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Search references for HDAC8. Phrases containing HDAC8
See searches and references containing HDAC8!HDAC8
Protein-coding gene in the species Homo sapiens
Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene. Histones play a critical role in transcriptional regulation, cell cycle
HDAC8
Biological processes used in gene regulation
cross-talk between factors. HDAC3 has been found to be most closely related to HDAC8. HDAC3 contains a non-conserved region in the C-terminal region that was
Histone acetylation and deacetylation
Histone_acetylation_and_deacetylation
Medical condition
found (SMC1A, SMC3 and HDAC8, RAD21) that cause CdLS when changed. In July 2012, the fourth "CdLS gene"—HDAC8—was announced. HDAC8 is an X-linked gene,
Cornelia_de_Lange_syndrome
Medical condition
found to be linked to the X chromosome and caused by a mutation in the HDAC8 gene, which is located on the q arm at locus 13.1. Individuals with Wilson–Turner
Wilson–Turner_syndrome
Congenital extreme form of developmental delay and neoteny
mutations in a set of genes. Mutations in three of these genes (DDX3X, TLK2 and HDAC8) were shared with those found in databases of individuals with developmental
Neotenic_complex_syndrome
Chemical compound (CH3CH2CH2COOH)
HCA2. It is also an HDAC inhibitor (specifically, HDAC1, HDAC2, HDAC3, and HDAC8), a drug that inhibits the function of histone deacetylase enzymes, thereby
Butyric_acid
Medication used for epilepsy, bipolar disorder and migraine
deacetylase inhibitor, specifically of the class I HDAC1, HDAC2, HDAC3, and HDAC8, but not of other HDACs. Earlier studies found a wide range of inhibitory
Valproate
Pharmaceutical compound
1,510 HDAC2 750 HDAC3 96 HDAC4 >20,000 HDAC5 >20,000 HDAC6 >20,000 HDAC7 >20,000 HDAC8 >20,000 HDAC9 >20,000 HDAC10 6,640–10,000 HDAC11 27,700 Refs:
RGFP963
Chemical compound
The GCS regulates glycine concentrations. HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are targets of the reduced form (open dithiol) of (R)-lipoic
Lipoic_acid
Protein complex that regulates the separation of sister chromatids during cell division
Cornelia de Lange Syndrome (CdLS) Cause: Mutations in NIPBL, SMC1A, SMC3, HDAC8, and RAD21. Symptoms: Growth retardation, intellectual disability, and limb
Cohesin
Chemical compound
HDAC1 5,300 HDAC2 ND HDAC3 2,400 HDAC4 4,500 HDAC5 ND HDAC6 48,500 HDAC7 ND HDAC8 ND HDAC9 ND HDAC10 ND HDAC11 ND Note: BHB can circulate at mM levels. Refs:
Β-Hydroxybutyric_acid
Pharmaceutical compound
>80,000 nM). Potential actions against other HDACs, such as HDAC4, HDAC7, HDAC8, and HDAC9, were not described. The drug has been found to enhance CREB-mediated
Tianeptinaline
Pharmaceutical compound
HDAC2 3,010–17,680 HDAC3 80–401 HDAC4 >20,000 HDAC5 >20,000 HDAC6 >20,000 HDAC7 >20,000 HDAC8 >100,000 HDAC9 >20,000 HDAC10 >20,000 HDAC11 >20,000 Refs:
RGFP966
Pharmaceutical compound
I HDAC1, HDAC2, and HDAC3, the class IIb HDAC6, and weakly the class I HDAC8, with no significant inhibition of the class IIa HDAC4, HDAC5, HDAC7, or
Crebinostat
Form taken by the inactive X chromosome in a female somatic cell
includes the bi-allelic expression of X-linked genes such as TBL1X and HDAC8, which may alter key pathways of transcriptional regulation, contributing
Barr_body
Pharmaceutical compound
HDACs, with IC50 values of 2,000 to 5,000 nM at HDAC1, HDAC2, HDAC7, and HDAC8 and no significant inhibition of other HDACs including HDAC3, HDAC4, HDAC5
CKD-506
syndrome SLC4A11 autosomal recessive Cornelia de Lange syndrome (CDLS) HDAC8, SMC1A, NIPBL, SMA3, RAD21 1:10,000-30,000 Cowden syndrome PTEN 1:200,000
List_of_genetic_disorders
Pharmaceutical compound
41–636 HDAC2 147–696 HDAC3 46–472 HDAC4 >33,000 HDAC5 >33,000 HDAC6 >33,000 HDAC7 >33,000 HDAC8 >33,000 HDAC9 >33,000 HDAC10 >10,000 HDAC11 >10,000 Refs:
Tacedinaline
Pharmaceutical compound
1,140–5,200 nM and 3,000 nM, respectively). It shows weak inhibition of HDAC8 and no inhibition of several other HDACs, including HDAC4, HDAC5, HDAC6
