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Family of transcription factors
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six
E2F
Protein complex
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex is a protein complex responsible for the regulation of cell cycle-dependent
DREAM_complex
Cell signaling pathway
(Rb). Hypo-phosphorylated Rb, is normally bound to transcription factor E2F in early G1 and inhibits its transcriptional activity, preventing expression
MAPK/ERK_pathway
Mammalian protein found in humans
partner (E2F-DP) dimers, which are transcription factors of the E2F family that push the cell into S phase. By keeping E2F-DP inactivated, RB1
Retinoblastoma_protein
Control mechanism in the eukaryotic cell cycle
for E2F 4 and E2F 5, which work to repress transcription of G1-to-S promoting factors. The third pocket protein, Rb, binds to and represses E2F 1, E2F 2
Cell_cycle_checkpoint
Events leading to cell division
E2F/DP1/Rb complex (which was bound to the E2F responsive genes, effectively "blocking" them from transcription), activating E2F. Activation of E2F results
Cell_cycle
Family of proteins
winged-helix transcription factors. The FOX proteins and 2 other families (E2F and RFX) are sometimes grouped into a common “Forked head / winged helix
Winged-helix transcription factors
Winged-helix_transcription_factors
Protein family
DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma
Transcription_factor_DP
Protein-coding gene in the species Homo sapiens
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle
E2F1
Protein-coding gene in the species Homo sapiens
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle
E2F4
Stage in cell cycle
D-Cdk4/6 dimer phosphorylates retinoblastoma releasing transcription factor E2F, which then drives the transition from G1 to S phase. The G1/S transition
G1/S_transition
Protein-coding gene in humans
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle
E2F5
Protein-coding gene in the species Homo sapiens
protein that in humans is encoded by the TFDP2 gene that dimerises with E2F, a key transcriptional activator involved in the regulation of the cell cycle
TFDP2
Quiescent stage of the cell cycle in which the cell does not divide
repression of the E2F family of transcription factors regulates the G0 to G1 transition just as it does the G1 to S transition. Activating E2F complexes are
G0_phase
Protein family
Hyperphosphorylated pRb can no longer bind E2F, E2F is released and cyclin A genes, and other crucial genes for S phase, are transcribed. E2F initiates transcription of
Cyclin_A
Replication of the nuclear genome without mitosis
activated by E2F transcription factors that were shown to be required for endoreduplication. Recent work suggests that observed oscillations in E2F and cyclin
Endoreduplication
Animal cell cycle checkpoint
Unphosphorylated Rb acts as an inhibitor of G1 by preventing E2F-mediated transcription. Once phosphorylated, E2F activates the transcription of cyclins E and A. Active
Restriction_point
Protein-coding gene in the species Homo sapiens
E2F-associated phosphoprotein is a protein that in humans is encoded by the EAPP gene. This gene encodes a phosphoprotein that interacts with several
EAPP
Protein-coding gene in the species Homo sapiens
(November 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". Journal of Molecular
Transcription_factor_Sp1
Protein-coding gene in the species Homo sapiens
promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. GRCh38: Ensembl release 89: ENSG00000088808 – Ensembl
PPP1R13B
Protein family
roles in the metazoan cell cycle through interaction with members of the E2F transcription factors family. Cobrinik D (2005). "Pocket proteins and cell
Pocket_protein_family
Human disease
in turn, halting cell cycle progression by preventing the activation of E2F. In short, p53 is a tumor-suppressor protein that arrests the cell cycle
Human papillomavirus infection
Human_papillomavirus_infection
Cancerous tumor of the developing eye
principally arises from binding and inactivation of the transcription factor E2F, thus repressing the transcription of genes which are required for the S
Retinoblastoma
Protein-coding gene in humans
factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene. The E2F transcription factor family (see MIM 189971) regulates the expression of
TFDP1
Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)
cell growth through multiple mechanisms, including regulation of cyclin D1, E2F factors and their target genes. c-Jun, which is one of the AP-1 subunits
AP-1_transcription_factor
Cell cycle regulator
