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Irreversible reaction step at the branch points of biochemical pathways
In biochemistry, the committed step (also known as the first committed step) is an effectively irreversible, enzyme-catalyzed reaction that occurs at a
Committed_step
Protein family
cofactor, NAD+. The reaction this enzyme catalyses represents the first committed step in the production of all inositol-containing compounds, including phospholipids
Inositol-3-phosphate_synthase
Chemical compound
olpyruvyltransferase, also known as MurA. This enzyme catalyzes the committed step in peptidoglycan biosynthesis, namely the ligation of phosphoenolpyruvate
Fosfomycin
Chemical reactions and pathways involving lysis of purine nucleotides
not the committed step to purine synthesis because PRPP is also used in pyrimidine synthesis and salvage pathways. The first committed step is the reaction
Purine_metabolism
Class of enzymes
The reaction catalyzed by DGAT is considered the terminal and only committed step in the acyl-CoA-dependent triglyceride synthesis, universally important
Diglyceride_acyltransferase
Coenzyme, notable for its synthesis and oxidation role
by the enzyme pantothenate kinase (PanK; CoaA; CoaX). This is the committed step in CoA biosynthesis and requires ATP. A cysteine is added to 4′-phosphopantothenate
Coenzyme_A
Class of enzymes
by many activators and inhibitors. PFK-1 catalyzes the important "committed" step of glycolysis, the conversion of fructose 6-phosphate and ATP to fructose
Phosphofructokinase_1
The following is an episode list for the American television sitcom Step by Step. The series originally ran for six seasons on ABC from September 20, 1991
List_of_Step_by_Step_episodes
Chemical compound
synthase to form δ-aminolevulinic acid (dALA). This process is the committed step in the biosynthesis of porphobilinogen and thus hemoglobin. Succinyl
Succinyl-CoA
Slowest step in a series of biochemical reactions
Branched pathways Metabolic control analysis Biochemical systems theory Committed step Nelson, David L.; Cox, Michael M. (2005). Lehninger Principles of Biochemistry
Rate-limiting step (biochemistry)
Rate-limiting_step_(biochemistry)
Class of enzymes
both the urea cycle and polyamine synthesis, and this reaction is the committed step in that latter polyamine pathway. In the urea cycle, ornithine is instead
Ornithine_decarboxylase
Class of enzymes
1-carboxyvinyltransferase (EC 2.5.1.7) is an enzyme that catalyzes the first committed step in peptidoglycan biosynthesis of bacteria: phosphoenolpyruvate +
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
UDP-N-acetylglucosamine_1-carboxyvinyltransferase
Phosphatidylcholine biosynthetic process
cells phosphorylate choline by the enzyme choline kinase, the first committed step of CDP-choline pathway. Choline kinase (CK) is a cytosolic protein that
CDP-choline_pathway
Species of evergreen shrub
Dephosphorylation of xanthosine-5'-monophosphate into xanthosine is the committed step for the xanthosines entering the beginning of the most common pathway
Camellia_sinensis
Type of chemical compound
and protozoa, as well as the α-proteobacteria group of bacteria, the committed step for porphyrin biosynthesis is the formation of δ-aminolevulinic acid
Porphyrin
Family where one parent has children that are not genetically related to the other parent
child from another relationship. The earliest recorded use of the prefix step-, in the form steop-, is from an 8th-century glossary of Latin-Old English
Stepfamily
2014 American film
Step Up: All In is a 2014 American dance film directed by Trish Sie and written by John Swetnam. The film is the sequel to Step Up Revolution (2012) and
Step_Up:_All_In
Class of enzymes
trans-cinnamate + NH3 Phenylalanine ammonia lyase (PAL) is the first and committed step in the phenyl propanoid pathway and is therefore involved in the biosynthesis
Phenylalanine_ammonia-lyase
Chemical compound
also uses two molecules of ATP in its initial stages as a committed and irreversible step. For this reason glycolysis is not reversible and has a net
1,3-Bisphosphoglyceric_acid
Carotenoid pigment
tail-to-tail configuration to give the 40-carbon phytoene, the first committed step in carotenoid biosynthesis. Through several desaturation steps, phytoene
Lycopene
Class of enzymes
3-α(S)-strictosidine Since the condensation of tryptamine and secologanin is the first committed step in alkaloid synthesis, strictosidine synthase plays a fundamental role
Strictosidine_synthase
Carboxylic acid
