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Enzyme
In molecular biology, elastase is an enzyme from the class of proteases (peptidases) that break down proteins, specifically one that can break down elastin
Elastase
Protein-coding gene in the species Homo sapiens
Neutrophil elastase (EC 3.4.21.37, leukocyte elastase, ELANE, ELA2, elastase 2, neutrophil, elaszym, serine elastase, subtype human leukocyte elastase (HLE))
Neutrophil_elastase
Class of enzymes
Pancreatic elastase is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an inactive zymogen and later activated
Pancreatic_elastase
Inability to properly digest food due to a lack of digestive enzymes from the pancreas
'moderate' EPI is when fecal elastase levels are <200 ug/g, whereas 'severe' EPI is considered to be when fecal elastase levels is <100 ug/g. The exocrine
Exocrine pancreatic insufficiency
Exocrine_pancreatic_insufficiency
Mammalian protein found in humans
only binds to neutrophil elastase from inflammatory cells but also to elastase on the cell surface. In this latter role, elastase acts as a signaling molecule
Alpha-1_antitrypsin
Macrophage elastase (EC 3.4.24.65, metalloelastase, human macrophage metalloelastase (HME), MMP-12) is an enzyme. This enzyme catalyses the following chemical
Macrophage_elastase
Type of white blood cell
[citation needed] In alpha 1-antitrypsin deficiency, the important neutrophil elastase is not adequately inhibited by alpha 1-antitrypsin, leading to excessive
Neutrophil
Medical condition
environmental dust. The underlying mechanism involves unblocked neutrophil elastase and buildup of abnormal A1AT in the liver. It is autosomal co-dominant
Alpha-1 antitrypsin deficiency
Alpha-1_antitrypsin_deficiency
Pancreatic elastase II (EC 3.4.21.71, pancreatic elastase 2) is an enzyme. This enzyme catalyses the following chemical reaction Preferential cleavage:
Pancreatic_elastase_II
Protein-coding gene in the species Homo sapiens
Chymotrypsin-like elastase family member 3B also known as elastase-3B, protease E, or fecal elastase is an enzyme that in humans is encoded by the CELA3B
CELA3B
Protein-coding gene in the species Homo sapiens
Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins
SERPINB1
Protein-coding gene in the species Homo sapiens
seminal fluids. SLPI inhibits human leukocyte elastase, human cathepsin G, human trypsin, neutrophil elastase, and mast cell chymase. X-ray crystallography
SLPI
Topics referred to by the same term
Elaszym may refer to one of two enzymes: Pancreatic elastase Neutrophil elastase This disambiguation page lists articles associated with the title Elaszym
Elaszym
Protein family
WAP regulate the proliferation of mammary epithelial cells by preventing elastase-type serine proteases from carrying out laminin degradation and by suppressing
Whey_acidic_protein
Chemical compound
name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase. It is used in the treatment of acute respiratory failure and preliminary
Sivelestat
Mammalian protein found in Homo sapiens
protein that in humans is encoded by the PI3 gene. This gene encodes an elastase-specific protease inhibitor, which contains a WAP-type four-disulfide core
Elafin
Enzyme involved in breakdown of extracellular matrix
(MMP-12) also known as macrophage metalloelastase (MME) or macrophage elastase (ME) is an enzyme that in humans is encoded by the MMP12 gene. Proteins
Matrix_metallopeptidase_12
Biological molecule
acid, it forms hyaluronan. GlcNAc has been reported to be an inhibitor of elastase release from human polymorphonuclear leukocytes (range 8–17% inhibition)
N-Acetylglucosamine
Enzyme that cleaves other proteins into smaller peptides
Each family may contain many hundreds of related proteases (e.g. trypsin, elastase, thrombin and streptogrisin within the S1 family). Currently more than
Protease
Localized enlargement of the abdominal aorta
induced), and the elastase model (non-dissecting, chemically induced model). A recent study has shown that β-Aminopropionitrile plus elastase application to
Abdominal_aortic_aneurysm
Protein found in humans
Chymotrypsin C, also known as caldecrin or elastase 4, is an enzyme that in humans is encoded by the CTRC gene. Chymotrypsin C is a member of the peptidase
Chymotrypsin-C
Pseudolysin (EC 3.4.24.26, Pseudomonas elastase, Pseudomonas aeruginosa neutral metalloproteinase) is an enzyme. This enzyme catalyses the following chemical