RGFP136
inhibit four specific histone-modifying enzymes: HDAC1, HDAC2, HDAC3, and HDAC8. Most of the animal research with HDAC inhibitors has been conducted with
Treatment and management of addiction
Treatment_and_management_of_addiction
Chemical compound
were 4.99 nM, 5.21 nM, 27.6 nM, 16.4 nM and 24.3 nM, respectively), except HDAC8 (IC50 value was 486 nM) that needed a much higher concentration for the
Trichostatin_A
Pharmaceutical compound
have 10- to 21-fold selectivity for HDAC6 over HDAC1, HDAC2, HDAC3, and HDAC8 and greater than 1,000-fold selectivity for HDAC6 over other HDACs. It has
Ricolinostat
Class of enzymes important in regulating DNA transcription
Class I HDACs, HDAC1, 2, and 3 are found primarily in the nucleus, whereas HDAC8 is found in both the nucleus and the cytoplasm, and is also membrane-associated
Histone_deacetylase
Protein-coding gene in the species Homo sapiens
Chen J, Cao L, Ma J, Yue C, Zhu D, An R, Wang X, Guo Y, Gu B (2022). "HDAC8 Promotes Liver Metastasis of Colorectal Cancer via Inhibition of IRF1 and
SUCNR1
Protein
inhibit four specific histone-modifying enzymes: HDAC1, HDAC2, HDAC3, and HDAC8. Most of the animal research with HDAC inhibitors has been conducted with
FOSB
Pharmaceutical compound
400-fold selectivity over HDAC3 (IC50 = 398–458 nM) and no inhibition of HDAC8 or class II HDACs (IC50 = >30,000 nM). However, although originally reported
BRD-6929
Japanese molecular biologist (born 1965)
Nature paper tracing a form of Cornelia de Lange syndrome to mutations in HDAC8 and showing how they disturb the cohesin acetylation cycle. Three years
Katsuhiko_Shirahige
Compounds that inhibit histone deacetylases
were 4.99 nM, 5.21 nM, 27.6 nM, 16.4 nM and 24.3 nM, respectively), except HDAC8 (IC50 value was 486 nM) that needed a much higher concentration for the
Histone_deacetylase_inhibitor
Pharmaceutical compound
activity against the class IIa HDAC5 was observed. Activities at the class I HDAC8 and at the class IIb HDAC4, HDAC7, and HDAC9 were not assessed nor described
Neurinostat
cohesinopathies. Genetic alterations in genes NIPBL, SMC1A, SMC3, RAD21 and HDAC8 are associated with Cornelia de Lange Syndrome. The proteins encoded by
Establishment of sister chromatid cohesion
Establishment_of_sister_chromatid_cohesion
Chemical compound
HDAC1 133–198 HDAC2 293–325 HDAC3 136–157 HDAC4 1,059 HDAC5 532 HDAC6 312–315 HDAC7 524 HDAC8 837–854 HDAC9 512–541 HDAC10 331–340 HDAC11 287–292 Refs:
Givinostat
Pharmaceutical drug
(nM) HDAC1 1–48 HDAC2 2–73 HDAC3 3–21 HDAC4 >25,000 HDAC5 >15,000 HDAC6 0.5–100 HDAC7 >25,000 HDAC8 290–1,410 HDAC9 >25,000 HDAC10 60 HDAC11 31 Refs:
Vorinostat
Chemical compound
concentration (nM) HDAC1 0.3 HDAC2 0.8–2.0 HDAC3 0.6 HDAC4 1,970 HDAC5 352 HDAC6 4.1 HDAC7 >20,000 HDAC8 >15,000 HDAC9 >15,000 HDAC10 ND HDAC11 ND Refs:
Martinostat
Pharmaceutical compound
306–753 HDAC3 248–1,577 HDAC4 >100,000 HDAC5 >30,000 HDAC6 >100,000 HDAC7 >30,000 HDAC8 2,700–82,500 HDAC9 >30,000 HDAC10 94,700 HDAC11 >10,000 Refs:
Entinostat
Field of study
three classes of HDACs are class I, consisting of HDAC1, HDAC2, HDAC3, HDAC8, class II, consisting of HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, HDAC10, class
Epigenetics of anxiety and stress–related disorders
Epigenetics_of_anxiety_and_stress–related_disorders
(2001). "Cloning and characterization of a novel human histone deacetylase, HDAC8". Biochem. J. 350 (1): 199–205. doi:10.1042/0264-6021:3500199. PMC 1221242
HIST4H4
Q9UQL6 6967 HDAC6 HGNC:14064; Q9UBN7 6968 HDAC7 HGNC:14067; Q8WUI4 6969 HDAC8 HGNC:13315; Q9BY41 6970 HDAC9 HGNC:14065; Q9UKV0 6971 HDAC10 HGNC:18128;
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
Protein-coding gene in humans
(2001). "Cloning and characterization of a novel human histone deacetylase, HDAC8". Biochem. J. 350 (1): 199–205. doi:10.1042/0264-6021:3500199. PMC 1221242
HIST3H3
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HDAC8
HDAC8
HDAC8
HDAC8
HDAC8
HDAC8
HDAC8
HDAC8
HDAC8
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