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Protein domain
A leucine-rich repeat (LRR) is a protein structural motif that forms an α/β horseshoe fold. It is composed of repeating 20–30 amino acid stretches that
Leucine-rich_repeat
Protein kinase found in humans
Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling) and PARK8 (from early identified association
LRRK2
Protein-coding gene in the species Homo sapiens
Leucine rich repeat containing 15 is a cell membrane-expressed protein. In humans it is encoded by the LRRC15 gene. It is located on chromosome 3 at 3q29
Leucine rich repeat containing 15
Leucine_rich_repeat_containing_15
Class of proteins
or NOD-like receptors (NLRs) (also known as nucleotide-binding leucine-rich repeat receptors), are intracellular sensors of pathogen-associated molecular
NOD-like_receptor
Protein family
Leucine-rich repeat receptor like protein kinase (PEPR1 and PEPR2 in Arabidopsis thaliana and Xa21 in rice) are plant cell membrane localized Leucine-rich
Leucine-rich repeat receptor like protein kinase
Leucine-rich_repeat_receptor_like_protein_kinase
Genes in plant genomes
class of R-genes consist of a nucleotide binding domain (NB) and a leucine rich repeat (LRR) domain(s) and are often referred to as (NB-LRR) R-genes or
R_gene
Protein-coding gene in the species Homo sapiens
Leucine rich repeat containing 61 is a protein that in humans is encoded by the LRRC61 gene. GRCh38: Ensembl release 89: ENSG00000127399 – Ensembl, May
Leucine rich repeat containing 61
Leucine_rich_repeat_containing_61
Protein-coding gene in the species Homo sapiens
TLR4 interactor with leucine rich repeats, also known as KIAA0644, is a protein that in humans is encoded by the TRIL gene. The exact function of KIAA0644
TLR4 interactor with leucine rich repeats
TLR4_interactor_with_leucine_rich_repeats
Protein-coding gene in the species Homo sapiens
Leucine-rich repeats and IQ motif containing 1 is a protein that in humans is encoded by the LRRIQ1 gene. The protein is likely a nuclear encoding mitochondrial
Leucine-rich repeats and IQ motif containing 1
Leucine-rich_repeats_and_IQ_motif_containing_1
Human LRRC27 gene
Leucine rich repeat containing 27 (LRRC27) a is a protein which in humans is encoded by the LRRC27 gene. Homo sapiens gene Leucine Rich Repeat containing
Leucine rich repeat containing 27
Leucine_rich_repeat_containing_27
Protein-coding gene in the species Homo sapiens
F-box and leucine rich repeat protein 15 is a protein that in humans is encoded by the FBXL15 gene. GRCh38: Ensembl release 89: ENSG00000107872 – Ensembl
F-box and leucine rich repeat protein 15
F-box_and_leucine_rich_repeat_protein_15
Protein-coding gene in the species Homo sapiens
Leucine-rich repeat and Immunoglobulin-like domain-containing protein 1 also known as LINGO-1 is a protein which is encoded by the LINGO1 gene in humans
LINGO1
Protein-coding gene in the species Homo sapiens
Leucine rich repeat containing 3 is a protein that in humans is encoded by the LRRC3 gene. Leucine rich repeat GRCh38: Ensembl release 89: ENSG00000160233
Leucine rich repeat containing 3
Leucine_rich_repeat_containing_3
Protein-coding gene in the species Homo sapiens
Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a protein which in humans is
PIDD1
Membrane receptor
(GPIbα, GPIbβ, GPIX and GPV) is part of the leucine rich repeat motif superfamily. These leucine rich repeat sequences tend to be about 24 amino acids in
Glycoprotein_Ib-IX-V_complex
Protein-coding gene in the species Homo sapiens
Leucine-rich repeats and death domain containing 1 is a protein that in humans is encoded by the LRRD1 gene. GRCh38: Ensembl release 89: ENSG00000240720
Leucine-rich repeats and death domain containing 1
Leucine-rich_repeats_and_death_domain_containing_1
Investigational Parkinson's disease drugs
neurogenesis stimulant [34] ION-859 (BIIB-094; ION859; IONIS-BIIB7Rx) – leucine-rich repeat kinase 2 (LRRK2) inhibitor [35] Lazucirnon (AKST-4290; ALK-429; ALK-4290)
