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A multicenter research trial is a clinical trial that involves more than one independent medical institutions in enrolling and following trial participants
Multicenter_trial
Multicenter Automatic Defibrillator Implantation Trial and MADIT II are implantable cardioverter defibrillator (or ICD) trials which investigate whether
Multicenter Automatic Defibrillator Implantation Trial
Multicenter_Automatic_Defibrillator_Implantation_Trial
Form of scientific experiment
combined with "stratified randomization", for example by center in a multicenter trial, to "ensure good balance of participant characteristics in each group
Randomized_controlled_trial
Experimental antisense oligonucleotide drug for lowering lipoprotein(a)
the Lp(a)HORIZON trial (NCT04023552), a global, multicenter, double-blind, placebo-controlled study conducted by Novartis. The trial enrolled 8,323 patients
Pelacarsen
Medical condition
medications target interleukin-1 (IL-1), particularly IL-1β. A randomized, multicenter trial reported better outcomes in a group of 12 patients treated with anakinra
Adult-onset_Still's_disease
Pharmaceutical drug
AEGEAN (NCT03800134), a randomized, double-blind, placebo-controlled multicenter trial in 802 participants with previously untreated and resectable squamous
Durvalumab
Inflammatory disease of the skin in humans
therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial". Arch Dermatol. 140 (12): 1453–9. doi:10.1001/archderm.140.12.1453
Dyshidrosis
SNRI medication
Waninger AL, Iyengar S, et al. (2005). "A double-blind, randomized multicenter trial comparing duloxetine with placebo in the management of diabetic peripheral
Duloxetine
Type of cancer
Polish Adult Leukemia Group (PALG) of a prospective, randomized, multicenter trial". Blood. 109 (9): 3672–5. doi:10.1182/blood-2006-08-042929. PMID 17209059
Leukemia
Spinal medical implant
large multicenter trial, TOPS demonstrated significantly higher rates of clinical success compared with fusion at two years. An earlier multicenter study
TOPS_System
Benzodiazepine medication
1988). "Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. II. Patient acceptance, side effects, and safety". Archives of General
Alprazolam
Staples used in surgery in place of sutures
versus Sutured Gastrointestinal Anastomoses in the Trauma Patient: A Multicenter Trial". Journal of Trauma-Injury Infection & Critical Care. 51 (6): 1054–1061
Surgical_staple
Chemical compound
States was based on a randomized, active-controlled, open-label, multicenter trial (COLUMBUS; NCT01909453) in 577 participants with BRAF V600E or V600K
Encorafenib
Clinical trial stages using human subjects
in clinical practice. Phase III studies are randomized controlled multicenter trials on large patient groups (300–3,000 or more depending upon the disease/medical
Phases_of_clinical_research
Medication
Efficacy was evaluated in QUILT-3.032 (NCT0302285), a single-arm, multicenter trial of 77 participants with BCG-unresponsive, high-risk non-muscle invasive
Nogapendekin_alfa_inbakicept
Bipolar spectrum disorder
experimental doses of 400 mg have rendered little response. A large, multicenter trial comparing carbamazepine and lithium over two and a half years found
Bipolar_II_disorder
Type of clinical trial
A platform trial is a type of prospective, disease-focused, adaptive, randomized clinical trial (RCT) that compares multiple, simultaneous and possibly
Platform_trial
American physician
Pittsburgh Compound B (PiB). He directed an eight-year NIH-funded national multicenter trial to assess whether Ginkgo biloba can prevent or delay onset of dementia
Steven_T._DeKosky
Neurosurgical procedure to treat swelling
anticipation of the cranioplasty. The RESCUEicp study is an international multicenter trial that finished recruitment in March 2014. The aim of this study is
Decompressive_craniectomy
X chromosome monosomy
failure in toddlers with Turner syndrome: a randomized, controlled, multicenter trial". The Journal of Clinical Endocrinology and Metabolism. 92 (9): 3406–3416