Pseudolysin
Abnormally low concentration of neutrophils (a type of white blood cell) in the blood
mostly caused by heterozygous mutations in the ELANE gene (neutrophil elastase). Neutropenia can be acute (temporary) or chronic (long lasting). The term
Neutropenia
Secretion of mammalian genitals
Littré. Smegma contains cathepsin B, lysozymes, chymotrypsin, neutrophil elastase and cytokines, which aid the immune system. According to Wright, the production
Smegma
Cellular object readily stainable with a RomanowskI stain
Azurophils may contain myeloperoxidase, phospholipase A2, acid hydrolases, elastase, defensins, neutral serine proteases, bactericidal permeability-increasing
Azurophilic_granule
Hungarian biochemist
contraction. She and her husband József Mátyás Baló discovered the first elastase – an enzyme capable of degrading the protein elastin which gives tissues
Ilona_Banga
Active ingredient in fermented drinks
PMID 3280601. Leeds JS, Oppong K, Sanders DS (May 2011). "The role of fecal elastase-1 in detecting exocrine pancreatic disease". Nature Reviews. Gastroenterology
Alcohol_(drug)
Class of enzymes
followed by Pro. Cuts more slowly after His, Met or Leu. Works best at pH 8. Elastase - cuts after Ala, Gly, Ser, or Val, unless followed by Pro. Thermolysin
Endopeptidase
Protein-coding gene in the species Homo sapiens
most closely related to other immune serine proteases, such as neutrophil elastase and the granzymes. As a neutrophil serine protease, was first identified
Cathepsin_G
Liquid secreted by the pancreas
number of digestive enzymes, including trypsinogen, chymotrypsinogen, elastase, carboxypeptidase, pancreatic lipase, nucleases, and amylase. The pancreas
Pancreatic_juice
Wound that does not heal quickly
certain level of elastase and proteases for proper healing, too high a concentration is damaging. Leukocytes in the wound area release elastase, which increases
Chronic_wound
Lung disease involving long-term poor airflow
proteinase-antiprotease imbalance. In this genotype, unchecked activity of elastase in white blood cells, called neutrophils leads to early-onset emphysema
Chronic obstructive pulmonary disease
Chronic_obstructive_pulmonary_disease
Protein-coding gene in the species Homo sapiens
Chymotrypsin-like elastase family member 3A is an enzyme that in humans is encoded by the CELA3A gene. Elastases form a subfamily of serine proteases that
CELA3A
Class of enzymes
their substrate specificity as either trypsin-like, chymotrypsin-like or elastase-like. Trypsin-like proteases cleave peptide bonds following a positively
Serine_protease
Skin which is abnormally inelastic and hangs loosely
well as abundant neutrophils. One hypothesis for the cause is excessive elastase release from neutrophils and macrophages. It has also been considered that
Cutis_laxa
Molecule to signal group actions in cells
las system regulates the lasB gene that encodes the lasB elastase enzyme. The lasB elastase enzyme is a secreted protease that functions in causing tissue
Pseudomonas_quinolone_signal
Protein-coding gene in the species Homo sapiens
Chymotrypsin-like elastase family member 2A is an enzyme that in humans is encoded by the CELA2A gene. Elastases form a subfamily of serine proteases that
CELA2A
Pentacyclic chemical compound in plant leaves and fruit
Oleanolic acid is also used as standard for comparison of hyaluronidase, elastase and matrix-metalloproteinase-1 inhibition of other substances in primary
Oleanolic_acid
Inflammation of the pancreas
in other disease states. In chronic pancreatitis, the fecal pancreatic elastase-1 (FPE-1) test is a marker of exocrine pancreatic function. Additional
Pancreatitis
Permanent enlargement of the lung airways
susceptible to bronchiectasis, due to the loss of inhibition to enzyme elastase which cleaves elastin. This decreases the ability of the alveoli to return
Bronchiectasis
Breakdown of proteins into smaller polypeptides or amino acids
chains by digestive enzymes such as pepsin, trypsin, chymotrypsin, and elastase, and into amino acids by various enzymes such as carboxypeptidase, aminopeptidase
Proteolysis
Injectable drug
lysosomal enzymes that cause proteoglycans to dissociate from hyaluronic acid; elastase; metalloproteinases such as stromelysin, which degrade cartilage matrix
Polysulfated glycosaminoglycan
Polysulfated_glycosaminoglycan
