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Complete set of molecular interactions in a biological cell
In molecular biology, an interactome is the whole set of molecular interactions in a particular cell. The term specifically refers to physical interactions
Interactome
Protein–protein interactions in human cells
The human interactome is the set of protein–protein interactions (the interactome) that occur in human cells. The sequencing of reference genomes, in
Human_interactome
Small protein domain found in some kinases and GTPases
domain-mediated protein-protein interaction networks, i.e., SH3 interactomes, revealed that worm SH3 interactome resembles the analogous yeast network because it is
SH3_domain
Rod-shaped, gram-negative bacterium
on histidine and 501 phosphorylated threonines and 162 tyrosines. The interactome of E. coli has been studied by affinity purification and mass spectrometry
Escherichia_coli
Species of virus
the figure indicate positions in the RNA sequence. The protein-protein interactome among HEV proteins has been mapped by Osterman et al. (2015), who found
Hepatitis_E_virus
Mental disorder with psychotic symptoms
"Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes". Translational Psychiatry. 3 (12): e329. doi:10.1038/tp
Schizophrenia
Totality of lipids in cells
The lipidome (in yellow) as a part of the metabolome and the total interactome of a cell.
Lipidome
American bioengineer
Fields Bioengineering Metabolic Engineering Biomolecular Interaction The Interactome Carbohydrate Analysis Structural Biology Glycobiology Glycomics Synthetic
Robert_J._Linhardt
Mitochondrial protein interactome database
mitochondrial protein interactome database. Reja, Rohit; et al. (3 December 2009). "MitoInteractome: Mitochondrial protein interactome database, and its application
Mitointeractome
Physical interactions and constructions between multiple proteins
discovering protein interactions on human interactome, specifically the interactome of Membrane proteins and the interactome of Schizophrenia-associated proteins
Protein–protein_interaction
Protists that live in saltwater or brackish water
Krabberød, Anders K.; Logares, Ramiro (2020). "The planktonic protist interactome: where do we stand after a century of research?". The ISME Journal. 14
Marine_protists
University, as well as the Director of the National Center for Dynamic Interactome Research (NCDIR). Rout's research focuses on the assembly and interactions
Michael_Rout
Genus of flies
analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture". Nature Protocols. 16 (1). Nature Portfolio: 27–60. doi:10
Drosophila
whole set of molecular interactions in the human cell, also known as the interactome, can be used for disease identification and prevention. These networks
Network_medicine
Macromolecule
extracellular proteins. These are often collectively called the “heparin interactome” or "heparin-binding proteins", because they are isolated by affinity
Heparan_sulfate
Biomolecule consisting of chains of amino acid residues
complement of biologically possible such interactions is known as the interactome. A systematic attempt to determine the structures of proteins representing
Protein
interactome networks by cross-species comparisons". BMC Systems Biology. 4: 36. doi:10.1186/1752-0509-4-36. PMC 2859380. PMID 20353594. Interactome.org
Interolog
Part of the University of New South Wales in Australia
epigenetic gene regulation. Identification of methylation across the interactome is poorly documented. Researchers at the System Biology Initiative have
UNSW_Faculty_of_Science
Technique in molecular biology
differentiation, proliferation, and development. By creating ChIA-PET interactome maps for DNA-binding regulatory proteins and promoter regions, we can
ChIA-PET
Type of stable macromolecular complex
transient interactions are very important for cell biology: the human interactome is enriched in such interactions, these interactions are the dominating
Protein_complex
Family of proteins
Gagné P, et al. (April 2010). "Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry". Proteome Science. 8 22.
