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Temporary abstinence from addictive technologies
Dopamine fasting or dopamine detoxing is the general practice of abstaining from any impulsive and behavioral addictions in order to cope with such addictions
Dopamine_fasting
Organic chemical that functions both as a hormone and a neurotransmitter
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic
Dopamine
Game whose outcome is determined by random events
experiences correspond to significant dopamine spikes, particularly following periods of abstinence and "dopamine fasting." Governments that authorize games
Game_of_chance
Inability to feel pleasure
from listening to music. Avolition Disorders of diminished motivation Dopamine fasting Apathy Rizvi SJ, Pizzagalli DA, Sproule BA, Kennedy SH (June 2016)
Anhedonia
Compound that activates dopamine receptors
A dopamine agonist is a compound that activates dopamine D2 receptors and belong to one of two different subclasses: ergoline and non-ergoline. Examples
Dopamine_agonist
Projection neurons in the brain that synthesize and release dopamine
Dopaminergic pathways (dopamine pathways, dopaminergic projections) in the human brain are involved in both physiological and behavioral processes including
Dopaminergic_pathways
Psychological theory
(operationalizations) of the basic ego depletion effect. Akrasia Decision fatigue Dopamine fasting Emotional self-regulation Free will Replication crisis Self-control
Ego_depletion
Hormone used as a medication
Dopamine, sold under the brand name Intropin among others, is a medication most commonly used in the treatment of very low blood pressure, a slow heart
Dopamine_(medication)
Process of not using digital devices
device. Delayed gratification Digital media use and mental health Dopamine fasting Internet addiction Problematic social media use Shutdown Day Minimalist
Digital_detox
Cross-platform distraction-blocking software
ambient audio to support concentration and deep work Time management Dopamine fasting Internet addiction disorder Attention economy Deep Work Digital detox
Freedom_(application)
Class of drugs
A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI or TUI), is a type of drug that acts as
Serotonin–norepinephrine–dopamine reuptake inhibitor
Serotonin–norepinephrine–dopamine_reuptake_inhibitor
Method of chemical analysis
vivo in rats and mice as well as measurement of dopamine and serotonin concentration in fruit flies. In fast-scan cyclic voltammetry (FSCV), a small carbon
Fast-scan_cyclic_voltammetry
Chemical substance that enables neurotransmission
Common neurotransmitters include glutamate, GABA, acetylcholine, glycine, dopamine and norepinephrine. Neurotransmitters are generally synthesized in neurons
Neurotransmitter
Scientific model
The dopamine hypothesis of schizophrenia or the dopamine hypothesis of psychosis is a model that attributes the positive symptoms of schizophrenia to a
Dopamine hypothesis of schizophrenia
Dopamine_hypothesis_of_schizophrenia
Weight loss medication
component of the "fen-phen" combination. Phentermine is a norepinephrine and dopamine releasing agent (NDRA) and produces stimulant, rewarding, and appetite
Phentermine
Class of pharmaceutical drugs
(AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), are a group of antipsychotic drugs (also generally
Atypical_antipsychotic
Medical condition
related to the neurotransmitter dopamine, and common medications for both conditions among other systems, affect dopamine levels in the brain. A 2005 study
Restless_legs_syndrome
Chemical compound
(MDPV) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). MDPV acts as a stimulant and has been reported
Methylenedioxypyrovalerone
Proposed medical diagnosis related to overuse of social media
health effects of using digital media Dopamine fasting – Temporary abstinence from addictive technologies Dopamine-hit sites – Websites that simulate online
Problematic_social_media_use
Drug mixture used mainly to treat ADHD and narcolepsy
dopamine receptors typically slow timing;... Depletion of dopamine in healthy volunteers impairs timing, while amphetamine releases synaptic dopamine
Adderall
