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Family of transcription factors
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six
E2F
Events leading to cell division
E2F/DP1/Rb complex (which was bound to the E2F responsive genes, effectively "blocking" them from transcription), activating E2F. Activation of E2F results
Cell_cycle
Control mechanism in the eukaryotic cell cycle
for E2F 4 and E2F 5, which work to repress transcription of G1-to-S promoting factors. The third pocket protein, Rb, binds to and represses E2F 1, E2F 2
Cell_cycle_checkpoint
Cell signaling pathway
(Rb). Hypo-phosphorylated Rb, is normally bound to transcription factor E2F in early G1 and inhibits its transcriptional activity, preventing expression
MAPK/ERK_pathway
Mammalian protein found in humans
partner (E2F-DP) dimers, which are transcription factors of the E2F family that push the cell into S phase. By keeping E2F-DP inactivated, RB1
Retinoblastoma_protein
Protein complex
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex is a protein complex responsible for the regulation of cell cycle-dependent
DREAM_complex
Protein-coding gene in the species Homo sapiens
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle
E2F4
Stage in cell cycle
D-Cdk4/6 dimer phosphorylates retinoblastoma releasing transcription factor E2F, which then drives the transition from G1 to S phase. The G1/S transition
G1/S_transition
Protein family
DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma
Transcription_factor_DP
Protein-coding gene in the species Homo sapiens
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle
E2F1
Protein-coding gene in humans
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle
E2F5
Mammalian protein found in Homo sapiens
both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities
Retinoblastoma-like_protein_1
Quiescent stage of the cell cycle in which the cell does not divide
repression of the E2F family of transcription factors regulates the G0 to G1 transition just as it does the G1 to S transition. Activating E2F complexes are
G0_phase
Protein-coding gene in the species Homo sapiens
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle
E2F3
Protein-coding gene in humans
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle
E2F2
Protein family
Hyperphosphorylated pRb can no longer bind E2F, E2F is released and cyclin A genes, and other crucial genes for S phase, are transcribed. E2F initiates transcription of
Cyclin_A
Protein family
roles in the metazoan cell cycle through interaction with members of the E2F transcription factors family. Cobrinik D (2005). "Pocket proteins and cell
Pocket_protein_family
Protein-coding gene in humans
mitogenic signals through a transcriptional control mechanism involving E2F proteins. CDC6 has been shown to interact with ORC1L, ORC2L, Cyclin A2, PPP2R3B
CDC6
Family of proteins
winged-helix transcription factors. The FOX proteins and 2 other families (E2F and RFX) are sometimes grouped into a common “Forked head / winged helix
Winged-helix transcription factors
Winged-helix_transcription_factors
Protein-coding gene in the species Homo sapiens
protein that in humans is encoded by the TFDP2 gene that dimerises with E2F, a key transcriptional activator involved in the regulation of the cell cycle
TFDP2
Second subphase of interphase
release of E2F transcription factor, which in turn initiates expression of S-phase genes. Several E2F target genes promote further release of E2F, creating
S_phase
Animal cell cycle checkpoint
Unphosphorylated Rb acts as an inhibitor of G1 by preventing E2F-mediated transcription. Once phosphorylated, E2F activates the transcription of cyclins E and A. Active
Restriction_point
Protein-coding gene in humans
(Oct 2003). "Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation". J Biol Chem. 278
E2F7
Protein found in humans
allows for the partial phosphorylation of Rb, and partial activation of E2F at the beginning of G1 phase, which promotes cyclin E synthesis and increased
Cyclin-dependent_kinase_2
Human disease
in turn, halting cell cycle progression by preventing the activation of E2F. In short, p53 is a tumor-suppressor protein that arrests the cell cycle
Human papillomavirus infection
Human_papillomavirus_infection
