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Protein-coding gene in the species Homo sapiens
Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene. The protein encoded by this gene is a member of the E2F family of transcription
E2F4
Family of transcription factors
are activators: E2F1, 2 and E2F3a. Six others act as repressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of
E2F
Protein complex
are homologs of RB (p105) and bind repressive E2F transcription factors E2F4 and E2F5; DP1, DP2 and DP3, dimerization partners of E2F; and MuvB, which
DREAM_complex
Protein-coding gene in humans
of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130
E2F5
Genus of crustaceans
64648 IRMNG: 1286850 ITIS: 94169 NBN: NBNSYS0000175931 NCBI: 371448 NZOR: f7633344-e2f4-4774-b5b9-808e541ffd1f Open Tree of Life: 1011199 WoRMS: 101571
Jassa
Family of proteins
present, a repressor complex composed of Smad3, and the transcription factors E2F4 and p107 exist in the cytoplasm. However, when TGF-B signal is present, this
SMAD_(protein)
Mammalian protein found in humans
E2F1, E2F2 and E2F3 while the repressor E2Fs are E2F4, E2F5 and E2F6. Activator E2Fs along with E2F4 bind exclusively to pRb. pRb is able to bind to the
Retinoblastoma_protein
Protein-coding gene in the species Homo sapiens
factors with conservation include (but are not limited to) EGR1, p53, E2F3, E2F4, PLAG1, NeuroD2, Myf5, IKZF1, SMAD3, KRAB, MZF1, and c-Myb. Expression of
QSER1
Investigational cognition and memory disorder drugs
synthetic α-klotho protein [19] TET-104 – AAV-based gene therapy modulating E2F4 [20] Amdiglurax (NSI-189; ALTO-100) – unknown mechanism of action (hippocampal
List of investigational cognition and memory disorder drugs
List_of_investigational_cognition_and_memory_disorder_drugs
Mammalian protein found in Homo sapiens
Jiang, Yuyang (23 March 2012). "Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation"
Zbtb7
ENSG00000112242 E2F Known motif – High-throughput in vitro [173] TTTTGGCGCCMTTTTY E2F4 ENSG00000205250 E2F Known motif – High-throughput in vitro [174] TTTGGCGCCAAA
List of human transcription factors
List_of_human_transcription_factors
Gene which maintains basic cellular functions
Homo sapiens basic transcription factor 3 E2F4 Homo sapiens E2F transcription factor 4, p107/p130-binding (E2F4), mRNA ERH (gene) Enhancer of rudimentary
Housekeeping_gene
Quiescent stage of the cell cycle in which the cell does not divide
acetyltransferases, which activate gene expression necessary for G1 entry, while E2F4 complexes recruit histone deacetylases, which repress gene expression. Phosphorylation
G0_phase
Animal cell cycle checkpoint
causing a G1 arrest. TGF-β signaling activates Smads, which complex with E2F4/5 to repress Myc expression and also associate with Miz1 to activate expression
Restriction_point
Protein-coding gene in the species Homo sapiens
in cell transformation by MYC. It is required for p53/TP53-, E2F1-, and E2F4-mediated transcription activation. It is also involved in transcription activation
Transformation/transcription domain-associated protein
Transformation/transcription_domain-associated_protein
CDC45L onto replication origins. GEMC1 and MCIDAS transcriptionally activate E2F4/5-target genes during multiciliogenesis, including CCNO, which is necessary
Geminin coiled-coil domain-containing protein 1
Geminin_coiled-coil_domain-containing_protein_1
Cdk1/FOXO1/Bad pathway (Giovanni et al., 2000). The downregulation of p130/E2F4 (a complex which has been shown to maintain the post mitotic nature of neurons)
Neuronal_cell_cycle
Protein-coding gene in the species Homo sapiens
factors to help module DREAM in cell cycle arrest. The results showed that the E2F4 along with P130 and other transcription factors mediate the repression of
C16orf86
Protein-coding gene in the species Homo sapiens
factor Kaiso (ZBTB33) 0.991 SP4 transcription factor Sp4 0.908 ZBTB24 zinc finger and BTB domain containing 24 0.864 E2F4 E2F transcription factor 4 0.982
SLC46A3
Protein-coding gene in the species Homo sapiens
DNA consists of 8,379 base pairs. KIAA0895L is located between EXOC3L and E2F4 on the right, and NOL3 and HSF4 on the left. The promoter for KIAA0895L is
KIAA0895L
Protein-coding gene in the species Homo sapiens
OR (Nov 2007). "Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct
LIN9
Protein-coding gene in the species Homo sapiens
Activation of genes in early development Expression in neural crest cell lineages E2F4 Cell cycle control Tumor suppression c-Myb Regulation of hematopoiesis Elk-1
C21orf58
HGNC:3113; Q01094 4663 E2F2 HGNC:3114; Q14209 4664 E2F3 HGNC:3115; O00716 4665 E2F4 HGNC:3118; Q16254 4666 E2F5 HGNC:3119; Q15329 4667 E2F6 HGNC:3120; O75461
List of human protein-coding genes 3
List_of_human_protein-coding_genes_3
Protein-coding gene in humans
a consensus E2F site, which is capable of binding at least SMAD3, SMAD4, E2F4, and p107. Increased SMAD3 activity has been implicated in the pathogenesis
SMAD3
Mammalian protein found in Homo sapiens
M308953200. PMID 12947099. Chen CR, Kang Y, Siegel PM, Massagué J (Jul 2002). "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression"
Retinoblastoma-like_protein_1
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List of MeSH codes (D12.776.930)
List_of_MeSH_codes_(D12.776.930)
E2F4
E2F4
E2F4
E2F4
Surname or Lastname
English
English : from an early Middle English personal name, Mert or Mart, or perhaps a nickname from Old English mearð ‘(pine) marten’.German (Alsace-Lorraine) : from a short form of Martin.
Boy/Male
Tamil
Best studier
Girl/Female
Gujarati, Hindu, Indian
Creative; Cool
Boy/Male
Hindu
Lord Shiva
Boy/Male
Tamil
A cavalier, A Hindu month, Medical God
Girl/Female
Australian, Japanese
Flower Viewing
Girl/Female
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sindhi, Tamil, Telugu
Pride; Bold; Strong
Girl/Female
Australian, Latin
Laurel; Form of Laura
Boy/Male
Indian
Devi Festival
Girl/Female
Australian, French, Hebrew
He who Supplants
E2F4
E2F4
E2F4
E2F4
E2F4