Poly_(ADP-ribose)_polymerase
Prediction by observation and computation
Microscale Thermophoresis (MST). Efforts to experimentally determine the interactome of numerous species are ongoing. Experimentally determined interactions
Protein–protein interaction prediction
Protein–protein_interaction_prediction
Large-scale study of proteins
proteomics is to identify binary protein interactions, protein complexes, and interactomes. Several methods are available to probe protein–protein interactions
Proteomics
Protein coding
Timescale of Life". www.timetree.org. Retrieved 2019-04-29. "mentha: the interactome browser". www.mentha.uniroma2.it. Retrieved 2019-04-29. "LRSAM1 - E3
FAM178B
Species of bacteria
SILAC. About 50% of the proteome has been quantified. Studies of the interactome have identified more than 3000 protein-protein interactions. This has
Helicobacter_pylori
Transmembrane molecule in the mitochondria
anti-apoptotic Bcl-x(L) protein, a new piece in the puzzle of cytochrome c interactome". PLOS ONE. 6 (4) e18329. Bibcode:2011PLoSO...618329B. doi:10.1371/journal
Bcl-xL
Signal pathway enzyme chain
Schulze, Waltraud X.; Deng, Lei; Mann, Matthias (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Molecular Systems Biology. 1 2005
Phosphorylation_cascade
Protein-coding gene in the species Homo sapiens
alongside other HSP70 proteins in a core sub-network of the wider chaperome interactome that functions as a proteostasis safeguard and that is repressed in aging
HSPA8
Species of bacterium
Chowdhury S, Hepper S, Lodi MK, Saier MH, Uetz P (April 2021). "The Protein Interactome of Glycolysis in Escherichia coli". Proteomes. 9 (2): 16. doi:10.3390/proteomes9020016
Mycoplasma_pneumoniae
Canadian scientist
coupled with mass spectrometry to generate high-resolution maps of the interactome of human RNA polymerases. In 2012, the Coulombe laboratory discovered
Benoit_Coulombe
Biological interrelationship
host interactome have a higher impact in pathogen fitness during infection. These observations suggest that hubs in the host–pathogen interactome should
Host–pathogen_interaction
Microtubule element of the tubulin family
situations of oxidative stress could provide a protective benefit. The interactome of class III β-tubulin comprises the GTPase GBP1 (guanylate binding protein
Tubulin_beta-3_chain
Protein-coding gene in the species Homo sapiens
(300 nM). Both RPSA and laminin belong to the heparin/heparan sulfate interactome. Heparin binds in vitro to the N-domain of RPSA but not to its C-domain
Ribosomal_protein_SA
Protein-coding gene in the species Homo sapiens
Hsp90Int.DB website. Gene ontology analysis of both Hsp90A and Hsp90B interactomes indicate that each paralogs is associated with unique biological processes
Heat shock protein 90kDa alpha (cytosolic), member A1
Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1
; Oliver, S. G. (2004). "A critical and Integrated View of the Yeast Interactome". Comparative and Functional Genomics. 5 (5): 382–402. doi:10.1002/cfg
Stephen_Oliver_(scientist)
Process of determining the nucleic acid sequence
cell-free display technology for high-throughput production of reliable interactome data". Scientific Reports. 2 691. Bibcode:2012NatSR...2..691F. doi:10
DNA_sequencing
Online bioinformatics tool
Gygi, S.P; Hong, P; Perrimon, N (2013). "The Hippo Signaling Pathway Interactome". Science. 342 (6159): 737–40. Bibcode:2013Sci...342..737K. doi:10.1126/science
COMPLEAT (bioinformatics tool)
COMPLEAT_(bioinformatics_tool)
Series of interconnected biochemical reactions
Chowdhury S, Hepper S, Lodi MK, Saier MH, Uetz P (April 2021). "The Protein Interactome of Glycolysis in Escherichia coli". Proteomes. 9 (2): 16. doi:10.3390/proteomes9020016
Glycolysis
Mammalian gene
1976. PMC 354828. PMID 59816. Schmidt MH, Dikic I (Dec 2005). "The Cbl interactome and its functions". Nature Reviews. Molecular Cell Biology. 6 (12): 907–918
CBL_(gene)
Organelle found within the chloroplasts of algae and hornworts
Silvia; Adams, Christopher M.; Jonikas, Martin C. (2017-09-21). "A Spatial Interactome Reveals the Protein Organization of the Algal CO2-Concentrating Mechanism"
Pyrenoid
German-American physicist
S2CID 9907900. Łukasiewicz-Topos Models of Neural Networks, Cell Genome and Interactome Nonlinear Dynamic Models http://en.scientificcommons.org/23394472 Darwin
Walter_M._Elsasser
Family of protein kinases