Protein-coding gene in the species Homo sapiens
(November 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". Journal of Molecular
Transcription_factor_Sp1
Human protein
dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the
Cyclin-dependent_kinase_4
Protein-coding gene in the species Homo sapiens
cancer pathway in which EZH2 plays a role is the pRB-E2F pathway. It is downstream from the pRB-E2F pathway, and signals from this pathway lead to EZH2
EZH2
Replication of the nuclear genome without mitosis
activated by E2F transcription factors that were shown to be required for endoreduplication. Recent work suggests that observed oscillations in E2F and cyclin
Endoreduplication
Molecular biology method
reported the isolation of nine chromatin fragments containing weak and strong E2F binding site was done by Peggy Farnham's lab in collaboration with Michael
ChIP-on-chip
Protein-coding gene in the species Homo sapiens
promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. GRCh38: Ensembl release 89: ENSG00000088808 – Ensembl
PPP1R13B
Protein-coding gene in humans
factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene. The E2F transcription factor family (see MIM 189971) regulates the expression of
TFDP1
Protein-coding gene in humans
regulation process as it participates to the ARF-MDM2-p53 pathway and the Rb-E2F-1 pathway. It is the physiological inhibitor of MDM2, an E3 ubiquitin ligase
CDKN2A
Protein-coding gene in the species Homo sapiens
bind E2F, leading to cyclin A2 transcription. The cyclin A2-CDK2 complex eventually phosphorylates E2F, turning off cyclin A2 transcription. E2F promotes
Cyclin_A2
Biological process
phosphorylate the Retinoblastoma (Rb) protein, a tumor suppressor bound with the E2F family of transcription factors. The binding of this Rb protein ensures that
Cell_division
Member of the cyclin protein family
and Rb is phosphorylated as a result. Rb reduces its binding to E2F and thereby allows E2F-mediated activation of the transcription of cyclin E and cyclin
Cyclin_D
First subphase of interphase
methods of preventing Cdk activity are found in G1 phase: pRB binding to E2F family transcription factors downregulate expression of S phase cyclin genes;
G1_phase
Indian scientist and professor of cancer biology
carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes". Carcinogenesis. 24 (3): 555–563. doi:10.1093/carcin/24.3.555
Rana_P_Singh
American thoracic surgeon
cycle and development. Brook showed that the cell cycle transcription factor E2F was required to activate differentiation in mammalian and Drosophila post-mitotic
Adam_Brook
Protein-coding gene in the species Homo sapiens
E2F-associated phosphoprotein is a protein that in humans is encoded by the EAPP gene. This gene encodes a phosphoprotein that interacts with several
EAPP
Family of regulator genes
novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins". Cell. 94 (3): 363–74. doi:10.1016/s0092-8674(00)81479-8. PMID 9708738
Myc
Cancerous tumor of the developing eye
principally arises from binding and inactivation of the transcription factor E2F, thus repressing the transcription of genes which are required for the S
Retinoblastoma
Mono-phosphorylated Rb inactivates E2F TFs, but hyper-phosphorylation of Rb results in Rb inactivation, causing the release of E2F proteins from the Rb binding
Cyclin_E/Cdk2
Cell cycle regulator
cell cycle, peaking during the G1 phase and diminishing in early mitosis. E2F transcription factor, a key regulator of the G1-S transition of the cell
Early_Mitotic_Inhibitor_1
Protein that initiates male sex determination in therian mammals
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
Sex-determining region Y protein
Sex-determining_region_Y_protein
Human protein
exit. The Rb protein limits cell proliferation by blocking the activity of E2F transcription factors, which activate the transcription of genes needed for
P14arf
Extracellular protein in Homo sapiens
predicted transcription factors of various types including various zinc fingers, E2F factors, and CDF factors. Of particulate note is the presence of a XGene
PRP36
Protein-coding gene in the species Homo sapiens
Cobrinik D, Geng Y, Onufryk C, Chen A, et al. (Mar 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle"
Retinoblastoma-like_protein_2