carboxylated by acetyl-CoA carboxylase into malonyl-CoA, the first committed step in the synthesis of fatty acids. Malonyl-CoA is then involved in a repeating
Fatty_acid
gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides". J. Biol. Chem. 286 (9):
Delta6-protoilludene_synthase
Enzyme
which is also the committed step in the formation of creatine. L-arginine + glycine ornithine + glycocyamine The second step of the process
Arginine:glycine amidinotransferase
Arginine:glycine_amidinotransferase
Class of enzymes
squalene, with the consumption of NADPH. Catalysis by SQS is the first committed step in sterol synthesis, since the squalene produced is converted exclusively
Farnesyl-diphosphate farnesyltransferase
Farnesyl-diphosphate_farnesyltransferase
Protein family
molecules of farnesyl diphosphate (FPP) into squalene. It is the first committed step in the cholesterol biosynthetic pathway. The reaction carried out by
Squalene/phytoene synthase family
Squalene/phytoene_synthase_family
Biological molecules constituting nucleic acids
glycine (N&C), aspartate (N), folic acid (C1), or CO2. This is the committed step in purine synthesis. The reaction occurs with the inversion of configuration
Nucleotide
ring opening of guanosine triphosphate (GTP). This reaction is the committed step in the biosynthesis of multiple coenzymes (such as riboflavin and folate)
GTP_cyclohydrolase
Chemical compound
characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis". Plant Journal. 40 (2):
4-Hydroxyphenylacetaldehyde
Chemical compound
biosynthesis of carotenoids. The synthesis of phytoene is the first committed step in the synthesis of carotenoids in plants. Phytoene is produced from
Phytoene
Set of biological processes
carboxylated by acetyl-CoA carboxylase into malonyl-CoA, the first committed step in the synthesis of fatty acids. Acetyl-CoA is formed into malonyl-CoA
Fatty_acid_metabolism
United States federal statute
powder cocaine convictions—retroactively. Under the First Step Act, prisoners who committed offenses "covered" by the Fair Sentencing Act are permitted
First_Step_Act
Metabolic enzyme PHGDH
transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the committed step in the phosphorylated pathway of L-serine biosynthesis. It is also essential
Phosphoglycerate dehydrogenase
Phosphoglycerate_dehydrogenase
Class of enzymes
bifunctional enzyme with GTP cyclohydrolase II that catalyses the first committed step in the biosynthesis of riboflavin. No sequences with significant homology
3,4-dihydroxy-2-butanone-4-phosphate synthase
3,4-dihydroxy-2-butanone-4-phosphate_synthase
"Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew". J. Biol. Chem. 270 (15): 8686–90
Taxadiene_synthase
Class of chemical compounds
a phosphocholine from phosphatidylcholine to a ceramide. The first committed step of sphingomyelin synthesis involves the condensation of L-serine and
Sphingomyelin
Process of fatty acid breakdown
mitochondria in eukaryotes to generate acetyl-CoA. The acetyl-CoA product of this step of fatty acid metabolism enters the citric acid cycle, generating NADH and
Beta_oxidation
Konig WA, Bouwmeester HJ (1998). "(+)-Germacrene A Biosynthesis : The Committed Step in the Biosynthesis of Bitter Sesquiterpene Lactones in Chicory". Plant
Germacrene-A_synthase
RNA family
carbamoyl phosphate synthase, which is an enzyme that catalyzes the first committed step in pyrimidine and arginine biosynthesis. CarA ncRNA has been found in
CarA_ncRNA_motif
Class of chemical compounds
G, Breitel D, Grossman N, et al. (2016). "Elucidation of the first committed step in betalain biosynthesis enables the heterologous engineering of betalain
Betalain
Class of enzymes
second ATP to give carbamoyl phosphate plus ADP. It represents the first committed step in pyrimidine and arginine biosynthesis in prokaryotes and eukaryotes
Carbamoyl phosphate synthetase
Carbamoyl_phosphate_synthetase
Protein-coding gene in the species Homo sapiens
coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject
PANK2
Global conflict (1939–1945)
mass rape. Soviet soldiers also committed mass rapes in occupied territories, especially Germany. War crimes were committed by the Western Allied powers
World_War_II
Series of interconnected biochemical reactions
carboxylated by acetyl-CoA carboxylase into malonyl CoA, the first committed step in the synthesis of fatty acids, or it can be combined with acetoacetyl-CoA
Glycolysis
American actor (born 1982)
Awards for Shadowhunters. Shum has appeared in the films Step Up 2: The Streets (2008), Step Up 3D (2010), White Frog (2012), Revenge of the Green Dragons
Harry_Shum_Jr.
