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Medical condition
Digoxin toxicity, also known as digoxin poisoning, is a type of poisoning that occurs in people who take too much of the medication digoxin or eat plants
Digoxin_toxicity
Plant-derived medication
digoxin toxicity. Digoxin can lead to cardiac arrhythmias when given with thiazides and loop diuretics. This is because co-administration of digoxin with
Digoxin
Pharmaceutical drug
for digoxin toxicity. Digoxin toxicity can emerge during long-term therapy as well as after an overdose. It can occur even when the serum digoxin concentration
Digoxin_immune_fab
Pesticide classification system
nematicides, or rodenticides. Assignment to a toxicity class is based typically on results of acute toxicity studies such as the determination of LD50 values
Toxicity_class
Excess potassium in the blood
achieved clinically. In confirmed digoxin toxicity, current guidance recommends treating hyperkalemia primarily with digoxin-specific antibody fragments (Fab)
Hyperkalemia
Medical condition (poisoning)
Methanol toxicity (also methanol poisoning) is poisoning from methanol, characteristically via ingestion. Symptoms may include an altered/decreased level
Methanol_toxicity
Medical condition
severe toxicity hemodialysis is recommended. The risk of death is generally low. Acute toxicity generally has better outcomes than chronic toxicity. In the
Lithium_toxicity
Toxic effects of breathing oxygen at high partial pressures
system toxicity is caused by short exposure to high partial pressures of oxygen at greater than atmospheric pressure. Pulmonary and ocular toxicity result
Oxygen_toxicity
Type of metal poisoning
copper level in the blood) can lead to copper toxicity if it persists and rises high enough. Chronic toxicity by copper is rare. The suggested safe level
Copper_toxicity
Medical condition
severe outcomes. Older people are at higher risks of toxicity for any given dose. Salicylate toxicity has potentially serious consequences, sometimes leading
Salicylate_poisoning
Broad-spectrum poisoning
After the fire, the technical institution INTI found that the level of toxicity due to the materials and volume of the building was 225 ppm of cyanide
Cyanide_poisoning
Genus of flowering plants
commonly used. Mild toxicity is treated by stopping the medication and general supportive measures; severe toxicity is treated with anti-digoxin antibody fragments
Digitalis
Abnormal heart rhythm originating from an atrial location
triggered rapid rhythm due to other pathological circumstances, i.e. digoxin toxicity or Adverse drug reaction. Signs and symptoms of atrial tachycardia
Atrial_tachycardia
Class of organic compounds
example, in 2008 US poison centers reported 2,632 cases of digoxin toxicity, and 17 cases of digoxin-related deaths. Because cardiac glycosides affect the
Cardiac_glycoside
Harmful effects of certain metals
Metal toxicity or metal poisoning is toxicity affecting plants, animals, or humans due to excessive concentration of metals. At low concentrations, metals
Metal_toxicity
Symptoms caused by an excess of serotonin in the central nervous system
features of NMS differ significantly from those of serotonin toxicity. Serotonin toxicity has a rapid onset after the administration of a serotonergic
Serotonin_syndrome
Species of plant commonly known as oleander
Therefore, clinical features of oleander poisoning are similar to digoxin toxicity and include nausea, diarrhoea, and vomiting due to stimulation of the
Nerium
Toxicity from too much ethylene glycol
failure and brain damage. Toxicity and death may occur after drinking even a small amount as ethylene glycol is more toxic than other diols. Ethylene
Ethylene_glycol_poisoning
Medical condition
Toluene toxicity refers to the harmful effects caused by toluene on the body. While a significant amount of toluene, 25%–40%, is exhaled unchanged via
Toluene_toxicity
Toxicity due to paracetamol overdose
death from toxicity occurs 4 to 18 days later. Paracetamol poisoning can occur accidentally or as a suicide attempt. Risk factors for toxicity include alcoholism
Paracetamol_poisoning
