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One of several isotypes of antibody
Immunoglobulin M (IgM) is the largest of several isotypes of antibodies (also known as immunoglobulin) that are produced by vertebrates. IgM is the first
Immunoglobulin_M
Antibody isotype
Immunoglobulin G (IgG) is a type of antibody. Representing approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found
Immunoglobulin_G
Antibody that plays a crucial role in the immune function of mucous membranes
Immunoglobulin A (IgA, also referred to as sIgA in its secretory form) is an antibody that plays a role in the immune function of mucous membranes. The
Immunoglobulin_A
Protein(s) forming a major part of an organism's immune system
An antibody (Ab), or immunoglobulin (Ig), is a large protein belonging to the immunoglobulin superfamily which is used by the immune system to identify
Antibody
Protein-coding gene in humans
facilitates the transcytosis of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M (pIg) and immune complexes. pIgRs are mainly located on
Polymeric immunoglobulin receptor
Polymeric_immunoglobulin_receptor
Medical condition
Hyper IgM syndrome type 1 (HIGM-1) is the X-linked variant of the hyper IgM syndrome. The affected individuals are virtually always male, because males
Hyper-IgM_syndrome_type_1
Medical condition
Isolated primary immunoglobulin M deficiency is a poorly defined dysgammaglobulinemia. It is characterized by decreased levels of IgM. The levels of other
Isolated primary immunoglobulin M deficiency
Isolated_primary_immunoglobulin_M_deficiency
Primary immune deficiency disorders
severe immunosuppression. This group of syndromes is also known as immunoglobulin class switch recombination (Ig-CSR) deficiencies. The most common causes
Hyper_IgM_syndrome
Type of immune disorder
other immunoglobulins. Isolated primary immunoglobulin M deficiency often presents as recurring infections. Patients often improve with immunoglobulin therapy
Dysgammaglobulinemia
Type of immunoglobulin
Immunoglobulin Y (abbreviated as IgY) is a type of immunoglobulin which is the major antibody in amphibian, bird, reptile, and lungfish blood. It is also
Immunoglobulin_Y
Immunoglobulin E (IgE) Antibody
Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isoform"), a protein complex that has been found only in mammals. IgE is synthesised
Immunoglobulin_E
Medical treatment
Immunoglobulin therapy is the use of a mixture of antibodies (normal human immunoglobulin) to treat several health conditions. These conditions include
Immunoglobulin_therapy
Protein-coding gene in the species Homo sapiens
"Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M". Biochemistry. 31 (50): 12643–12647. doi:10.1021/bi00165a014. PMID 1472500
J_chain
Protein that detects other antibodies
Anti-immunoglobulin antibodies are protein that detects other antibodies from an organism. Specifically, anti-immunoglobulin antibodies are created by
Anti-immunoglobulin
Rare disorder
levels of IgM and IgD. Immunoglobulin M deficiency Immunoglobulin M Skin lesion List of cutaneous conditions "X-linked hyper-IgM syndrome". Orphanet. Retrieved
Immunodeficiency with hyperimmunoglobulin M
Immunodeficiency_with_hyperimmunoglobulin_M
Medical condition
IgM nephropathy or immunoglobulin M nephropathy (IgMN) is a kind of idiopathic glomerulonephritis that is marked by IgM diffuse deposits in the glomerular
IgM_nephropathy
Large protein superfamily of cell surface and soluble proteins
The immunoglobulin superfamily (IgSF) is a large protein superfamily of cell surface and soluble proteins that are involved in the recognition, binding
Immunoglobulin_superfamily
Classifications of antibodies
In immunology, antibodies (immunoglobulins (Ig)) are classified into several types called isotypes or classes. The variable (V) regions near the tip of
Isotype_(immunology)
Type of blood cancer
characterized by having high levels of a circulating antibody, immunoglobulin M (IgM), which is made and secreted by the cells involved in the disease
Waldenström_macroglobulinemia
Excess amounts of gamma globulin in the blood
hypergammaglobulinemias are caused by an excess of immunoglobulin M (IgM), because this is the default immunoglobulin type prior to class switching. Some types
Hypergammaglobulinemia
Human cell line
three variations of the Raji cell line, but some cells synthesize immunoglobulin M with light chains of the kappa type, in contrast to the usual concordance