characterized by the upregulation of cyclin D-cdk4/6 and downregulation of E2F, followed by cell death (Frade and Ovejero-Benito, 2015). In cerebellar granule
Neuronal_cell_cycle
Medical condition
exocrine insufficiency, maldigestion, and malnutrition). Lacking genes in the E2F group. The condition can be managed by many factors.[citation needed] Medications
Type_3c_diabetes
inactive, which through a downstream signalling cascade allows the release of E2F and thus, progression through the Restriction point (R point) in G1 phase
Src_homology_domain
Protein molecule receiving signals for a cell
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
Receptor_(biochemistry)
Multi-protein structure
phase of the cell cycle), Retinoblastoma protein (Rb) is bound with the E2F transcription factor. During the G0 to G1 transition, growth factor stimulates
Cyclin_D/Cdk4
Localization technology company
Translate by Humans, WritePath, Farsi Translation Services, Bureau Translations, e2f, Web-lingo, Leanlane, and Acclaro.[citation needed] Crowdin has integrated
Crowdin
Gene that inhibits tumorigenic phenotype
the cell cycle progression from G1 phase into the S phase by binding to E2F and repressing the necessary gene transcription. This prevents the cell from
Tumor_suppressor_gene
Protein-coding gene in humans
Nojima H, Sekiya S, Oda K (Aug 1998). "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer"
ARID3A
Series of molecular signals
Specifically, it mediates the G1/S transition by promoting dE2F activation (Drosophila E2F), a member of the E2F transcription factor family, which regulates the
Notch_signaling_pathway
Mammalian protein found in Homo sapiens
CDKN3 DAB2, FANCC, GADD45A, LATS1, LYN, P53, and UBC. Biology portal E2F#E2F.2FpRb complexes Hyperphosphorylation cdc25 Maturation promoting factor
Cyclin-dependent_kinase_1
American aircraft engine
700 rpm, Minimum fuel grade 91/96 avgas, compression ratio 8.50:1. Same as E2F except with high compression pistons. O-320-D2G 160 hp (119 kW) at 2,700 rpm
Lycoming_O-320
Centrioles are nine triplets microtubules
(June 1999). "Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A". Nature Cell Biology. 1 (2): 88–93. doi:10.1038/10054
Centrosome_cycle
Protein-coding gene in humans
is a composite element, composed of an overlapping RSBE and a consensus E2F site, which is capable of binding at least SMAD3, SMAD4, E2F4, and p107.
SMAD3
Protein-coding gene in the species Homo sapiens
novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins". Cell. 94 (3): 363–74. doi:10.1016/S0092-8674(00)81479-8. PMID 9708738
Transformation/transcription domain-associated protein
Transformation/transcription_domain-associated_protein
Family of transcription factor protein complexes
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
NF-κB
Protein-coding gene in the species Homo sapiens
forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters". Nature Genetics. 25 (3): 338–342. doi:10.1038/77124
DNMT1
indicator 4683 – Directly heated power triode, side-contact 8 base 4695/E2F (956) – Indirectly heated Acorn pentode RCA: 4042 – Ceramic/metal pencil-type
List_of_vacuum_tubes
Protein
This leads to the inactivation of p53-dependent promoters and induction of E2F-dependent genes. Studies have also shown that LANA-1 can transactivate the
LANA
American immunologist
(November 19, 2012). "RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry". Journal of Experimental
David_H._Raulet
Protein-coding gene in the species Homo sapiens
PMID 15178447. Unoki M, Nishidate T, Nakamura Y (October 2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain"
UHRF1
Member of the cyclin family
promote G1 progression. Hyper-phosphorylated Rb will no longer interact with E2F transcriptional factor, thus release it to promote expression of genes that
Cyclin_E
Protein-coding gene in humans
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
PROX1
Type of pluripotent blastocystic stem cell
inhibitors. Retinoblastoma proteins that inhibit the transcription factor E2F until the cell is ready to enter S phase are hyperphosphorylated and inactivated
Embryonic_stem_cell
Protein-coding gene in the species Homo sapiens
YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal. 21 (21): 5775–86. doi:10.1093/emboj/cdf577.