Chemical compound
Sarrion-Perdigones A, Weithorn E, Pliner M, et al. (2016). "Elucidation of the first committed step in betalain biosynthesis enables the heterologous engineering of betalain
L-DOPA
Species of virus
peptidoglycan by binding to MurA, which catalyzes the first enzymatically committed step in cell wall biosynthesis. RNA from Bacteriophage Qβ was used by Sol
Bacteriophage_Qbeta
Chemical reaction
product. All steps of the Henry reaction are reversible. The lack of a committed step in the reaction is a practical problem, with low yields common because
Henry_reaction
Type of plant tissue culture
Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway". Journal of Biotechnology. 176:
Hairy_root_culture
Large biological molecule that acts as a catalyst
first enzymes of the pathway (usually the first irreversible step, called committed step), thus regulating the amount of end product made by the pathways
Enzyme
delay learning to drive. Ty talks to Cassandra, she realizes she wants a committed relationship with Caleb. Georgie decides to face her fears and has Tim
List_of_Heartland_episodes
Chemical compound
carboxylation by acetyl-CoA carboxylase into malonyl CoA, the first committed step in the synthesis of fatty acids. This conversion occurs primarily in
Acetyl-CoA
Protein-coding gene in the species Homo sapiens
encodes a 1-phosphatidylinositol 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian
PI4KA
Class of enzymes
Glyceollin synthase is an enzyme that catalyzes the last committed step in glyceollin biosynthesis. It has been classified as a cytochrome dependent monooxygenase
Glyceollin_synthase
Rare autosomal recessive human diseases
transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the committed step in the phosphorylated pathway of L-serine biosynthesis. It is also essential
D-glycerate dehydrogenase deficiency
D-glycerate_dehydrogenase_deficiency
Token used in addiction programs
5 in) in diameter. In other twelve-step programs it is to mark time abstaining from whatever the recipient has committed to renounce. There is no official
Sobriety_coin
Class of enzymes
Irino F, Yoneyama N, Fujimura T, Ashihara H (July 2003). "The first committed step reaction of caffeine biosynthesis: 7-methylxanthosine synthase is closely
7-methylxanthosine_synthase
humanity and the crime of genocide, which Israeli security forces have committed or been accused of committing since the founding of Israel in 1948. These
Israeli_war_crimes
Enzyme
It is a zinc-dependent metalloamidase that catalyses the second and committed step in the biosynthesis of lipid A. Lipid A anchors lipopolysaccharide (the
UDP-3-O-N-acetylglucosamine deacetylase
UDP-3-O-N-acetylglucosamine_deacetylase
4-dideoxy-d-arabino-heptulosonic acid 7-phosphate has been proposed to be the first committed step in the aminoshikimate pathway. Guo and Frost demonstrated that the unusual
Aminoshikimate_pathway
Set of biochemical processes
AK-III catalyzes the phosphorylation of aspartic acid that is the committed step in this biosynthetic pathway. Aspartate kinase becomes downregulated
Amino_acid_synthesis
Protein-coding gene in the species Homo sapiens
coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject
PANK4
American anthology series (1959–1961)
Alcoa Presents: One Step Beyond (also known as One Step Beyond) is an American anthology series created by Merwin Gerard. The original series was broadcast
Alcoa Presents One Step Beyond
Alcoa_Presents_One_Step_Beyond
Protein-coding gene in the species Homo sapiens
coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject
PANK1
salvage — AIR synthetase is a component of the de novo pathway. The first committed step of the de novo pathway begins with phosphoribosyl pyrophosphate (PRPP)
AIR_synthetase_(FGAM_cyclase)