norepinephrine–dopamine reuptake inhibitor Methylphenidate [fast dissolve tablet] [Samyang Holdings Biopharmaceuticals] – norepinephrine–dopamine reuptake inhibitor
List of investigational attention deficit hyperactivity disorder drugs
List_of_investigational_attention_deficit_hyperactivity_disorder_drugs
Medical condition
block the effects of dopamine. Symptoms include high fever, confusion, rigid muscles, variable blood-pressure, sweating, and fast heart-rate. Complications
Neuroleptic malignant syndrome
Neuroleptic_malignant_syndrome
Chemical compound
catechol-O-methyltransferase on dopamine. Homovanillic acid is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain
Homovanillic_acid
Central nervous system stimulant
doses. Methylphenidate is believed to work by blocking the reuptake of dopamine and norepinephrine by neurons. It is a CNS stimulant of the phenethylamine
Methylphenidate
Central nervous system stimulant
brain, with its most pronounced effects targeting the norepinephrine and dopamine neurotransmitter systems. At therapeutic doses, amphetamine causes emotional
Amphetamine
Consuming excessive food relative to energy expenditure
instances, overeating has been linked to the use of medications known as dopamine agonists, such as pramipexole. Compulsive overeating Counterregulatory
Overeating
Dissociative hallucinogenic drug, mostly used recreationally
PCP has also been shown to inhibit dopamine reuptake, and thereby leads to increased extracellular levels of dopamine and hence increased dopaminergic neurotransmission
Phencyclidine
Cognitive process
from dopaminergic neurons at baseline conditions. Phasic dopamine include fast bursts of dopamine activity, represented by spikes in activation or inhibition
Motivational_salience
Atypical antipsychotic medication
work by blocking a number of receptors, including those for serotonin and dopamine. Quetiapine was developed in 1985 and was approved for medical use in the
Quetiapine
Central nervous system stimulant
amphetamine chemical classes and as a drug acts as a serotonin–norepinephrine–dopamine releasing agent. It is related to the other dimethylphenethylamines as
Methamphetamine
Diagnostic method
DaT Scan (DaT scan or Dopamine Transporter Scan) commonly refers to a diagnostic method, based on SPECT imaging, to investigate if there is a loss of dopaminergic
DaT_scan
CNS stimulant and isomer of amphetamine
monoamine neurotransmitters (namely the serotonin, norepinephrine and dopamine transporters) either via trace amine-associated receptor 1 (TAAR1) or in
Dextroamphetamine
Atypical antipsychotic
action at dopamine-D3 receptors that potentiates phosphorylation levels of Protein kinase A (PKA) and counteracts decreased activity at the dopamine-D1 and/or
Blonanserin
Group of neurons on the floor of the midbrain
of the dopaminergic cell bodies of the mesocorticolimbic dopamine system and other dopamine pathways; it is widely implicated in the drug and natural
Ventral_tegmental_area
Intense feelings of well-being
study from January 2019 that assessed the effect of a dopamine precursor (levodopa), dopamine antagonist (risperidone), and a placebo on reward responses
Euphoria
Short-form section of video-sharing platform
triggering dopamine surges like other addictive behaviors. The rapid and easily consumable nature of short-form videos can elicit high levels of dopamine; since
YouTube_Shorts
Tropane alkaloid and stimulant drug
administration. Pharmacologically, cocaine acts as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), producing reinforcing effects such as euphoria
Cocaine
Abnormal condition of the mind
cause. Psychosis is not well-understood at the neurological level, but dopamine (along with other neurotransmitters) is known to play an important role
Psychosis
Drug that increases alertness
concentrations of excitatory neurotransmitters, particularly norepinephrine and dopamine. Other stimulants work by binding to the receptors of excitatory neurotransmitters
Stimulant
Chemical compound
is not used therapeutically as a neuroleptic because it does not block dopamine receptors well.[citation needed] Propiomazine has been used in the treatment
Propiomazine
