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Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1
Fibroblast_growth_factor_1
Family of proteins involved in anatomical development
Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by the macrophages. They are involved in a wide variety of processes
Fibroblast_growth_factor
Growth factor and signaling protein otherwise known as FGF2
Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by
Fibroblast_growth_factor_2
Protein-coding gene in mammals
Fibroblast growth factor 21 (FGF-21) is a protein found in humans and other mammals that is encoded by the FGF21 gene. This protein is a member of the
Fibroblast_growth_factor_21
Protein found in humans
Fibroblast growth factor 23 (FGF-23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate
Fibroblast_growth_factor_23
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 8 (FGF-8) is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene belongs to the fibroblast
Fibroblast_growth_factor_8
Protein found in humans
Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome
Fibroblast growth factor receptor 1
Fibroblast_growth_factor_receptor_1
Mammalian protein found in Homo sapiens
Fibroblast growth factor 18 (FGF-18) is a protein that is encoded by the FGF18 gene in humans. The protein was first discovered in 1998, when two newly-identified
Fibroblast_growth_factor_18
Family of proteins that bind to fibroblast growth factors
The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of
Fibroblast growth factor receptor
Fibroblast_growth_factor_receptor
Cytokine
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different
Transforming growth factor beta
Transforming_growth_factor_beta
Protein or other substance that stimulates cellular proliferation
Ephrin Fibroblast growth factor (FGF) Foetal Bovine Somatotrophin (FBS) GDNF family of ligands Growth differentiation factor-9 (GDF9) Hepatocyte growth factor
Growth_factor
This article is about the role of fibroblast growth factor signaling in mesoderm formation. Mesoderm formation is a complex developmental process involving
Fibroblast growth factor and mesoderm formation
Fibroblast_growth_factor_and_mesoderm_formation
RNA element
The FGF-1 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of fibroblast growth factor 1 and allows cap-independent
FGF-1 internal ribosome entry site (IRES)
FGF-1_internal_ribosome_entry_site_(IRES)
Gene involved in the most common form of dwarfism
Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster
Fibroblast growth factor receptor 3
Fibroblast_growth_factor_receptor_3
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster
Fibroblast growth factor receptor 4
Fibroblast_growth_factor_receptor_4
Factor that stimulates the growth of bone tissue
insulin-like growth factor-2 (IGF-2), transforming growth factor beta (TGF-β), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), parathyroid
Bone_growth_factor
Biomarker indicative of breast cancer patients' prognosis
cell culture system, rat kidney fibroblasts. Application of the transforming growth factors to normal rat kidney fibroblasts induces the cultured cells to
Transforming_growth_factor
Protein found in humans
Insulin-like growth factor 1 (IGF1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in
Insulin-like_growth_factor_1
Protein-coding gene in the species Homo sapiens
Teratocarcinoma-derived growth factor 1 is a protein that in humans is encoded by the CRIPTO gene (previously TDGF1). The protein is an extracellular
Teratocarcinoma-derived growth factor 1
Teratocarcinoma-derived_growth_factor_1
Protein found in humans
Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene. The protein encoded by this gene is a member of the
Fibroblast growth factor receptor-like 1
Fibroblast_growth_factor_receptor-like_1
Cells responsible for connecting and repairing skin layers
fibroblast growth factor (FGF). Fibroblasts do not appear to be fully differentiated or specialized. After examining the CD markers of the fibroblast
Dermal_fibroblast
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects
FGF19
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene
Fibroblast growth factor receptor 2
Fibroblast_growth_factor_receptor_2
Transmembrane protein
epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Class of enzymes
tumors. Fibroblast growth factors comprise the largest family of growth factor ligands at 23 members. The natural alternate splicing of four fibroblast growth
Receptor_tyrosine_kinase
Series of events that restore integrity to damaged tissue after an injury