Turner_syndrome
Mental disorder featuring beliefs with inadequate grounding
with a combination of amitriptyline and haloperidol--a double-blind multicenter trial". Journal of Psychiatric Research. 43 (7): 702–710. doi:10.1016/j
Delusional_disorder
Professor of Diagnostic Imaging
Group Z4033 (Alliance) Trial. Percutaneous image-guided cryoablation of painful metastases involving bone: multicenter trial. Evaluation of a Novel Thermal
Damian_E._Dupuy
Precancerous tissue formation in the esophagus
ablation for Barrett's esophagus: 5-year outcomes from a prospective multicenter trial". Endoscopy. 42 (10): 781–9. doi:10.1055/s-0030-1255779. PMID 20857372
Barrett's_esophagus
Antiandrogen medication
prostatic carcinoma: final report of a double-blind, randomized, multicenter trial. Casodex Combination Study Group". Urology. 50 (3): 330–336. doi:10
Bicalutamide
Pharmaceutical compound
Daugherty B, et al. (1 June 2023). A Randomized Placebo-Controlled Multicenter Trial of Monotherapy with TNX-601 ER (Tianeptine Hemioxalate Extended-Release
Estianeptine
Abnormal growth of tissue within bone
ablation of painful osseous metastases: a multicenter American College of Radiology Imaging Network trial". Cancer. 116 (4): 989–997. doi:10.1002/cncr
Bone_tumor
American eye surgeon (born 1958)
the light-adjustable intraocular lens (IOL). He published the first multicenter trial using the excimer laser to treat corneal abnormalities. He showed
Robert_Maloney_(doctor)
48-week, randomized, double-blind, double-observer, placebo-controlled multicenter trial of combination METhotrexate and intramuscular GOld therapy in rheumatoid
Clinical trial naming conventions
Clinical_trial_naming_conventions
Gene therapy medication
Lisocabtagene maraleucel's safety and efficacy were established in a multicenter clinical trial of more than 250 adults with refractory or relapsed large B-cell
Lisocabtagene_maraleucel
American diabetes-technology company
Raghinaru, Dan; Lum, John W. (October 31, 2019). "Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes". The New England Journal
Tandem_Diabetes_Care
Chemical compound
(Astelin NS) for seasonal allergic rhinitis: a 4-week comparative multicenter trial". Annals of Allergy, Asthma & Immunology. 76 (2): 181–8. doi:10
Azelastine
Antivenom drug
John Sullivan and Findlay Russell, developed clinically via multicenter clinical trials in the United States and commercialized by BTG Limited (formerly
Crotalidae polyvalent immune Fab
Crotalidae_polyvalent_immune_Fab
Design of tasks
support replication of results. An experimental design or randomized clinical trial requires careful consideration of several factors before actually doing
Design_of_experiments
Pharmaceutical compound
1158/2159-8290.CD-NW2026-0046. PMID 42047474. Clinical trial number NCT05379985 for "A Multicenter Open-Label Study of RMC-6236 in Patients With Advanced
Daraxonrasib
American surgeon and academic
descending thoracic aortic aneurysms in low-risk patients: a multicenter comparative trial." The Journal of thoracic and cardiovascular surgery 133, no
Joseph_Bavaria
Monoclonal antibody
approved amivantamab based on CHRYSALIS, a multicenter, non-randomized, open label, multicohort clinical trial (NCT02609776) which included participants
Amivantamab
Pharmaceutical compound
CAPItello-291 (NCT04305496), a randomized, double-blind, placebo-controlled, multicenter trial in 708 participants with locally advanced or metastatic HR-positive
Capivasertib
Type of therapy
sustained: a 24-month follow-up of the prospective randomized controlled multicenter trial of the effectiveness of spinal cord stimulation". Neurosurgery. 63
Neuromodulation_(medicine)
Hematological malignancy
Polish Adult Leukemia Group (PALG) of a prospective, randomized, multicenter trial". Blood. 109 (9): 3672–5. doi:10.1182/blood-2006-08-042929. PMID 17209059
Hairy_cell_leukemia
Anxiety disorder characterized by reoccurring unexpected panic attacks
