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HDAC9

  • HDAC9
  • Protein-coding gene in the species Homo sapiens

    Histone deacetylase 9 is an enzyme that in humans is encoded by the HDAC9 gene. Histones play a critical role in transcriptional regulation, cell cycle

    HDAC9

    HDAC9

    HDAC9

  • Histone acetylation and deacetylation
  • Biological processes used in gene regulation

    discovered variants of HDAC9 including HDAC9a, HDAC9b and HDAC9c/HDRP, while more have been suspected. The variants of HDAC9 have been found to have

    Histone acetylation and deacetylation

    Histone acetylation and deacetylation

    Histone_acetylation_and_deacetylation

  • Caffeine dependence
  • Medical condition

    GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences

    Caffeine dependence

    Caffeine dependence

    Caffeine_dependence

  • Substance dependence
  • Need for a drug, whose discontinuation results in withdrawal symptoms

    GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences

    Substance dependence

    Substance_dependence

  • Butyric acid
  • Chemical compound (CH3CH2CH2COOH)

    bound HDAC6 2,000,000 Lower bound HDAC7 2,000,000 Lower bound HDAC8 15,000 HDAC9 2,000,000 Lower bound CA1 511,000 CA2 1,032,000 GPCR target pEC50 Entry

    Butyric acid

    Butyric acid

    Butyric_acid

  • Motivational salience
  • Cognitive process

    GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences

    Motivational salience

    Motivational_salience

  • Reward system
  • Group of neural structures responsible for motivation and desire

    GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences

    Reward system

    Reward system

    Reward_system

  • Substance use disorder
  • Continual use of drugs despite negative consequences

    GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences

    Substance use disorder

    Substance use disorder

    Substance_use_disorder

  • Behavioral addiction
  • Compulsion to engage in a non-substance related behavior

    GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences

    Behavioral addiction

    Behavioral_addiction

  • Cannabis use disorder
  • Continued use of cannabis despite clinically significant impairment

    GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences

    Cannabis use disorder

    Cannabis use disorder

    Cannabis_use_disorder

  • Sexual addiction
  • Proposed compulsive sexual disorder

    GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences

    Sexual addiction

    Sexual_addiction

  • Addiction
  • Disorder resulting in compulsive behaviors

    GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences

    Addiction

    Addiction

    Addiction

  • IPEX syndrome
  • Medical condition

    in Treg cells. FOXP3 forms complexes with histone deacetylase (HDAC)7, HDAC9, and the histone acetyl transferase TIP60, which alters epigenetic activity

    IPEX syndrome

    IPEX syndrome

    IPEX_syndrome

  • Amphetamine dependence
  • Medical condition

    GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences

    Amphetamine dependence

    Amphetamine dependence

    Amphetamine_dependence

  • USF1
  • Protein-coding gene in the species Homo sapiens

    genes to regulate chromatin structure and gene transcription. In contrast, HDAC9 deacetylates USF1 during cell fasting, prevents the recruitment of USF1-interacting

    USF1

    USF1

    USF1

  • Histone deacetylase
  • Class of enzymes important in regulating DNA transcription

    androgen receptor, Tip60 Maintenance of vascular integrity, increase in MMP10 HDAC9 1 Nucleus / cytoplasm brain, skeletal muscle – FOXP3 Cardiac defect IIB

    Histone deacetylase

    Histone deacetylase

    Histone_deacetylase

  • Treatment and management of addiction
  • GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences

    Treatment and management of addiction

    Treatment_and_management_of_addiction

  • FOSB
  • Protein

    GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences

    FOSB

    FOSB

    FOSB

  • MEF2C
  • Protein-coding gene in the species Homo sapiens

    proteolytic cleavage. MEF2C has been shown to interact with: EP300, HDAC4, HDAC7, HDAC9, MAPK7, SOX18 SP1, and TEAD1. SETD1A This gene is involved in cardiac morphogenesis

    MEF2C

    MEF2C

    MEF2C

  • EHMT2
  • Protein-coding gene in the species Homo sapiens

    GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ... Dependence Concepts Adverse childhood experiences

    EHMT2

    EHMT2

    EHMT2

  • CHUK
  • Protein-coding gene in humans

    have an anti-tumorigenic effect. IKK-α has been shown to interact with: HDAC9, AKT1, CTNNB1, FANCA, IKBKG IKK2, IRAK1, MAP3K14, MAP3K7, MAP3K8, NFKBIA

