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Protein-coding gene in the species Homo sapiens
Histone-lysine-methyltransferase 2A is an enzyme that in humans is encoded by the KMT2A gene. It is a transcriptional coactivator and histone methyltransferase
KMT2A
Type of chromosomal translocation
KMT2A rearrangements are chromosomal translocations involving the KMT2A gene that create fusion proteins and occur in certain blood cancers such as acute
KMT2A_rearrangements
Chemical compound
lysine methyltransferase 2A gene (KMT2A) rearrangements. It is designed to disrupt the interaction between menin and KMT2A (also known as MLL), which plays
Revumenib
Pharmaceutical compound
interaction with KMT2A. Bleximenib is a selective inhibitor of menin preventing its interaction with the lysine methyltransferase KMT2A. The menin/KMT2A complex
Bleximenib
Pharmaceutical compound
and mixed-lineage leukemia (MLL) proteins. Enzomenib targets tumors with KMT2A (MLL) rearrangements or NPM1 mutations. The U.S. Food and Drug Administration
Enzomenib
Tumors that affect the blood, bone marrow, lymph, and lymphatic system
Acute promyelocytic leukaemia with PML-RARA AML with t(9;11)(p21.3;q23.3); KMT2A-MLLT3 AML with t(6;9)(p23;q34.1); DEK-NUP214 AML with inv(3)(q21.3q26.2)
Tumors of the hematopoietic and lymphoid tissues
Tumors_of_the_hematopoietic_and_lymphoid_tissues
Medication
Ziftomenib blocks the interaction between two proteins, menin (MEN1) and KMT2A (also known as mixed lineage leukemia protein, MLL). Ziftomenib was approved
Ziftomenib
Protein-coding gene in the species Homo sapiens
this gene with others like KMT2A, producing an uncontrolled activator protein. Translocation creates the fusion protein KMT2A-AFF1 which is the primary
AFF1
Protein complex
cancer. In acute leukemia, KMT2A::AFF1 or KMT2A::MLLT1 fusion proteins can inappropriately recruit SEC components to KMT2A target genes, thus promoting
Super_elongation_complex
Blood cancer characterized by overproduction of lymphoblasts
Infant ALL is a rare variant that occurs in babies under one year of age. KMT2A (formerly MLL) gene rearrangements are most common and happen in the embryo
Acute_lymphoblastic_leukemia
Cancer of the myeloid line of blood cells
with translocations between chromosome 9 and 11 – [t(9;11)(p21.3;q23.3);] KMT2A–MLLT3; AML with translocations between chromosome 6 and 9 – [t(6;9)(p23;q34
Acute_myeloid_leukemia
Diverse collection of blood-related cancers
mutations, FLT3 mutations, and partial tandem duplication mutations of KMT2A (MLL) were strong predictors of adverse outcomes. Some SF3B1 mutations were
Myelodysplastic_syndrome
Medical condition
Wiedemann–Steiner syndrome results from mutations in the MLL (also known as KMT2A) gene on the long arm of chromosome 11. The gene encodes a histone-modification
Wiedemann–Steiner_syndrome
Protein-coding gene in humans
of a family of six Set1-like H3K4 methyltransferases that also contains KMT2A (or MLL1), KMT2B (or MLL2), KMT2C (or MLL3), KMT2F (or SET1A), and KMT2G
KMT2D
Medical condition
gene). The KMT2A and KMT2D gene product proteins regulate gene transcription and may contribute to the development of various cancers (see KMT2A and KMT2D)
Sclerosing epithelioid fibrosarcoma
Sclerosing_epithelioid_fibrosarcoma
Topics referred to by the same term
Lightfoot, mayor of Chicago Morel-Lavallée lesion An enzyme encoded by the KMT2A gene This disambiguation page lists articles associated with the title MLL
MLL
Protein family
"MLL site", named after the proto-oncogene MLL (Mixed Lineage Leukemia, KMT2A). The paralogous coactivators CBP (CREBBP) and P300 (EP300) are recruited
KIX_domain
Medical condition
chromosome 13, or NRC1 locus on the long arm of chromosome 5; 3) fusions of KMT2A on the long arm of chromosome 11 with MLLT1 on the short arm of chromosome
Blastic plasmacytoid dendritic cell neoplasm
Blastic_plasmacytoid_dendritic_cell_neoplasm
relapsed or refractory acute leukemia with a lysine methyltransferase 2A gene (KMT2A) translocation in people aged one year of age and older Seladelpar Treatment
List of drugs granted breakthrough therapy designation
List_of_drugs_granted_breakthrough_therapy_designation
Human gene
as a complex with MLL (myeloid/lymphoid or mixed-lineage leukaemia 1) (KMT2A), a positive global regulator of gene transcription that is named after
Tet methylcytosine dioxygenase 2
Tet_methylcytosine_dioxygenase_2
Known motif – from protein with 100% identical DBD – in vitro [474] TAACGG KMT2A ENSG00000118058 CxxC; AT hook Known motif – High-throughput in vitro [475]
List of human transcription factors
List_of_human_transcription_factors
resistance to cell death. In the latter case, there is translocation of MLL (KMT2A) gene at chromosome 11q23. The aberrant gene produces fusion proteins that
Mixed-phenotype acute leukemia
Mixed-phenotype_acute_leukemia
Medical diagnostic method
mutations, FLT3 mutations, and partial tandem duplication mutations of KMT2A (MLL) were strong predictors of adverse outcomes. Some SF3B1 mutations were
International Prognostic Scoring System
International_Prognostic_Scoring_System
HGNC:24778; A4D1S0 8309 KLRK1 HGNC:18788; P26718 8310 KMO HGNC:6381; O15229 8311 KMT2A HGNC:7132; Q03164 8312 KMT2B HGNC:15840; Q9UMN6 8313 KMT2C HGNC:13726; Q8NEZ4
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
Field of study
repression. Mice deficient in a particular histone-methyltransferase gene, KMT2A (also known as MLL1), in adult excitatory neurons show impairments in
Epigenetics of physical exercise
Epigenetics_of_physical_exercise
Medical condition
cell death) and the product protein of KMT2a viz., MLL regulates cell maturation. Abnormalities in BCL2 and KMT2A are associated with other types of B-cell
Intravascular_lymphomas
Phenotype of senescent cells which secrete certain substances
expression is induced by a number of transcription factors, including MLL1 (KMT2A), C/EBPβ, and NF-κB. NF-κB has been referred to as the master transcription
Senescence-associated secretory phenotype
Senescence-associated_secretory_phenotype
Protein-coding gene in the species Homo sapiens
2018). "Comprehensive genetic analysis of donor cell derived leukemia with KMT2A rearrangement". Pediatric Blood & Cancer. 65 (2) e26823. doi:10.1002/pbc
TASOR2
Type of stem cell
suppressing the activity of the histone methyltransferase MLL1, also known as KMT2A. The inhibition of MLL1 via the small-molecule inhibitor MM-401 in EpiSCs
Epiblast-derived_stem_cell
Rare forms of the breast cancer
involved with chromatin remodeling (i.e. modifying chromatin architecture), KMT2A and CREBBP, have also been identified in the tumor cells of some EPS cases
Papillary carcinomas of the breast
Papillary_carcinomas_of_the_breast
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