of other substituted cinnamoyl-CoA's as well. Catalyzing the first committed step in monolignol biosynthesis, this enzyme plays a critical role in lignin
Cinnamoyl-CoA_reductase
Class of enzymes
via an increased rate of messenger RNA degradation. CHS, as the first committed step in the flavonoid pathway, facilitate production of flavanoids, isoflavonoid-type
Chalcone_synthase
Chemical compound
Bouwmeester HJ (August 1998). "(+)-Germacrene A Biosynthesis : The Committed Step in the Biosynthesis of Bitter Sesquiterpene Lactones in Chicory". Plant
Absinthin
Parent of one's parents
25% genetic overlap. A step-grandparent can be the step-parent of the parent or the step-parent's parent or the step-parent's step-parent (though technically
Grandparent
Class of enzyme
barrel topology. The conversion of chorismate to prephenate is the first committed step in the pathway to the production of the aromatic amino acids: tyrosine
Chorismate_mutase
Chemical compound
4′-phosphopantothenate by the enzyme pantothenate kinase. This is the committed step in CoA biosynthesis and requires ATP. A cysteine is added to 4′-phosphopantothenate
Pantothenic_acid
Protein family
2015). "The bacterial signal transduction protein GlnB regulates the committed step in fatty acid biosynthesis by acting as a dissociable regulatory subunit
Pii nitrogen regulatory proteins
Pii_nitrogen_regulatory_proteins
synthetase) apart from the promoter and operator region. The first committed step of purine biosynthesis starts from 5-phosphoribosyl 1 pyrophosphate
Gua_Operon
Email service provided by Google
Gmail supports two-step verification, an optional additional measure for users to protect their accounts when logging in. Once 2-Step Verification (2SV)
Gmail
Businessman and public official (born 1971)
presidential election. Musk also promised to step down as CEO after a Twitter poll, and five months later, Musk stepped down as CEO and transitioned his role
Elon_Musk
Recessive genetic condition
two FPP leads to the formation of squalene; this represents the first committed step towards cholesterol biosynthesis. Squalene leads to the creation of
Smith–Lemli–Opitz_syndrome
Country in West Africa
October 2023.[citation needed] In Africa, Ivorian diplomacy favours step-by-step economic and political cooperation. In 1959, Ivory Coast formed the Council
Ivory_Coast
Enzyme
and CTP. CTP (cytidine triphosphate) synthetase catalyzes the last committed step in pyrimidine nucleotide biosynthesis: ATP + UTP + glutamine → ADP +
CTP_synthetase
Chemical compound
treatment of primary hyperoxaluria. By inhibiting the final and only committed step in hepatic oxalate synthesis, CHK-336 could in principle treat all forms
CHK-336
Family of transferases enzymes
2014). "Structure and Mechanism of Soybean ATP Sulfurylase and the Committed Step in Plant Sulfur Assimilation". Journal of Biological Chemistry. 289
Sulfate_adenylyltransferase
American businessman (born 1964)
committed to doing our part and filling this capital need by coming together in a new coalition. We will form a network of private capital committed to
Jeff_Bezos
Prime Minister of Israel (1996–1999; 2009–2021; 2022–present)
step in the right direction. The acceptance of a Palestinian state was present there". Obama's press secretary said the speech was an "important step
Benjamin_Netanyahu
Enzyme
and UDP-galactose 4′-epimerase. Galactokinase catalyzes the first committed step of galactose catabolism, forming galactose 1-phosphate. Galactosemia
Galactokinase
Italian basketball player (born 2007)
James Harden as his idol, particularly regarding his perimeter play and step-back shooting technique. Suigo played for the youth teams of Pallacanestro
Luigi_Suigo
International governing body of association football
