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DOT1L

DOT1L

Protein-coding gene in the species Homo sapiens

methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes. DOT1L has been reported to play an important

DOT1L

YEATS domain

Protein domain found in a variety of proteins from eukaryotic organisms

Li W, Li H, Shi X (2014). "AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation". Cell. 159 (3): 558–71. doi:10.1016/j.cell.2014

YEATS domain

YEATS_domain

ELL3

Protein-coding gene in the species Homo sapiens

Kim JE (April 2010). "Characterization of the DOT1L network: implications of diverse roles for DOT1L". The Protein Journal. 29 (3): 213–23. doi:10

ELL3

Histone

Protein family around which DNA winds to form nucleosomes

Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, et al. (April 2008). "DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene

Histone

TBR1

Protein-coding gene in Homo sapiens

of Af9 with the methyltransferase DOT1L, which methylates histone H3 lysine 79 (H3K79). Af9 association with DOT1L enhances methylation of H3K79 at the

TBR1

Yi Zhang (biochemist)

Chinese-American biochemist

including the H4R3 methyltransferase PRMT1, the H3K79 methyltransferase Dot1L, and the H3K27me3 methyltransferase EZH2/PRC2. He went on to demonstrate

Yi Zhang (biochemist)

Yi_Zhang_(biochemist)

Histone methyltransferase

Class of enzymes

encoding proteins with histone methyltransferase activity include: ASH1L DOT1L EHMT1, EHMT2, EZH1, EZH2 MLL, MLL2, MLL3, MLL4, MLL5 NSD1 PRDM2 SET, SETBP1

Histone methyltransferase

Histone_methyltransferase

List of human transcription factors

specific TF according to literature or domain structure – No motif [158] DOT1L ENSG00000104885 AT hook Likely sequence specific TF according to literature

List of human transcription factors

List_of_human_transcription_factors

Histone code

Proposed biochemical transcription of genetic information

Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR (April 2008). "DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene

Histone code

Histone_code

Chromatin remodeling

Form of dynamic modification

Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR (April 2008). "DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene

Chromatin remodeling

Chromatin_remodeling

Weiping Zou

Professor of pathology, immunology, biology, and surgery

transcription factor activation and induction of the methyltransferase DOT1L. Immunity, doi:10.1016/j.immuni.2014.03.010 (2014). Cui, T. X., et al. Myeloid-derived

Weiping Zou

Weiping_Zou

List of human protein-coding genes 2

Q5JWR5 4477 DOP1B HGNC:1291; Q9Y3R5 4478 DORIP1 HGNC:19834; Q4W4Y0 4479 DOT1L HGNC:24948; Q8TEK3 4480 DPAGT1 HGNC:2995; Q9H3H5 4481 DPCD HGNC:24542; Q9BVM2

List of human protein-coding genes 2

List_of_human_protein-coding_genes_2

H3K79me2

Histone methylation on tail of histone H3

methylation (H3K79me1; H3K79me2; H3K79me3) are catalyzed by DOT1 in yeast or DOT1L in mammals. H3K79 methylation participates in the DNA damage response and

H3K79me2

MLLT10

Protein-coding gene in the species Homo sapiens

Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y (2005). "hDOT1L links histone methylation to leukemogenesis". Cell. 121 (2): 167–78. doi:10

MLLT10