Presence of excess fat in feces
days). Other tests include the (13)C-mixed triglycerides test and fecal elastase, to detect possible fat maldigestion due to exocrine pancreatic insufficiency
Steatorrhea
Organ found in mammalian skin
response involves the proteolysis of type XVII collagen by neutrophil elastase in response to the DNA damage in the hair follicle stem cells. Proteolysis
Hair_follicle
cleavage sites for several proteases in the linker region (chymotrypsin, elastase, matrix metalloproteases, cathepsin G, plasmin, urokinase plasminogen activator
Soluble urokinase plasminogen activator receptor
Soluble_urokinase_plasminogen_activator_receptor
Primary organ of the respiratory system
to develop into COPD. Elastase breaks down the elastin in the lung's connective tissue that can also result in emphysema. Elastase is inhibited by the acute-phase
Lung
Protein family
system, inhibit neutrophil elastase strongly while ecotin from the plant pathogen Pantoea citrea inhibits neutrophil elastase 1000-fold less potently. Ecotins
Ecotin
Chemical compound
plasma or sputum samples can be a marker for elastin breakdown due to high elastase activity related to certain diseases. Desmosine and its isomer isodesmosine
Desmosine
These clinical results, associated with a reduction in plasma neutrophil elastase, have implications for better understanding the role of food intolerance
ALCAT_test
Protein-coding gene in the species Homo sapiens
peptides for presentation to the MHC class II. Cathepsin S can function as an elastase over a broad pH range in alveolar macrophages. Cathepsin S is a lysosomal
Cathepsin_S
Common label for a group of three types of fungus
host response ranging from mild to severe. Acid proteinases (proteases), elastase, keratinases, and other proteinases reportedly act as virulence factors
Dermatophyte
disease (AD) and cathepsin B is increased in multiple sclerosis (MS). Elastase, another protease, could have large negative effects on the extracellular
Role_of_microglia_in_disease
Protein-coding gene in the species Homo sapiens
multifunctional inflammatory mediator. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All
Azurocidin_1
Networks of fibres which bind pathogens
Together with content from their azurophilic granules, such as neutrophil elastase (NE) and myeloperoxidase (MPO) neutrophils can externalize their decondensed
Neutrophil extracellular traps
Neutrophil_extracellular_traps
Species of fungus
amount of elastase production and tissue invasion was first discovered in 1984. Clinical isolates have also been found to have greater elastase activity
Aspergillus_fumigatus
Medical condition
Presence of exocrine pancreatic insufficiency (according to monoclonal fecal elastase-1 or direct function tests). Pathological pancreatic imaging: (by endoscopic
Type_3c_diabetes
Loss of hair from the head or body
response involves the proteolysis of type XVII collagen by neutrophil elastase in response to DNA damage in hair follicle stem cells. Proteolysis of collagen
Hair_loss
Nasal condition associated with cocaine use
perinuclear anti-neutrophil cytoplasmic antibody (ANCA) and neutrophil elastase specific ANCA. Although not entirely understood, CIMDL is thought to be
Cocaine-induced midline destructive lesions
Cocaine-induced_midline_destructive_lesions
Enzyme-encoding gene in humans
Chymotrypsin-like elastase family member 1 (CELA1) also known as elastase-1 (ELA1) is an enzyme that in humans is encoded by the CELA1 gene. Elastases form a subfamily
CELA1
Protein family
structure of the complex formed between subtilisin Carlsberg and eglin c, an elastase inhibitor from the leech Hirudo medicinalis. Structural analysis, subtilisin
Subtilase
Highly modified saliva containing zootoxins
Bitis gabonica Fibrinolytic enzyme Crotalinae Prothrombin activator Crotalinae Collagenase Viperidae Elastase Viperidae Lyases Glucosaminate ammonia-lyase
Snake_venom
Name; Designation in the laboratory; Laboratory) Pancreatic elastase;Feces-Pancreatic elastase;Clinical Biochemistry Laboratory; Adenovirus DNA PCR;Adenovirus
List_of_medical_tests
Mammalian protein found in Homo sapiens
elastase and porcine pancreatic elastase toward peptide 4-nitroanilides containing model desmosine residues. Evidence that human leukocyte elastase is
Lysyl_oxidase
Species of bacterium