2022 vote if corruption could be proved, but urged taking the matter "step by step". The FIFA president said his organisation is "anxiously awaiting" more
FIFA
catalyzed by ent-copalyl diphosphate synthase can be seen as the first committed step in gibberellin biosynthesis. Gibberellins form an important group of
Ent-Copalyl diphosphate synthase
Ent-Copalyl_diphosphate_synthase
Japanese samurai class woman
and once again attacked Osaka Castle. Yodo-dono and her son, Hideyori, committed suicide as Osaka Castle burned, ending the Toyotomi legacy. No eyewitness
Yodo-dono
Enzyme
decarboxylation of a C4 molecule, creating a C3 molecule. As the first committed step in gluconeogenesis, PEPCK decarboxylates and phosphorylates oxaloacetate
Phosphoenolpyruvate carboxykinase
Phosphoenolpyruvate_carboxykinase
Biochemical process in which fatty acids are derived from acetyl-CoA and NADPH
carboxylated by acetyl-CoA carboxylase into malonyl-CoA, the first committed step in the synthesis of fatty acids. The main fuel stored in the bodies
Fatty_acid_synthesis
Prime Minister of the United Kingdom since 2024
as we have so often in our past, the challenges of an insecure world. Committed to a calm and patient rebuilding. So with respect and humility, I invite
Keir_Starmer
Legality of sexual relationships between family members
and their natural or adoptive child, a step-parent and their step-child, whether the step-child's parent and step-parent are married under the Marriage
Legality_of_incest
Approach to finding numerical solutions of ordinary differential equations
truncation error is the cumulative effect of the local truncation errors committed in each step. The number of steps is easily determined to be t i − t 0 h {\textstyle
Euler_method
Protein-coding gene in the species Homo sapiens
expression of the human GlcNAc-1-P transferase, the enzyme for the committed step of the dolichol cycle, by heterologous complementation in Saccharomyces
DPAGT1
American rapper and singer-songwriter (1998–2018)
Onfroy was a child, he discovered his uncle's deceased body after the man committed suicide by hanging. He referenced his trauma from the incident in multiple
XXXTentacion
American-Canadian comedian and actor
up and are the oldest of five children, with two full siblings, and two step siblings. Michaelis attended the University of Toronto Scarborough for two
Vic_Michaelis
American artificial intelligence company
Jan; Schulman, John; Sutskever, Ilya; Cobbe, Karl (2023). "Let's Verify Step by Step". arXiv:2305.20050 [cs.LG]. Tong, Anna; Dastin, Jeffrey; Hu, Krystal
OpenAI
Chemical reactions and pathways
capsulatus. Anaerobic pathway in which cobalt insertion is the first committed step towards cobalamin synthesis; found in Salmonella typhimurium, Bacillus
Cobalamin_biosynthesis
American serial killer (1946–1989)
murder charges in Colorado, Bundy engineered two dramatic escapes and committed further assaults in Florida, including three murders, before being recaptured
Ted_Bundy
American skateboarder and stuntman (born 1979)
leading to friends and family members coming together to have Margera committed to a mental health treatment facility. Margera was released from treatment
Bam_Margera
English serial killer (1941–1995)
1 January 1995) was an English serial killer and child molester, who committed at least twelve murders between 1967 and 1987 in Gloucestershire, England—the
Fred_West
COMMITTED STEP
COMMITTED STEP
Surname or Lastname
English
English : patronymic from the personal name Stephen (see Steven).
Female
English
Celtic legend name of a tragic heroine who committed suicide after the murder of her lover. She is sometimes referred to as Deirdre of the Sorrows. The name is of uncertain derivation. Some sources give the DEIRDRE means "young girl."
Boy/Male
Shakespearean American Greek English Biblical
King Richard The Second' Sir Stephen Scroop.
