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Cancerous tumour in a bone
An osteosarcoma (OS) or osteogenic sarcoma (OGS) is a cancerous tumor in a bone. Specifically, it is an aggressive malignant neoplasm that arises from
Osteosarcoma
Cancer originating in connective tissue
Common examples of sarcoma include liposarcoma, leiomyosarcoma, and osteosarcoma. Sarcomas are primary connective tissue tumors, meaning that they arise
Sarcoma
Protein
protein 3 (G0S3), is a protein that in humans is encoded by the FBJ murine osteosarcoma viral oncogene homolog B (FOSB) gene. The FOS gene family consists of
FOSB
Abnormal growth of tissue within bone
with bone and joint cancer is 68%. The earliest known bone tumor was an osteosarcoma in a foot bone discovered in South Africa, between 1.6 and 1.8 million
Bone_tumor
Medical condition
autosomal dominant hereditary disorder. Its name is an initialism of "osteosarcoma, limb anomalies, and erythroid macrocytosis with megaloblastic marrow
OSLAM_syndrome
Malignant tumor that grows within a bone
on tissue type – an osteosarcoma, a Ewing's sarcoma, and a chondrosarcoma. The three main types of bone sarcoma are an osteosarcoma, most frequently found
Bone_sarcoma
2012 novel by John Green
17-year-old Augustus Waters, an ex-basketball player, amputee, and survivor of osteosarcoma. An American feature film adaptation of the same name as the novel directed
The_Fault_in_Our_Stars
Mammalian protein found in Homo sapiens
has been implicated in transformation and progression of cancer. In osteosarcoma and endometrial carcinoma, c-Fos overexpression was associated with high-grade
Protein_c-Fos
2020 film by Justin Baldoni
It tells the story of Zach Sobiech, a teenager from Minnesota who has osteosarcoma and decides to follow his dream of becoming a musician after finding
Clouds_(2020_film)
Unmineralized, organic portion of the bone matrix
historically. Osteosarcoma: The most common primary malignant bone tumor, osteosarcoma is characterized by malignant cells that produce osteoid. Osteosarcoma is
Osteoid
Domesticated species of canid
urinary incontinence and pyometra in bitches, prostate cancer in dogs, and osteosarcoma, hemangiosarcoma, cruciate ligament rupture, obesity, and diabetes mellitus
Dog
Addition of fluoride to a water supply to reduce tooth decay
bone cancer and osteosarcoma. Series of research concluded that concentration of fluoride in water does not associate with osteosarcoma. The beliefs regarding
Water_fluoridation
Chemotherapy and immunosuppressant medication
leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and osteosarcoma, as well as autoimmune diseases such as psoriasis, rheumatoid arthritis
Methotrexate
Pharmaceutical drug
Mifamurtide (trade name Mepact, marketed by Takeda) is a drug against osteosarcoma, a kind of bone cancer mainly affecting children and young adults, which
Mifamurtide
Type of cancer
similar clinical presentations include osteomyelitis, osteosarcoma (especially telangiectatic osteosarcoma), and eosinophilic granuloma. Soft-tissue neoplasms
Ewing_sarcoma
Chinese computational biologist
Jinghui Zhang is a computational biologist and osteosarcoma researcher. She is the Chair of Department of Computational Biology and Endowed Chair of Bioinformatics
Jinghui_Zhang
Canadian athlete (1958–1981)
University. His right leg was amputated in 1977 after he was diagnosed with osteosarcoma, though he continued to run using an artificial leg. He also played wheelchair
Terry_Fox
Brazilian ocean rower
rower. In 2015, he rowed across the North Atlantic Ocean to promote osteosarcoma research. He has a Master of Law from Harvard Law School. Altafin was
Caetano_Altafin
Protein-coding gene in humans
functions are especially important when discussing bone cancer, particularly osteosarcoma development, that can be attributed to aberrant cell proliferation control
RUNX2
American singer-songwriter
attended Stillwater Area High School. At age 14, Sobiech was diagnosed with osteosarcoma, a bone cancer that mostly affects children. CBS reported that during
Zach_Sobiech
Rare autosomal recessive skin condition
skin condition. There have been several reported cases associated with osteosarcoma. A hereditary basis, mutations in the DNA helicase RECQL4 gene, causing
