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Protein-coding gene in the species Homo sapiens
Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans is encoded by the DDX41 gene. DEAD box proteins, characterized by the conserved
DDX41
Diverse collection of blood-related cancers
neoplasms with germ line predisposition and organ dysfunction includes CEBPA/DDX41/RUNX1 disorders, GATA2 deficiency and SAMD9/9L syndromes. The goals of therapy
Myelodysplastic_syndrome
Tumors that affect the blood, bone marrow, lymph, and lymphatic system
leukaemia with germline CEBPA mutation Myeloid neoplasms with germline DDX41 mutation Myeloid neoplasms with germline RUNX1 mutation Myeloid neoplasms
Tumors of the hematopoietic and lymphoid tissues
Tumors_of_the_hematopoietic_and_lymphoid_tissues
Biomolecular condensates of mRNA and RNA binding proteins found in eukaryotic cells
No APOBEC3F ABC3F No NOP58 NOP58 Yes RPF2 RPF2 No S100A9 S100A9 Yes DDX41 DDX41 No KIF23 KIF23 Yes AZGP1 ZA2G No DDX50 DDX50 Yes SERPINB3 SPB3 No SBSN
P-bodies
Protein-coding gene in the species Homo sapiens
infected cells. Several DNA sensors, such as DAI, RNA polymerase III, IFI16, DDX41 and cGAS, can detect foreign nucleic acids. After recognizing viral DNA
Stimulator of interferon genes
Stimulator_of_interferon_genes
Q9H8H2 4090 DDX39A HGNC:17821; O00148 4091 DDX39B HGNC:13917; Q13838 4092 DDX41 HGNC:18674; Q9UJV9 4093 DDX42 HGNC:18676; Q86XP3 4094 DDX43 HGNC:18677;
List of human protein-coding genes 2
List_of_human_protein-coding_genes_2
Expansion of blood cells
myeloid malignancy, particularly when there are germ line mutations in CEBPA, DDX41, GATA2, RUNX1, or SAMD9/9L. Examples include ribosomopathies such as Schwachman–Diamond
Clonal_hematopoiesis
Protein-coding gene in humans
PITRM1 has been shown to interact with the following proteins: CCL22, CGB2, DDX41, DEFB104A, HDHD3, MRPL12, NDUFV2, PRDX6, PRKCSH, RARS2, RIF1, SUCLG2, TEKT3
PITRM1
Age at which one acquires a disease or disorder
; Schreiber, A. W.; Feng, J.; Babic, M. (2015-12-28). "Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid
Age_of_onset
Chemical compound
genes) to detect damaged DNA. The nucleotide either binds to the helicase DDX41, which in turn activates the STING pathway, or directly binds to the STING
Cyclic_di-AMP
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