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Protein found in humans
Nicastrin, also known as NCSTN, is a protein that in humans is encoded by the NCSTN gene. Nicastrin (abbreviated NCT) is a protein that is part of the
Nicastrin
Type of protein
secretase complex consists of four individual proteins: PSEN1 (presenilin-1), nicastrin, APH-1 (anterior pharynx-defective 1), and PEN-2 (presenilin enhancer
Gamma_secretase
Protein gene product
Caenorhabditis elegans as a regulator of the cell-surface localization of nicastrin and an essential component in the Notch signaling pathway. APH-1 homologs
APH-1
Alzheimer's disease developed before the age of 65
Presenilins 1 and 2 are the enzymatic centers of this complex along with nicastrin, Aph1, and PEN-2. Alpha-secretase cleavage of APP, which precludes the
Early-onset Alzheimer's disease
Early-onset_Alzheimer's_disease
Topics referred to by the same term
Dakota Nuclear Compton Telescope, a balloon-borne gamma-ray detector Nicastrin, a protein component of the gamma secretase enzyme complex Nocturnal clitoral
NCT
Protein-coding gene in the species Homo sapiens
protein (APP). The gamma secretase complex consists of PEN-2, APH-1, nicastrin, and the catalytic subunit presenilin. PEN-2 is a 101-amino acid integral
PEN-2
Protein-coding gene in the species Homo sapiens
interact with: BCL2-like 1, CAPN1, CIB1, Calsenilin, FHL2, FLNB, KCNIP4, Nicastrin, and UBQLN1. GRCh38: Ensembl release 89: ENSG00000143801 – Ensembl, May
Presenilin-2
Protein-coding gene in the species Homo sapiens
mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes". J. Biol. Chem. 278 (9): 7374–80
Presenilin-1
complex imaged using cryo-electron microscopy. The structure contains nicastrin (red), presenilin-1 (orange), PEN-2 (blue), and APH-1 (green). This is
Alzheimer's disease in the Hispanic/Latino population
Alzheimer's_disease_in_the_Hispanic/Latino_population
British-Canadian neurologist and neuroscientist
disease. These include the discovery of the presenilins (PSEN1 and PSEN2), Nicastrin, TREM2, Apolipoprotein E and SORL1 genes. Presenilin mutations are the
Peter_St_George-Hyslop
Protein-coding gene in the species Homo sapiens
presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin". Biochem. J. 391 (Pt 3): 513–25. doi:10.1042/BJ20050491. PMC 1276952
UBQLN2
Type of enzyme
domain. γ-secretase is actually a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. Presenilin is believed to harbor the protease domain
Amyloid-beta precursor protein secretase
Amyloid-beta_precursor_protein_secretase
American biologist (1928–2019)
Liao, F; Li, F; Wong, PC; Farquhar, MG; Thinakaran, G; Xu, H (2005). "Nicastrin is critical for stability and trafficking but not association of other
Marilyn_Farquhar
Family of related multi class transmembrane proteins
intramembrane protease, a four-member protein complex consisting of presenilin, nicastrin, APH-1, and PEN-2. It has a very broad range of substrates for its proteolytic
Presenilin
American immunologist and geneticist
Yu, Gang; Beutler, Bruce (March 3, 2020). "Essential requirement for nicastrin in marginal zone and B-1 B cell development". Proceedings of the National
Bruce_Beutler
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