Rothmund–Thomson_syndrome
Type of autograft involving limb rotation
knee joint following removal of a distal femoral bone tumor, such as osteosarcoma. The limb is rotated because the ankle flexes in the opposite direction
Rotationplasty
Chemical compound
receptor. Phase 2 clinical trials in patients with colorectal cancer, osteosarcoma and Ewing sarcoma are complete. Merck has since discontinued development
Robatumumab
Italian venerable
3 July 1937), nicknamed "Nennolina", was an Italian girl who died of osteosarcoma. Currently, she is the youngest person the Catholic Church has considered
Antonietta_Meo
Human osteosarcoma cell line
differentiated human osteosarcoma (OS) cell line. U2OS cells were derived from the tibial bone of a 15-year-old female patient with osteosarcoma by scientists
U2OS_cell_line
Chemical compound
murine xenograft models. In osteosarcoma Dinacliclib induces the apoptosis of osteosarcoma cells. Apoptosis of osteosarcoma cultures can be induced by
Dinaciclib
New growth of bone following the raising of periosteum away from the bone
periosteal reaction.[citation needed] The main causes for this sign are osteosarcoma, Ewing's sarcoma, eumycetoma, and a subperiosteal abscess. "Codman's
Codman_triangle
Dog breed
to hemangiosarcoma and osteosarcoma. A study in the UK of more than 900,000 dogs looking at the annual prevalence of osteosarcoma found the Leonberger to
Leonberger
Condition in veterinary medicine
called osteosarcoma, and typically affects middle-age to older dogs of large and giant breeds. Osteosarcoma is less common in cats. Osteosarcoma is an
Bone_cancer_in_cats_and_dogs
American lawyer and politician (born 1961)
Kennedy (born 1967). In 1973, when Kennedy was about to turn twelve, osteosarcoma (a form of bone cancer) was diagnosed in his right leg. After rounds
Edward_M._Kennedy_Jr.
Chemotherapy medication
types of cancer. This includes testicular cancer, soft tissue sarcoma, osteosarcoma, bladder cancer, small cell lung cancer, cervical cancer, and ovarian
Ifosfamide
American boxer (born 1987)
the "Miracle Man", Jacobs' career was almost cut short in 2011 due to osteosarcoma, a rare form of bone cancer. He went on to make a full recovery after
Daniel_Jacobs_(boxer)
2012 single by Zach Sobiech
Handshake). Proceeds from the sale of "Clouds" go to the Zach Sobiech Osteosarcoma Fund, which is a branch of the Children's Cancer Research Fund. In the
Clouds_(Zach_Sobiech_song)
Czech Paralympic athlete and para cross-country skier
Paralympics. In 2015, Sedláčková fell and broke her arm which developed into osteosarcoma then she retired from sport. After retirement, she has become a lawyer
Miroslava_Sedláčková
Chemical compound
is commonly used in lung cancer, prostate cancer, breast cancer, and osteosarcoma. Side effects include the following: Black, tarry stools Blood in urine/stool
Samarium_(153Sm)_lexidronam
Chinese basketball player
had to end his basketball career at age 19 after being diagnosed with osteosarcoma. Xu Yong came out of the youth program of Yao Ming's Shanghai Dongfang
Xu_Yong_(basketball)
Oncology Division of Takeda Pharmaceuticals
rest of the world. MEPACT mifamurtide Mifamurtide is a drug against osteosarcoma, a kind of bone cancer mainly affecting children and young adults, which
Takeda_Oncology
Spanish football manager (born 1970)
años al no superar un osteosarcoma" [Luis Enrique announces death of his nine-year-old daughter after not overcoming osteosarcoma] (in Spanish). Cadena
Luis_Enrique
Upcoming South Korean television series
mechanical engineering following the amputation of his right leg due to osteosarcoma. Though focused on prosthetic research, he maintains a list of personal
Love_Doctor_(TV_series)
bone Leiomyosarcoma Malignant fibrous histiocytoma of bone/osteosarcoma Myxosarcoma Osteosarcoma Rhabdomyosarcoma Astrocytoma Anaplastic astrocytoma Brainstem
List_of_cancer_types
Brazilian Venerable (1955–1964)
"Nelsinho" (31 July 1955 – 24 December 1964), was a Brazilian boy who died of osteosarcoma. He came to be widely venerated in his hometown Ibitinga, and Pope Francis
Nelson_Santana
US nonprofit organization
1998. In 2013, the Zach Sobiech Osteosarcoma Fund was established to designate funding specifically for osteosarcoma research. It's administered by the
