of UDCA to chenodeoxycholic acid may be the mechanism for this side
Ursodeoxycholic_acid
Chemical compound
acid (OCA), sold under the brand name Ocaliva, is a semi-synthetic bile acid analogue which has the chemical structure 6α-ethyl-chenodeoxycholic acid
Obeticholic_acid
Dark greenish-brown fluid aiding in the digestion of fats
concentration of certain naturally occurring bile acids, such as chenodeoxycholic acid and ursodeoxycholic acid. On an empty stomach – after repeated vomiting
Bile
Chemical compound
for absorption. Bacterial action in the colon produces LCA from chenodeoxycholic acid by reduction of the hydroxyl functional group at carbon-7 in the
Lithocholic_acid
Species of bacterium
acids, such as cholic acid and chenodeoxycholic acid, after which gut commensals like C. scindens convert them into unconjugated secondary bile acids
Clostridium_scindens
Disease where stones form in the gallbladder
£1000 less per patient). The medications ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) have been used in treatment to dissolve gallstones
Gallstone
Genetic bile acid metabolism disorder
The CYP27A1 gene, responsible for bile acid production, is mutated, reducing chenodeoxycholic acid and cholic acid, leading to increased synthesis of
Cerebrotendinous xanthomatosis
Cerebrotendinous_xanthomatosis
Chemical compound
Glycochenodeoxycholic acid, also abbreviated as GCDCA, is a bile salt formed in the liver from chenodeoxycholic acid and glycine, usually found as the
Glycochenodeoxycholic_acid
Chemical compound
Taurolithocholic acid is a bile acid. More than 50 types of secondary bile acids produced by microbes from the primary bile acids (cholic acid and chenodeoxycholic acid
Taurolithocholic_acid
Group of bile acids found as one of the main forms in mice
forms, α- and β-muricholic acids, differ from the primary bile acids found in humans, cholic acid and chenodeoxycholic acid, by both having a hydroxyl
Muricholic_acid
Chemical compound
tweezer based on a hyodeoxycholic acid showed a high selectivity the towards the fluorine radical. Chenodeoxycholic acid for a similar molecular tweezer
Hyodeoxycholic_acid
Chemical compound
Taurochenodeoxycholic acid is a bile acid formed in the liver of most species, including humans, by conjugation of chenodeoxycholic acid with taurine. It is
Taurochenodeoxycholic_acid
Type of bile acid
for the 6-hydroxylation reaction of chenodeoxycholic acid in the pig is the cytochrome P450 CYP4A21. Hyocholic acid can be found in humans with cholestasis
Hyocholic_acid
Chemical compound
cholic acid, the major primary bile acid in humans. Alternatively, it can be converted into 5β-cholestane-3α,7α-diol and then to chenodeoxycholic acid, the
7α-Hydroxy-4-cholesten-3-one
Congenital disorder of nervous system
Bile acid synthesis is defective due to lack of side chain modifications; for example, the last steps in the synthesis of chenodeoxycholic acid and cholic
Zellweger_syndrome
Index of chemical compounds with the same molecular formula
may refer to: Chenodeoxycholic acid, a bile acid Deoxycholic acid, a bile acid Hyodeoxycholic acid, a bile acid Ursodiol, a bile acid This set index
C24H40O4
2025 American television series
Sasha discovers Watson's theory, and the team treat Holmes with chenodeoxycholic acid. Shinwell tracks down and confronts Moran, culminating in his arrest
Watson_(TV_series)
Protein-coding gene in the species Homo sapiens
expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear
Farnesoid_X_receptor
Malignant neoplastic disease of the esophagus
adenocarcinoma. Bile reflux containing unconjugated bile acids, including deoxycholic acid and chenodeoxycholic acid, appears to contribute to esophageal adenocarcinoma
Esophageal_cancer
Community of microorganisms in the gut
and chenodeoxycholic acid (CDCA) into secondary bile acids (BAs) lithocholic acid (LCA) and deoxy cholic acid (DCA) respectively. Primary bile acids which
Gut_microbiota
