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Protein-coding gene in the species Homo sapiens
Lin-28 homolog B is a protein that in humans is encoded by the LIN28B gene. Lin28 is a gene found in both invertebrates and vertebrates, from worms to
LIN28B
Tissue of bone marrow
2015-09-10. Yuan J, Nguyen CK, Liu X, Kanellopoulou C, Muljo SA (2012). "Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like
Myeloid_tissue
Protein-coding gene in humans
expressed and in vertebrates, there are two paralogs present, Lin28a and Lin28b. In nematodes, the LIN28 homolog lin-28 is a heterochronic gene that determines
LIN28A
Puberty occurring at an unusually early age
Loos, Ruth J; Wareham, Nicholas J (16 May 2009). "Genetic variation in LIN28B is associated with the timing of puberty". Nature Genetics. 41 (6): 729–733
Precocious_puberty
Ratio of lengths of fingers
B, Nyholt DR, Gordon SD, Wright MJ, et al. (April 2010). "A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker
Digit_ratio
Small non-coding ribonucleic acid molecule
tumor progression and chemoresistance (including the RNA-binding protein LIN28B and the multidrug resistance transporter ABCC5/MRP5). Restoring let-7-5p
MicroRNA
Pluripotent stem cell generated directly from a somatic cell
S (November 2012). "Recognition of the let-7g miRNA precursor by human Lin28B". FEBS Letters. 586 (22): 3986–90. Bibcode:2012FEBSL.586.3986S. doi:10.1016/j
Induced_pluripotent_stem_cell
Biological process of gene regulation
upregulation of oncogenes including c-MYC, CDK6, and the RNA-binding protein LIN28B, as well as efflux ATP-binding cassette (ABC) transporters that govern multidrug
RNA_interference
Human chromosome
matrix proteoglylcan 1 (6q14.1) KIAA0408 LGSN: encoding protein lengsin LIN28B: lin-28 homolog B (6q16.3-q21) MAN1A1: mannosidase alpha class 1A member
Chromosome_6
motif from similar protein – High-throughput in vitro [494] CGCHGYYHYWYCGCG LIN28B ENSG00000187772 CSD Known motif – High-throughput in vitro [495] CGCHGYYHYWYCGCG
List of human transcription factors
List_of_human_transcription_factors
RNA family
adaptive immunity as well. Down-modulation of let-7 negative regulator Lin28b in human T lymphocytes is believed to accrue during early neonate development
Let-7_microRNA_family
Chemical compound
γ-globin in individuals with β thalassemia. Recent work has shown that the LIN28B pathway influences BCL11A translation in humans, and additional regulators
Embryonic_hemoglobin
Protein-coding gene
Filipek S (2012). "Recognition of the let-7g miRNA precursor by human Lin28B". FEBS Letters. 586 (22): 3986–90. Bibcode:2012FEBSL.586.3986S. doi:10.1016/j
GLIS1
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
Man1 LIG3 DNA Ligase 3 DNA Ligase 3 LIN28A LIN28A Lin-28 Homolog A LIN28B LIN28B Lin-28 Homolog B LMNA LMNA Prelamin-A/C LPP LPP Lipoma-preferred partner
Stress_granule
Cell compartment found in the nucleus's interchromatin space
LaPierre RJ, Pothoulakis C, Hagan JP, et al. (November 2011). "Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms". Cell. 147 (5):
Paraspeckle
Q9NUP9 8741 LIN9 HGNC:30830; Q5TKA1 8742 LIN28A HGNC:15986; Q9H9Z2 8743 LIN28B HGNC:32207; Q6ZN17 8744 LIN37 HGNC:33234; Q96GY3 8745 LIN52 HGNC:19856;
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
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LIN28B
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