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CHRNA5

  • Nicotinic acetylcholine receptor
  • Acetylcholine receptors named for their selective binding of nicotine

    three types. α genes: CHRNA1 (muscle), CHRNA2 (neuronal), CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA8, CHRNA9, CHRNA10 β genes: CHRNB1 (muscle), CHRNB2

    Nicotinic acetylcholine receptor

    Nicotinic acetylcholine receptor

    Nicotinic_acetylcholine_receptor

  • CHRNA5
  • Nicotinic receptor involved in pain regulation

    subunit alpha-5 (or α5 nAChR) is a protein that in humans is encoded by the CHRNA5 gene. This protein is a type of ligand gated neuronal type subunit of the

    CHRNA5

    CHRNA5

    CHRNA5

  • Nicotine dependence
  • Chronic disease

    CHRNA5-CHRNA3-CHRNB4 nicotinic acetylcholine receptors and complete smoking cessation. Increasing evidence indicates that the genetic variant CHRNA5 predicts

    Nicotine dependence

    Nicotine dependence

    Nicotine_dependence

  • Ligand-gated ion channel
  • Type of ion channel transmembrane protein

    acetylcholine (nAChR) alpha α1 α2 α3 α4 α5 α6 α7 α9 α10 CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNA10 ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS beta

    Ligand-gated ion channel

    Ligand-gated ion channel

    Ligand-gated_ion_channel

  • Effects of nicotine on human brain development
  • Effects of cigarettes on the developing human brain

    dependence is a mutation at rs16969968 in the nicotinic acetylcholine receptor CHRNA5, resulting in an amino acid alteration from aspartic acid to asparagine

    Effects of nicotine on human brain development

    Effects_of_nicotine_on_human_brain_development

  • Addictive personality
  • Set of personality traits

    genes receptive of dopamine and nicotine, including DRD2 and CHRNA5. For example, the CHRNA5 gene has been associated with a reduced aversion to nicotine

    Addictive personality

    Addictive_personality

  • Behavioural genetics
  • Study of genetic-environment interactions influencing behaviour

    to this rule, including the effect of APOE on Alzheimer's disease, and CHRNA5 on smoking behaviour, and ALDH2 (in individuals of East Asian ancestry)

    Behavioural genetics

    Behavioural genetics

    Behavioural_genetics

  • Peer pressure
  • Influencing peers to conform

    lower effect on nicotine dependence for those with the high risk allele (CHRNA5). This suggests that social contexts do not play a significant role in substance

    Peer pressure

    Peer_pressure

  • Lung cancer susceptibility
  • chromosome. The locus 15q25 on chromosome 15 has genetic variants such as the CHRNA5-CHRNA3 locus, which also increases lung cancer susceptibility. Smoke is

    Lung cancer susceptibility

    Lung_cancer_susceptibility

  • List of human protein-coding genes 2
  • Q15822 2989 CHRNA3 HGNC:1957; P32297 2990 CHRNA4 HGNC:1958; P43681 2991 CHRNA5 HGNC:1959; P30532 2992 CHRNA6 HGNC:15963; Q15825 2993 CHRNA7 HGNC:1960;

    List of human protein-coding genes 2

    List_of_human_protein-coding_genes_2

  • Autosomal dominant nocturnal frontal lobe epilepsy
  • Medical condition

    these families show strong linkage on chromosome 15 (15q24) near CHRNA3, CHRNA5, and CHRNB4. Causative genes in this area are still unknown. Three mutations

    Autosomal dominant nocturnal frontal lobe epilepsy

    Autosomal_dominant_nocturnal_frontal_lobe_epilepsy

  • Epigenetics of anxiety and stress–related disorders
  • Field of study

    Boscarino JA, Erlich PM, Hoffman SN, Zhang X (2012). "Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma

    Epigenetics of anxiety and stress–related disorders

    Epigenetics_of_anxiety_and_stress–related_disorders

  • Tommaso A. Dragani
  • Italian genetic epidemiologist

    Clin Oncol. 2006;24:1672-8). He demonstrated that polymorphisms in the CHRNA5 gene promoter modulated the transcription of this gene, and thereby showed

    Tommaso A. Dragani

    Tommaso_A._Dragani

  • Index of biophysics articles
  • Index of articles on biophysics

    CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CD22 CD33 CHRNA10 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB1 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG CLCA1

    Index of biophysics articles

    Index_of_biophysics_articles

  • CLPTM1L
  • Protein-coding gene in humans

    Houlston RS (2010). "Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers". Carcinogenesis

    CLPTM1L

    CLPTM1L

    CLPTM1L

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CHRNA5