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Chronic neurological sleep disorder
Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement)
Narcolepsy
Symptom of narcolepsy
terror. Cataplexy is the first symptom to appear in about 10% of cases of narcolepsy, caused by an autoimmune destruction of hypothalamic neurons that produce
Cataplexy
Topics referred to by the same term
Narcolepsy is a neurological condition most characterized by Excessive Daytime Sleepiness (EDS). Narcolepsy may also refer to: "Narcolepsy" (Third Eye
Narcolepsy_(disambiguation)
Sleeping disorder
condition may occur in those who are otherwise healthy or those with narcolepsy, or it may run in families as a result of specific genetic changes. The
Sleep_paralysis
Investigational narcolepsy and hypersomnia drugs
investigational narcolepsy and hypersomnia drugs, or drugs that are currently under development for clinical use for the treatment of narcolepsy and/or hypersomnia
List of investigational narcolepsy and hypersomnia drugs
List_of_investigational_narcolepsy_and_hypersomnia_drugs
Central nervous system stimulant prodrug
are responsible for narcolepsy in a canine model, knockout of the orexin gene produces narcolepsy in mice, and humans with narcolepsy have low or absent
Lisdexamfetamine
Medication to treat narcolepsy
used for the treatment of excessive daytime sleepiness in adults with narcolepsy. It is an inverse agonist of the histamine H3 receptor. It is the first
Pitolisant
Sleep disorder in children
Pediatric narcolepsy refers to conditions of narcolepsy during childhood and adolescence (during the ages 18 years and younger). In a pediatric setting
Pediatric_narcolepsy
Wakefulness-promoting medication
used to treat narcolepsy, sleep apnea, and shift work sleep disorder. It is taken by mouth. Modafinil is a first-line treatment for narcolepsy in the United
Modafinil
Sleep disorder of unknown cause
oxybates; in addition to several off-label treatments (primarily FDA-approved narcolepsy medications). Idiopathic hypersomnia may also be referred to as IH, IHS
Idiopathic_hypersomnia
Temporary episode of sleep or drowsiness
million people. Other disorders that may be tied to microsleeps include narcolepsy, hypersomnia, schizophrenia, and other causes of excessive daytime sleepiness
Microsleep
This is a list of notable people who have narcolepsy. Jinkx Monsoon, American drag performer. Known for competing on RuPaul's Drag Race. Gabe Barham, drummer
List of people with narcolepsy
List_of_people_with_narcolepsy
Flu vaccine
strain. Pandemrix was found to be associated with an increased risk of narcolepsy following investigations by Swedish and Finnish health authorities and
Pandemrix
Medication used for the treatment of excessive sleepiness
medication used in the treatment of excessive sleepiness related to narcolepsy and sleep apnea. It is taken by mouth. Common side effects of solriamfetol
Solriamfetol
CNS stimulant and isomer of amphetamine
the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used illicitly to enhance cognitive and athletic performance
Dextroamphetamine
Pharmaceutical compound
treatment of narcolepsy. It is taken orally. The drug is under development by Eisai. As of May 2026, it is in phase 2 clinical trials for narcolepsy. List of
Ledasorexton
Medication to treat symptoms of narcolepsy
brand name Xyrem among others, is a medication used to treat symptoms of narcolepsy: sudden muscle weakness and excessive daytime sleepiness. It is used sometimes
Sodium_oxybate
Pharmaceutical compound
wakefulness-promoting agent which is under development for the treatment of narcolepsy (types 1 and 2) and idiopathic hypersomnia. It is taken by mouth. The
Oveporexton
Central nervous system stimulant
the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy; it is also used to treat binge eating disorder in the form of lisdexamfetamine
Amphetamine
Pharmaceutical compound
OX2 receptor agonist which is under development for the treatment of narcolepsy and idiopathic hypersomnia. It is taken orally. The drug is under development
Balumorexton
Neuropeptide that regulates arousal, wakefulness, and appetite
exists in the forms of orexin-A and orexin-B. The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone
Orexin
Pharmaceutical compound