List of investigational Parkinson's disease drugs
List_of_investigational_Parkinson's_disease_drugs
Protein-coding gene in humans
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) also known as G-protein coupled receptor 49 (GPR49) or G-protein coupled receptor 67
LGR5
Protein-coding gene in the species Homo sapiens
Leucine-rich repeat neuronal protein 3, also known as neuronal leucine-rich repeat protein 3 (NLRR-3), is a protein that in humans is encoded by the LRRN3
LRRN3
Human chromosome
RNA 1137 LRRC39: Leucine-rich repeat-containing protein 39 LRRC40: Leucine-rich repeat-containing protein 40 LRRC41: Leucine-rich repeat-containing protein
Chromosome_1
Leucine-rich repeat protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene. This protein was initially identified in Caenorhabditis elegans
SHOC2
Protein-coding gene in the species Homo sapiens
Leucine rich repeat containing 57, also known as LRRC57, is a protein encoded in humans by the LRRC57 gene. The exact function of LRRC57 is not known
LRRC57
Protein-coding gene in humans
Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene. Along with the other G-protein coupled
LGR6
Protein-coding gene in the species Homo sapiens
LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate
LRRTM1
Protein-coding gene in humans
Leucine-rich repeat-containing protein 8C is a protein encoded by the human LRRC8C gene. LRRC8C is one of five LRRC8 proteins—along with LRRC8A, LRRC8B
LRRC8C
Protein-coding gene in the species Homo sapiens
encoded by the PRELP gene. The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein
Prolargin
Protein-coding gene in the species Homo sapiens
Leucine rich repeat containing 25 is a protein that in humans is encoded by the LRRC25 gene. GRCh38: Ensembl release 89: ENSG00000175489 – Ensembl, May
LRRC25
Human protein and coding gene
protein 1) LRR – leucine-rich repeat, a term also included within the term "NLR", for nucleotide-binding domain, leucine-rich repeat" PYD – PYRIN domain
NLRP3
Protein-coding gene in the species Homo sapiens
Leucine rich repeat and fibronectin type III domain containing 4 is a protein that in humans is encoded by the LRFN4 gene. Fibronectin type III domain
Leucine rich repeat and fibronectin type iii domain containing 4
Leucine_rich_repeat_and_fibronectin_type_iii_domain_containing_4
Protein-coding gene in the species Homo sapiens
Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene. This gene encodes a member of the
FLRT2
Protein-coding gene in the species Homo sapiens
Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 is a protein that in humans is encoded by the LRIT3 gene. GRCh38: Ensembl release
LRIT3
Protein-coding gene in the species Homo sapiens
Leucine rich repeat containing 24 is a protein that, in humans, is encoded by the LRRC24 gene. The protein is represented by the official symbol LRRC24
LRRC24
Protein-coding gene in the species Homo sapiens
F-box and leucine-rich repeat protein 4 is a protein that in humans is encoded by the FBXL4 gene. This gene encodes a member of the F-box protein family
FBXL4
Leucine-rich repeat-containing protein 23 is a protein that in humans is encoded by the LRRC23 gene. The function of LRRC23 is unknown. It is a member
LRRC23
Human gene
region and has a shorter N-terminus with 193 amino acids. LRRC73 is a leucine-rich repeat-containing protein mostly involved in mediating protein-protein interactions
LRRC73
Protein-coding gene in the species Homo sapiens
Leucine-rich repeat flightless-interacting protein 1 is a protein that in humans is encoded by the LRRFIP1 gene. LRRFIP1 has been shown to interact with
LRRFIP1
Protein-coding gene in the species Homo sapiens
Leucine-rich repeat-containing protein 8A is a protein that in humans is encoded by the LRRC8A gene. Researchers have found out that this protein, along
LRRC8A
Protein-coding gene in the species Homo sapiens