Raji_cell
Primary immune deficiency disorder
steps necessary to class switch from immunoglobulin M (IgM) to the other three immunoglobulins types. Hyper IgM syndromes is a group of primary immune
Hyper-IgM_syndrome_type_5
ophthalmic disease IgG4-TIN IgG4-related tubulointerstitial nephritis IgM immunoglobulin M IGT impaired glucose tolerance IHC immunohistochemistry IHD ischaemic
List of medical abbreviations: I
List_of_medical_abbreviations:_I
Category of antigens in immunology
isotype of antibodies in this type of immune reaction is low-affinity immunoglobulin M (IgM). For most protein antigens, the production of antibodies by B lymphocytes
T_independent_antigen_(TI)
Index of articles associated with the same name
Immunoglobulin-binding protein, or sometimes Immunoglobulin binding protein is a generic name for any protein that binds immunoglobulins. It, therefore
Immunoglobulin-binding protein
Immunoglobulin-binding_protein
Species of bacterium
is sometimes associated with underlying immunodeficiency, including immunoglobulin M deficiency, various cancer chemotherapies, inhaled steroids, surgical
Achromobacter_xylosoxidans
Overproduction of primary immune system cells or antibodies
increased levels of immunoglobulins in the blood serum. Five different hypergammaglobulinemias are caused by an excess of immunoglobulin M (IgM), and some types
Immunoproliferative_disorder
Surgical removal of the spleen
Peters A, Boehm T, Plebani A, Quinti I, Carsetti R (April 2003). "Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are
Splenectomy
Marker in blood/cerebrospinal fluid testing
Oligoclonal bands (OCBs) are bands of immunoglobulins observed in a patient's blood serum, or cerebrospinal fluid (CSF) for the diagnosis of various neurological
Oligoclonal_band
Medical condition
plasmacytic, or intermediate morphology, which secrete a monoclonal immunoglobulin M component. There is diffuse infiltration by the malignant cells of
Macroglobulinemia
the total levels of antibody isotypes or classes: Immunoglobulin M, Immunoglobulin G, and Immunoglobulin A. It is important in quantification of free light
Nephelometry_(medicine)
Primary immune deficiency disorder
and somatic hypermutation. Immunoglobulin (Ig) class switch recombination deficiencies are characterized by elevated serum IgM levels and a considerable
Hyper-IgM_syndrome_type_2
Common viral infectious disease
the Epstein–Barr virus. Immunoglobulin G (IgG), when positive, mainly reflects a past infection, whereas immunoglobulin M (IgM) mainly reflects a current
Infectious_mononucleosis
Medical condition
and somatic hypermutation. Immunoglobulin (Ig) class switch recombination deficiencies are characterized by elevated serum IgM levels and a considerable
Hyper-IgM_syndrome_type_4
Aspect of immunity
types of antibodies: immunoglobulin A, immunoglobulin D, immunoglobulin E, immunoglobulin G, and immunoglobulin M. Each immunoglobulin class differs in its
Humoral_immunity
Human viral disease
healthy child initiates the production of host immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA) antibodies; IgG antibodies persist
Chickenpox
Medical condition
disorders that present with kidney damage due to nephrotoxic monoclonal immunoglobulins (M proteins) secreted by clonal plasma cells or B cells. By definition
Monoclonal gammopathy of renal significance
Monoclonal_gammopathy_of_renal_significance
Protein
Sharks, and possibly other cartilaginous fishes, have immunoglobulin M (IgM) and immunoglobulin W (IgW) as well, both types with two heavy and two light
Heavy-chain_antibody
Immune organ that filters blood
Boehm, T; Plebani, A; Quinti, I; Carsetti, R (Apr 7, 2003). "Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are
Spleen
Test for syphilis
expensive. Nontreponemal tests (NTT) measure levels of immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies produced by the host in response to lipoidal
Rapid_plasma_reagin
Involuntary muscle contraction
systemic illnesses. It is most commonly observed in patients with an immunoglobulin M paraproteinaemic neuropathy (IgMNP), but also in patients with chronic
Tremor
Small antibody polypeptide subunit (immunoglobin)
The immunoglobulin light chain is the small polypeptide subunit of an antibody (immunoglobulin). A typical antibody is composed of two immunoglobulin (Ig)
Immunoglobulin_light_chain
