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DDX41

  • DDX41
  • Protein-coding gene in the species Homo sapiens

    Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans is encoded by the DDX41 gene. DEAD box proteins, characterized by the conserved

    DDX41

    DDX41

    DDX41

  • Myelodysplastic syndrome
  • Diverse collection of blood-related cancers

    neoplasms with germ line predisposition and organ dysfunction includes CEBPA/DDX41/RUNX1 disorders, GATA2 deficiency and SAMD9/9L syndromes. The goals of therapy

    Myelodysplastic syndrome

    Myelodysplastic syndrome

    Myelodysplastic_syndrome

  • Tumors of the hematopoietic and lymphoid tissues
  • Tumors that affect the blood, bone marrow, lymph, and lymphatic system

    leukaemia with germline CEBPA mutation Myeloid neoplasms with germline DDX41 mutation Myeloid neoplasms with germline RUNX1 mutation Myeloid neoplasms

    Tumors of the hematopoietic and lymphoid tissues

    Tumors of the hematopoietic and lymphoid tissues

    Tumors_of_the_hematopoietic_and_lymphoid_tissues

  • P-bodies
  • Biomolecular condensates of mRNA and RNA binding proteins found in eukaryotic cells

    No APOBEC3F ABC3F No NOP58 NOP58 Yes RPF2 RPF2 No S100A9 S100A9 Yes DDX41 DDX41 No KIF23 KIF23 Yes AZGP1 ZA2G No DDX50 DDX50 Yes SERPINB3 SPB3 No SBSN

    P-bodies

    P-bodies

  • Stimulator of interferon genes
  • Protein-coding gene in the species Homo sapiens

    infected cells. Several DNA sensors, such as DAI, RNA polymerase III, IFI16, DDX41 and cGAS, can detect foreign nucleic acids. After recognizing viral DNA

    Stimulator of interferon genes

    Stimulator of interferon genes

    Stimulator_of_interferon_genes

  • List of human protein-coding genes 2
  • Q9H8H2 4090 DDX39A HGNC:17821; O00148 4091 DDX39B HGNC:13917; Q13838 4092 DDX41 HGNC:18674; Q9UJV9 4093 DDX42 HGNC:18676; Q86XP3 4094 DDX43 HGNC:18677;

    List of human protein-coding genes 2

    List_of_human_protein-coding_genes_2

  • Clonal hematopoiesis
  • Expansion of blood cells

    myeloid malignancy, particularly when there are germ line mutations in CEBPA, DDX41, GATA2, RUNX1, or SAMD9/9L. Examples include ribosomopathies such as Schwachman–Diamond

    Clonal hematopoiesis

    Clonal_hematopoiesis

  • PITRM1
  • Protein-coding gene in humans

    PITRM1 has been shown to interact with the following proteins: CCL22, CGB2, DDX41, DEFB104A, HDHD3, MRPL12, NDUFV2, PRDX6, PRKCSH, RARS2, RIF1, SUCLG2, TEKT3

    PITRM1

    PITRM1

    PITRM1

  • Age of onset
  • Age at which one acquires a disease or disorder

    ; Schreiber, A. W.; Feng, J.; Babic, M. (2015-12-28). "Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid

    Age of onset

    Age_of_onset

  • Cyclic di-AMP
  • Chemical compound

    genes) to detect damaged DNA. The nucleotide either binds to the helicase DDX41, which in turn activates the STING pathway, or directly binds to the STING

    Cyclic di-AMP

    Cyclic di-AMP

    Cyclic_di-AMP

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