Aymerich I, Mayor F Jr (2007). "The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling". Biochim Biophys Acta
G protein-coupled receptor kinase
G_protein-coupled_receptor_kinase
Database of nematode genomics
wiring diagram of the worm nervous system; Protein-protein interaction Interactome data; Genetic regulatory relationships; Details of intra- and inter-specific
WormBase
resides in can give better context for its action. Human proteome project Interactome Proteome anon. "BioPlex". harvard.edu. harvard.edu. Retrieved 24 May
BioPlex
Branch of food chemistry
Visualisation of the human interactome network topology with the blue lines between proteins (represented as points) showing protein-protein interactions
Food_physical_chemistry
lacks the catalytic Asp residue in the HRD motif. The PSKH2 protein interactome is complex, and involves a number of membrane-associated proteins alongside
PSKH2
Amino acid sequence
Cai, Lili; Chen, Yanmei; Zhong, Fan; Lin, Chengzhao; et al. (2011). "Interactome study suggests multiple cellular functions of hepatoma-derived growth
SBP-tag
Computational analysis of large, complex sets of biological data
MT, Palzkill T, et al. (May 2008). Hall N (ed.). "The binary protein interactome of Treponema pallidum--the syphilis spirochete". PLOS ONE. 3 (5) e2292
Bioinformatics
Medical condition
(OGT-CDG): Potential mechanistic targets revealed by evaluating the OGT interactome". Journal of Biological Chemistry. 300 (9) 107599. doi:10.1016/j.jbc
X-linked intellectual disability
X-linked_intellectual_disability
Protein-coding gene in the species Homo sapiens
LM, Collura V, Rain JC, et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic
KIF3A
Protein-coding gene in the species Homo sapiens
Patel, Sandip; Marchant, Jonathan S. (2014). "The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and
TMEM33
Mammalian protein found in Homo sapiens
"IntAct Portal". www.ebi.ac.uk. Retrieved 2020-05-03. "CCSB Interactome Database". interactome.dfci.harvard.edu. Retrieved 2020-05-03. "THAP1 - THAP domain-containing
C7orf50
Branch of biology
(2004). "Łukasiewicz-Topos Models of Neural Networks, Cell Genome and Interactome Nonlinear Dynamic Models" (PDF). Archived from the original on 2007-07-13
Mathematical and theoretical biology
Mathematical_and_theoretical_biology
Inflammatory bowel disease that causes ulcers in the colon
PMC 8407332. PMID 34291816. De Souza, H.; Fiocchi, C.; Iliopoulos, D. The IBD interactome: An integrated view of aetiology, pathogenesis and therapy. Nat. Rev
Ulcerative_colitis
Protein family
Gerber SA, Dunlap JC (2009). "Quantitative proteomics reveals a dynamic interactome and phase-specific phosphorylation in the Neurospora circadian clock"
Frequency_(gene)
Human protein-encoding gene on chromosome 7
interacts uniquely with 11 different proteins, according to the Mentha interactome browser. In particular, c7orf26 interacts with the entire family of 'INTS'
INTS15
Protein-RNA binding probing method
Sven (2017-06-02). "sCLIP—an integrated platform to study RNA–protein interactomes in biomedical research: identification of CSTF2tau in alternative processing
Ribonucleoprotein Networks Analyzed by Mutational Profiling
Ribonucleoprotein_Networks_Analyzed_by_Mutational_Profiling
Protein-coding gene in the species Homo sapiens
failed to implicate DISC1 as a risk gene at the gene level, the DISC1 interactome gene set was associated with schizophrenia, showing evidence from genome-wide
DISC1
(2015). "The BioPlex Network: A Systematic Exploration of the Human Interactome". Cell. 162 (2): 425–40. doi:10.1016/j.cell.2015.06.043. PMC 4617211
C8orf82
Protein-coding gene in the species Homo sapiens
W, et al. (April 2020). "A reference map of the human binary protein interactome". Nature. 580 (7803): 402–408. Bibcode:2020Natur.580..402L. doi:10
TBC1D30
American neuroscientist
Xiaoming. (2012). Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain. Neuron. 75. 41-57. 10.1016/j.neuron.2012.05.024.
Michelle Gray (neuroscientist)
Michelle_Gray_(neuroscientist)
Protein found in humans
PMID 7797522. 9614078 Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1 (1): E1–E13.
Adapter_molecule_crk
Protein-coding gene in the species Homo sapiens
Innate Immune Response". innatedb.com. Retrieved May 3, 2020. "Results - mentha: the interactome browser". mentha.uniroma2.it. Retrieved May 3, 2020.