Human disease
vitamin D and thus to vitamin toxicity without high oral intake (see Vitamin D § Excess). Symptoms of vitamin D toxicity may include the following: Dehydration
Vitamin_D_toxicity
Dose dependant harmfulness of substances
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on
Toxicity
Medical condition
cases of calcium channel blocker toxicity were reported in the United States in 2010. Along with beta blockers and digoxin, calcium channel blockers have
Calcium channel blocker toxicity
Calcium_channel_blocker_toxicity
Type of metal poisoning
poisoning typically occurs from ingestion of excess iron that results in acute toxicity. Mild symptoms which occur within hours include vomiting, diarrhea, abdominal
Iron_poisoning
side effects of digoxin and digoxin toxicity. Often lowering the dose is considered by the prescriber. The side effects related to toxicity are used to assess
List of side effects of digoxin
List_of_side_effects_of_digoxin
Condition in which there are elevated levels of the fluoride ion in the body
Fluoride toxicity is a condition in which there are elevated levels of the fluoride ion in the body. Although fluoride is safe for dental health at low
Fluoride_toxicity
Medical condition
Chromium toxicity refers to any poisonous toxic effect in an organism or cell that results from exposure to specific forms of chromium—especially hexavalent
Chromium_toxicity
Medical condition
Zinc toxicity is a medical condition involving an overdose on, or toxic overexposure to, zinc. Such toxicity levels have been seen to occur at ingestion
Zinc_toxicity
Toxic effects of thallium
Toxicity at eMedicine "Biology of Thallium". Web Elements. Retrieved 11 November 2008. Kemnic, Tyler R.; Coleman, Meghan (2022), "Thallium Toxicity"
Thallium_poisoning
Medical condition
other conditions, such as bidirectional ventricular tachycardia from digoxin toxicity and atrioventricular tachycardia. The echocardiogram of the heart demonstrated
Electrical_alternans
Medical condition
sinus node damage. In cases of digoxin toxicity, a physician may decrease the dose, change medications, or cease digoxin therapy. Kashou, Anthony H.; Basit
Wandering_atrial_pacemaker
Medical condition
role for physostigmine in the treatment of tricyclic toxicity as it may increase cardiac toxicity and cause seizures. In cases of severe TCA overdose that
Tricyclic antidepressant overdose
Tricyclic_antidepressant_overdose
Toxic effects of ingesting too much vitamin A
several toxic effects regarding the redox environment and mitochondrial function. Assessing vitamin A status in persons with sub-toxicity or toxicity is complicated
Hypervitaminosis_A
Antiarrhythmic medication
concurrent use of these medications increases digoxin levels in the body, potentially leading to digoxin toxicity); statins (amiodarone can inhibit enzymes
Amiodarone
Constipation and surgery medication
glycosides can increase digoxin toxicity in patients taking digoxin by reducing serum potassium levels, thereby enhancing the effects of digoxin. Sennosides increase
Senna_glycoside
Medical condition
January 2017). Tarabar, A; VanDeVoort, JT; Burns, MJ (eds.). "Barbiturate Toxicity: Pathophysiology". eMedicine. New York, USA: WebMD. Archived from the original
Barbiturate_overdose
Medical condition
"The Bioinorganic Chemistry of Cadmium in the Context of Its Toxicity". Cadmium: From Toxicity to Essentiality. Metal Ions in Life Sciences. Vol. 11. pp
Cadmium_poisoning
Historical line of inquiry
form of digoxin toxicity from the foxglove plants used to treat his epilepsy. His yellow period ("yellow vision"), missing ear ("oto-toxicity") and penchant
Health_of_Vincent_van_Gogh
Shannon D. Langford & Paul J. Boor (1996). "Oleander toxicity: an examination of human and animal toxic exposures". Toxicology. 109 (1): 1–13. Bibcode:1996Toxgy
List_of_poisonous_plants
Illness from ingesting arsenic
people of low income and minorities. Acute poisoning is uncommon. The toxicity of arsenic has been described as far back as 1500 BC in the Ebers papyrus
Arsenic_poisoning
Medical condition