γ-hydroxybutyrate (GHB; oxybate) which is under development for the treatment of narcolepsy. It is also being investigated for treatment of excessive daytime sleepiness
Valiloxybate
Chemical compound
used in medicine as a general anesthetic and as treatment for cataplexy, narcolepsy, and alcoholism. It is also used illicitly for performance enhancement
Γ-Hydroxybutyric_acid
Non-profit organisation
Narcolepsy Network, Inc. is a non-profit national patient support organization that helps raise awareness and advocates for research and development for
Narcolepsy_Network
American actress (born 1967)
2007, Walsh has been the spokesperson for Narcolepsy Network, working to promote national awareness of narcolepsy through infomercials and DVDs. In January
Kate_Walsh_(actress)
Medical disorder of a person's sleep patterns
obstructive sleep apnea), central disorders of hypersomnolence (such as narcolepsy), circadian rhythm sleep disorders, parasomnias, and sleep-related movement
Sleep_disorder
Experimental drug to treat narcolepsy
receptor inverse agonist which is under development for the treatment of narcolepsy. It was also under development for the treatment of cognition disorders
Samelisant
Drug mixture used mainly to treat ADHD and narcolepsy
the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used as an athletic performance enhancer, cognitive enhancer
Adderall
narcolepsy (previously narcolepsy with cataplexy) and a reduced risk of type 1 diabetes. It is present in >90% of individuals with type 1 narcolepsy and
HLA_DQB1*06:02
Antihistaminic drug
deficit hyperactivity syndrome (ADHD), schizophrenia (SCH), pain, and narcolepsy. Narcolepsy is a sleeping disorder which is characterised by chronic sleepiness
H3_receptor_antagonist
Drug class
improve cognitive performance, as well as treating ADHD, depression, and narcolepsy. Amphetamine-type stimulants are also known for their addictive properties
Norepinephrine–dopamine releasing agent
Norepinephrine–dopamine_releasing_agent
Neurological disorder of excessive time spent sleeping or excessive sleepiness
sleepiness. Obstructive sleep apnea "occurs frequently in narcolepsy and may delay the diagnosis of narcolepsy by several years and interfere with its proper management
Hypersomnia
Stimulant, used in the treatment of ADHD
the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It has since been discontinued in most countries due to rare but serious
Pemoline
Symptom characterized by persistent sleepiness
sleep is a symptom, or as a symptom of another underlying disorder like narcolepsy, circadian rhythm sleep disorder, sleep apnea or idiopathic hypersomnia
Excessive_daytime_sleepiness
Novel chemistry compound
is under development for the treatment of sleep disorders, including narcolepsy and idiopathic hypersomnia. Alixorexton is being developed by Alkermes
Alixorexton
Drug that inhibits the reuptake of norepinephrine and dopamine
conditions including attention deficit hyperactivity disorder (ADHD), narcolepsy, and depression. Examples of well-known NDRIs include methylphenidate
Norepinephrine–dopamine reuptake inhibitor
Norepinephrine–dopamine_reuptake_inhibitor
1997 studio album by Third Eye Blind
No. Title Writer(s) Length 1. "Losing a Whole Year" 3:20 2. "Narcolepsy" 3:48 3. "Semi-Charmed Life" Jenkins 4:28 4. "Jumper" Jenkins 4:32 5. "Graduate"
Third_Eye_Blind_(album)
Medication used to treat insomnia
as well as sleep attacks and fragmented sleep. Narcolepsy with cataplexy, also known as type 1 narcolepsy, is thought to be caused by loss of orexin-producing
Suvorexant
French sleep researcher
authority on sleep research and medicine, and is mostly known for his work on narcolepsy. He is the Craig Reynolds Professor of Sleep Medicine at Stanford Medical
Emmanuel_Mignot
Drug that increases wakefulness
vigilance and motivation. Wakefulness-promoting agents are used to treat narcolepsy and hypersomnia and to increase wakefulness and performance in healthy
Wakefulness-promoting_agent
Chemical compound
of March 2021, danavorexton is under development for the treatment of narcolepsy, idiopathic hypersomnia, and sleep apnea. It is related to another orexin
Danavorexton
Central nervous system stimulant
the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It may be taken by mouth or applied to the skin, and different formulations