cell cycle, peaking during the G1 phase and diminishing in early mitosis. E2F transcription factor, a key regulator of the G1-S transition of the cell
Early_Mitotic_Inhibitor_1
Protein-coding gene in the species Homo sapiens
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle
E2F2
Biological process
phosphorylate the Retinoblastoma (Rb) protein, a tumor suppressor bound with the E2F family of transcription factors. The binding of this Rb protein ensures that
Cell_division
Protein-coding gene in humans
regulation process as it participates to the ARF-MDM2-p53 pathway and the Rb-E2F-1 pathway. It is the physiological inhibitor of MDM2, an E3 ubiquitin ligase
CDKN2A
Multi-protein structure
phase of the cell cycle), Retinoblastoma protein (Rb) is bound with the E2F transcription factor. During the G0 to G1 transition, growth factor stimulates
Cyclin_D/Cdk4
Protein-coding gene in the species Homo sapiens
forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters". Nature Genetics. 25 (3): 338–342. doi:10.1038/77124
DNMT1
Protein-coding gene in the species Homo sapiens
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle
E2F3
Human protein
dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the
Cyclin-dependent_kinase_4
Protein-coding gene in humans
mitogenic signals through a transcriptional control mechanism involving E2F proteins. CDC6 has been shown to interact with ORC1L, ORC2L, Cyclin A2, PPP2R3B
CDC6
Human protein
exit. The Rb protein limits cell proliferation by blocking the activity of E2F transcription factors, which activate the transcription of genes needed for
P14arf
Mammalian protein found in Homo sapiens
both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities
Retinoblastoma-like_protein_1
Protein-coding gene in the species Homo sapiens
Cobrinik D, Geng Y, Onufryk C, Chen A, et al. (Mar 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle"
Retinoblastoma-like_protein_2
Protein that initiates male sex determination in therian mammals
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
Sex-determining region Y protein
Sex-determining_region_Y_protein
American aircraft engine
2700 rpm, Minimum fuel grade 91/96 avgas, compression ratio 8.50:1. Same as E2F except with high compression pistons. O-320-D2G 160 hp (119 kW) at 2700 rpm
Lycoming_O-320
Second subphase of interphase
release of E2F transcription factor, which in turn initiates expression of S-phase genes. Several E2F target genes promote further release of E2F, creating
S_phase
Molecular biology method
reported the isolation of nine chromatin fragments containing weak and strong E2F binding site was done by Peggy Farnham's lab in collaboration with Michael
ChIP-on-chip
Mono-phosphorylated Rb inactivates E2F TFs, but hyper-phosphorylation of Rb results in Rb inactivation, causing the release of E2F proteins from the Rb binding
Cyclin_E/Cdk2
Family of regulator genes
novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins". Cell. 94 (3): 363–74. doi:10.1016/s0092-8674(00)81479-8. PMID 9708738
Myc
Protein found in humans
allows for the partial phosphorylation of Rb, and partial activation of E2F at the beginning of G1 phase, which promotes cyclin E synthesis and increased
Cyclin-dependent_kinase_2
Localization technology company
Translate by Humans, WritePath, Farsi Translation Services, Bureau Translations, e2f, Web-lingo, Leanlane, and Acclaro.[citation needed] Crowdin has integrated
Crowdin
First subphase of interphase
methods of preventing Cdk activity are found in G1 phase: pRB binding to E2F family transcription factors downregulate expression of S phase cyclin genes;
G1_phase
Nuclear protein that binds to CREB
100 known substrates for CBP's KAT domain including proteins such as p53, E2F-1-3, GATA-1, MyoD and CREB. The ability of CBP to acetylate p53 via its KAT
CREB-binding_protein
Protein-coding gene in the species Homo sapiens
the general transcription factor TFIIB, and both E2F and E2F transcription factor binding sites. The E2F transcription factors are involved in mediating
Tetratricopeptide repeat protein 39C
Tetratricopeptide_repeat_protein_39C
Protein-coding gene in the species Homo sapiens
PMID 15178447. Unoki M, Nishidate T, Nakamura Y (October 2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain"
UHRF1
Medical condition
exocrine insufficiency, maldigestion, and malnutrition). Lacking genes in the E2F group. The condition can be managed by many factors.[citation needed] Medications
Type_3c_diabetes
Protein-coding gene in the species Homo sapiens
cancer pathway in which EZH2 plays a role is the pRB-E2F pathway. It is downstream from the pRB-E2F pathway, and signals from this pathway lead to EZH2
EZH2
Protein-coding gene in the species Homo sapiens
