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Protein-coding gene in humans
lipid-gated potassium channel protein coded for by the gene KCNQ2. Mutations in the KCNQ2 gene are dominant autosomally inherited causes of benign familial
KCNQ2
Rare genetic disorder
KCNQ2 developmental and epileptic encephalopathy is a rare genetic disorder that typically presents with tonic seizures from the first week of life. The
KCNQ2 developmental and epileptic encephalopathy
KCNQ2_developmental_and_epileptic_encephalopathy
American author and nephew of Donald Trump (born 1962)
advocate for people with disabilities. His son William Trump has a rare KCNQ2 mutation that results in severe disability. He is a nephew of U.S. President
Fred_Trump_III
Medical condition
genetic causes of BFNE, two being the voltage-gated potassium channels KCNQ2 (BFNC1) and KCNQ3 (BFNC2) and the third being a chromosomal inversion (BFNC3)
Benign familial neonatal seizures
Benign_familial_neonatal_seizures
include Kv7.1 (KCNQ1) - KvLQT1, Kv7.2 (KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), and Kv7.5 (KCNQ5). Four of these (KCNQ2-5) are expressed in the nervous system
KCNQ_channels
Experimental anticonvulsant
major depressive disorder. Azetukalner works by selectively opening the KCNQ2/3 (Kv7.2/Kv7.3) voltage-gated potassium channels via positive allosteric
Azetukalner
Protein family
molecular biology, the ankyrin-G binding motif of KCNQ2-3 is a protein motif found in the potassium channels KCNQ2 and KCNQ3. Interactions with ankyrin-G (ankyrin-3)
Ankyrin-G binding motif of KCNQ2-3
Ankyrin-G_binding_motif_of_KCNQ2-3
Protein-coding gene in the species Homo sapiens
protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are
KCNQ3
Chemical compound
cognition-enhancing drug with a novel mechanism of action. Linopirdine blocks the KCNQ2\3 heteromer M current with an IC50 of 2.4 micromolar disinhibiting acetylcholine
Linopirdine
Anticonvulsant, which works as a potassium-channel opener
Dupere JR, Cox B, Clare JJ, Burbidge SA (August 2000). "Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine". Molecular
Retigabine
Pharmaceutical compound
PMID 42046889. CB03-154, a selective voltage-gated potassium channel (KCNQ2/3) opener developed by Shanghai Zhimeng Biopharma, targets neuronal hyperexcitability
CB03-154
Class of transport proteins
Shaw-related: Kv3.1 (KCNC1), Kv3.2 (KCNC2) Kvα7.x: Kv7.1 (KCNQ1) - KvLQT1, Kv7.2 (KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), Kv7.5 (KCNQ5) Kvα10.x: Kv10.1 (KCNH1) rapidly
Voltage-gated potassium channel
Voltage-gated_potassium_channel
List of pharmaceutical drugs under clinical development for treatment of depression
– vasopressin V1b receptor antagonist CB-03 (CB-04; CB-003; CB03-154) – KCNQ2 and KCNQ3 potassium channel stimulant Centanafadine (CTN; EB-1020) – serotonin
List of investigational antidepressants
List_of_investigational_antidepressants
stimulation on spines can increase cAMP-PKA-calcium signaling to open HCN, KCNQ2, and/or SK channels to rapidly weaken a connection, e.g. as occurs during
Dynamic functional connectivity
Dynamic_functional_connectivity
Cluster of signs and symptoms that define a unique epileptic condition
commonly KCNQ2 or KCNQ3 in self-limited neonatal epilepsy, PRRT2 or less commonly SCN2A or SCN8A in self-limited infantile epilepsy and SCN2A or KCNQ2 in self-limited
Epilepsy_syndromes
Species of flowering plant