Methylphenidate
1999 studio album by Ben Folds Five
album. During the WASO Live in Perth concert, Folds describes the song "Narcolepsy" as "about going to sleep, but it's about the kind of going to sleep that
The Unauthorized Biography of Reinhold Messner
The_Unauthorized_Biography_of_Reinhold_Messner
Appetite suppressant
short-term treatment of obesity. It is also used off-label in the treatment of narcolepsy and cataplexy. The drug is taken orally. Mazindol was developed by Sandoz-Wander
Mazindol
Pharmaceutical compound
OX2 receptor agonist which is under development for the treatment of narcolepsy and idiopathic hypersomnia. It is taken orally. The drug was originated
Cleminorexton
Medical symptom
insomnia and shift work sleep disorder. It can also occur in hypersomnia and narcolepsy. In addition, NRS is frequently a symptom of conditions like fibromyalgia
Non-restorative_sleep
Protein-coding gene in the species Homo sapiens
with a predisposition to narcolepsy, specifically HLA-DQB1*0602, which is carried by over 90% of patients with type 1 narcolepsy. Major histocompatibility
HLA-DQB1
State of desire for sleep, for unusually long periods
as are a number of other conditions such as sleep apnea, insomnia and narcolepsy. The body clock disorders are classified as extrinsic (externally caused)
Somnolence
Pharmaceutical compound
receptor antagonist which was under development for the treatment of narcolepsy and attention deficit hyperactivity disorder (ADHD) but was never marketed
Bavisant
described sleeplessness, nightmares, sleepwalking and sleep-talking. Narcolepsy, hypnogogic hallucination, wakefulness and somnolence were mentioned by
Classification of sleep disorders
Classification_of_sleep_disorders
Pharmaceutical compound
an experimental drug under investigation as a potential treatment for narcolepsy. It is a member of the histamine H3 receptor antagonist/inverse agonist
Enerisant
CNS stimulant and isomer of amphetamine
treatment of attention deficit hyperactivity disorder (ADHD), obesity, and narcolepsy in some countries. Levoamphetamine is taken by mouth. Levoamphetamine
Levoamphetamine
Medication used to treat ADHD and depression
granted the medication an orphan designation for treatment of cataplexy and narcolepsy with the tentative brand name Catatrol. For unknown reasons however, it
Viloxazine
Drug for wakefulness and alertness
certain sleep disorders, including excessive daytime sleepiness (EDS) in narcolepsy or obstructive sleep apnea (OSA). Eugeroics are also often prescribed
Eugeroic
Medical condition
Autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCADN) is a rare progressive genetic disorder that primarily affects the nervous system
Autosomal dominant cerebellar ataxia, deafness, and narcolepsy
Autosomal_dominant_cerebellar_ataxia,_deafness,_and_narcolepsy
Category of small signaling proteins
correlation between plasma interleukin IL-2 and fatigue in patients with type 1 narcolepsy. Autoantibodies against cytokines also plays a role in health and disease
Cytokine
Vaccine ingredient
each of England, Norway and France in 2013, found an association between narcolepsy and Pandemrix; the rates ranged from one in 16,000 doses to one in 50
AS03
Drug that increases alertness
B.C.E. Stimulants have been used to treat various conditions, such as narcolepsy, attention deficit hyperactivity disorder (ADHD), obesity, depression
Stimulant
Component of vaccines
immunity despite using very little antigen; but the same vaccine also caused narcolepsy in a very small amount of people, all sharing one specific gene variant
Immunologic_adjuvant
Tricyclic antidepressant
and the cataplexy associated with narcolepsy. It may also address certain fundamental features surrounding narcolepsy besides cataplexy (especially hypnagogic
Clomipramine
Combination drug
of age and older with narcolepsy; and for idiopathic hypersomnia. Xywav is recommended to be dosed twice nightly in narcolepsy and idiopathic hypersomnia
Xywav
Chemical compound
agent in the treatment of idiopathic hypersomnia and narcolepsy. List of investigational narcolepsy and hypersomnia drugs GABAA receptor negative allosteric
Pentylenetetrazol
Pharmaceutical compound
(γ-hydroxybutyrate; GHB) which is under development for the treatment of narcolepsy. It is taken orally. In a clinical study, JZP-386 showed greater circulating