macrophage and mast cells release fibroblast growth and chemotactic factors to activate fibroblasts from adjacent tissue. Fibroblasts at this stage loosen themselves
Wound_healing
Blood vessel formation, when new vessels emerge from existing vessels
prostaglandins, including several growth factors e.g. VEGF, FGF. The fibroblast growth factor (FGF) family with its prototype members FGF-1 (acidic FGF) and FGF-2
Angiogenesis
Signaling glycoprotein regulating cell proliferation
the growth of blood vessels from already-existing blood vessel tissue, mitogenesis, i.e. proliferation, of mesenchymal cells such as fibroblasts, osteoblasts
Platelet-derived growth factor
Platelet-derived_growth_factor
Protein-coding gene in the species Homo sapiens
Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein
TGF_beta_1
Pharmaceutical compound
Efimosfermin alfa (development code BOS-580) is a long-acting fibroblast growth factor 21 analog that can be injected once monthly. It was acquired by
Efimosfermin_alfa
Cell surface receptors
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family
Platelet-derived growth factor receptor
Platelet-derived_growth_factor_receptor
Medication
cholangiocarcinoma (bile duct cancer). It is a kinase inhibitor that blocks fibroblast growth factor receptor 2. It is taken by mouth. Lirafugratinib was approved for
Lirafugratinib
List of pharmaceutical drugs under clinical development for treatment of depression
antagonist and dopamine D4 receptor antagonist Fibroblast growth factor 1 (FGF-1) – fibroblast growth factor receptor (FGFR) agonist Filorexant (MK-6096)
List of investigational antidepressants
List_of_investigational_antidepressants
Protein-coding gene in the species Homo sapiens
1998). "S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro". The Journal of Biological Chemistry
SYT1
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene. The protein encoded by this gene is a substrate
FRS3
Family of biomolecules
factors include: glia maturation factor, insulin, insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), fibroblast growth factor
Neurotrophic_factors
Experimental drug
investigational drug developed by Akero Therapeutics, acting as a fibroblast growth factor 21 (FGF21) analog developed to treat metabolic dysfunction-associated
Efruxifermin
Genetic disorder of the skull
caused by mutations in the fibroblast growth factor receptors FGFR1 and FGFR2. The syndrome is grouped into three types: type 1 (classic Pfeiffer syndrome)
Pfeiffer_syndrome
Mammalian protein found in Homo sapiens
Fibroblast growth factor 5 is a protein that in humans is encoded by the FGF5 gene. The majority of FGF family members are glycosaminoglycan binding proteins
FGF5
Investigational drug
Loxo Oncology for the treatment of genitourinary cancer. It is a fibroblast growth factor receptor 3 antagonist. "Vepugratinib". AdisInsight. Springer Nature
Vepugratinib
Topics referred to by the same term
one of the Hamburger–Hamilton stages in chick development Fibroblast growth factor receptor 1 (HH2) HH2, a model in the series of Honda Acty trucks Kaman
HH2
Human recombinant FGF18
Sprifermin (INN; development code AS-902330) is a recombinant human fibroblast growth factor 18 (rhFGF18) analog, originally developed by Merck, and now being
Sprifermin
InterPro family
the epithelium. KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b). For signalling to occur, a dimer is required
Keratinocyte_growth_factor
Mammalian protein found in Homo sapiens
Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells
Hepatocyte_growth_factor
Investigational drug
for the treatment of achondroplasia and solid tumors. It is a fibroblast growth factor receptor 3 receptor antagonist. "Dabogratinib - TYRA Biosciences"
Dabogratinib
First stage of pregnancy
histamine-releasing factor Tissue plasminogen activator as well as its inhibitors Estradiol β1-integrins Fibroblast growth factor Transforming growth factor alpha Inhibin
Implantation_(embryology)
Type of brain cell
neuronal cell specification, canonical signaling factors like sonic hedgehog (SHH), fibroblast growth factor (FGFs), WNTs and bone morphogenetic proteins
Astrocyte
Protein-coding gene in the species Homo sapiens
Glia-activating factor is a protein that in humans is encoded by the FGF9 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF)
FGF9
Chemical compound
resemble those of endogenous proneurogenic peptides such as fibroblast growth factor 1 (FGF-1), and the proneurogenic activity of P7C3 was around thirty