PMID 14158532. Kamel M, Hanafi M, Bassiouni M (1991). "Inhibition of elastase enzyme release from human polymorphonuclear leukocytes by N-acetyl-galactosamine
Akkermansia_muciniphila
Group of opioid peptides
"Release of opioid peptides, gluten exorphins by the action of pancreatic elastase". FEBS Letters. 412 (3): 475–9. Bibcode:1997FEBSL.412..475F. doi:10
Gluten_exorphin
Epithelium of the inside of the foreskin
glands, which secrete cathepsin B, lysozyme, chymotrypsin, neutrophil elastase, and hormones such as androsterone. The first four substances have protective
Preputial_mucosa
2CHA), chymotrypsinogen (PDB file 1CHG), trypsin (PDB file 1PTN), and elastase (PDB file 1EST). They also were the first protein structures that showed
List of biophysically important macromolecular crystal structures
List_of_biophysically_important_macromolecular_crystal_structures
Medication to treat high blood pressure and alopecia
levels in the mesenteric, abdominal, and renal arteries by a decrease in elastase enzyme activity in these tissues. In rats, potassium channel openers decrease
Minoxidil
Human glycoprotein
proteases, including trypsin, chymotrypsin, kallikrein, plasmin, granulocyte elastase, cathepsin, thrombin, and factors IXa, Xa, XIa, and XlIa. However, although
Ulinastatin
Medical condition
Exocrine pancreatic insufficiency can be confirmed by also checking a fecal elastase level, with low levels specifying exocrine pancreatic insufficiency. A
Chronic_pancreatitis
Genus of roundworms
immune-related host proteases, which include pepsin, trypsin, chymotrypsin/elastase, cathepsins, and metallocarboxypeptidases (MCPs). Ascaris species inhibit
Ascaris
Type of white blood cell
proteoglycans (e.g. heparin and chondroitin), and proteolytic enzymes (e.g. elastase and lysophospholipase). They also secrete lipid mediators like leukotrienes
Basophil
Medical condition
ELANE (formerly ELA2) gene on chromosome 19p13.3, which encodes neutrophil elastase. Over a hundred ELANE mutations have been found in SCN1. This same gene
Severe_congenital_neutropenia
Single-chain polypeptide capable of inhibiting blood clotting Factor Xa
Higuchi DA, Wun TC, Likert KM, Broze GJ (1992). "The effect of leukocyte elastase on tissue factor pathway inhibitor". Blood. 79 (7): 1712–9. doi:10.1182/blood
Tissue factor pathway inhibitor
Tissue_factor_pathway_inhibitor
Absence, blockage, or narrowing of bile ducts in the liver at birth
aflatoxin damaged liver cells and bile duct cells are removed by neutrophil elastase and by involvement of immune system mediators such as CCL-2 or MCP-1, tumor
Biliary_atresia
Type of autoantibody
antigens that may also result in a p-ANCA pattern. These include lactoferrin, elastase, and cathepsin G.[citation needed] When the condition is a vasculitis,
P-ANCA
Protein-coding gene in the species Homo sapiens
Chymotrypsin-like elastase family member 2B is and enzyme that in humans is encoded by the CELA2B gene. Elastases form a subfamily of serine proteases
CELA2B
Digestive system in humans
enzymes which work on proteins, are trypsinogen and chymotrypsinogen. Elastase is also produced. Smaller amounts of lipase and amylase are secreted. The
Human_digestive_system
Short educational film rendered using 3D computer graphics
molecular dynamicists, applied to hydrogen bonds in the active site of elastase". Journal of Molecular Graphics. 7 (4): 240–2, 223–4. doi:10.1016/0263-7855(89)80009-8
Medical_animation
Human protease (enzyme)
serine proteases (NSPs; i.e., cathepsin G, proteinase 3 and neutrophil elastase) as they are synthesised as inactive proenzymes during neutrophil maturation
Cathepsin_C
Genus of cyanophyceae
relationship with fungi to produce a lichen. Scyptolins are a type of elastase inhibitors isolated from some species of Scytonema. A study comparing red
Scytonema
Genus of bacteria
nov., a New Species That Produces a Novel Inhibitor of Human Leukocyte Elastase Isolated from Soil". Current Microbiology. 33 (2): 89–93. doi:10.1007/s002849900080
Flexibacter
Species of fungus
The (+) mating type synthesizes the elastase enzyme, where as the (-) mating type is unable to produce the elastase. Experiments involving the mating types
Microsporum_fulvum
Superfamily of proteins with similar structures and diverse functions
centred on a methionine in alpha1-antitrypsin as an inhibitor of tissue elastase and on arginine in antithrombin as an inhibitor of thrombin. The critical