Endocrine disease of horses
used for insulin resistance: the oral sugar test and fasting insulin blood concentration. The fasting insulin concentration involves giving a horse a single
Pituitary pars intermedia dysfunction
Pituitary_pars_intermedia_dysfunction
Typical antipsychotic medication
use, routine monitoring including measurement of BMI, blood pressure, fasting blood sugar, and lipids, is recommended due to the risk of side effects
Haloperidol
Decreased movement due to basal ganglia dysfunction
diagnosis of Parkinsonism is made. Dopamine The main neurotransmitter thought to be involved in hypokinesia is dopamine. Essential to the basal ganglionic-thalamocortical
Hypokinesia
Dopamine agonist medication
under the brand name Parlodel among others, is an ergoline derivative and dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's
Bromocriptine
Quality related to inquisitive thinking
activation—such as the release of dopamine in investigating response to novel or exciting stimuli. The fast dopamine release observed during childhood
Curiosity
Field of study
affect dopamine and its interactions in the brain. In Parkinson's disease, a disease that decreases the amount of dopamine in the brain, the dopamine precursor
Neuropharmacology
Pharmaceutical compound
orally. The drug acts as a competitive low-affinity dopamine D2 receptor antagonist with a fast dissociation rate in vitro. It inhibits dextroamphetamine-induced
Ordopidine
Sensation experienced when one feels the physiological need to eat food
well-nourished individual can survive for weeks without food intake (see fasting), with claims ranging from three to ten weeks. Satiety is the opposite
Hunger_(physiology)
Soundtrack to the 2023 film Fast X
your brain to understand where the music is supposed to go. It's like a dopamine hit, that's different and reminds you there's something off about him."
Fast_X_(soundtrack)
Chemical compound
among others, is a type of aporphine that functions as a non-selective dopamine agonist which activates both D2-like and, to a much lesser extent, D1-like
Apomorphine
American musician
nine more albums: Blue (1999), Out of the Vein (2003), Ursa Major (2009), Dopamine (2015), We Are Drugs (2016), Thanks for Everything (cover album) (2018)
Stephan_Jenkins
Class of compounds
The monoamine neurotransmitters include serotonin, norepinephrine, and dopamine; MRAs can induce the release of one or more of these neurotransmitters
Monoamine_releasing_agent
Medication to prevent nausea and vomiting
a serotonin 5-HT3 receptor antagonist. It does not have any effect on dopamine receptors or muscarinic acetylcholine receptor and therefore does not cause
Ondansetron
Evolution and neuroscience of romantic love
anthropology, and neuroscience. Neurochemicals and hormones, such as dopamine and oxytocin, are studied along with a variety of interrelated brain systems
Biology_of_romantic_love
Any condition that is significantly different from a normal waking state
they had not been experiencing sleep deprivation. Fasting is another form of deprivation. Fasting can be deliberate, including for religious reasons
Altered state of consciousness
Altered_state_of_consciousness
Wakefulness-promoting medication
Armodafinil acts as a selective atypical dopamine reuptake inhibitor (DRI) and hence as an indirect dopamine receptor agonist. Nonetheless, other mechanisms
Armodafinil
Causes of low blood sugar in humans
due to diabetes or iatrogenic glucose administration Sepsis Prolonged fasting (e.g., due to inadequate breast milk or condition interfering with feeding)
List of causes of hypoglycemia
List_of_causes_of_hypoglycemia
CNS stimulant and isomer of amphetamine
have a fast onset of action, with a peak of effect after about 30 to 45 minutes, are large in magnitude (e.g., 700–1,500% of baseline for dopamine and 400–450%
Levoamphetamine
Field of study
increased presynaptic indicators of dopamine function, but no difference in the availability of dopamine transporters or dopamine D2/D3 receptors. Both studies
Causes_of_schizophrenia
Medication for nausea, psychosis, and anxiety
typical antipsychotic which is believed to work by reducing the action of dopamine in the brain. Prochlorperazine was approved for medical use in the United