JZP-386
Chemical compound
Pharmaceutical Company. Firazorexton was studied by Takeda for the treatment of narcolepsy. It is a small-molecule and orally active compound and acts as a highly
Firazorexton
Cast of neo-Western crime media franchise
pickpocketing skills than his intelligence, he has a condition approximating narcolepsy (e.g., he falls asleep at odd times, such as when standing up or while
List of characters in the Breaking Bad franchise
List_of_characters_in_the_Breaking_Bad_franchise
Medical condition
disorders. These include insomnia disorders, hypersomnolence disorders, narcolepsy, obstructive sleep apnea hypopnea, central sleep apnea, sleep-related
Sleep_sex
has described the syndrome as a dissociation reaction, or a possible narcolepsy-cataplexy syndrome. The syndrome concludes with complete remission, usually
Soul_wandering
Withdrawn antidepressant medication
wakefulness-promoting effects in animals and might be useful in the treatment of narcolepsy. Amineptine Diclofensine Perafensine Tesofensine The combination of Clobazam
Nomifensine
American rock musician (1967–1994)
Cobain had depression. In 1993, he told Michael Azerrad that he had narcolepsy and manic depression. His cousin brought attention to the family history
Kurt_Cobain
Protection against the H1N1/09 virus
campaign of 2009 and 2010 and narcolepsy epidemic in Finland: there was a nine times higher probability to get narcolepsy with vaccination than without
2009 swine flu pandemic vaccine
2009_swine_flu_pandemic_vaccine
Topics referred to by the same term
community network, operating in Patras, Greece Person with narcolepsy, as abbreviated by narcolepsy chat and support groups Phrack World News, a service of
PWN
Wakefulness-promoting medication
excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. It is also used off-label for certain other
Armodafinil
Irish-domiciled healthcare company
five proprietary commercial drug products approved for the treatment of narcolepsy, schizophrenia, bipolar I disorder, alcohol dependence and opioid dependence
Alkermes_plc
Amphetamine psychostimulant
used in the Soviet Union. It was used in the treatment of depression, narcolepsy, post-encephalitis sequelae, alcoholic psychoses, asthenia, and other
Phenatine
Medication, stimulant and decongestant
low blood pressure during anesthesia. It has also been used for asthma, narcolepsy, and obesity but is not the preferred treatment. It is of unclear benefit
Ephedrine
Central nervous system stimulant
20–25 mg/day. Methamphetamine is sometimes prescribed off-label for obesity, narcolepsy, and idiopathic hypersomnia. In the United States, methamphetamine's levorotary
Methamphetamine
Fictional character
portrayed by River Phoenix. He is a sensitive, homeless teenage hustler with narcolepsy, directly foiling his best friend, Scott Favor (Keanu Reeves), a type-A
Mikey_Waters
Chemical compound
tends to be energizing instead of sedating, and is sometimes used for narcolepsy to achieve a wakefulness-promoting effect. TCAs including protriptyline
Protriptyline
Amphetamine-derived stimulant drug
developed in the 1970s and used for the treatment of obesity, ADHD, and narcolepsy. It has largely been withdrawn from clinical use following problems with
Amfetaminil
Short period of sleep during typical waking hours
sleepiness (EDS) can be improved by prescribed napping in narcolepsy. Apart from narcolepsy, it has not been demonstrated that naps are beneficial for
Nap
Substance that mimics effects of catecholamines
psychiatric conditions such as ADHD, neurological conditions such as narcolepsy, among other things. These drugs can act through several mechanisms, such
Sympathomimetic_drug
Medical intervention
MSLT is used to test for central disorders of hypersomnolence such as narcolepsy or idiopathic hypersomnia, or to distinguish between physical tiredness
Multiple_Sleep_Latency_Test
Naturally recurring resting state of mind and body
sleep disorders, including dyssomnias, such as insomnia, hypersomnia, narcolepsy, and sleep apnea; parasomnias, such as sleepwalking and rapid eye movement
Sleep
Medical specialty
by an identifiable and treatable sleep disorder," such as sleep apnea, narcolepsy, idiopathic hypersomnia, Kleine-Levin syndrome, menstrual-related hypersomnia