    CHUK

    CHUK

    CHUK

  • SUV39H1
  • Protein-coding gene in humans

    SUV39H1 has been shown to interact with: CBX1, CBX5, DNMT3A, HDAC1, HDAC3, HDAC9, Histone deacetylase 2, MBD1, RUNX1, Retinoblastoma protein, and SBF1. PIN1

    SUV39H1

    SUV39H1

    SUV39H1

  • Myocyte-specific enhancer factor 2A
  • Protein-coding gene in the species Homo sapiens

    enhancer factor 2A has been shown to interact with: ASCL1, EP300, HDAC4, HDAC9, Histone deacetylase 5, MAPK14, MEF2D, Mothers against decapentaplegic homolog

    Myocyte-specific enhancer factor 2A

    Myocyte-specific enhancer factor 2A

    Myocyte-specific_enhancer_factor_2A

  • Protein BTG2
  • Protein-coding gene in the species Homo sapiens

    has been shown to interact with PRMT1, HOXB9, CNOT8 and HDAC1 HDAC4 and HDAC9. It has also been studied with Pax6 and Tbr2 when observing the role of

    Protein BTG2

    Protein BTG2

    Protein_BTG2

  • IKK2
  • Protein-coding gene in the species Homo sapiens

    with knee osteoarthritis. IKK-β (IKBKB) has been shown to interact with HDAC9, CDC37, CHUK CTNNB1, FANCA, IKBKG IRAK1, NFKBIA, MAP3K14, NFKB1, NFKBIB

    IKK2

    IKK2

    IKK2

  • CBX5 (gene)
  • Protein-coding gene in humans

    (gene) has been shown to interact with: CBX1, CBX3, CHAF1A, DNMT3B, HDAC4, HDAC9, Histone deacetylase 5, Ku70, Lamin B receptor, MBD1, MIS12, SMARCA4, SUV39H1

    CBX5 (gene)

    CBX5 (gene)

    CBX5_(gene)

  • HDAC1
  • Protein-coding gene in the species Homo sapiens

    Micheli L, D'Andrea G, Leonardi L, Tirone F (July 2017). "HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle

    HDAC1

    HDAC1

    HDAC1

  • List of human protein-coding genes 4
  • Q9UBN7 6968 HDAC7 HGNC:14067; Q8WUI4 6969 HDAC8 HGNC:13315; Q9BY41 6970 HDAC9 HGNC:14065; Q9UKV0 6971 HDAC10 HGNC:18128; Q969S8 6972 HDAC11 HGNC:19086;

    List of human protein-coding genes 4

    List_of_human_protein-coding_genes_4

  • Epigenetics of anxiety and stress–related disorders
  • Field of study

    HDAC2, HDAC3, HDAC8, class II, consisting of HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, HDAC10, class III, consisting of NAD+-dependent HDACS, and class IV, consisting

    Epigenetics of anxiety and stress–related disorders

    Epigenetics_of_anxiety_and_stress–related_disorders

  • Nuclear receptor co-repressor 1
  • Protein found in humans

    Calcitriol receptor GPS2, Glucocorticoid receptor, HDAC3, HDAC4, HDAC7A, HDAC9, HEY2, Histone deacetylase 5, MAP3K7IP2, MECP2, Peroxisome proliferator-activated

    Nuclear receptor co-repressor 1

    Nuclear receptor co-repressor 1

    Nuclear_receptor_co-repressor_1

  • HDAC4
  • Protein found in humans

    Micheli L, D'Andrea G, Leonardi L, Tirone F (July 2017). "HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle

    HDAC4

    HDAC4

    HDAC4

  • HDAC3
  • Protein-coding gene in humans

    with: CBFA2T3, CCND1, GATA1, GATA2, GPS2, GTF2I, HDAC4, HDAC5, HDAC7A, HDAC9, MAP3K7IP2, MAPK11, NCOR1, NCOR2, PPARD, PPARG, PML RBBP4, RELA, RP, RUNX2

    HDAC3

    HDAC3

    HDAC3

  • SIN3A
  • Protein-coding gene in the species Homo sapiens

    Mad-Max complex. SIN3A has been shown to interact with: CABIN1 HBP1, HDAC1, HDAC9, Histone deacetylase 2, Host cell factor C1, IKZF1, ING1, KLF11, MNT, MXD1

    SIN3A

    SIN3A

    SIN3A

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