P7C3
TrkA and TrkB positive modulator
kinases, including the insulin-like growth factor 1 receptor (IGF1R) and the fibroblast growth factor receptor 1 (FGFR1). However, its efficacies at the
ACD856
Enzyme in humans
Substance P (SP), and B-type natriuretic peptide (BNP), human fibroblast growth factor 21 (FGF-21), human alpha2 antiplasmin and denatured collagen I
Fibroblast activation protein, alpha
Fibroblast_activation_protein,_alpha
Investigational sexual dysfunction drugs
testosterone (androgen) – female sexual dysfunction [47] Fibroblast growth factor 1 (FGF-1; FGF1; Acidic FGF; aFGF; Cardio Vascu-Grow; CVBT-141P; CVBT-141S;
List of investigational sexual dysfunction drugs
List_of_investigational_sexual_dysfunction_drugs
Protein-coding gene in humans
identified as Macrophage inhibitory cytokine-1 (MIC-1). It is a protein belonging to the transforming growth factor beta superfamily. Under normal conditions
GDF15
Protein-coding gene in the species Homo sapiens
heparin-binding epidermal growth factor-like growth factor on pterygium epithelial cells and fibroblasts". Invest. Ophthalmol. Vis. Sci. 45 (1): 110–3. doi:10.1167/iovs
Heparin-binding EGF-like growth factor
Heparin-binding_EGF-like_growth_factor
Chemical compound
collagen and glycosaminoglycan synthesis in skin fibroblasts and promotion of blood vessels growth. Recent studies revealed its ability to modulate expression
Copper_peptide_GHK-Cu
Biological process in primates
induce the expression of growth factors, such as amphiregulin, epidermal growth factor (EGF), IGF-1, and fibroblast growth factor (FGF), which in turn have
Breast_development
Genetic disorder of the skull and face
a gene on chromosome 10 that controls the body's production of fibroblast growth factor receptor 2 (FGFR2). Crouzon syndrome is named for Octave Crouzon
Crouzon_syndrome
348.383.110 – fibroblast growth factor 1 MeSH D23.348.383.120 – fibroblast growth factor 2 MeSH D23.348.383.130 – fibroblast growth factor 3 MeSH D23.348
List_of_MeSH_codes_(D23)
Protein
Transforming growth factor alpha (TGF-α) is a protein that in humans is encoded by the TGFA gene. As a member of the epidermal growth factor (EGF) family
TGF_alpha
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene. The protein encoded by this gene is a member of the fibroblast growth
FGF13
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene. FGFBP1, or HBP17, binds to both acidic FGF1 and basic
FGFBP1
Pharmaceutical compound
(AZD4547) is an experimental drug which acts as an inhibitor of the fibroblast growth factor receptors, having high affinity for FGFR1, FGFR2 and FGFR3 and
Fexagratinib
Chemical compound
Specifically, it inhibits fibroblast growth factor receptors (FGFRs) 1–3, janus kinase (JAK) 1/2, vascular endothelial growth factor receptors (VEGFRs), and
Tinengotinib
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 14 is a biologically active protein that in humans is encoded by the FGF14 gene. The protein encoded by this gene is a member
FGF14
Protein-coding gene in the species Homo sapiens
Vestweber D (Mar 1995). "The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor". Nature. 373 (6515): 615–20. Bibcode:1995Natur
GLG1
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene. The protein encoded by this gene is a member of the fibroblast growth
FGF12
Protein-coding gene in the species Homo sapiens
1998). "S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro". The Journal of Biological Chemistry
S100A13
Disease that causes scarring of the lungs
receptors (including platelet-derived growth factor, fibroblast growth factor, and vascular endothelial growth factor). A randomized clinical trial showed
Pulmonary_fibrosis
RNA family
entry site is an RNA element present in the 5' UTR of the mRNA of fibroblast growth factor-2. It has been found that the FGF-2 internal ribosome entry site
FGF-2 internal ribosome entry site (IRES)
FGF-2_internal_ribosome_entry_site_(IRES)
Formation of blood vessels
These growth factors often act in a paracrine or autocrine fashion; they include fibroblast growth factor, placental growth factor, insulin-like growth factor
Vascularisation
Experimental drug for the treatment of achondroplasia
disproportionate growth. Achondroplasia is caused by a genetic mutation that increases the activity of a certain growth regulation gene called fibroblast growth factor
Vosoritide
Protein-coding gene in the species Homo sapiens
Hayashi H, Misono T, Kaul SC, Wadhwa R, Imamura T (Oct 1999). "Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin".