Sleep_medicine
American psychologist
causative gene in canine familial narcolepsy. In 2000, he identified the main developmental mechanism of human narcolepsy as the center of the group. In
Seiji_Nishino
Sleep disorder
physiological defect in the wake/sleep system, as in idiopathic hypersomnia or narcolepsy. Similarly, it should not be confused with dysania, which describes a
Clinophilia
Wakefulness-promoting drug/Dopamine reuptake inhibitor
conditions. These include chronic fatigue syndrome, idiopathic hypersomnia, narcolepsy, attention deficit hyperactivity disorder (ADHD), and Alzheimer's disease
Flmodafinil
Specialty pharmaceutical company
Missouri and Lyon, France. It was a developer of the US FDA-approved anti-narcolepsy medication LUMRYZ (sodium oxybate). It was acquired by Alkermes in February
Avadel_Pharmaceuticals
British pharmaceutical and biotechnology company
vaccination campaign of 2009 and 2010, and the narcolepsy epidemic in Finland. A total of 152 cases of narcolepsy were found in Finland during 2009–2010, and
GSK_plc
Irish tax-registered pharmaceutical corporation
Sunosi with indications for treating excessive daytime sleepiness (EDS) in narcolepsy as well as obstructive sleep apnea (OSA). In 2022, it was announced that
Jazz_Pharmaceuticals
Medical term meaning "characteristic for a particular disease"
Granulosa cell tumour Call-Exner bodies Malakoplakia Michaelis–Gutmann bodies Narcolepsy (with cataplexy) Cataplexy Endodermal sinus tumor Schiller–Duval body
Pathognomonic
Antibiotic medication
treatment of central hypersomnolence (i.e., idiopathic hypersomnolence and narcolepsy without cataplexy). There was no apparent improvement on an objective
Clarithromycin
1999 psychological thriller film by David Fincher
same person, with Tyler taking control during the Narrator's apparent narcolepsy. The Narrator discovers Project Mayhem's ultimate objective: to erase
Fight_Club
German actress (born 1961)
interview in The Daily Telegraph that she was affected by the sleep disorder narcolepsy. The awards and nominations received by Nastassja Kinski include one Art
Nastassja_Kinski
Scale to measure daytime sleepiness via a questionnaire
score of 16 and above indicates the possibility of severe sleep apnea or narcolepsy. Certain questions in the scale were shown to be better predictors of
Epworth_Sleepiness_Scale
Medical specialty dealing with disorders of the nervous system
muscular dystrophy, migraine, attention deficit hyperactivity disorder, narcolepsy Significant tests Computed axial tomography, MRI scan, lumbar puncture
Neurology
United States drug-regulating law
GHB (gamma-Hydroxybutyric acid), a general anesthetic and treatment for narcolepsy-cataplexy and alcohol withdrawal with a limited safe dosage range and
Controlled_Substances_Act
Brain region
that involve dysfunctions of the orexinergic projection system include narcolepsy, motility disorders or functional gastrointestinal disorders involving
Lateral_hypothalamus
Coding resource for sleep and sleep-related disorders
insomnia, narcolepsy and parasomnia. Primary vs. secondary (i.e. comorbid) insomnia has been reunited into a single disorder: chronic insomnia. Narcolepsy has
International Classification of Sleep Disorders
International_Classification_of_Sleep_Disorders
Transition from wakefulness into sleep
eye movement sleep (NREM sleep) but under certain circumstances (e.g. narcolepsy) it is possible to transit from wakefulness directly into rapid eye movement
Sleep_onset
NARCOLEPSY
NARCOLEPSY
NARCOLEPSY
NARCOLEPSY
Boy/Male
Indian
Firm, Solid
Female
Polish
Feminine form of Polish Iwo, IWONA means "yew tree."
Male
Egyptian
, a chief of signet bearers.
Male
English
Anglicized form of Greek AmÅs, AMOS means "strong." In the New Testament bible, this is the name of an ancestor of Christ.
Boy/Male
Arabic, Muslim, Sindhi
An Ascetic and Authority for Hadith; This was the Name of Abu Bakr Muhammad
Boy/Male
Tamil
Evening
Girl/Female
French
Veiled.
Girl/Female
Latin
First.
Girl/Female
Hindu
Goddess Durga, One who strives with pertinacity of purpose, One who makes the people obtain the divine wisdom by reducing the ignorance
Girl/Female
Indian, Sanskrit
One who Takes the Devotees Up to Other World
NARCOLEPSY
NARCOLEPSY
NARCOLEPSY
NARCOLEPSY
NARCOLEPSY