Prochlorperazine
Drop in blood pressure when standing up or sitting down
heart or as a side effect of dopaminomimetic therapy. Another disease, dopamine beta hydroxylase deficiency, also thought to be underdiagnosed, causes
Orthostatic_hypotension
Species of flowering plant
treatment, and two studies on lab rats show T. laurifolia may stimulate dopamine production. Iridoid glucosides have been isolated from T. laurifolia. Microwave-dried
Thunbergia_laurifolia
Peripheral D2 receptor antagonist
Domperidone, sold under the brand name Motilium among others, is a dopamine antagonist medication which is used to treat nausea and vomiting and certain
Domperidone
Antipsychotic medication
is not entirely clear, but is believed to be related to its action as a dopamine and serotonin antagonist. Study of risperidone began in the late 1980s
Risperidone
and GABAergic circuits, dopamine can influence synaptic transmission and plasticity through these indirect mechanisms. Dopamine-dependent heterosynaptic
Heterosynaptic_plasticity
Nucleus in the basal ganglia of the brain
cholinergic interneurons themselves are affected by dopamine through D5 dopamine receptors. Dopamine also directly controls communication between cholinergic
Striatum
American rapper (born 2002)
(2023), was followed by his fourth and fifth albums, Plan A (2024) and Dopamine (2025), both of which continued his series of top ten debuts on the chart
Lil_Tecca
2020 studio album by the Smashing Pumpkins
later, the band released another single, which featured "Confessions of a Dopamine Addict" and "Wrath". This release also included 2 animated episodes of
Cyr_(album)
Type of associative learning process for behavioral modification
regions. Evidence also exists that dopamine is activated at similar times. There is considerable evidence that dopamine participates in both reinforcement
Operant_conditioning
Social media platform owned by Meta
triggering dopamine surges akin to other addictive behaviors. The rapid and easily consumable nature of short-form videos can elicit high levels of dopamine; since
Chemical compound
compound which acts as a partial agonist at both dopamine D2 receptors and 5-HT2A receptors. It acts as a dopamine stabilizer in a similar manner to the closely
OSU-6162
Degradation of functioning of the brain
The STAC model looks at factors like neural changes to the white matter, dopamine depletion, shrinkage, and cortical thinning. CT scans have found that the
Aging_brain
Class of medications used to alleviate anxiety
which may be mediated by neurotransmitters like norepinephrine, serotonin, dopamine, and gamma-aminobutyric acid (GABA) in the central nervous system. Anti-anxiety
Anxiolytic
Chemical compound
phenyltropane-based dopamine reuptake inhibitor (DRI) that is derived from methylecgonidine. Troparil is a few times more potent than cocaine as a dopamine reuptake
Troparil
Withdrawn anti-obesity drug combination
releasing agent. Phentermine also induces the release of serotonin and dopamine, although to a far lesser extent than it induces the release of norepinephrine
Fenfluramine/phentermine
Chemical compound
Dopexamine is a synthetic analogue of dopamine that is administered intravenously in hospitals to reduce exacerbations of heart failure and to treat heart
Dopexamine
American rock band
The new lineup led to increased output with less time between releases - Dopamine (2015), and a string of EPs, We Are Drugs (2016) and Thanks for Everything
Third_Eye_Blind
Language disorder characterized by involuntary repetition
physical trauma, neurodegenerative disorders, genetic disorders, or a loss of dopamine in these brain regions. Palilalia occurs most commonly in Tourette syndrome
Palilalia
Antipsychotic medication
not entirely clear but is believed to involve effects on serotonin and dopamine in the brain. Ziprasidone was approved for medical use in the United States
Ziprasidone
Rapid closing and opening of the eyelid
pathways dopamine production in the striatum is associated with a higher rate of spontaneous eye blinking. Conditions in which there is reduced dopamine availability
Blinking