(Oct 2004). "Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes". Cell
LIN9
Protein-coding gene in the species Homo sapiens
in cell cycle regulation and synthesis of DNA in mammalian cells (e.g.: E2F-1) induces the expression of p73. Many researchers believe that these results
P73
Family of VHF/UHF vacuum tubes
4676, 4695 Mullard-Philips: D1C, D2C, D1F, D2F, D3F, D11F, D12F, E1C, E1F, E2F Russian: 6С1Ж, 6Ж1Ж, 6К1Ж Japanese: UN954, UN955 Larger, higher-power types
Acorn_tube
Family of transcription factors involved in anatomical development
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
FOX_proteins
Indian scientist and professor of cancer biology
carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes". Carcinogenesis. 24 (3): 555–563. doi:10.1093/carcin/24.3.555
Rana_P_Singh
inactive, which through a downstream signalling cascade allows the release of E2F and thus, progression through the Restriction point (R point) in G1 phase
Src_homology_domain
Chemical compound
Cheng X, Qian R, Zhang X (2007) Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells. Eur
Oxymatrine
Mammalian protein found in Homo sapiens
DV (Jun 2002). "Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth". The EMBO Journal. 21 (12): 3019–28. doi:10.1093/emboj/cdf302
Prohibitin
Protein-coding gene in the species Homo sapiens
DV (Jun 2002). "Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth". The EMBO Journal. 21 (12): 3019–28. doi:10.1093/emboj/cdf302
SMARCA2
Mammalian protein found in Homo sapiens
CDKN3 DAB2, FANCC, GADD45A, LATS1, LYN, P53, and UBC. Biology portal E2F#E2F.2FpRb complexes Hyperphosphorylation cdc25 Maturation promoting factor
Cyclin-dependent_kinase_1
Protein-coding gene in the species Homo sapiens
bind E2F, leading to cyclin A2 transcription. The cyclin A2-CDK2 complex eventually phosphorylates E2F, turning off cyclin A2 transcription. E2F promotes
Cyclin_A2
Protein-coding gene in humans
(Oct 2003). "Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation". J Biol Chem. 278
E2F7
Protein-coding gene in the species Homo sapiens
novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins". Cell. 94 (3): 363–74. doi:10.1016/S0092-8674(00)81479-8. PMID 9708738
Transformation/transcription domain-associated protein
Transformation/transcription_domain-associated_protein
Protein-coding gene in the species Homo sapiens
(November 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. 293
Sp2_transcription_factor
Series of molecular signals
Specifically, it mediates the G1/S transition by promoting dE2F activation (Drosophila E2F), a member of the E2F transcription factor family, which regulates the
Notch_signaling_pathway
Protein molecule receiving signals for a cell
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
Receptor_(biochemistry)
Protein
This leads to the inactivation of p53-dependent promoters and induction of E2F-dependent genes. Studies have also shown that LANA-1 can transactivate the
LANA
Class of enzymes
Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syväoja JE (Jul 2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase
DNA polymerase alpha subunit 2
DNA_polymerase_alpha_subunit_2
Protein-coding gene in the species Homo sapiens
"Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation". Nature Cell Biology. 1 (1): 14–19. doi:10
SKP2
Protein-coding gene in humans
novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins". Cell. 94 (3): 363–374. doi:10.1016/S0092-8674(00)81479-8.
MAX_(gene)
characterized by the upregulation of cyclin D-cdk4/6 and downregulation of E2F, followed by cell death (Frade and Ovejero-Benito, 2015). In cerebellar granule
Neuronal_cell_cycle
Human chromosome
2 (C. elegans) DTX3: encoding protein Deltex e3 ubiquitin ligase 3 E2F7: E2F transcription factor 7 EMP1: Epithelial membrane protein 1 ENDOU: encoding
Chromosome_12
Gene that inhibits tumorigenic phenotype
the cell cycle progression from G1 phase into the S phase by binding to E2F and repressing the necessary gene transcription. This prevents the cell from
Tumor_suppressor_gene
Protein-coding gene in the species Homo sapiens
Choubey D, Li SJ, Datta B, Gutterman JU, Lengyel P (Oct 1996). "Inhibition of E2F-mediated transcription by p202". The EMBO Journal. 15 (20): 5668–78. doi:10
TP53BP1
Type of pluripotent blastocystic stem cell
inhibitors. Retinoblastoma proteins that inhibit the transcription factor E2F until the cell is ready to enter S phase are hyperphosphorylated and inactivated
Embryonic_stem_cell
American geneticist
Nicholas Dyson Known for E2F and pRB Scientific career Institutions Massachusetts General Hospital Cancer Center Academic advisors Ed Harlow Doctoral