Children's Cancer Research Fund
Children's_Cancer_Research_Fund
American professional golfer (born 1996)
for Scheffler's childhood friend James Ragan, who was diagnosed with osteosarcoma in 2006 and died in 2014. Scheffler donated $50,000 to the foundation
Scottie_Scheffler
social and cultural history. In the year 2016, a 1.7 million year old osteosarcoma was reported by Dr Edward John Odes (a doctoral student in Anatomical
History_of_cancer
Saos-2 ("sarcoma osteogenic") is a cell line derived from the primary osteosarcoma of an 11-year-old Caucasian girl in 1973 by Fogh et al. The cell line
Saos-2_cells
Medical condition of bone growth
excessive growth of the bone. Onion skin periosteal reaction is seen in osteosarcoma, Ewing sarcoma and Langerhans cell histiocytosis. In radiological images
Onion skin periosteal reaction
Onion_skin_periosteal_reaction
Cast of American crime drama TV series
health/nursing business. During her childhood, Svetlana developed an osteosarcoma in her leg, which had to be amputated soon afterward. Svetlana's first
List of The Sopranos characters
List_of_The_Sopranos_characters
2000 US romantic drama film by Mark Piznarski
returning to the small town, Sam's parents soon learn that their daughter's osteosarcoma has relapsed, which was initially discovered after a track injury, and
Here_on_Earth_(film)
Fictional character on television series The Sopranos
home care nursing business. During her childhood, Svetlana developed osteosarcoma in her leg, which was amputated soon afterward. Tony comments that she
Tony_Soprano
Medical condition
tumor invasions into bones. Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing sarcoma are rare; the most common bone tumor
Bone_metastasis
Chemical element with atomic number 62 (Sm)
kills cancer cells in lung cancer, prostate cancer, breast cancer and osteosarcoma. Another isotope, samarium-149, is a strong neutron absorber and so is
Samarium
Pharmaceutical drug for treating osteoporosis
case report, it was found to potentially be associated with developing osteosarcoma in test subjects after over two years of use. Adverse effects of teriparatide
Teriparatide
American football player (1999–2026)
seasons, he transferred to Louisiana Tech in 2022. Lee was diagnosed with osteosarcoma in July 2022. He went into remission following several surgeries, but
Devonta_Lee
American medical teen drama television series
stand with Dr. McAndrew. Charlie Rowe as Leo Roth, an amputee and former osteosarcoma patient who is undergoing rehabilitation. He is the creator and unofficial
Red_Band_Society
Chemical compound
expression of the gene Nanog. RepSox suppresses the proliferation of osteosarcoma cells via suppression of the JNK/Smad3 signalling pathway, and was able
RepSox
American Pharmaceutical Company
evaluating an Lm-LLO-based immunotherapy in a Phase 1 study in canine osteosarcoma. Advaxis was a Delaware corporation when it was acquired by a shell corporation
Advaxis
Benign bone tumor consisting of blood
cases. Less frequently, it results from some malignant tumors, such as osteosarcoma, chondrosarcoma, and hemangioendothelioma.[citation needed] Histologically
Aneurysmal_bone_cyst
Indian actor (1986–2020)
Sanghi and played the character of Manny, a patient of the bone cancer osteosarcoma; the role in the Hindi remake was a reprisal of the role of Ansel Elgort
Sushant_Singh_Rajput
British surgeon and academic
of the Hunterian Professorship, awarded for his work on surgery and osteosarcoma. Together with engineer Brian Davies from Imperial, he developed the
Justin_Cobb
Irish activist (1996–2013)
Independent as "a teenager who inspired a nation", Walsh was diagnosed with osteosarcoma at the age of twelve. He became well known for his activism against teenage
Donal_Walsh_(activist)
in placentas. His work at the NIH on the FBJ (Finkel-Biskis-Jinkins) osteosarcoma virus provided the background for the subsequent discovery of the fos/jun
Jay_A._Levy
Drug mixture used mainly to treat ADHD and narcolepsy
transcription factors that produce these alterations are Delta FBJ murine osteosarcoma viral oncogene homolog B (ΔFosB), cAMP response element binding protein
Adderall
Italian saint (1991–2006)