C14orf119
Hungarian-American physicist (born 1967)
2015). "Uncovering disease-disease relationships through the incomplete interactome". Science. 347 (6224) 1257601. doi:10.1126/science.1257601. PMC 4435741
Albert-László_Barabási
Protein-coding gene in the species Homo sapiens
contribute to the stability, structure, and folding of the protein. The interactome of PRR29 is not yet well characterized. One experimental study found
PRR29
Medical diagnostic technique
detects protein–protein co-localizations at a global scale. This helps map interactome dynamics under various conditions, making it possible to understand protein
Proteomic_profiling
Protein-coding gene in the species Homo sapiens
S2CID 42806147. Schulze WX, Deng L, Mann M (2006). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1 (1) 2005.0008
SH3BGRL
Protein-coding gene in the species Homo sapiens
Database – An ELIXIR Core Resource". Retrieved 2019-05-06. "Mentha: the interactome browser". www.mentha.uniroma2.it. Retrieved 2019-05-06. Vlaikou AM, Manolakos
C4orf51
Transmembrane Protein 144
Michael A. (16 April 2020). "A reference map of the human binary protein interactome". Nature. 580 (7803): 402–408. Bibcode:2020Natur.580..402L. doi:10
TMEM144
Oxygen-delivering blood cell and the most common type of blood cell
D, Daescu O (December 2007). "The human red blood cell proteome and interactome". Experimental Biology and Medicine. 232 (11): 1391–1408. doi:10.3181/0706-MR-156
Red_blood_cell
Class of chemical compounds
Protein-Binding Small Molecules That Can Change Protein-Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases"
Molecular_glue
Medical model that tailors medical practices to the individual patient
difference in the exposome, which influence disease processes through the interactome within the tissue microenvironment, differentially from person to person
Personalized_medicine
Indian academic research organization
Gandhi T.K.B.; et al. (March 2006). "Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets". Nature
Institute of Bioinformatics, Bengaluru
Institute_of_Bioinformatics,_Bengaluru
Human protein
Fan C, et al. (June 2011). "Next-generation sequencing to generate interactome datasets". Nature Methods. 8 (6): 478–480. doi:10.1038/nmeth.1597. PMC 3188388
KIAA1143
Cell signaling pathway
PMID 16293107. Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Molecular Systems Biology. 1 (1):
MAPK/ERK_pathway
Protein-coding gene in the species Homo sapiens
Recognition Server". www.sbg.bio.ic.ac.uk. Retrieved 2019-04-20. "mentha: the interactome browser". mentha.uniroma2.it. Retrieved 2019-04-20. "2 binary interactions
KIAA0895
Enzyme
Aymerich I, Mayor F Jr (2007). "The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling". Biochim Biophys Acta
G protein-coupled receptor kinase 2
G_protein-coupled_receptor_kinase_2
Canadian molecular and systems biologist
to fight them. In 2020, Krogan led the work to create the SARS-CoV-2 interactome and assembled the QBI Coronavirus Research Group (QCRG) to study SARS-CoV-2
Nevan_Krogan
American geneticists
elegans, a worm, as a model system. Li, S. (2004-01-23). "A Map of the Interactome Network of the Metazoan C. elegans". Science. 303 (5657): 540–543. Bibcode:2004Sci
Susan_Strome
Anion and chemical group (–N3)
"Photoaffinity labelling strategies for mapping the small molecule-protein interactome". Org Biomol Chem. 19 (36): 7792–7809. doi:10.1039/d1ob01353j. PMC 8489259
Azide
Animal flesh produced by culturing cells
the field. Research continues on many fronts, including entomoculture, interactome maps of cardiac tissue, substrate design, scaffold design, nutritional
Cultured_meat
Enzyme which catalyzes the removal of a phosphate group from a molecule
Castagnoli, Luisa; Cesareni, Gianni (2012-08-14). "The human phosphatase interactome: An intricate family portrait". FEBS Letters. 586 (17): 2732–2739. Bibcode:2012FEBSL
Phosphatase
Protein and gene in humans
Sahni N, et al. (November 2014). "A proteome-scale map of the human interactome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588
TMEM128
e1000353. Vidal, Marc, Michael E. Cusick, and Albert-Laszlo Barabasi. "Interactome networks and human disease." Cell 144.6 (2011): 986-998. Zhou, XueZhong
Human_disease_network
American biochemist (born 1959)
(2022-09-15). "Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission". eLife. 11 e77779.