therapy more effective than either CBT or SSRI alone? Results of a multicenter trial on panic disorder with or without agoraphobia". Acta Psychiatrica
Panic_disorder
Monoclonal anti-PD-L1 antibody
based on IMpassion130 (NCT02425891), a multicenter, international, double-blinded, placebo-controlled, randomized trial that included 902 participants with
Atezolizumab
Chemical compound
Efficacy was evaluated in a single-arm cohort of an open-label, multicenter trial (SNDX-5613-0700, NCT04065399; AUGMENT-101) in 104 adult and pediatric
Revumenib
Diagnostic tools for latent tuberculosis infection
results are less subject to reader bias and error. In a CDC-sponsored multicenter trial, QFT and TST results were moderately concordant (overall kappa value
Quantiferon
Chemical compound
in a randomized, controlled, double-blind, multinational, multicenter trial. In the trial, researchers randomly assigned 390 participants to receive
Ceftobiprole
Chemical compound
(NCT01908426), a randomized (2:1), double-blind, placebo-controlled, multicenter trial in participants with hepatocellular carcinoma who had previously received
Cabozantinib
Chemical compound
INAVO120 (NCT04191499), a randomized, double-blind, placebo-controlled, multicenter trial in 325 participants with endocrine-resistant, PIK3CA-mutated HR-positive
Inavolisib
Interventional procedure
Reentrant Tachycardia (the CYRANO Study): Results From a Large Multicenter Prospective Randomized Trial". Circulation. 122 (22): 2239–45. doi:10.1161/circulationaha
Radiofrequency_ablation
Mitochondrially inherited degeneration of retinal nerve cells
leber hereditary optic neuropathy: an open-labeled, nonrandomized multicenter trial of topical brimonidine purite". Am. J. Ophthalmol. 140 (3): 407–15
Leber's hereditary optic neuropathy
Leber's_hereditary_optic_neuropathy
requirement(s). (ICH E6) Multicenter study A clinical trial that is carried out at more than one medical institution. (NCI) A clinical trial conducted according
Glossary_of_clinical_research
Italian doctor
(Revascularization CHoices Among under-Represented Groups Evaluation) trial, a multicenter trial aiming to compare length of life and quality of life for women
Mario_Gaudino
Medical diagnostic method
therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial". Annals of Internal Medicine. 110 (9): 685–90. doi:10.7326/0003-4819-110-9-685
Modified Maddrey's discriminant function
Modified_Maddrey's_discriminant_function
Monoclonal antibody used as vaccine against RSV
nirsevimab based on three trials, two of which were randomized, double-blind, placebo-controlled, multicenter clinical trials (Trials 03, 04 and 05). The key
Nirsevimab
Norwegian doctor and professor
Investigator and Steering Committee Chairperson of the SMARTEX-HF multicenter trial and is a collaborating partner of Cardiac Exercise Research Group
Øyvind_Ellingsen
Chemical compound
ECHO (NCT02972840), a randomized, double-blind, placebo controlled, multicenter trial in 598 participants with untreated mantle cell lymphoma who were ≥65
Acalabrutinib
Clinical trial Women's Interagency HIV Study Brenda Wilson (April 24, 2009), AIDS Study Marks 25th Year, National Public Radio Multicenter AIDS Cohort
Multicenter_AIDS_Cohort_Study
Chemical compound
It was approved based on the results of the OLYMPUS (NCT02793128) multicenter trial involving 71 subjects with low-grade upper urinary tract urothelial
Mitomycin_C
Antibody-drug conjugate
govitecan-hziy was approved based on the results of IMMU-132-01, a multicenter, single-arm clinical trial (NCT01631552) of 108 participants with metastatic triple-negative
Sacituzumab_govitecan
Medical condition
colonoscopy, may improve detection of serrated lesions; however, one multicenter trial did not show improved detection. If polyps are very numerous, very
Serrated_polyposis_syndrome
Medical procedure to replace blood or immune stem cells
"Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life". Blood. 105 (6):
Hematopoietic stem cell transplantation
Hematopoietic_stem_cell_transplantation
Species of bacterium
ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial". Digestive Endoscopy. 28 (1): 67–74. doi:10.1111/den.12553. Yang
Bifidobacterium_longum
Plan for research in clinical medicine
ethics. Randomized controlled trial Blind trial Non-blind trial Adaptive clinical trial Platform Trials Nonrandomized trial (quasi-experiment) Interrupted
Clinical_study_design
Medical research using human test subjects
study Longitudinal study Minimisation Multicenter trial Nested case-control study Observational study Open-label trial Placebo-controlled studies Prospective
Outline_of_clinical_research
Medication
Gilbert EM, Miller RH, Keefe DL, Somberg JC, et al. (October 1986). "Multicenter trial of sotalol for suppression of frequent, complex ventricular arrhythmias:
Sotalol
Medication
eXALT3 (NCT02767804), an open-label, randomized, active-controlled, multicenter trial in 290 participants with locally advanced or metastatic ALK-positive
Ensartinib
Type of hormone therapy
failure in toddlers with Turner syndrome: a randomized, controlled, multicenter trial". J. Clin. Endocrinol. Metab. 92 (9): 3406–16. doi:10.1210/jc.2006-2874
Growth_hormone_therapy
Surgical procedure
Degeneration: Analysis of the 7-Year Postoperative Results of a Multicenter Randomized Controlled Trial". International Journal of Spine Surgery. 16 (1): 186–193
Total_disc_replacement
Chemical compound
M, Lucky A, Shavin J, Goldberg G, Dunlap F, et al. (July 1995). "Multicenter trial for long-term safety and efficacy comparison of 0.05% desonide and
Desonide
Realization of a certain method or idea in order to demonstrate its feasibility
III. Phase III studies involve larger numbers of patients—commonly multicenter trials—treated at doses and durations representative of marketed use, and
Proof_of_concept
Medical condition
micafungin versus voriconazole for chronic pulmonary aspergillosis: A multicenter trial in Japan". Journal of Infection. 61 (5). Elsevier BV: 410–418. doi:10
Aspergilloma
Treatment of Hemorrhagic Shock when Blood Is Unavailable: The USA Multicenter Trial". J Am Coll Surg. 208 (1): 1–13. doi:10.1016/j.jamcollsurg.2008.09
PolyHeme
Medical condition
collagenous colitis. A double-blind, randomized, placebo-controlled, multicenter trial". International Journal of Colorectal Disease. 22 (12): 1445–51. doi:10
Collagenous_colitis
Selective estrogen receptor modulator
"Tamoxifen treatment for precocious puberty in McCune-Albright syndrome: a multicenter trial". The Journal of Pediatrics. 143 (1): 60–66. doi:10.1016/S0022-3476(03)00128-8
Tamoxifen
EU research project (2020 to 2021)
2022). "A phase 2 randomized, double-blinded, placebo-controlled, multicenter trial evaluating the efficacy and safety of raloxifene for patients with
Exscalate4Cov
Chemical compound
Fischer-Cornelssen KA (1984). "Fluperlapine in 104 schizophrenic patients. Open multicenter trial". Arzneimittel-Forschung. 34 (1A): 125–30. PMID 6145428. Woggon B
Fluperlapine
Medical condition
"Endovascular treatment of thoracic aortic aneurysms: results of phase II multicenter trial of the GORE TAG thoracic endoprosthesis". J. Vasc. Surg. 41 (1): 1–9
Thoracic_aortic_aneurysm
Pharmaceutical drug
evaluated in IMCgp100-202 (NCT03070392), a randomized, open-label, multicenter trial of 378 participants with metastatic uveal melanoma. Participants were
Tebentafusp
Anticoagulant drug
HORIZONS AMI was a prospective, randomized, open-label, double-arm multicenter trial in STEMI patients undergoing primary PCI. 30 Day Results The incidence
Bivalirudin
15 minutes and was designed for epidemiological studies and multicenter clinical trials. Diagnostic classification and rating scales used in psychiatry
Mini-international Neuropsychiatric Interview
Mini-international_Neuropsychiatric_Interview
Antibody against interleukin 6
on Hemodialysis: Results from a Phase 1/2 Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial". Journal of the American Society of Nephrology
Ziltivekimab
Monoclonal antibody
was evaluated in AGAVE-201 (NCT04710576), a randomized, open-label, multicenter trial investigating three dosages of axatilimab in people with recurrent