Kulig K, Rumack BH (January 1988). "Cigarette and nicotine chewing gum toxicity in children". Human Toxicology. 7 (1): 27–31. doi:10.1177/096032718800700105
Nicotine_poisoning
SLC30A10. Manganese may affect liver function, but the threshold of acute toxicity is very high. On the other hand, more than 95 percent of manganese is eliminated
Manganese_poisoning
Examination of the heart's electrical activity
arrhythmias Medication monitoring (e.g., drug-induced QT prolongation, digoxin toxicity) and management of overdose (e.g., tricyclic overdose) Electrolyte
Electrocardiography
Harmful effects from ingestion of toxic substances present in a mushroom
mushrooms contain a variety of different toxins that can differ markedly in toxicity. Symptoms of mushroom poisoning may vary from gastric upset to organ failure
Mushroom_poisoning
Poisoning caused by mercury chemicals
systemic toxicity from accidental swallowing are rare, and attempted suicide via intravenous injection does not appear to result in systemic toxicity, though
Mercury_poisoning
Medical condition
of working with silver or silver compounds. While silver is potentially toxic to humans at high doses, the risk of serious harm from low doses, given
Argyria
Academic area of substances harmful to living organisms
substance causes cancer and to examine other forms of toxicity. Factors that influence chemical toxicity: Dosage Both large single exposures (acute) and continuous
Toxicology
Toxic effect of pesticides
to the toxicity of pesticides, like chlorpyrifos. Animal experiments indicate that while PON1 plays a significant role in regulating the toxicity of OPs
Organophosphate_poisoning
Chemical compound
specific treatment for digoxin poisoning, are also effective in serious digitoxin toxicity. Drugs that can increase digitoxin toxicity include: calcium substances
Digitoxin
Medical condition resulting from overconsumption of bromine (Br)
neurons, which progressively impairs neuronal transmission, leading to toxicity, known as bromism. Bromide has an elimination half-life of 9 to 12 days
Bromism
Toxic effects of carbon monoxide
Bernard between 1846 and 1857. Carbon monoxide is not toxic to all forms of life, and the toxicity is a classical dose-dependent example of hormesis. Small
Carbon_monoxide_poisoning
Species of toxic flowering plant
many cultivars available. It is the original source of the heart medicine digoxin (also called digitalis or digitalin). This biennial plant grows as a rosette
Digitalis_purpurea
Plant chemical
associated with the toxicity of oleander sap, and has similar properties to digoxin. Oleandrin and other oleander chemicals are potentially toxic to the heart
Oleandrin
Toxicology adage
all chemicals—even water and oxygen—can be toxic if too much is eaten, drunk, or absorbed. "The toxicity of any particular chemical depends on many factors
The_dose_makes_the_poison
Medical condition
Hypervitaminosis A Hypervitaminosis D Vitamin B3 § Toxicity Megavitamin-B6 syndrome Vitamin E toxicity Prevention in healthy individuals not having any
Hypervitaminosis
Syndrome marked by sensory neuropathy induced by excess vitamin B6
vitamin B6. While it is also known as hypervitaminosis B6, vitamin B6 toxicity and vitamin B6 excess, megavitamin-b6 syndrome is the name used in the
Megavitamin-B6_syndrome
Anti-seizure medication
antiarrhythmic. Digoxin toxicity: Intravenous phenytoin formulation is a medication of choice for arrhythmias caused by cardiac glycoside toxicity. Trigeminal
Phenytoin
Medical condition
organisms. It is not easily absorbed by animals including humans. The low toxicity is relevant to the widespread use of tin in dinnerware and canned food
Tin_poisoning
Skipped human heartbeat with ventricular origin
These are often seen in patients with ventricular arrhythmias due to digoxin toxicity and reperfusion therapy after myocardial infarction (MI). This ectopy
Premature ventricular contraction
Premature_ventricular_contraction
Substance that causes death, injury or harm to organs
any toxicity appears. Human toxicity is, however, hard to avoid with pesticides targeting mammals, such as rodenticides. The risk from toxicity is also
Poison