American physician (born 1961)
amount of dopamine free in the cytosol of the dopaminergic neurons in people with Parkinson's. While confirming that tissue levels of dopamine are markedly
Jonathan_Sackner-Bernstein
American rapper (born 2006)
sound design. His sound includes "glitchy, fast-paced textures", sounds and arrangements designed to spike dopamine, with little silence or breathing room
Che_(rapper)
Pill that dissolves on contact with saliva
and 18-22% of all patients in long-term care facilities ODTs may have a faster onset of effect than tablets or capsules, and have the convenience of a
Orally_disintegrating_tablet
Stimulant designer drug
These molecules interact with monoamine transporters, in particular the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter
3-Chloromethcathinone
Chemical compound
ALDH, disulfiram is a dopamine β-hydroxylase (DBH) inhibitor. DBH is an enzyme that converts the monoamine neurotransmitter dopamine into norepinephrine
Disulfiram
Muscle relaxant medication
dose range of 1 to 20 mg. The time to peak levels with tizanidine under fasting conditions is 1 hour and under fed conditions is 1.5 to 3 hours. The pharmacokinetics
Tizanidine
Psychological capability to respond positively
correlated with social anxiety and depression, due to decreased levels of dopamine. Happiness, a feeling of well-being, and high levels of self-esteem are
Positive_affectivity
Process of developing strong feelings of attachment and love
theory by Wolfram Schultz states that rather than encoding reward per se, dopamine encodes a "reward prediction error" (RPE): the difference between the predicted
Falling_in_love
Neurological problem in dogs
Belanger, Janelle M.; Furrow, Eva (3 June 2021). "Association analysis of dopamine transporter gene ( SLC6A3 ) variants with risk for seizures and aggression
Rage_syndrome
Type of progressive dementia
imaging may show reduced dopamine transporter activity. A DLB diagnosis may be warranted if other conditions with reduced dopamine transporter uptake can
Dementia_with_Lewy_bodies
Chemical stimulant produced by some plants
peripheral tissues. This results in the release of neurotransmitters such as dopamine, acetylcholine, and norepinephrine, producing effects including increased
Nicotine
Phobia of roller coaster rides
coasters. It is believed that individuals with lower natural levels of dopamine are more prone to being fearful of roller coasters. The fear of roller
Fear_of_roller_coasters
Group of stereoisomers
and is found in the liver. 4-Hydroxyamphetamine is then metabolized by dopamine β-hydroxylase into 4-hydroxynorephedrine or eliminated in the urine. Hydroxyamphetamine
4-Hydroxyamphetamine
Medication which strengthens heart contractions
on dopamine receptors to inhibit the release of norepinephrine (another α1 agonist), dobutamine is less prone to induce hypertension than is dopamine. Dobutamine
Dobutamine
Yeah!" (Grace Kuhlenschmidt on robotic flamethrowers, robotic toilets, a dopamine delivery app, and Tilly Norwood's big break); Ann M. Martin discusses The
List of The Daily Show episodes (2026)
List_of_The_Daily_Show_episodes_(2026)
Chemical compound
RTI-336, also known as RTI-4229-336 or LS-193,309 is a potent and selective dopamine reuptake inhibitor that was initially developed by the Research Triangle
RTI-336
Disorder resulting in compulsive behaviors
depend on dopamine signaling in the nucleus accumbens, the same pathway that responds to natural rewards such as food and sex. Altered dopamine neurotransmission
Addiction
Medication
primarily as a NMDA receptor antagonist. Esketamine has faster clearance and stronger dopamine inhibition than arketamine, contributing to its dissociative
Esketamine
Process of withdrawing from nicotine addiction
nicotinic receptors in the brain that, in turn, cause an increase in dopamine. Dopamine is the major chemical that stimulates reward centers in the brain
Nicotine_withdrawal
Pleasure, enjoyment, or amusement
in long-term memory. When it is unable to do this, the brain releases dopamine, a chemical which stimulates the amygdala, the site of emotion, and creates
Fun
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