HSPA9
Fibroblast growth factor 11 also known as FGF11 is a human gene. The protein encoded by this gene is a member of the intracellular fibroblast growth factor
FGF11
Form of localized cell signaling
similar structures: fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective
Paracrine_signaling
Chemical compound
treatment of other types of solid tumors. Surufatinib targets fibroblast growth factor receptor 1 (FGFR1). Syed YY (April 2021). "Surufatinib: First Approval"
Surufatinib
Protein-coding gene in humans
of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during
FGF3
Novel gene
(EMS). The study aimed to identify the partner genes to the fibroblast growth factor receptor 1 (FGFR1) involved in the syndrome. Using the 5'-RACE PCR technique
FGFR1OP2
Medical condition
disorder caused by an autosomal dominant genetic defect in the fibroblast growth factor receptor 3 gene (FGFR3) that results in a disproportionately short
Hypochondroplasia
Tumour-promoting cell type
secreting growth factors such as Vascular Endothelial Growth Factor (VEGF), Platelet Derived Growth Factor (PDGF) and Fibroblast Growth Factor (FGF) and other
Cancer-associated_fibroblast
Class of proteins
Hemopoietic growth factors regulate the differentiation and proliferation of particular progenitor cells. Made available through recombinant DNA technology
Hemopoietic_growth_factor
Human enzyme
be a circulating factor detectable in serum that declines with age. β-Klotho: The binding of the endocrine fibroblast growth factors (FGF's, viz., FGF19
Klotho_(biology)
Protein-coding gene in the species Homo sapiens
Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene. Acidic fibroblast growth factor is
FIBP
Protein fold
interleukin 1 cytokine family (interleukin-1 alpha, interleukin-1 beta and interleukin-1 receptor antagonist); and in fibroblast growth factors 1 and 2. CATH
Beta_trefoil_fold
Experimental drug
HEC88473 is an experimental dual GLP-1 and fibroblast growth factor 21 (FGF21) receptor agonist. It is developed by the Chinese company HEC Pharm for diabetes
HEC88473
Human chromosome
double SH3 domain protein 1 FGF1: fibroblast growth factor 1 (acidic fibroblast growth factor) FGFR4: fibroblast growth factor receptor 4 GM2A: GM2 ganglioside
Chromosome_5
Bone marrow cell which produces platelets
production of regulatory factors such as CXCL4 (platelet factor 4), transforming growth factor-β1, and fibroblast growth factor 1. Cycling megakaryocytes:
Megakaryocyte
Genetic condition, the most common form of dwarfism
immunodeficiency. Achondroplasia is caused by a mutation in the fibroblast growth factor receptor 3 (FGFR3) gene (located in chromosome 4) that results
Achondroplasia
Medication
hypochondroplasia. Infigratinib is an oral small molecule that targets the fibroblast growth factor receptors FGFR1, FGFR2, and FGFR3. Unlike other therapeutics in
Infigratinib
Protein family
ligands including fibroblast growth factors, vascular endothelial growth factor, transforming growth factor-beta, fibronectin and antithrombin-1. Interactions
Syndecan
Chemical compound
the VEGF receptors 1, 2 and 3, as well as the fibroblast growth factor receptors 1 and 2, and the platelet-derived growth factor receptors alpha and
Lucitanib
Protein-coding gene in the species Homo sapiens
GRB14 has been shown to interact with Epidermal growth factor receptor, Fibroblast growth factor receptor 1 and TNKS2. GRCh38: Ensembl release 89: ENSG00000115290
GRB14
Endogenous tag expressed in different cells along neurogenesis and differentiated cells
"Characterization of induced neural progenitors from skin fibroblasts by a novel combination of defined factors". Scientific Reports. 3 1345. Bibcode:2013NatSR
Neuronal_lineage_marker
625 – epidermal growth factor MeSH D12.644.276.750 – fibroblast growth factors MeSH D12.644.276.750.110 – fibroblast growth factor 1 MeSH D12.644.276
List_of_MeSH_codes_(D12.644)
Protein-coding gene in the species Homo sapiens
growth factor is a protein that in humans is encoded by the FGF7 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF)
FGF7
Protein involved in blood clotting, wound healing and inflammation
glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor". Biochemistry. 33 (46):
Platelet_factor_4
Chemical compound
targeting vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Ofev was developed
Nintedanib
Secreted glycoprotein of the extracellular matrix
assessment and mutation analysis of Kallmann syndrome 1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1, or KAL2) in five families and 18 sporadic patients"
Anosmin-1
Measurable indicators of diabetes
Oxytocin (OXT) Omentin Endothelin-1 Nesfatin-1 Irisin Betatrophin Hepatocyte growth factor (HGF) Fibroblast growth factor -Biomarkers with insulin-sensitizing
Biomarkers_of_diabetes
Protein-coding gene in humans
Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene. The protein encoded by this gene is a member of the fibroblast growth
FGF6
Chemical compound
(KIN-3248) is an experimental anticancer medication which acts as a fibroblast growth factor receptor inhibitor (FGFRi) and is in early stage human clinical
Resigratinib
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FIBROBLAST GROWTH-FACTOR-1
FIBROBLAST GROWTH-FACTOR-1
FIBROBLAST GROWTH-FACTOR-1
FIBROBLAST GROWTH-FACTOR-1
FIBROBLAST GROWTH-FACTOR-1
FIBROBLAST GROWTH-FACTOR-1
FIBROBLAST GROWTH-FACTOR-1
FIBROBLAST GROWTH-FACTOR-1
FIBROBLAST GROWTH-FACTOR-1
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