Leucine rich repeat and Ig domain containing 2 is a protein that in humans is encoded by the LINGO2 gene. GRCh38: Ensembl release 89: ENSG00000174482
LINGO2
Protein-coding gene in humans
Leucine-rich repeat neuronal protein 2 is a protein that in humans is encoded by the LRRN2 gene. The protein encoded by this gene belongs to the leucine-rich
LRRN2
Protein
interstitial leucine-rich repeat proteoglycans (SLRPs). It can have up to four N-linked keratan sulfate chains attached to the core protein within the leucine-rich
Fibromodulin
Protein-coding gene in the species Homo sapiens
Leucine-rich repeat-containing protein 17 is a protein that in humans is encoded by the LRRC17 gene. GRCh38: Ensembl release 89: ENSG00000128606 – Ensembl
LRRC17
Protein-coding gene in humans
Leucine-rich repeat-containing protein 41 is a protein that in humans is encoded by the LRRC41 gene. GRCh38: Ensembl release 89: ENSG00000132128 – Ensembl
LRRC41
Leucine-rich repeat-containing protein 8B is a protein that in humans is encoded by the LRRC8B gene. Researchers have found out that this protein, along
LRRC8B
Protein-coding gene in the species Homo sapiens
protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila
FLII
Protein-coding gene in the species Homo sapiens
Leucine-rich repeat neuronal protein 1 is a protein that in humans is encoded by the LRRN1 gene. GRCh38: Ensembl release 89: ENSG00000175928 – Ensembl
LRRN1
Protein-coding gene in the species Homo sapiens
In humans, the immunoglobulin super family containing leucine-rich repeat (ISLR) protein is encoded by the ISLR gene. Current RNA-seq studies show that
ISLR
Protein-coding gene in the species Homo sapiens
PH domain leucine-rich repeat-containing protein phosphatase 1, also known as PHLPP1, is an enzyme which in humans is encoded by the PHLPP1 gene (previously
PHLPP1
Concept in plant genetics
conferred by the leucine rich repeats. LRRs are multiple, serial repeats of a motif of roughly 24 amino acids in length, with leucines or other hydrophobic
Gene-for-gene_relationship
specifically, the proteins contain leucine-rich repeat segments that interact outside of the cell. This leucine-rich repeat is a structural motif present in
PEPR1_and_PEPR2
Medical condition
the NYX gene (Nyctalopin on X-chromosome), which encodes a small leucine-rich repeat (LRR) family protein of unknown function. This protein consists of
Congenital stationary night blindness
Congenital_stationary_night_blindness
Protein-coding gene in the species Homo sapiens
Lysine-specific demethylase 2A (KDM2A) also known as F-box and leucine-rich repeat protein 11 (FBXL11) is an enzyme that in humans is encoded by the KDM2A
KDM2A
Non-coding RNA in the species Homo sapiens
Leucine rich repeat containing 37A is a protein in humans that is encoded by the LRRC37A gene. The LRRC37 gene family has been expanded in the genome
LRRC37A
Protein found in humans
encoded by the OPTC gene. Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated
Opticin
Protein family
inhibitor (RI) is a large (~450 residues, ~49 kDa), acidic (pI ~4.7), leucine-rich repeat protein that forms extremely tight complexes with certain ribonucleases
Ribonuclease_inhibitor
Starchy tuber used as a staple food
a wild potato native to Mexico. Rpi-blb1 is a nucleotide-binding leucine-rich repeat (NB-LRR/NLR), an R-gene-produced immunoreceptor. In October 2011
Potato
Protein-coding gene in the species Homo sapiens
a family of leucine-rich repeat (LRR) proteins associated with the cartilage matrix. The name asporin reflects the unique aspartate-rich N terminus and
Asporin
Human chromosome
LRRC17: leucine-rich repeat containing protein 17 LRRC61: encoding protein Leucine rich repeat containing 61 LRRD1: encoding protein Leucine-rich repeats and
Chromosome_7
Protein-coding gene in the species Homo sapiens
Leucine rich repeat containing 26 (LRRC26) is a protein that in humans is encoded by the LRRC26 gene. GRCh38: Ensembl release 89: ENSG00000184709 – Ensembl