Medical condition
ventricular ectopic beats, QRS and QT prolongation, and findings similar to digoxin toxicity. Echocardiography assists with finding atherosclerotic stenosis and
Kounis_syndrome
Medical condition
lethal toxicity specific to plants. Indeed, 2,4-D is not a poison, but is classified as harmful. Many substances regarded as poisons are toxic only indirectly
Poisoning
Puncture wound caused by a bee's stinger
v t e Poisoning Toxicity Overdose Poison History Inorganic Metals Toxic metals Beryllium Cadmium Lead Mercury Nickel Thallium Tin Dietary minerals Chromium
Bee_sting
Medical condition
natural range of the junction. It happens in some instances such as digoxin toxicity, and usually has a rate of between 60 and 100 bpm. Junctional tachycardia
Junctional_rhythm
Medical condition
initial dose, they have a good prognosis. The sine qua non of strychnine toxicity is the "awake" seizure, in which tonic-clonic activity occurs but the patient
Strychnine_poisoning
Medical condition
phlegm, and asthma. Occupational exposures constitute the highest risk of toxicity and common domestic exposures result from the mixing of chlorine bleach
Chlorine_gas_poisoning
Bite caused by a spider
bite is not a serious concern for humans. However, it is generally the toxicity of spider venom that poses the most risk to human beings; several spiders
Spider_bite
Species of amphibian
RM, Cohen RA, Khan IA (2003). "Toad venom poisoning: resemblance to digoxin toxicity and therapeutic implications". Heart. 89 (4): 14e–14. doi:10.1136/heart
Colorado_River_toad
Species of flowering plant
Shannon D. Langford & Paul J. Boor (1996). "Oleander toxicity: an examination of human and animal toxic exposures". Toxicology. 109 (1): 1–13. Bibcode:1996Toxgy
Cascabela_thevetia
Abnormal depolarizations of cardiac myocytes
to elevated cytosolic calcium concentrations, classically seen with digoxin toxicity. The overload of the sarcoplasmic reticulum may cause spontaneous Ca2+
Afterdepolarization
Type of poisoning
test on gastric aspirate, diluted gastric content can be positive. The toxicity of aluminium phosphide is attributed to the liberation of phosphine gas
Aluminium_phosphide_poisoning
Psychedelic drug found in toads, mushrooms and plants
Cohen RA, Khan IA (April 2003). "Toad venom poisoning: resemblance to digoxin toxicity and therapeutic implications". Heart. 89 (4) e14. doi:10.1136/heart
Bufotenin
Poisoning of humans from pesticide exposure
certain organophosphates have long been known to cause a delayed-onset toxicity to nerve cells, which is often irreversible. Several studies have shown
Pesticide_poisoning
Foodborne illness that typically results from eating spoiled fish
v t e Poisoning Toxicity Overdose Poison History Inorganic Metals Toxic metals Beryllium Cadmium Lead Mercury Nickel Thallium Tin Dietary minerals Chromium
Scombroid_food_poisoning
Poisoning caused by lead in the body
lead's toxicity is its interference with a variety of enzymes because it binds to sulfhydryl groups found on many enzymes. Part of lead's toxicity results
Lead_poisoning
Effect of long-term ergot poisoning
contaminated with the fungus Claviceps purpurea was the cause of ergotism. The toxic ergoline derivatives are found in ergot-based drugs (such as methylergometrine
Ergotism
Medical condition
are taken in overdose in combination with other medications. Significant toxicity may result following recreation drug misuse in conjunction with other CNS
Benzodiazepine_overdose
Quantitative measurement of the relative safety of a drug
between efficacy and toxicity, achieving the greatest therapeutic benefit without resulting in unacceptable side-effects or toxicity. Classically, for clinical
Therapeutic_index
Illness from a Latrodectus spider bite
is an uncommon complication. Spider venoms are a complex collection of toxic agents. Unique to the widows is latrotoxin. The venom acts on nerves causing
Latrodectism
Nontoxic or minimally toxic gas which can displace oxygen in breathing air
asphyxiant gas, also known as a simple asphyxiant, is a nontoxic or minimally toxic gas which reduces or displaces the normal oxygen concentration in breathing