Scientific study of serum and other bodily fluids
serologic tests measure one of two types of antibodies: immunoglobulin M (IgM) and immunoglobulin G (IgG). IgM is produced in high quantities shortly after a person
Serology
alpha-2-macroglobulin, von Willebrand factor, LDL cholesterol and immunoglobulin M. It is an experimental treatment for dry age-related macular degeneration
Rheopheresis
Medical condition
IgG subclass deficiency, IgA with IgG subsclass deficiency, selective immunoglobulin A deficiency Transient hypogammaglobulinemia of infancy (THI) Secondary
Humoral_immune_deficiency
Classification based on antibodies and antigens on RBC surfaces
and anti-B antibodies are usually immunoglobulin M, abbreviated IgM, antibodies. It has been hypothesized that ABO IgM antibodies are produced in the first
Blood_type
Family of receptors found on NK cells
Killer-cell immunoglobulin-like receptors (KIRs) are a family of type I transmembrane glycoproteins expressed on the plasma membrane of natural killer
Killer-cell immunoglobulin-like receptor
Killer-cell_immunoglobulin-like_receptor
Medication made up of antibodies against the rabies virus
Rabies immunoglobulin (RIG) is a medication made up of antibodies against the rabies virus. It is used to prevent rabies following exposure. It is given
Rabies_immunoglobulin
Biological mechanism
mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG. During this process
Immunoglobulin class switching
Immunoglobulin_class_switching
Gene in the species Homo sapiens
pairing with immunoglobulin M.". Biochemistry. 31 (50): 12643–7. doi:10.1021/bi00165a014. PMID 1472500. Neale GA, Kitchingman GR (1991). "mRNA transcripts
IGHM
Viral disease
CM (September 2006). "Altered enzyme-linked immunosorbent assay immunoglobulin M (IgM)/IgG optical density ratios can correctly classify all primary or
Yellow_fever
Vaccine to prevent infection by the bacteria Streptococcus pneumoniae
CRM197-specific type 2 helper T cells, which allow for immunoglobulin type switching (to produce non-IgM immunoglobulin) and production of memory B cells. Among other
Pneumococcal_vaccine
Autoimmune endocrine disease
The disorder results from an antibody, called thyroid-stimulating immunoglobulin (TSI), that has a similar effect to thyroid-stimulating hormone (TSH)
Graves'_disease
Topics referred to by the same term
Militare, Italian national mapping agency Intersex genital mutilation Immunoglobulin M, an antibody This disambiguation page lists articles associated with
IGM
Chemical compound
recognizes alpha gal as a foreign substance and produce xenoreactive immunoglobulin M (IgM) antibodies, leading to organ rejection after xenotransplantation
Galactose-α-1,3-galactose
Antibody isotype
called IgM. IgD is also produced in a secreted form that is found in very small amounts in blood serum, representing 0.25% of immunoglobulins in serum
Immunoglobulin_D
Medical condition
the same and are under the broad category of HIES. Isolated primary immunoglobulin M deficiency List of cutaneous conditions List of dental abnormalities
Hyperimmunoglobulin E syndrome
Hyperimmunoglobulin_E_syndrome
Viral outbreak in California, US
2026. Retrieved May 10, 2026. Landry, Marie Louise (July 2016). "Immunoglobulin M for Acute Infection: True or False?". Clinical and Vaccine Immunology
2012 Yosemite hantavirus outbreak
2012_Yosemite_hantavirus_outbreak
Transmembrane protein on the surface of a B cell
known as the membrane immunoglobulin (mIg), which is composed of two immunoglobulin light chains (IgLs) and two immunoglobulin heavy chains (IgHs) as
B-cell_receptor
Human disease caused by West Nile virus infection
also been attempts to treat infections using ribavirin, intravenous immunoglobulin, or alpha interferon. GenoMed, a U.S. biotech company, has found that
West_Nile_fever
Biomedical technique
identification and quantification of antibodies and antigens, such as immunoglobulins and extractable nuclear antigens. The technique is named after Örjan
Ouchterlony double immunodiffusion
Ouchterlony_double_immunodiffusion
German neurologist and multiple sclerosis researcher
disease progression in multiple sclerosis (JAMA Neurology). Intrathecal immunoglobulin M synthesis is an independent biomarker for higher disease activity and
Jens_Kuhle
Type of animal allergy caused by felines