Serpin
Theory of aging
response involves the proteolysis of type XVII collagen by neutrophil elastase in response to the DNA damage in the hair follicle stem cells. Proteolysis
Stem_cell_theory_of_aging
Medical condition
Briot A, Gonthier M, Lamant L, Dubus P, Monsarrat B, Hovnanian A (2010). "Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function
Trichorrhexis_invaginata
Protein-coding gene in the species Homo sapiens
(MMPs) 2 and 9, which are key effectors of ECM remodeling. MMP9, along with elastase, appears to be a regulatory factor in neutrophil migration across the basement
MMP9
Regenerative medical device platform
vascularogenesis, and modulate matrix metalloproteinase and neutrophil elastase. The porous structure of OFM has been characterized by differential scanning
Ovine_forestomach_matrix
Hollow cavity found in the lungs
alveoli is broken down by an imbalance between the production of neutrophil elastase (elevated by cigarette smoke) and alpha-1 antitrypsin (the activity varies
Pulmonary_alveolus
Staphopain A is elastinolytic to a degree fairly equal to that of neutrophil elastase, and has a very broad specificity proteolysis. Staphopain A is inhibited
Staphopain A (Staphylococcus aureus)
Staphopain_A_(Staphylococcus_aureus)
Movement of cells according to local rigidity gradient
Lutchen, KR; Ingenito, EP; Suki, B (July 2000). "Effects of collagenase and elastase on the mechanical properties of lung tissue strips". Journal of Applied
Durotaxis
Cell membrane engulfing a large particle
conditions for bacteria. Other enzymes like hyaluronidase, lipase, collagenase, elastase, ribonuclease, deoxyribonuclease also play an important role in preventing
Phagocytosis
Genus of fungi
named EI-1941-1 and EI-1941-2. The enzymes they specifically inhibit are elastase and cathepsin B. EI-1941-2 is degraded by the presence of cysteine, but
Farrowia
Chemical compound
against representative serine and cysteine proteases, human leukocyte elastase and cathepsin B (IC50 > 30 μM). Its development was halted in phase Ib
Ciluprevir
Species of bacterium
(including those of medical devices) and production of several enzymes such as elastase and gelatinase. Also relevant might be their ability to survive attacks
Burkholderia_cepacia_complex
Biologist
Steven D.; Weiss, Jerrold; Zychlinsky, Arturo (2005-05-02). "Neutrophil elastase targets virulence factors of enterobacteria". Nature. 417 (6884): 91–94
Arturo_Zychlinsky
American pharmaceutical company
and peripheral arterial disease (PAD). PRT-201 is a recombinant human elastase manufactured for Proteon by Lonza. In September 2008, the company announced
Proteon_Therapeutics
Glycoprotein spike on a viral capsid or viral envelope
this position. Others may be cleaved by extracellular proteases such as elastase, by proteases located on the cell surface after receptor binding, or by
Coronavirus_spike_protein
Selective adenosine A3 receptor modulator
Yoon-Seok (April 2020). "Imbalance Between α1-Antitrypsin and Neutrophil Elastase in Simple Steatosis Promotes Inflammation and Fibrosis Through Regulation
FM101
Mammalian protein found in Homo sapiens
Fink TM, Mattmann C, Lichter P, Jenne DE (September 1992). "Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized
Proteinase_3
ELASTASE
ELASTASE
ELASTASE
ELASTASE
Boy/Male
Hindu, Indian
Lord of Music
Surname or Lastname
English
English : metonymic occupational name for a grower or seller of costards (Anglo-Norman French, from coste ‘rib’), a variety of large apples, so called for their prominent ribs. In some cases, it may have been a nickname (from the same word) for a person with an apple-shaped (i.e. round) head.Dutch : status name for a churchwarden, from Late Latin custor ‘guard’, ‘warden’.Variant spelling of German Koster.This name is recorded in Beverwijck in New Netherland (Albany, NY) in the mid 17th century.
Surname or Lastname
English
English : patronymic from Sprigg.
Girl/Female
Hindu
Respectable
Male
Scottish
Variant spelling of Scottish Gaelic Ian, IAIN means "God is gracious."
Boy/Male
Arabic, Muslim
Gift of Truth Allah
Male
Egyptian
, the deity of the setting sun.
Girl/Female
Hindu
Sweet Basil, Sweet smelling plant
Girl/Female
Danish, French, German, Greek, Norse, Swedish
Pure; Innocent; Form of Catherine
Male
German
German form of Old Norse EirÃkr, ERICH means "ever-ruler."
ELASTASE
ELASTASE
ELASTASE
ELASTASE
ELASTASE