Asphyxiant_gas
Necrotising sore caused by some spider bites
carcinoma, neoplasia, localized vasculitis, syphilis, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema nodosum, erythema multiforme, gonococcemia
Loxoscelism
Medical condition
cumulative toxicity. Several lines of evidence have been shown to explain the mechanism of toxicity of argemone oil/alkaloid. The toxicity of sanguinarine
Epidemic_dropsy
Medical condition
response that may result from excessive vagal tone on the SA node (e.g. digoxin toxicity), a pathological slowing of the SA discharge, or a complete AV block
Junctional_escape_beat
Medical condition
breathing, anorexia, and increased fatigue. In addition to beryllium's toxicity when inhaled, when brought into contact with skin at relatively low doses
Acute_beryllium_poisoning
Species of plant
extracts have potential toxicity, with side effects occurring at certain dose levels when ingested or applied topically. Although toxicity may decrease when
Aloe_vera
Chemical compound
contraindicated in patients with AV (atrioventricular) heart block or digoxin toxicity. Bretylium should be used only in an ICU or emergency department setting
Bretylium
Medical condition
most toxic gases, the dose inhaled determines the toxicity on the respiratory tract. Occupational exposures constitute the highest risk of toxicity and
Nitrogen_dioxide_poisoning
Toxicity due to excessive consumption of opiates
An opioid overdose is toxicity due to excessive consumption of opioids, such as morphine, codeine, heroin, fentanyl, tramadol, Oxycodone, and methadone
Opioid_overdose
v t e Poisoning Toxicity Overdose Poison History Inorganic Metals Toxic metals Beryllium Cadmium Lead Mercury Nickel Thallium Tin Dietary minerals Chromium
Shellfish_poisoning
Syndrome of shellfish poisoning
ISSN 1874-3919. PMID 26316331. "Paralytic Shellfish Poisoning — Southeast Alaska, May–June 2011". www.cdc.gov. Retrieved 2022-05-12. Toxicity, Shellfish
Paralytic_shellfish_poisoning
Foodborne illness
made from mangrove buttons, purportedly high in B vitamins, to flush the toxic symptoms from the system.[citation needed] There has never been a funded
Ciguatera_fish_poisoning
Cardiac arrest deaths in China
revealed that they had isolated a significant factor common in every case: a toxic mushroom which was unintentionally gathered and consumed during wild mushroom
Yunnan_sudden_death_syndrome
Chemical compound
needed] This makes the renal function an important factor in the toxicity of digoxin and perhaps for cerberin as well. There is very little formal, modern
Cerberin
v t e Poisoning Toxicity Overdose Poison History Inorganic Metals Toxic metals Beryllium Cadmium Lead Mercury Nickel Thallium Tin Dietary minerals Chromium
List_of_types_of_poison
Neurological disease of humans, caused by eating certain legumes of the genus Lathyrus
Particularly the toxin β-cyanoalanine from seeds of V. sativa enhances the toxicity of such a mixture through its inhibition of sulfur amino acid metabolism
Neurolathyrism
Index of chemical compounds with the same name
and known to exhibit "dioxin-like" toxicity. 2,3,7,8-Tetrachlorodibenzodioxin (TCDD), the prototypical and most toxic example of the above class, often
Dioxin
Toxin secreted by an animal
that there are certain protein structures that are favored to evolve into toxic molecules. This provides more evidence of why venom has become a homoplastic
Venom
Chemical, often household, breathed in to cause intoxication
Benzene use can cause bone marrow depression. It is also a known carcinogen. Toxicity may also result from the pharmacological properties of the drug; excess
Inhalant
Species of flowering plant in the plantain family
natural sources have toxic effects, producing ventricular automaticity and vagal effects, resulting in AV nodal blocking. Acute toxicity produces nausea,
Digitalis_lanata
Species of plant
of the foxglove species in its high toxicity and medicinal use as a source for the heart-regulating drug digoxin. Its strikingly distinctive amber- to
Digitalis_obscura
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