1 chains were broken to reduce the binding between the allergen and immunoglobulin E (IgE), inhibiting an allergic response. Due to cat allergies being
Allergy_to_cats
Large polypeptide subunit of an antibody
The immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin). In the human genome, the IgH gene loci are on chromosome
Immunoglobulin_heavy_chain
Viral disease spread by a type of mouse
Goba A, Fullah M, Momoh M, Grant DS, Garry RF (4 October 2011). "Emerging Trends in Lassa Fever: Redefining the Role of Immunoglobulin M and Inflammation
Lassa_fever
American immunologist
sequence of IgM, IgG, and IgA. His experiments indicated a single lineage of B cells switch from IgM to producing other immunoglobulin isotypes, as opposed
Max_Dale_Cooper
Fetal and neonatal alloimmune blood condition
nonimmune-mediated. Immune-mediated hemolytic transfusion reactions caused by immunoglobulin M (IgM) anti-A, anti-B, or anti-A, B typically result in severe, potentially
Hemolytic disease of the newborn
Hemolytic_disease_of_the_newborn
Primary immune deficiency disorder
and somatic hypermutation. Immunoglobulin (Ig) class switch recombination deficiencies are characterized by elevated serum IgM levels and a considerable
Hyper-IgM_syndrome_type_3
Abnormal immunoglobulin fragment
myeloma protein is an abnormal antibody (immunoglobulin) or (more often) a fragment thereof, such as an immunoglobulin light chain, that is produced in excess
Myeloma_protein
Antibodies Immunoglobulin A (IgA) 5-39 ×10−4 Immunoglobulin D (IgD) 0.5-8.0 ×10−5 Immunoglobulin G (IgG) 5.0-19 ×10−3 Immunoglobulin M (IgM) 3.0-30 ×10−4
List of human blood components
List_of_human_blood_components
Adaptive immunity variety-generation process
maturation. It results in the highly diverse repertoire of antibodies/immunoglobulins and T cell receptors (TCRs) found in B cells and T cells, respectively
V(D)J_recombination
Class of molecules found in the outer membrane of Gram-negative bacteria
970. PMID 9218618. Boes M, Prodeus AP, Schmidt T, Carroll MC, Chen J (December 1998). "A critical role of natural immunoglobulin M in immediate defense against
Lipopolysaccharide
Medical condition
Monoclonal immunoglobulin deposition disease, or MIDD, is a disease characterised by the deposition of monoclonal immunoglobulins on the basement membrane
Monoclonal immunoglobulin deposition disease
Monoclonal_immunoglobulin_deposition_disease
Antibodies sensitive to cold temperature
vasculitis, respectively. Cold agglutinins are antibodies, typically immunoglobulin M (IgM), that are acquainted with and then binding the antigens on red
Cold_sensitive_antibodies
Region on human chromosome 14
Immunoglobulin heavy locus, also known as IGH@, is a region on human chromosome 14 that contains many gene segments for the heavy chains of human antibodies
IGH@
Protein-coding gene in the species Homo sapiens
Immunoglobulin lambda-like polypeptide 1 is a protein that in humans is encoded by the IGLL1 gene. IGLL1 has also recently been designated CD179B (cluster
IGLL1
Topics referred to by the same term
significance MYOM2 (Myomesin-2), a protein composing the M-line of muscle cell sarcomeres Protein M, immunoglobulin-binding protein found on the surface of the bacterium
M_protein
Medical food product
proteins, SBI contains a concentrated source of ~60 immunoglobulin (>50% IgG, 1% IgA, and 5% IgM), 5% albumin and other proteins and peptides that may
Serum-derived bovine immunoglobulin/protein isolate
Serum-derived_bovine_immunoglobulin/protein_isolate
Tolerance of a fetus during pregnancy
possible targets, but these preformed antibodies are usually of the immunoglobulin M type, and therefore usually do not cross the placenta. Still, rarely
Immune_tolerance_in_pregnancy
Chronic rash that occurs during pregnancy
autoimmune condition, from a single study it has been seen that Immunoglobulin M (IgM) deposition at the dermal-epidermal membrane has been associated
Pruritic urticarial papules and plaques of pregnancy
Pruritic_urticarial_papules_and_plaques_of_pregnancy
Testing to identify incompatibilities between blood types
antibodies occur in two major forms: immunoglobulin M (IgM) and immunoglobulin G (IgG). Antibodies that are predominantly IgM, such as the ABO antibodies, typically
Blood_compatibility_testing
Medical condition
cases of pericarditis, myocarditis, or pleurodynia by demonstration of immunoglobulin M antibody". Infect. Immun. 8 (3): 341–8. doi:10.1128/iai.8.3.341-348
Bornholm_disease