Circulation of substances in the human digestive system
Hepatocytes metabolize cholesterol to cholic acid and chenodeoxycholic acid. These lipid-soluble bile acids are conjugated (reversibly attached) mainly
Enterohepatic_circulation
Italian pharmaceutical company
abusing its dominant market position when it increased the price of chenodeoxycholic acid from €0.28 per capsule to €140 per capsule in 2018. They said “This
Leadiant_Biosciences
Medication for parasite infestations
1038/ncomms2924. PMID 23728580. Kim SG, Kim BK, Kim K, Fang S (December 2016). "Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic
Ivermectin
Chemical compound
Bear bile contains several bile acids including taurochenodeoxycholic acid, ursodeoxycholic acid, and chenodeoxycholic acid. UDCA and its taurine conjugates
Ursodoxicoltaurine
Medical condition
cholic acid and chenodeoxycholic acid (and their conjugated forms), and a decreased abundance of secondary bile acids such as lithocholic acid and deoxycholic
Inflammatory_bowel_disease
Impaired flow of bile from the liver to the small intestine
and secondary bile acids may lead to PSC via the gut-liver axis. The primary bile acids cholic acid (CA) and chenodeoxycholic acid (CDCA) are synthesized
Cholestasis
Organ system cancer located in gastrointestinal tract
and found that higher fecal concentrations of the bile acids cholic acid and chenodeoxycholic acid are associated with a high risk and higher incidence
Gastrointestinal_cancer
Pharmaceutical company
disorder, bile acid diarrhea. The company's lead product is Ocaliva (obeticholic acid, OCA), also known as 6-ethyl-chenodeoxycholic acid or INT-747. OCA
Intercept_Pharmaceuticals
Cancer of the colon or rectum
of bile acids, particularly deoxycholic acid, are higher. Higher fecal concentrations of the bile acids cholic acid and chenodeoxycholic acid are associated
Colorectal_cancer
Medical condition
of gallstones and cholecystitis includes medication (for example chenodeoxycholic acid and ursodiol) to dissolve the stones. Because of side effects, ursodiol
Gallbladder_disease
Enzyme found in humans
activity of CYP7A1 regulates the production of chenodeoxycholic acid and cholic acid, which are primary bile acids produced in the liver through the oxidation
Cholesterol 7 alpha-hydroxylase
Cholesterol_7_alpha-hydroxylase
"Cofactor requirements for 7 alpha-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, Eubacterium
Bile-acid 7alpha-dehydroxylase
Bile-acid_7alpha-dehydroxylase
Chemical compound
The Australian biotech company Giaconda combines bezafibrate with chenodeoxycholic acid in an anti-hepatitis C drug combination called Hepaconda. Bezafibrate
Bezafibrate
Chemical compound
receptor Agonists: Bile acids Cafestol Chenodeoxycholic acid Cilofexor Fexaramine GW-4064 Ivermectin Nidufexor Obeticholic acid Tropifexor Antagonists:
Cafestol
Chemical compound
taurochenodeoxycholic acid, tauromuricholic acid, lithocholic acid, chenodeoxycholic acid, taurolithocholic acid, and an abundance of bile acids and salts.[citation needed]
2,3,7,8-Tetrachlorodibenzofuran
2,3,7,8-Tetrachlorodibenzofuran
Class of enzymes
Activity of this enzyme determines the balance between cholic and chenodeoxycholic acids in humans. Ishida H, Noshiro M, Okuda K, Coon MJ (October 1992)
7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase
7alpha-hydroxycholest-4-en-3-one_12alpha-hydroxylase
Pharmaceutical drug classification
A05AA01 Chenodeoxycholic acid A05AA02 Ursodeoxycholic acid A05AA03 Cholic acid A05AA04 Obeticholic acid A05AA05 Ursodoxicoltaurine A05AA06 Norucholic acid A05AB01
ATC_code_A05
Microbial enzymes that deconjugate primary bile acids
either cholic acid (CA) or chenodeoxycholic acid[clarification needed] (CDCA). These primary bile acids are then conjugated to the amino acids glycine or
Bile_salt_hydrolase
American physician (1931–2021)
and evaluation of the use of bile acid therapy to dissolve cholesterol gallstones, first using chenodeoxycholic acid. He published fundamental work on