Nicholas_Dyson
Extracellular protein in Homo sapiens
predicted transcription factors of various types including various zinc fingers, E2F factors, and CDF factors. Of particulate note is the presence of a XGene
PRP36
Protein-coding gene in the species Homo sapiens
regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity"
NPDC1
Protein-coding gene in the species Homo sapiens
WH, Jin YJ, Brandt-Rauf PW, Yin Y (Jun 2007). "A molecular link between E2F-1 and the MAPK cascade". The Journal of Biological Chemistry. 282 (25): 18521–31
DUSP4
Protein found in humans
T, Nojima H, Sekiya S, Oda K (1998). "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer"
Desmoplakin
Protein-coding gene in the species Homo sapiens
NJ (November 2006). "Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo". PLOS Genetics. 2 (11): e196. doi:10.1371/journal
API5
Protein-coding gene in the species Homo sapiens
Jin YJ, Calaf GM, et al. (2007). "PAC1 is a direct transcription target of E2F-1 in apoptotic signaling". Oncogene. 26 (45): 6526–35. doi:10.1038/sj.onc
DUSP2
indicator 4683 – Directly heated power triode, side-contact 8 base 4695/E2F (956) – Indirectly heated Acorn pentode RCA: 4042 – Ceramic/metal pencil-type
List_of_vacuum_tubes
The transcription factor family E2F are also thought to be very important in regulating cardiomyocyte proliferation. E2F transcription factors influence
Cardiomyocyte_proliferation
British biochemist
with Nancy Hopkins on genetic screens in zebrafish. Lees studies how the E2F family of mammalian transcription factors contributes to the regulation of
Jacqueline_Lees
Protein-coding gene in the species Homo sapiens
"Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation". Nat. Cell Biol. 1 (1): 14–9. doi:10.1038/8984
S-phase kinase-associated protein 1
S-phase_kinase-associated_protein_1
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
GSX2
Family of transcription factor protein complexes
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
NF-κB
Protein-coding gene in the species Homo sapiens
Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (June 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Molecular and Cellular
HDAC1
Protein-coding gene in the species Homo sapiens
DV (June 2002). "Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth". The EMBO Journal. 21 (12): 3019–28. doi:10.1093/emboj/cdf302
SMARCA4
Protein-coding gene in the species Homo sapiens
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
PROX1
Protein-coding gene in the species Homo sapiens
Genomatix predicted that IRX1 expression is regulated by factors that include E2F cell cycle regulators, NRF1, and ZF5, and brachyury. Expression data from
IRX1
Protein family
essential gene homologous to human TRRAP, an essential cofactor for c-Myc- and E2F-mediated oncogenic transformation. Finally, the ability of NuA4 to stimulate
NuA4 histone acetyltransferase complex
NuA4_histone_acetyltransferase_complex
Protein-coding gene in the species Homo sapiens
org/cgi-bin/carddisp.pl?gene=LRRFIP1". www.genecards.org. Retrieved 2016-05-09. "E2F1 E2F transcription factor 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm
C8orf48
Protein-coding gene in the species Homo sapiens
"HES-1 inhibits 17beta-estradiol and heregulin-beta1-mediated upregulation of E2F-1". Oncogene. 23 (54): 8826–33. doi:10.1038/sj.onc.1208139. PMID 15467735
GATD3
Human protein-coding gene
adenoma gene 160 182 - FOX proteins Fork head domain factors 35 51 + E2FF E2F-myc activator/cell cycle regulator 357 373 - MZF1 Myeloid zinc finger 1 factors
C7orf25
RNA family
function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway". The Journal of Biological Chemistry
Mir-449 microRNA precursor family
Mir-449_microRNA_precursor_family
Gene known for its role in breast cancer
variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases". Oncogene. 15 (2): 143–57. doi:10
BRCA1
Undesirable occurrence in eukaryotic cells
accumulate and prevent origin re-licensing. Cdt1 is usually upregulated by E2F-mediated transcriptional activation and by binding of human acetylase to
DNA_re-replication
E2F
E2F
E2F
E2F
Boy/Male
Hindu, Indian, Traditional
Lord of Conquerers
Girl/Female
Arabic, Muslim
Graceful; Elegant
Girl/Female
Hindu
Male
English
Variant spelling of English unisex Addison, ADISSON means "son of Adam."
Girl/Female
American, Australian, Greek, Hebrew, Spanish
Bethlehem; An Arrow
Boy/Male
Hindu, Indian, Marathi
One who Directs; Guide
Girl/Female
Latin Spanish Italian
Blooming.
Girl/Female
Australian, British, Dutch, English
Changeable
Boy/Male
Indian, Tamil
South Queen
Boy/Male
Tamil
Gifts
E2F
E2F
E2F
E2F
E2F