Kinase that plays a role in B cell development
2018). "Hypomorphic Mutations in the BCR Signalosome Lead to Selective Immunoglobulin M Deficiency and Impaired B-cell Homeostasis". Frontiers in Immunology
Bruton's_tyrosine_kinase
Development of antibodies in the blood serum
responds by generating weakly binding immunoglobulin M (IgM) antibodies; although they individually bind weakly, each IgM antibody has many binding regions
Seroconversion
immunogenicity – immunoglobulin (Ig) – immunoglobulin A (IgA) – immunoglobulin D (IGD) – immunoglobulin E (IGE) – immunoglobulin G (IGG) – immunoglobulin M (IGM)
Index of HIV/AIDS-related articles
Index_of_HIV/AIDS-related_articles
Medical condition
(mainly lymphoma and leukemia) develop in up to a third of patients. Immunoglobulin M (IgM) levels are reduced, IgA and IgE are elevated, and IgG levels can
Wiskott–Aldrich_syndrome
Library of Medicine. Retrieved 1 March 2011. Hillman, RS; Ault, KA; Leporrier, M; Rinder, HM. (2011). Hematology in Clinical Practice (5th ed.). McGraw-Hill
List of hematologic conditions
List_of_hematologic_conditions
Reaction occurring within an organism as a defence against a pathogen
two-step process. Firstly, B cell receptors, which are just Immunoglobulin M (IgM) and Immunoglobulin D (IgD) antibodies specific to the particular B cell,
Immune_response
Acute inflammation diseases of the optic nerve and spinal cord
IgG, Immunoglobulin M (IgM), inflammatory cells, and complement deposits around blood vessels. AQP4-IgG is a member of the IgG1 immunoglobulin family
Neuromyelitis optica spectrum disorder
Neuromyelitis_optica_spectrum_disorder
Medical condition
nonimmune-mediated. Immune-mediated hemolytic transfusion reactions caused by immunoglobulin M (IgM) anti-A, anti-B, or anti-A,B typically result in severe, potentially
Hemolytic disease of the newborn (anti-Kell)
Hemolytic_disease_of_the_newborn_(anti-Kell)
Rare autoimmune disease
autoimmune hemolytic anemia (WAIHA) caused by immunoglobulin G (IgG) may also have a high number of immunoglobulin M (IgM) antibodies. These antibodies are active
Mixed autoimmune hemolytic anemia
Mixed_autoimmune_hemolytic_anemia
Zhenglin; Zhang, Kang; Hou, Fan Fan (5 June 2020). "Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China". Nature Medicine. 26
Chinese government response to COVID-19
Chinese_government_response_to_COVID-19
Blood disorder in which cold sensitive antibodies target red blood cells
agglutinin disease, the Coombs test is almost always positive for immunoglobulin M (IgM). Avoid cold weather. Treat the underlying lymphoma. No cold drinks;
Cold_agglutinin_disease
Medical condition
Selective immunoglobulin A (IgA) deficiency (SIgAD) is a kind of immunodeficiency, a type of hypogammaglobulinemia. People with this deficiency lack immunoglobulin
Selective immunoglobulin A deficiency
Selective_immunoglobulin_A_deficiency
Medication used to prevent RhD isoimmunization
Efficacy and Safety of Monoclonal Anti-Rh (D) Immunoglobulin with Polyclonal Anti-Rh (D) Immunoglobulin for the Prevention of Maternal Rh-Isoimmunization"
Rho(D)_immune_globulin
Medication
tract infections Headache Common (1–10% frequency): Back pain Blood immunoglobulin M decreased Oral herpes Adverse effects of ofatumumab (Arzerra) by frequency:
Ofatumumab
Species of tick
and elderly persons. Spotted fever is diagnosed by two blood tests (immunoglobulin M and Weil-Felix tests) taken 10 days apart. PCR analysis of skin biopsies
Ixodes_holocyclus
Species of virus
of Chandipura virus infection is confirmed with immunoglobulin M enzyme-linked immunosorbent assay (IgM ELISA) or reverse transcription polymerase chain
Chandipura_virus
Rare autoinflammatory condition
biopsies show inflammation of the capillaries and microthrombosis. Immunoglobulin M and C3 deposition may be present.[citation needed] Lung biopsies show
STING-associated vasculopathy with onset in infancy
STING-associated_vasculopathy_with_onset_in_infancy
Monoclonal antibody medication
to free human immunoglobulin E (IgE) in the blood and interstitial fluid and to the membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing
Omalizumab
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IMMUNOGLOBULIN M
IMMUNOGLOBULIN M
IMMUNOGLOBULIN M
IMMUNOGLOBULIN M
IMMUNOGLOBULIN M
IMMUNOGLOBULIN M
IMMUNOGLOBULIN M
IMMUNOGLOBULIN M
IMMUNOGLOBULIN M
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