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LIN28

  • LIN28
  • LIN28 gene. LIN28 encodes an RNA-binding protein that binds to and enhances the translation of the IGF-2 (insulin-like growth factor 2) mRNA. Lin28 binds

    LIN28

    LIN28

    LIN28

  • Let-7 microRNA family
  • RNA family

    pluripotent stem (iPS) cell reprogramming, LIN28 expression is reciprocal to that of mature let-7. LIN28 selectively binds the primary and precursor

    Let-7 microRNA family

    Let-7_microRNA_family

  • Precocious puberty
  • Puberty occurring at an unusually early age

    as LIN28, and LEP and LEPR, which encode leptin and the leptin receptor, have been associated with precocious puberty. The association between LIN28 and

    Precocious puberty

    Precocious_puberty

  • Induced pluripotent stem cell
  • Pluripotent stem cell generated directly from a somatic cell

    and colleagues used a different set of factors, Oct4, Sox2, Nanog, and Lin28, using a lentiviral system. Obtaining fibroblasts to produce iPSCs involves

    Induced pluripotent stem cell

    Induced pluripotent stem cell

    Induced_pluripotent_stem_cell

  • LIN28B
  • Protein-coding gene in the species Homo sapiens

    Lin-28 homolog B is a protein that in humans is encoded by the LIN28B gene. Lin28 is a gene found in both invertebrates and vertebrates, from worms to humans

    LIN28B

    LIN28B

    LIN28B

  • Healing
  • Process of the restoration of health

    even allows some mammals (like mice) to heal wounds without scars. The LIN28 gene also plays a role in wound healing. It is dormant in most mammals.

    Healing

    Healing

    Healing

  • Stem cell
  • Unspecialized biological cell that can become specialized

    Wisconsin–Madison used a different set of factors, Oct4, Sox2, Nanog and Lin28, and carried out their experiments using cells from human foreskin. However

    Stem cell

    Stem cell

    Stem_cell

  • MicroRNA
  • Small non-coding ribonucleic acid molecule

    M510682200. PMID 16431920. Jun-Hao ET, Gupta RR, Shyh-Chang N (March 2016). "Lin28 and let-7 in the Metabolic Physiology of Aging". Trends in Endocrinology

    MicroRNA

    MicroRNA

    MicroRNA

  • Regenerative medicine
  • Medical field involved in regenerating tissues

    organ Biomedicine Cloning Induced pluripotent stem cell Life extension LIN28 Neuroregeneration Orthobiologics Osteoarthritis#Research Polyphyodont Regeneration

    Regenerative medicine

    Regenerative medicine

    Regenerative_medicine

  • ZCCHC6
  • Protein-coding gene in the species Homo sapiens

    PMID 23063654. Thornton JE, Chang HM, Piskounova E, Gregory RI (October 2012). "Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11

    ZCCHC6

    ZCCHC6

    ZCCHC6

  • V. Narry Kim
  • South Korean biochemist (born 1969)

    further identified uridylation-meditated pre-miRNA degradation pathway by LIN28 and TUT4, contributing to a better understanding of how microRNA-mediated

    V. Narry Kim

    V. Narry Kim

    V._Narry_Kim

  • Dental pulp stem cell
  • pluripotent-like stem cells (DPPSC). These cells are SSEA4+, OCT3/4+, NANOG+, SOX2+, LIN28+, CD13+, CD105+, CD34-, CD45-, CD90+, CD29+, CD73+, STRO1+, and CD146-,

    Dental pulp stem cell

    Dental pulp stem cell

    Dental_pulp_stem_cell

  • Oct-4
  • Mammalian protein found in Homo sapiens

    human fibroblast cells to iPSCs via Oct-4, along with Sox2, Nanog, and Lin28. The use of Thomson reprogramming factors avoids the need to overexpress

    Oct-4

    Oct-4

    Oct-4

  • MIR7-1
  • Non-coding RNA in the species Homo sapiens

    2011). Horwitz MS (ed.). "Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility". PLOS

    MIR7-1

    MIR7-1

    MIR7-1

  • George Q. Daley
  • Medical academic

    magazine in 2008), and demonstration of the role of the RNA-binding protein Lin28 in cancer and metabolic disease. He has been elected a fellow of the American

    George Q. Daley

    George Q. Daley

    George_Q._Daley

  • L1TD1
  • Protein-coding gene in the species Homo sapiens

    Rao A, Lahesmaa R (March 2012). "RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer

    L1TD1

    L1TD1

    L1TD1

  • Stress granule
  • Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress

    EG (January 2007). "Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules". RNA Biology. 4 (1): 16–25

    Stress granule

    Stress granule

    Stress_granule

  • GLIS1
  • Protein-coding gene

    used for reprogramming. Glis1 also up-regulates expression of the protein LIN28 which binds the let-7 microRNA precursor, preventing production of active

    GLIS1

    GLIS1

    GLIS1

  • Kevin Struhl
  • American biochemist

    Heather A; Struhl, Kevin (2009-11-13). "An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation". Cell

    Kevin Struhl

    Kevin_Struhl

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LIN28

Online names & meanings

  • Shamila |
  • Girl/Female

    Muslim

    Shamila |

    One of friendly and likable nature

  • Khunays
  • Boy/Male

    Indian

    Khunays

    Hidden

  • STEFÁN
  • Male

    Icelandic

    STEFÁN

    Icelandic form of Latin Stephanus, STEFÁN means "crown." 

  • Kishmish
  • Girl/Female

    Hindu, Indian, Kannada, Malayalam, Marathi, Sindhi, Telugu

    Kishmish

    Sweet as Grapes

  • Fayona |
  • Girl/Female

    Muslim

    Fayona |

    Beautiful, Pretty

  • Satmika
  • Girl/Female

    Hindu

    Satmika

    Good heart, Goddess of rain

  • Prakruthi
  • Boy/Male

    Hindu, Indian

    Prakruthi

    Weather

  • Navapriyan
  • Boy/Male

    Hindu

    Navapriyan

  • IZZIE
  • Female

    English

    IZZIE

    Variant spelling of English Izzy, IZZIE means "God is my oath."

  • Shonna
  • Girl/Female

    American, Australian, Chinese

    Shonna

    God is Gracious

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LIN28

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LIN28