died of osteosarcoma Chronological list of saints and blesseds in the 21st century Antonietta Meo – young Italian Venerable who died of osteosarcoma Cernuzio
Carlo_Acutis
Chemical compound
has a direct antitumor effect in vitro, inducing cancer cells such as osteosarcoma cells to undergo apoptosis or to be stuck in the S phase of the cell
Zoledronic_acid
1973 television film by Joseph Sargent
Shortly after Jill is born, Kate gets the shocking news that she has an osteosarcoma, which is a bone cancer. Kate has two options to treat her cancer: she
Sunshine_(1973_film)
German comedy-drama television series
he becomes the CTO of MyDrugs. He is a wheelchair user as a result of osteosarcoma. Damian Hardung as Daniel Riffert, Lisa's presumptive boyfriend and typical
How to Sell Drugs Online (Fast)
How_to_Sell_Drugs_Online_(Fast)
American basketball player (1964–2009)
In March 2007, Tisdale underwent treatment for cancer in his knee (osteosarcoma), which was discovered after he fell down a flight of stairs at his home
Wayman_Tisdale
Central nervous system stimulant
transcription factors that produce these alterations are Delta FBJ murine osteosarcoma viral oncogene homolog B (ΔFosB), cAMP response element binding protein
Amphetamine
Group of diseases involving cell growth
average have lower levels of these hormones and lower risk of cancer. Osteosarcoma may be promoted by growth hormones. Some treatments and prevention approaches
Cancer
Protein-coding gene in the species Homo sapiens
of diverse cancers. cIAP1 is involved in the development process of osteosarcoma and gastric cancer among others. The cellular localization of cIAP1 is
Baculoviral IAP repeat-containing protein 2
Baculoviral_IAP_repeat-containing_protein_2
Friesenbichler, J; Leithner, K; Windhager, R (July–August 2010). "Wikipedia and osteosarcoma: a trustworthy patients' information?". Journal of the American Medical
Reliability_of_Wikipedia
Protein-coding gene in humans
increased expression in osteosarcoma (OS) tumor cells and other tumor cells, and it could be a potential biomarker for detecting osteosarcoma. C12orf29 gene in
C12orf29
Australian author (born 1950)
surgery. Gawler and his proponents have claimed that he was diagnosed with osteosarcoma in 1974, and that resultant surgery involved amputation through the hip
Ian_Gawler
Chemical compound
well as induce apoptosis in osteosarcoma cells. Potentially, cinobufagin could be used to stop proliferation of osteosarcoma cells as well as to induce
Cinobufagin
Protein-coding gene in the species Homo sapiens
the OS9 gene. This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key
OS9_(gene)
Diagnosis classification
Fibroblastic osteosarcoma Osteofibrosarcoma M9183/3 Telangeictatic osteosarcoma M9184/3 Osteosarcoma in Paget disease of bone M9185/3 Small cell osteosarcoma Round
International Classification of Diseases for Oncology
International_Classification_of_Diseases_for_Oncology
gestational trophoblastic disease, acute leukaemias, non-Hodgkin lymphoma, osteosarcoma, brain tumours, graft-versus-host disease and systemic sclerosis. Myelosuppression
List_of_antineoplastic_agents
Removal of an animal's reproductive organ
at a twofold excess risk to develop osteosarcoma (bone cancer) as compared to intact dogs. The risk of osteosarcoma increases with increasing breed size
Neutering
Protein found in humans
found that ADAM10 enhances the proliferation, migration, and invasion of osteosarcoma cells by modulating the E-cadherin/β-catenin signaling pathway, with
ADAM10
Additionally, HES4 has emerged as a significant factor in the context of osteosarcoma (OS), a type of bone cancer, where its expression correlates with aggressive
HES4
heart, the spleen, the skin and subcutaneous tissues, and the liver. Osteosarcoma* is an aggressive bone tumor that commonly spreads to the lungs. It is
List_of_dog_diseases
ladder structures consistent with breakage-fusion-bridge cycle events in osteosarcoma". Genes, Chromosomes and Cancer. 42 (4): 392–403. doi:10.1002/gcc.20157
Breakage-fusion-bridge_cycle
Extinct genus of dinosaurs
from Dinosaur Provincial Park in 1989 was discovered to have crippling osteosarcoma in its right fibula. Examination of the cancerous lesions in the bone
Centrosaurus
American medical drama television series (2017–2024)