LRRC26
Protein found in humans
Leucine rich repeat containing 7 also known as LRRC7, Densin-180, or LAP1 is a protein which in humans is encoded by the LRRC7 gene. Found to be densely
LRRC7
Protein-coding gene in humans
Leucine-rich repeat-containing protein 8D is a protein that in humans is encoded by the LRRC8D gene. Researchers have found out that this protein, along
LRRC8D
Protein-coding gene in humans
divided into 3 classes: Fbws containing WD40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction
FBXL7
Part of the human immune system
NLRP (Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing), also abbreviated as NALP, is a type of NOD-like receptor
NLRP
Index of enzymes associated with the same name
density lipoprotein receptor-related protein Small leucine-rich repeat protein Small leucine-rich repeat proteoglycan This set index page lists enzyme articles
SLRP
Protein-coding gene in the species Homo sapiens
Leucine-rich repeat serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the LRRK1 gene. GRCh38: Ensembl release 89: ENSG00000154237
LRRK1
Topics referred to by the same term
LRR may refer to: Laminated root rot, a root disease in conifers Leucine-rich repeat, a type of protein domain LoadingReadyRun, a Canadian comedy troupe
LRR
Protein-coding gene in humans
Leucine rich repeat containing 40 (LRRC40) is a protein that in humans is encoded by the LRRC40 gene. LRRC40 is conserved throughout all of its orthologs
LRRC40
Protein-coding gene in the species Homo sapiens
Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene. LGR4 is known to have a role in the
LGR4
Type of gene involved in flagellin reception of bacteria
(RLK). RLKs are essentially tyrosine kinases fused to an N-terminal leucine-rich repeat domain, which controls its function. Although tyrosine kinases are
FLS2
Protein-coding gene in the species Homo sapiens
Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene. FLRT1, FLRT2 and FLRT3 are members of the fibronectin
FLRT3
Protein found in humans
LRRIQ3 (Leucine-rich repeats and IQ motif containing 3), which is also known as LRRC44, is a protein that in humans is encoded by the LRRIQ3 gene. It is
LRRIQ3
Protein-coding gene in the species Homo sapiens
Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene. It encodes a transmembrane protein
LRIG1
Protein-coding gene in the species Homo sapiens
protein is a small keratan sulfate proteoglycan which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants. The level of
Osteoglycin
cysteines 32 residues apart. There are four N-linked sites within the leucine-rich repeat domain of the protein core that can be substituted with keratan sulfate
Lumican
Cytosolic multiprotein complex that mediates the activation of Caspase 1
PRRs, including NLRs (nucleotide-binding oligomerization domain and leucine-rich repeat-containing receptors), AIM2 (absent in melanoma 2), IFI16 (IFN-inducible
Inflammasome
Class of enzymes
the attack. The polygalacturonase inhibitor proteins (PGIPs) are leucine-rich repeat proteins that have been reported to demonstrate both non-competitive
Polygalacturonase
Human chromosome
protein Leucine-rich repeat-containing protein 23 LRRIQ1: encoding protein Leucine-rich repeats and IQ motif containing 1 LRRK2: leucine-rich repeat kinase
Chromosome_12
Family of cell surface receptors
toll-like receptors (TLRs). TLRs share a typical structural motif, the leucine rich repeats (LRR), which give them their specific appearance and are also responsible
Pattern_recognition_receptor
Protein-coding gene in the species Homo sapiens
Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene. This gene is significantly downregulated in primary
LRRC4
alpha-helical coiled coils having structural and oligomerization functions; leucine-rich repeat proteins, which specifically bind some globular proteins by their
Protein_tandem_repeats
Protein-coding gene in humans
