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Protein-coding gene in the species Homo sapiens
Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene. It is one of the targets of an oncomiR, MIRN21. This gene encodes
PDCD4
Multiprotein complex used in gene expression
eIF4F. Each molecule of PDCD4 can bind two molecules of eIF4A, though physiological complexes are 1:1. By doing so it prevents PDCD4 from forming, inhibiting
Eukaryotic initiation factor 4F
Eukaryotic_initiation_factor_4F
Protein-coding gene in the species Homo sapiens
Cell Death Protein 4 (PDCD4) is known to inhibit ATG5 expression via inhibition of protein translation. Two MA3 domains on PDCD4 bind to RNA-helicase EIF4A
Autophagy_protein_5
Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)
Cmarik JL, Colburn NH (February 2001). "A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivation"
AP-1_transcription_factor
Protein complex
phosphorylate programmed cell death 4 (PDCD4), which marks it for degradation by ubiquitin ligase Beta-TrCP (BTRC). PDCD4 is a tumor suppressor that binds to
MTORC1
Protein-coding gene in the species Homo sapiens
protein translation, cell growth and survival. In response to mitogens, PDCD4, an inhibitor of the translation initiation factor eIF4A, is rapidly degraded
FBXW11
Protein-coding gene in humans
the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21". Science Signaling. 4 (199): ra75. doi:10.1126/scisignal
Decorin
Family of oncogenic microRNAs
hematopoietic cancers. It has been found to down-regulate the tumor suppressor PDCD4, thus aiding in the cancer's invasion, intravasation and metastasis. MicroRNA-155
Oncomir
Protein
invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4". Carcinogenesis. 32 (12): 1798–1805. doi:10.1093/carcin/bgr213. PMID 21934092
FOXO4
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
PMID 29070863. Bai Y, Dong Z, Shang Q, Zhao H, Wang L, Guo C, et al. (2016). "Pdcd4 Is Involved in the Formation of Stress Granule in Response to Oxidized Low-Density
Stress_granule
Lankat-Buttgereit B, Müller S, Schmidt H, et al. (2008). "Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of
SCG2
Protein coding gene in Humans
of eIF4A1. Conversely, eIF4A1 activity is suppressed when it is bound to PDCD4, a tumor suppressor itself modulated by mTOR and miR-21. PCDC4 is typically
EIF4A1
Protein-coding gene in the species Homo sapiens
protein translation, cell growth and survival. In response to mitogens, PDCD4, an inhibitor of the translation initiation factor eIF4A, is rapidly degraded
BTRC_(gene)
Protein found in humans
Ribosomal protein L5 has been shown to interact with: CSNK2B, EIF5A, Mdm2, and PDCD4. GRCh38: Ensembl release 89: ENSG00000122406 – Ensembl, May 2017 GRCm38:
60S_ribosomal_protein_L5
Chemical compound
R.; Shen, Ben (2011-09-23). "Actinopolysporins A–C and Tubercidin as a Pdcd4 Stabilizer from the Halophilic Actinomycete Actinopolyspora erythraea YIM
Tubercidin
Non-coding RNA in the species Homo sapiens
include: ANP32A, BTG2, Bcl2, P12/CDK2AP1, HNRPK, IL-12p35, JAG1, MEF2C, hMSH2, PDCD4, PTEN, RECK, RhoB, SMARCA4, TGFBRII, SPRY1, SPRY2, TP63, and Tropomyosin
MIRN21
Protein-coding gene in the species Homo sapiens
gene dispersed through the genome. RPS13 has been shown to interact with PDCD4. GRCh38: Ensembl release 89: ENSG00000110700 – Ensembl, May 2017 GRCm38:
40S_ribosomal_protein_S13
Protein-coding gene in the species Homo sapiens
Y, Zuber P, Du Y, et al. (August 2024). "Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit". Nature
EIF1
Protein found in humans
Ahn HS, Lee JY, Matsuhashi S, Park WY (April 2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research
60S acidic ribosomal protein P1
60S_acidic_ribosomal_protein_P1
Q9BQ51 11843 PDCD2 HGNC:8762; Q16342 11844 PDCD2L HGNC:28194; Q9BRP1 11845 PDCD4 HGNC:8763; Q53EL6 11846 PDCD5 HGNC:8764; O14737 11847 PDCD6 HGNC:8765; O75340
List of human protein-coding genes 6
List_of_human_protein-coding_genes_6
PDCD4
PDCD4
PDCD4
PDCD4
Male
Hungarian
Hungarian form of Latin Demetrius, DEMETER means "loves the earth" or "follower of Demeter."Â
Male
Egyptian
, surname of king Antef III.
Girl/Female
Tamil
One who can concentrate or female disciple or enchanted
Surname or Lastname
English
English : habitational name from Sheering in Essex, probably so called from an unattested Old English personal name, Scear(a), + the suffix -ingas, meaning ‘people, family, or followers of’.
Girl/Female
Indian, Kannada, Marathi
Great Warrior of an Arma
Girl/Female
American, British, English
From Great Britain
Boy/Male
Biblical American Hebrew
Increase; addition.
Boy/Male
Tamil
One who does his duty
Boy/Male
Tamil
Surname or Lastname
English (now most common in northern Ireland)
English (now most common in northern Ireland) : probably a habitational name from a lost or unidentified place, most likely somewhere in Lancashire or Yorkshire.
PDCD4
PDCD4
PDCD4
PDCD4
PDCD4