extract, MTX and isovaleric acid, synergistically activate heteromeric KCNQ2/3 (potassium) channels, indicating the molecular mechanism behind the anticonvulsant
Mallotus_oppositifolius
Type of drug
Dupere JR, Cox B, Clare JJ, Burbidge SA (August 2000). "Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine". Molecular
Potassium_channel_opener
time) mutations in genes encoding for voltage-gated potassium channels (KCNQ2, KCNQ3), and acute zinc deficiency in cerebrospinal fluid. Most frequently
Benign_neonatal_seizures
Medical condition
can be associated with mutations in ARX, CDKL5, SLC25A22, STXBP1, SPTAN1, KCNQ2, ARHGEF9, PCDH19, PNKP, SCN2A, PLCB1, SCN8A, ST3GAL3, TBC1D24, BRAT1 and
Ohtahara_syndrome
There are three known genetic causes of BFNE, two being in the channels KCNQ2 and KCNQ3. Valproic acid and retigabine are examples of medications used
M_current
Family of ion channel proteins
Shaw-related: Kv3.1 (KCNC1), Kv3.2 (KCNC2) Kvα7.x: Kv7.1 (KCNQ1) - KvLQT1, Kv7.2 (KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), Kv7.5 (KCNQ5) Kvα10.x: Kv10.1 (KCNH1) Kvα1
Cation_channel_superfamily
Protein-coding gene in humans
variants encoding different isoforms have been found for this gene. ML213: KCNQ2/Q4 channel opener. Voltage-gated potassium channel GRCh38: Ensembl release
KCNQ4
Centipede toxin
KCNQ channels. It has an IC50of 2.8 ± 0.5 µM for KCNQ1, 2.7 ± 0.4 µM for KCNQ2, 2.5 ± 0.4 µM for KCNQ4, and 2.7 ± 0.5 µM for KCNQ5. Luo, Lei; Li, Bowen;
Ssm_spooky_toxin
Protein-coding gene in the species Homo sapiens
inhibit complexes formed by KCNQ1 and KCNE1. KCNE4 has no known effect on KCNQ2, KCNQ3 or KCNQ5 channels, but augments activity of KCNQ4 in HEK cells, mesenteric
KCNE4
HGNC:6292; Q9UGI6 8048 KCNN4 HGNC:6293; O15554 8049 KCNQ1 HGNC:6294; P51787 8050 KCNQ2 HGNC:6296; O43526 8051 KCNQ3 HGNC:6297; O43525 8052 KCNQ4 HGNC:6298; P56696
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
Protein-coding gene in the species Homo sapiens
Adams DJ (Apr 20, 2007). "Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2". J. Biol. Chem
NEDD4L
neonatal, type 2; 121201; KCNQ3 Epilepsy, benign, neonatal, type 1; 121200; KCNQ2 Epilepsy, female-restricted, with mental retardation; 300088; PCDH19 Epilepsy
List_of_OMIM_disorder_codes
Protein-coding gene in the species Homo sapiens
channels formed with KCNQ1 and KCNE1. While reportedly not affecting KCNQ2, KCNQ2/3 or KCNQ5 channel activity, KCNE5 inhibits KCNQ4 in CHO cells but not
KCNE5
Protein-coding gene in the species Homo sapiens
Lauritzen I, Barhanin J, Lazdunski M, Borsotto M (September 2000). "M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit". FEBS Letters
KCNE2
kcnq1 potassium channel MeSH D12.776.157.530.400.600.900.124.249.750 – kcnq2 potassium channel MeSH D12.776.157.530.400.600.900.124.249.875 – kcnq3 potassium
List of MeSH codes (D12.776.157)
List_of_MeSH_codes_(D12.776.157)
autosomal dominant manner. This condition is also caused due to mutation in KCNQ2 or KCNQ3 gene that may be carried by people bearing no family history of
Neonatal_seizure
kcnq1 potassium channel MeSH D12.776.543.550.425.750.900.124.249.750 – kcnq2 potassium channel MeSH D12.776.543.550.425.750.900.124.249.875 – kcnq3 potassium
List of MeSH codes (D12.776.543)
List_of_MeSH_codes_(D12.776.543)
travel, tourism, insurance
KCNQ2
KCNQ2
KCNQ2
KCNQ2
KCNQ2
KCNQ2
KCNQ2
KCNQ2
KCNQ2
travel, tourism, insurance