certain bacteria. The C-terminal portion of the protein contains a leucine-rich repeat domain that is known to play a role in protein–protein interactions
NOD2
Class of jawless fish
vertebrate adaptive immunity. Generated from a somatic recombination of leucine-rich repeat gene segments, lamprey leukocytes express surface variable lymphocyte
Lamprey
Species of grass
2016 provides a genome assembly. The Lr42 nucleotide-binding site leucine-rich repeat (NLR) is a resistance gene used in hexaploid wheat but originating
Aegilops_tauschii
Model plant species in the family Brassicaceae
general co-evolved with the CCHELO family of nucleotide-binding–leucine-rich-repeat-receptors (NLRs). Xiao et al. 2005 have shown that the powdery mildew
Arabidopsis_thaliana
Movement disorder that causes involuntary tremors
respectively. Recent post mortem studies have displayed alterations in the leucine-rich repeat and immunoglobulin-like domain-containing protein 1 (LINGO1) gene
Essential_tremor
Protein domain
activating complex called Inflammasomes. For example, a NOD Like Leucine Rich Repeat NLRP3 will sense an efflux of potassium ions from the cell. This
Caspase
Genus of grass cultivated for grain
identification of "a detailed multi-genome-derived nucleotide-binding leucine-rich repeat protein repertoire" which contributes to disease resistance, while
Wheat
Topics referred to by the same term
one of the Hamburger–Hamilton stages in chick development FLRT3, leucine-rich repeat transmembrane protein 3, also called "HH21" Search for "hh19" or
HH21
Protein-coding gene in the species Homo sapiens
Leucine-rich repeat LGI family member 2 is a protein that in humans is encoded by the LGI2 gene. GRCh38: Ensembl release 89: ENSG00000153012 – Ensembl
LGI2
Protein-coding gene in humans
Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and
Biglycan
Human chromosome
ATP-sensitive inward rectifier potassium channel 15 LRRC3: encoding leucine-rich repeat-containing protein 3 LSS: encoding enzyme lanosterol synthase LTN1:
Chromosome_21
distinct domains, each containing variable numbers of leucine-rich repeats (LRRs), seven to nine EGF repeats, an ALPS domain (Agrin, Perlecan, Laminin, Slit)
Slit-Robo
Family of proteins
Thyrotropin receptor (TSHR) Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4, GPR48) Leucine-rich repeat-containing G protein-coupled
Rhodopsin-like_receptors
Plant peptide hormone
identified. A receptor for tomato systemin was identified as a 160KDa leucine-rich repeat receptor like kinase (LRR-RLK), SR160. After being isolated it was
Systemin
Protein found in humans
medlineplus.gov. Retrieved 2024-12-12. ""FBXL17 Gene - F-Box And Leucine Rich Repeat Protein 17"". GeneCards. December 9, 2024. ""IPP Gene - Intracisternal
Kelch-like_protein_28
Protein-coding gene in the species Homo sapiens
member X1, short for nucleotide-binding oligomerization domain, leucine rich repeat containing X1 is a protein that in humans is encoded by the NLRX1
NLRX1
Central nervous system disease
risk factor is age. Mutations in genes such as α-synuclein (SNCA), leucine-rich repeat kinase 2 (LRRK2), glucocerebrosidase (GBA), and tau protein (MAPT)
Neurodegenerative_disease
Class of enzymes
The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important
PHLPP
Protein domain
(InterPro: IPR004020), the HEAT repeat domain (InterPro: IPR004155), the WD40 repeat (InterPro: IPR001680), the leucine-rich repeat (LRR) or the BIR repeat (InterPro: IPR001370)
NACHT_domain
Protein-coding gene in the species Homo sapiens
occurring read-through transcript between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes
LRTOMT
Medical condition
Jean-Frédéric; Sahbatou, Mourad; Thomas, Gilles (2001). "Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease". Nature. 411 (6837):
Blau_syndrome
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LEUCINE RICH-REPEAT
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