Male
Greek
(ΚαπανεÏÏ‚) Greek name KAPANEUS means "arrogant." In mythology, this is the name of one of the Seven Against Thebes. He is said to have had a body of immense size and strength, but he was notoriously arrogant and was eventually struck and killed by a thunderbolt sent by Zeus. His wife Euadne committed suicide by throwing herself on his funeral pyre.Â
Female
Greek
(Ἀκελδαμά) Greek form of Aramaic ħqêl dmâ, AKELDAMA means "field of blood." In the bible, this is the name of the place where Judas Iscariot committed suicide.Â
Girl/Female
Hebrew
Wild goat. In the Old Testament, Jael committed murder by driving a tent peg through a male...
Female
English
Modern variant spelling of English Stephanie, STEPHANI means "crown."
Female
English
Feminine form of Latin Stephanus, STEPHANIA means "crown."Â
Boy/Male
Greek English
Crown; wreath. In the bible Stephen was the first Christian martyr. Surname.
Female
English
Modern variant spelling of English Stephanie, STEPHANY means "crown."
Boy/Male
German, Greek, Russian
Crowned with Laurels; Form of Stephen; Crowned
Surname or Lastname
English
English : variant spelling of Stephens.Reduced form of German Stephanhans, from a compound of the personal names Stephan (see Steven) + Hans.
Male
German
German form of Latin Stephanus, STEPHAN means "crown."
Female
English
Feminine form of English Stephen, STEPHENIE means "crown."Â
Male
Greek
(ΣτÎφανος) Greek name derived from the word stephanos, STEPHANOS means "crown." In the bible, this is the name of one of the seven deacons of the church at Jerusalem who was stoned to death by the Jews.Â
Surname or Lastname
English
English : nickname from Middle English step ‘step’ + toe ‘toe’, perhaps for someone who treads lightly.
Surname or Lastname
English (mainly Sussex)
English (mainly Sussex) : habitational name from Stepney in London, named probably with an unattested Old English personal name, Stybba (genitive Stybban) + h̄þ ‘hythe’, ‘landing place’.
Boy/Male
English American Greek
Crown; wreath. From biblical Stephen, the first Christian martyr.
Girl/Female
French Latin
From the Latin Lucretia. Famous bearer: Lucrece, a Roman matron who committed suicide as a public...
Female
English
Feminine form of English Stephen, STEPHANIE means "crown."Â
COMMITTED STEP
COMMITTED STEP
Boy/Male
Indian, Sanskrit
Possessing High Intelligence
Biblical
the Lord dwells; deer; goat
Girl/Female
English
Gives pleasure.
Male
Egyptian
, a priest of Amen Ra.
Boy/Male
Arabic, Muslim, Sindhi
Superior; Guardian; Patron
Male
Japanese
(å¤§ç• ) Japanese name, possibly AKIHIRO means "large glory."Â
Boy/Male
Hindu
Lord Ganesh
Male
Yiddish
(×–Ö´×™× Ö°×“Ö¶×¢×œ) Yiddish name ZINDEL means "son, sonny."
Surname or Lastname
English (chiefly Lancashire and Yorkshire)
English (chiefly Lancashire and Yorkshire) : habitational name from a place in Lancashire named Clegg, from Old Norse kleggi ‘haystack’, originally the name of a nearby hill.Manx : variant of Clague.
Boy/Male
Tamil
Wise, Ruler
COMMITTED STEP
COMMITTED STEP
COMMITTED STEP
COMMITTED STEP
COMMITTED STEP
n.
An under committee; a part or division of a committee.
imp. & p. p.
of Comment
imp. & p. p.
of Commit
n.
One to whom the keeping of sequestered property is committed.
a.
Capable of being committed; liable to be committed.
n.
One who commits; one who does or perpetrates.
a.
A person who has committed a felony.
a.
Capable of being omitted; that may be omitted.
imp. & p. p.
of Immit
imp. & p. p.
of Commix
v. t.
One to whom the charge of the person or estate of another, as of a lunatic, is committed by suitable authority; a guardian.
imp. & p. p.
of Comminute
n.
A member of a committee.
imp. & p. p.
of Commute
a.
Delivered; committed in trust.
a.
Capable of being committed.
n.
The act of committing, or the state of being committed; commitment.
n.
A fornicator.
n.
One or more persons elected or appointed, to whom any matter or business is referred, either by a legislative body, or by a court, or by any collective body of men acting together.