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is involved in CME, even though it does not contain the F-BAR domain Muniscins are known as alternate cargo adaptors. That is, they participate in selecting
Muniscins
Protein family
various clathrin adaptor protein complexes (AP1, AP2, AP3, AP4 and AP5) and muniscins. The C-terminal domain has an immunoglobulin-like beta-sandwich fold consisting
Adaptor complexes medium subunit domain
Adaptor_complexes_medium_subunit_domain
Protein-coding gene in the species Homo sapiens
FCH domain only 1 is a protein that in humans is encoded by the FCHO1 gene. GRCh38: Ensembl release 89: ENSG00000130475 – Ensembl, May 2017 GRCm38: Ensembl
FCHO1
Protein-coding gene in the species Homo sapiens
FCH domain only protein 2 is a protein that in humans is encoded by the FCHO2 gene. GRCh38: Ensembl release 89: ENSG00000157107 – Ensembl, May 2017 GRCm38:
FCHO2
Protein-coding gene in humans
SH3-containing GRB2-like protein 3-interacting protein 1 is a protein that in humans is encoded by the SGIP1 gene. GRCh38: Ensembl release 89: ENSG00000118473
SGIP1
sequence binding, and finally clathrin binding. A family of proteins called muniscins are thought to be the primary allosteric activators of the AP2 adaptor
AP2_adaptor_complex
Group of highly conserved protein dimerisation domains
domain family are CIP4/FBP17/Toca-1, Syndapins (also called PACSINs) and muniscins. or EFC for Extended FCH Homology) are BAR domains that are extensions
BAR_domain
and AP2 being the last to diverge. In addition, one component of TSET, a muniscin also known as the TCUP protein, appears to have evolved into part of the
Vesicular transport adaptor protein
Vesicular_transport_adaptor_protein
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