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Protein-coding gene in the species Homo sapiens
repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene. This gene encodes a member of the F-box protein family which is characterized
FBXW7
Medical condition
FBXW7 neurodevelopmental syndrome is a very rare genetic disorder characterized by gastrointestinal, brain, and muscle anomalies accompanied by intellectual
FBXW7 neurodevelopmental syndrome
FBXW7_neurodevelopmental_syndrome
via the ubiquitin-proteasome pathway. The analogous protein in humans is FBXW7. Cdc4 targets primarily cell cycle regulators for proteolysis. It serves
Cell division control protein 4
Cell_division_control_protein_4
Pharmaceutical compound
tumors with specific genetic alterations, including CCNE1 amplifications or FBXW7 and PPP2R1A loss of function mutations. It is currently in phase 1/2 clinical
Lunresertib
MYH11 dominant Feingold syndrome MYCN FG syndrome MED12 FBXW7 neurodevelopmental syndrome FBXW7 Fibular aplasia-ectrodactyly syndrome dominant Fine-Lubinsky
List_of_genetic_disorders
Protein domain
EML3, EML4, EML4-ALK, EML5, ERCC8, FBXW10, FBXW11, FBXW2, FBXW4, FBXW5, FBXW7, FBXW8, FBXW9, FZR1, GEMIN5, GNB1, GNB1L, GNB2, GNB2L1, GNB3, GNB4, GNB5
WD40_repeat
Protein-coding gene in the species Homo sapiens
In human colorectal carcinoma, RICTOR has been shown to association with FBXW7 (outside of mTORC2) to mediate the ubiquitination of growth-promoting factors
RICTOR
Family of viruses
called the LT-stabilization domain (LSD), that binds to and inhibits the FBXW7 E3 ligase regulating both cellular and viral oncoproteins. Unlike for SV40
Polyomaviridae
Protein found in humans
activity ubiquitin-protein transferase activity Cellular component Parkin-FBXW7-Cul1 ubiquitin ligase complex nucleoplasm cytosol cullin-RING ubiquitin
Cullin-1
Series of molecular signals
can be activated by mutations in Notch itself, inactivating mutations in FBXW7 (a negative regulator of Notch1), or rarely by t(7;9)(q34;q34.3) translocation
Notch_signaling_pathway
Type of acute lymphoblastic leukemia
epigenetic regulation have been identified. These mutations activate NOTCH1 and FBXW7, causing the tumour-suppressing gene to lose functionality, thereby leading
T-cell acute lymphoblastic leukemia
T-cell_acute_lymphoblastic_leukemia
Catalytically deficient enzymes
Regulation of signalling complex assembly STYX binds the F-box protein, FBXW7, to inhibit its recruitment to the SCF Ubiquitin ligase complex Pseudoprotease
Pseudoenzyme
Chinese-American academic
Karnak, D., Tan, M., Lawrence, T. S., Morgan, M. A., & Sun, Y. (2016). FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation
Yi_Sun_(academic)
Protein-coding gene in the species Homo sapiens
(ERR-β), estrogen-related receptor gamma (ERR-γ). Farnesoid X receptor FBXW7 MED1, MED12, MED14, MED17, NRF1 Peroxisome proliferator-activated receptor
PGC-1α
Protein-coding gene in the species Homo sapiens
Antibody". www.genecards.org. Retrieved 2020-12-15. "FBXW7 Gene - GeneCards | FBXW7 Protein | FBXW7 Antibody". www.genecards.org. Retrieved 2020-12-15.
C6orf136
Protein-coding gene in the species Homo sapiens
ligases and kinases. FBXW7, a member of the SCF ubiquitin ligase family, targets NFE2L1 for proteolytic degradation by the proteasome. FBXW7 requires the Cdc4
NFE2L1
Type of protein
Charles J.; Hruban, Ralph H.; Kern, Scott E. (October 2003). "BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) Mutations in Distinct Subsets of Pancreatic Cancer"
SCF_complex
Mammalian protein found in humans
(ligase) has been shown to interact with: Alpha-synuclein, CASK, CUL1, FBXW7 and GPR37, HSPA1A, HSPA8, Multisynthetase complex auxiliary component p38
Parkin_(protein)
Member of the cyclin family
is another mechanism. Loss-of-function mutations of FBXW7 were found in several cancer cells. FBXW7 encodes F-box proteins which target cyclin E for ubiquitination
Cyclin_E
Chemical compound
promotes ubiquitin-dependent Notch2 degradation via E3 ligases (KLHL6 and FBXW7), stopping mRNA expression of MYC and KRAS genes, which are involved in
Nirogacestat
Part of the [[exocrine gland]] ductal system in salivary glands
Mutations in PLAG1-intact and HMGA2-intact Cases, and Occasional TP53, FBXW7, and SMARCB1 Alterations in High-grade Cases". American Journal of Surgical
Epithelial-myoepithelial carcinoma
Epithelial-myoepithelial_carcinoma
Protein-coding gene in the species Homo sapiens
with: BTRC, CACYBP, CDCA3, CDK9, CUL1, FBXL3, FBXO4, FBXO5, FBXO7, FBXW2, FBXW7, and SKP2. GRCh38: Ensembl release 89: ENSG00000113558 – Ensembl, May 2017
S-phase kinase-associated protein 1
S-phase_kinase-associated_protein_1
Medical condition
condition has been covered by a small number of news networks from Spain. FBXW7 neurodevelopmental disorder CHAMP1-associated intellectual disability syndrome
Severe intellectual disability-progressive spastic diplegia syndrome
Severe_intellectual_disability-progressive_spastic_diplegia_syndrome
Type of tumor
genes (HES1, HEY2, and MYC), as well as down-regulation of Notch repressor (FBXW7) are found in pediatric ependymoma. Inhibition of Notch pathway impairs
Pediatric_ependymoma
Pediatric oncologist and researcher
hematopoietic stem cells Discovery of MYB duplications in T-ALL Discovery of FBXW7 mutations in T-ALL Discovery of MYBL2 as the crucial 20q tumor suppressor
A._Thomas_Look
RNA molecule
activity by modulating expression of the FBXW7 protein. In particular, overexpression of miR-223 reduces FBXW7 mRNA levels while increasing endogenous
Mir-223
Non-coding RNA in the species Homo sapiens
Facilitates the Progression of Laryngocarcinoma by Targeting the miR-5000-3p/FBXW7 Axis". Molecular and Cellular Biology. 40 (10) e00496-19. doi:10.1128/MCB
MIR22HG
Q9UKT8 5556 FBXW4 HGNC:10847; P57775 5557 FBXW5 HGNC:13613; Q969U6 5558 FBXW7 HGNC:16712; Q969H0 5559 FBXW8 HGNC:13597; Q8N3Y1 5560 FBXW9 HGNC:28136;
List of human protein-coding genes 3
List_of_human_protein-coding_genes_3
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