RYBP
Family of transcription factors involved in anatomical development
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
FOX_proteins
Viruses that can cause cancer
phase. In mammals, when Rb is active (unphosphorylated), it inhibits the E2F family of transcription factors, which regulate the Cyclin E-Cdk2 complex
Oncovirus
prevents downstream hyper-phosphorylation of Rb that allows release of the E2F transcription factor and transcription of cell cycle-related genes. Cyclin
CIP/KIP
Protein-coding gene in the species Homo sapiens
the general transcription factor TFIIB, and both E2F and E2F transcription factor binding sites. The E2F transcription factors are involved in mediating
Tetratricopeptide repeat protein 39C
Tetratricopeptide_repeat_protein_39C
Proteins activated by the hormone estrogen
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
Estrogen_receptor
Human chromosome
2 (C. elegans) DTX3: encoding protein Deltex e3 ubiquitin ligase 3 E2F7: E2F transcription factor 7 EMP1: Epithelial membrane protein 1 ENDOU: encoding
Chromosome_12
Protein family
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
Heterochromatin_protein_1
Protein-coding gene in the species Homo sapiens
regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity"
NPDC1
Mammalian protein found in Homo sapiens
DV (Jun 2002). "Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth". The EMBO Journal. 21 (12): 3019–28. doi:10.1093/emboj/cdf302
Prohibitin
Protein-coding gene in the species Homo sapiens
DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK
DBF4
Protein-coding gene in the species Homo sapiens
through its direct interactions with transcription factors, e.g. E2F-1 and Miz1. The E2F family of transcription factors mediate the expression of a multitude
TOPBP1
Protein-coding gene in the species Homo sapiens
"Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation". Nat. Cell Biol. 1 (1): 14–9. doi:10.1038/8984
S-phase kinase-associated protein 1
S-phase_kinase-associated_protein_1
Chemical compound
Cheng X, Qian R, Zhang X (2007) Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells. Eur
Oxymatrine
Class of enzymes
Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syväoja JE (Jul 2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase
DNA polymerase alpha subunit 2
DNA_polymerase_alpha_subunit_2
Phenomenon characterized by the cessation of cell division
mice, and in hyperplasias of the pituitary gland of mice with deregulated E2F activity. The key to these findings is that genetic manipulations that abrogated
Cellular_senescence
2016 video game
концепта до релиза". DTF (in Russian). Retrieved 2017-01-18. "GDC2016: Day 2". e2f. Archived from the original on 2017-01-19. Retrieved 2017-01-18. "Mushroom
Mushroom_Wars_2
Mammalian protein found in Homo sapiens
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
NK2_homeobox_1
Mammalian protein found in humans
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
PAX8
Gene which maintains basic cellular functions
BTF3 NM_001207 Homo sapiens basic transcription factor 3 E2F4 Homo sapiens E2F transcription factor 4, p107/p130-binding (E2F4), mRNA ERH (gene) Enhancer
Housekeeping_gene
Protein-coding gene in humans
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
DMRT1
Class of proteins
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
CREB
Protein-coding gene in the species Homo sapiens
Genomatix predicted that IRX1 expression is regulated by factors that include E2F cell cycle regulators, NRF1, and ZF5, and brachyury. Expression data from
IRX1
Protein-coding gene in the species Homo sapiens
PMC 528928. PMID 15489334. Unoki M, Nishidate T, Nakamura Y (2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain"
UHRF2
Nuclear protein that binds to CREB
100 known substrates for CBP's KAT domain including proteins such as p53, E2F-1-3, GATA-1, MyoD and CREB. The ability of CBP to acetylate p53 via its KAT
CREB-binding_protein
Human protein-coding gene
adenoma gene 160 182 - FOX proteins Fork head domain factors 35 51 + E2FF E2F-myc activator/cell cycle regulator 357 373 - MZF1 Myeloid zinc finger 1 factors
C7orf25
Nuclear receptor protein found in humans
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
Peroxisome proliferator-activated receptor alpha
Peroxisome_proliferator-activated_receptor_alpha
British epigenetics researcher
Lowe, S. W. (2003). "Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence". Cell. 113 (6): 703–16. doi:10
Edith_Heard
Protein-coding gene in the species Homo sapiens
VSX2 Bicoid GSC BICD2 OTX 1 2 PITX 1 2 3 (3.3) Fork head / winged helix E2F 1 2 3 4 5 FOX proteins A1 A2 A3 B1 B2 C1 C2 D1 D2 D3 D4 D4L1 D4L3 D4L4 D4L5
ZEB2
travel, tourism, insurance
E2F
E2F
E2F
E2F
E2F
E2F
E2F
E2F
E2F
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