(Season 1) that resembles Shaun's brother and is suffering from stage 4 osteosarcoma. Elfina Luk as Nurse Dalisay Villanueva. In season 5, she is revealed
The Good Doctor (American TV series)
The_Good_Doctor_(American_TV_series)
Joints connecting the jawbone to the skull
causing pain and swelling. These conditions include chondrosarcoma, osteosarcoma, giant cell tumor, and aneurysmal bone cyst. The temporomandibular joints
Temporomandibular_joint
American sports radio personality (2006–2020)
thereafter. After two diagnoses of retinoblastoma, he was diagnosed with osteosarcoma at the age of 6. Gaba had to leave on-site classes at George Cromwell
Mo_Gaba
Genetic disorder where bone and marrow is replaced with fibrous tissue
cases it may undergo a malignant transformation into cancers such as osteosarcoma or chondrosarcoma, so some clinicians may regard it as precancerous rather
Fibrous_dysplasia_of_bone
Type of asymmetric abnormality of the gait
as a chronic condition. Cancers including acute lymphocytic leukemia, osteosarcoma, and Ewing’s sarcoma may result in a gradual onset of limping in children
Limp
Chemical compound
Histone Deacetylase Inhibitor Entinostat/Syndax 275 in Osteosarcoma". Current Advances in Osteosarcoma. Advances in Experimental Medicine and Biology. Vol
Entinostat
American author and designer
in Beaver Dam, Wisconsin with her husband. Zieman was diagnosed with osteosarcoma, a type of bone cancer, in March of 2015. In July 2015, she was diagnosed
Nancy_Zieman
American–Haitian model and disabled rights activist (1989–2019)
20, 1989. She grew up in Haiti, and at age 14, she was diagnosed with osteosarcoma and lung cancer—doctors gave her three weeks to live. Two years later
Mama_Cax
American para-snowboarder
2010, at age 14, Huckaby had most of her right leg amputated due to osteosarcoma. She learned to snowboard at age 15 at the National Ability Center. While
Brenna_Huckaby
Cancer associated with asbestos
sarcoma Thymoma Metastatic clear cell renal cell carcinoma Metastatic osteosarcoma Staging of mesothelioma is based on the recommendation by the International
Mesothelioma
Type of disease cluster
include: scrotal cancer among chimney sweeps in 18th-century London; osteosarcoma among female watch dial painters in the 20th century; skin cancer in
Cancer_cluster
Canadian lacrosse player
at Cornell University that he was diagnosed as having osteosarcoma. His treatment for osteosarcoma included chemotherapy and surgery. He returned to playing
Kyle_Miller_(lacrosse)
networks) identified control targets in phenotypically characterized Osteosarcoma showing important role of genes and proteins responsible for maintaining
Network_controllability
Chemical compound
JH, Chueh FS, Chung JG (2011). "Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial
Wogonin
Protein-coding gene in the species Homo sapiens
regeneration. Overall Sp7 expression is decreased in mouse and human osteosarcoma cell lines when compared to endogenous osteoblasts and this decrease
Sp7_transcription_factor
Medical condition
infections, benign tumors such as osteoid osteoma, malignant tumors such as osteosarcoma, and problems that affect the shape and function of the legs, such as
Growing_pains
Medical condition
RAPADILINO syndrome are more likely to develop osteosarcoma or lymphoma. In those with RAPADILINO syndrome, osteosarcoma typically develops during childhood or
RAPADILINO_syndrome
OSTEOSARCOMA
OSTEOSARCOMA
OSTEOSARCOMA
OSTEOSARCOMA
Girl/Female
Indian
Happy, Glad, Jubilant
Girl/Female
Hindu
Girl/Female
Muslim
Gentle (Name of the daughter of the prophet (SAW))
Boy/Male
American, Australian, British, Chinese, Christian, English, Irish
Little Raven; Prince; Variant of Brendan
Girl/Female
Australian, Greek
A Flower Name; Similar to Samantha
Boy/Male
Arabic, Muslim
Holy; Most; Pure; Free from Any Defects; Al-quddus; The All-holy; One of the Names of Allah
Boy/Male
Arabic, Indian, Muslim
Warner; Cautioner
Surname or Lastname
English
English : variant of Calcote.
Boy/Male
Australian, French, German
Flower
Girl/Female
Tamil
Goddess Lakshmi
OSTEOSARCOMA
OSTEOSARCOMA
OSTEOSARCOMA
OSTEOSARCOMA
OSTEOSARCOMA
n.
A tumor having the structure of a sacroma in which there is a deposit of bone; sarcoma connected with bone.
pl.
of Osteosarcoma