Alan_Hofmann
Chemical compound
(December 2017). "Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic
Tropifexor
ursodeoxycholic acid as the bile acid in Hepaconda, but in 2006 the company shifted its attention to the use of chenodeoxycholic acid, having decided
Giaconda (pharmaceutical company)
Giaconda_(pharmaceutical_company)
225.261 – dehydrocholic acid MeSH D04.808.105.225.272 – deoxycholic acid MeSH D04.808.105.225.272.150 – chenodeoxycholic acid MeSH D04.808.105.225.272
List_of_MeSH_codes_(D04)
Biosciences Ltd, formerly known as Sigma-Tau Rare Disease, for chenodeoxycholic acid which is used to treat about 60 children with cerebrotendineous
Pharmaceutical Accountability Foundation
Pharmaceutical_Accountability_Foundation
Chemical compound
receptor Agonists: Bile acids Cafestol Chenodeoxycholic acid Cilofexor Fexaramine GW-4064 Ivermectin Nidufexor Obeticholic acid Tropifexor Antagonists:
Guggulsterone
Chemical compound
the farnesoid X receptor (FXR), which is a bile acid-activated nuclear receptor that controls bile-acid synthesis, conjugation and transport, as well as
Fexaramine
Protein-coding gene in the species Homo sapiens
bile acids including chenodeoxycholic acid, glycochenodeoxycholic acid and obeticholic acid in explants of ileal mucosa. FGF19 regulates new bile acid synthesis
FGF19
Describes a new class of consumer health testing
Ratio ✓ ✓ ✓ Chenodeoxycholic acid ✓ Cholic acid ✓ Deoxycholic acid ✓ Glycochenodeoxycholic acid ✓ Glycocholic acid ✓ Glycodeoxycholic acid ✓ Glycolithocholic
Direct-to-consumer blood testing
Direct-to-consumer_blood_testing
Charcocaps chaulmosulfone (INN) Chealamide Chemet Chenix Chenodal chenodeoxycholic acid (INN) Cheracol Cheratussin DAC CHG Scrub Chibroxin chiniofon (INN)
List_of_drugs:_Cf–Ch
Antiretroviral medication
receptor Agonists: Bile acids Cafestol Chenodeoxycholic acid Cilofexor Fexaramine GW-4064 Ivermectin Nidufexor Obeticholic acid Tropifexor Antagonists:
Efavirenz
Protein-coding gene in the species Homo sapiens
two primary bile acids, cholic acid and chenodeoxycholic acid, both of which are secreted in the bile. In the intestine these bile acids affect the solubility
CYP8B1
Nuclear receptor protein found in humans
Janowski BA, Lobaccaro JM, Hammer RE, et al. (May 1998). "Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR
Liver_X_receptor_alpha
Chemical compound
Fiorucci S, Biagioli M, Sepe V, Zampella A, Distrutti E (June 2020). "Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH)". Expert
Nidufexor
Chemical compound
receptor Agonists: Bile acids Cafestol Chenodeoxycholic acid Cilofexor Fexaramine GW-4064 Ivermectin Nidufexor Obeticholic acid Tropifexor Antagonists:
27-Hydroxycholesterol
Nuclear receptor
Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear
Liver_X_receptor
Class of enzymes
Holdeman LV (November 1982). "Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium
7beta-hydroxysteroid dehydrogenase (NADP+)
7beta-hydroxysteroid_dehydrogenase_(NADP+)
Protein-coding gene in the species Homo sapiens
"Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors". Proceedings of the National Academy of Sciences
Liver_X_receptor_beta
Protein-coding gene in the species Homo sapiens
H, Okada M, Akitaya S, et al. (2006). "Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3" (PDF)
Solute carrier organic anion transporter family member 1B3
Solute_carrier_organic_anion_transporter_family_member_1B3
American physician and pharmacologist
Johnson L.; Thomas, Fred B.; Tyor, Malcolm P. (1981). "Chenodiol (Chenodeoxycholic Acid) for Dissolution of Gallstones: The National Cooperative Gallstone
Ronald_Okun
Chemical compound
receptor Agonists: Bile acids Cafestol Chenodeoxycholic acid Cilofexor Fexaramine GW-4064 Ivermectin Nidufexor Obeticholic acid Tropifexor Antagonists:
22R-Hydroxycholesterol
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