Axatilimab
Chemical compound
Li Y, Zhou H, Feng Y, Gao G, et al. (February 2021). "A multicenter, randomized phase III trial of hetrombopag: a novel thrombopoietin receptor agonist
Hetrombopag
Chemical compound
(6-minute walk distance) compared with placebo in two double-blind, multicenter trials (ARIES-1 and ARIES-2). Like all endothelin receptor antagonists, Ambrisentan
Ambrisentan
Medical condition
the poor outcomes.[citation needed] Recently, a protocol used by a multicenter trial reported in the Journal of Clinical Oncology resulted in a 70% survival
Atypical teratoid rhabdoid tumor
Atypical_teratoid_rhabdoid_tumor
German pediatrician (born 1952)
Harms K, Herting E, McClure G, Reid M et al. Randomized European multicenter trial of surfactant replacement therapy for severe neonatal respiratory
Christian_P._Speer
Cell based gene therapy
Approval was based on ZUMA-2 (NCT02601313), an open-label, multicenter, single-arm trial of 74 participants with relapsed or refractory MCL who had previously
Brexucabtagene_autoleucel
Mammalian protein found in Homo sapiens
immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial". American Journal of Respiratory and Critical Care Medicine. 180
Granulocyte-macrophage colony-stimulating factor
Granulocyte-macrophage_colony-stimulating_factor
Traditional Chinese medicine formulation
controlled trials to evaluate its efficacy and safety. The most notable among these is the China Coronary Secondary Prevention Study (CCSPS), a multicenter trial
Xuezhikang
American physiologist (1904–2004)
prevention of heart disease. The department played an active role in multicenter trials of the 1970s–80s and population strategies of surveillance and preventive
Ancel_Keys
Synthetic vasoactive intestinal peptide
Infectious Diseases (NIAID) (2021-06-25). "A Multicenter, Adaptive, Randomized, Blinded Controlled Trial of the Safety and Efficacy of Investigational
Aviptadil
Chemical compound
and South Africa.[excessive citations] Randomized, double-blind, multicenter trial published in 2024 show that Riamilovir has demonstrated efficacy in
Riamilovir
Antibiotic medication
nosocomial pneumonia in intensive care patients: a prospective randomized multicenter trial". Intensive Care Medicine. 27 (3): 493–502. doi:10.1007/s001340000846
Piperacillin
Skin condition
therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial". Archives of Dermatology. 140 (12): 1453–9. doi:10.1001/archderm
Hand_eczema
Monoclonal antibody
et al. (8 August 2023). "S183: Phase III Randomized, Multicenter, Open-Label COMMODORE 1 Trial: Comparison of Crovalimab vs Eculizumab in Complement
Crovalimab
Pharmaceutical drug
refractory multiple myeloma. This randomized, open-label, phase 3, multicenter trial studied patients 18 years and older with multiple myeloma and measurable
Elotuzumab
Medication used for the treatment of gastro-intestinal diseases
multicenter trials of induction and maintenance therapy in Crohn's disease and ulcerative colitis have been published. An additional clinical trial,
Vedolizumab
Chemical compound
cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%
Chlormethine
coupling for distal anastomosis in coronary artery bypass grafting: A multicenter trial". The Journal of Thoracic and Cardiovascular Surgery. 126 (5): 1568–1574
Uwe_Klima
Swedish physician
distress syndrome: an international randomized clinical trial. Collaborative European Multicenter Study Group". Pediatrics. 82 (5): 683–91. November 1988
Bengt_Robertson
Patient and public engagement in health sector
means taking part in research, for example taking a drug in a clinical trial. Public involvement in medical research can be defined as research being
Patient and public involvement
Patient_and_public_involvement
Experimental atypical antipsychotic
clinical trial (NCT05184335).[citation needed] The RECOVER study was a 4-week, randomized, double-blind, placebo-controlled, multicenter trial where 411
Brilaroxazine
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