Wesley_Sundquist
Protein-coding gene in the species Homo sapiens
Lin ZY, Lacoste J, Lam MH, Qian WW, et al. (June 2021). "Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation
DNAJC28
Technique in molecular biology
data have played a pivotal role in building large-scale synthetic human interactomes and in dissecting mechanisms in human disease. However, there are still
Reporter_gene
Elaine G. Y. (2009). "An oestrogen-receptor-α-bound human chromatin interactome". Nature. 462 (7269): 58–64. Bibcode:2009Natur.462...58F. doi:10.1038/nature08497
Edison_Liu
Discipline combining epidemiology and pathology
epigenome, metabolome, transcriptome, proteome, microbiome, immunity and interactome. A putative risk factor can be linked to specific molecular signatures
Molecular pathological epidemiology
Molecular_pathological_epidemiology
Protein-coding gene in the species Homo sapiens
"BioGRID protein interaction browser results for C22orf31 protein". "Mentha interactome browser results for C22orf31 protein". "IntAct protein interaction browser
C22orf31
Argentine biophysicist
17, 2013. "Editorial Expression of Concern: Non-adaptive origins of interactome complexity". Nature. 516: 440. 2014. "Findings of Research Misconduct"
Ariel_Fernandez
Computational and mathematical modeling of complex biological systems
equation BioSystems (journal) Cellular model Computational systems biology Interactome List of omics topics in biology List of systems biology modeling software
Systems_biology
Openings in nuclear envelope of eukaryotic cells
microscopy structures of the NPC and constituent proteins from the EM Data Bank(EMDB) NCDIR - National Center for the Dynamic Interactome[permanent dead link]
Nuclear_pore_complex
Shalchian-Tabrizi, K. and Logares, R. (2017) "Exploring the oceanic microeukaryotic interactome with metaomics approaches". Aquatic Microbial Ecology, 79(1): 1–12. doi:10
Marine_microbial_symbiosis
Chemical compound
M, Moeck G, et al. (January 2011). "Genome annotation and intraviral interactome for the Streptococcus pneumoniae virulent phage Dp-1". Journal of Bacteriology
Queuosine
Bussey H, Michnick SW (June 2008). "An in vivo map of the yeast protein interactome" (PDF). Science. 320 (5882): 1465–70. Bibcode:2008Sci...320.1465T. doi:10
Protein-fragment complementation assay
Protein-fragment_complementation_assay
Mammalian protein found in humans
PMID 12379659. Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Molecular Systems Biology. 1 2005
HER2
Risk factors related to schizophrenia
"Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes". Transl Psychiatry. 3 (12): e329. doi:10.1038/tp.2013
Risk_factors_of_schizophrenia
Jagadish, H.V.; States, D. J. (2008). "Integrating and annotating the interactome using the MiMI plugin for cytoscape". Bioinformatics. 25 (1): 137–8.
National Center for Integrative Biomedical Informatics
National_Center_for_Integrative_Biomedical_Informatics
Comprehensive map of neural connections in the brain
estimators Connectomics Drosophila connectome Human Connectome Project Interactome List of animals by number of neurons Neural coding Outline of brain mapping
Connectome
INTERACTOME
INTERACTOME
INTERACTOME
INTERACTOME
Boy/Male
Muslim/Islamic
Sincere pure-hearted
Boy/Male
Arabic, Indian, Muslim
Forgiving
Boy/Male
Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Pure
Female
French
French form of Latin Euphemia, EUPHÉMIE means "Well I speak."
Boy/Male
Arabic, Australian
Successful
Girl/Female
Tamil
Kirtika | கிரà¯à®¤à¯€à®•à®¾, கீரà¯à®¤à¯€à®•à®¾Â
Famous action
Boy/Male
Australian, German, Hebrew
God is My Judge
Girl/Female
Tamil
Aakaansha | அகாநà¯à®·à®¾
Wish, Desire, Dream
Girl/Female
Indian
Wish, Desire, Purpose, Use
Girl/Female
Muslim
Gift of Allah, Concern, Solicitude
INTERACTOME
INTERACTOME
INTERACTOME
INTERACTOME
INTERACTOME