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In the brain, the perforant path or perforant pathway provides a connectional route from the entorhinal cortex to all fields of the hippocampal formation
Perforant_path
Component of brain anatomy
from the adjoining entorhinal cortex, via the axons of the so-called perforant path. These axons arise from layer 2 of the entorhinal cortex (EC), and terminate
Hippocampus_anatomy
Neural circuit in the hippocampus
the dentate gyrus via granule cell fibers known collectively as the perforant path. The dentate gyrus then synapses on pyramidal cells in CA3 via mossy
Trisynaptic_circuit
Region of the hippocampus in the brain
dentate gyrus via the perforant path. The dentate gyrus receives no direct inputs from other cortical structures. The perforant path is divided into the
Dentate_gyrus
Part of the brain of mammals
the entorhinal cortex via the perforant path. The mossy fiber pathway ends in the stratum lucidum. The perforant path passes through the stratum lacunosum
Hippocampal_subfields
Vertebrate brain region
and subcortical structures) comes from the entorhinal cortex via the perforant path. The entorhinal cortex (EC) is strongly and reciprocally connected with
Hippocampus
Ability of a synapse to strengthen or weaken over time according to its activity
The experiment described was conducted on the synapse between the perforant path and dentate gyrus in the hippocampi of anaesthetised rabbits. They were
Synaptic_plasticity
Persistent strengthening of synapses based on recent patterns of activity
dentate area of the anaesthetized rabbit following stimulation of the perforant path". The Journal of Physiology. 232 (2): 331–56. doi:10.1113/jphysiol.1973
Long-term_potentiation
Connection formed between neurons that allows neurotransmission
Vago, David R.; Kesner, Raymond P. (2008). "Disruption of the direct perforant path input to the CA1 subregion of the dorsal hippocampus interferes with
Neural_pathway
British neuroscientist
dentate area of the anaesthetized rabbit following stimulation of the perforant path". The Journal of Physiology. 232 (2): 331–56. doi:10.1113/jphysiol.1973
Timothy_Bliss
ventrolateral aspect of the lateral ventricle's temporal horn. It contains the perforant path (the main input to the hippocampus, extending from the entorhinal cortex
Angular_bundle
Electrical signal encouraging a neuron to fire
dentate area of the anaesthetized rabbit following stimulation of the perforant path. The Journal of physiology, 232(2), 331–356. doi:10.1113/jphysiol.1973
Excitatory postsynaptic potential
Excitatory_postsynaptic_potential
Memory about one's environment and spatial orientation
innervated by two afferent paths known as the perforant path (PPCA3) and the dentate gyrus (DG)-mediated mossy fibers (MFs). The first path is regarded as the
Spatial_memory
British neuroscientist and psychologist
dentate area of the anaesthetized rabbit following stimulation of the perforant path". J. Physiol. 232 (2): 331–56. Bibcode:1973JPhsg.232..331B. doi:10.1113/jphysiol
David_Marr_(scientist)
David R.; Kesner, Raymond P. (June 2008). "Disruption of the direct perforant path input to the CA1 subregion of the dorsal hippocampus interferes with
Schaffer_collateral
Form of neural negative feedback
how homosynaptic depression causes short-term synaptic depression. Perforant path–granule cells (PP-GC) in the dentate gyrus of the hippocampus in adult
Short-term synaptic depression
Short-term_synaptic_depression
have excitatory impact on granule cells with the help of perforant path inputs. The perforant pathway are fibers that connect the entorhinal cortex with
Supramammillary_nucleus
American neuroscientist
"Epileptogenesis is associated with enhanced glutamatergic transmission in the perforant path". Journal of Neurophysiology. 95 (2): 1213–1220. doi:10.1152/jn.00680
Annalisa_Scimemi
Psychological theory
dentate area of the anaesthetized rabbit following stimulation of the perforant path". The Journal of Physiology. 232 (2). Wiley: 331–356. doi:10.1113/jphysiol
Perceptual_control_theory
Pathway in the hippocampus
1002/cne.23469. PMC 4384686. PMID 24122645. Witter MP (2007). "The perforant path: projections from the entorhinal cortex to the dentate gyrus". The Dentate
Mossy_fiber_(hippocampus)
Type of dendrite found at the apex of cortical pyramidal cell pathways
the cell has a high probability of firing an AP. In CA3, it is the perforant path projection from the entorhinal cortical cells that provides synaptic
Apical_dendrite
Action potential generated in the dendrite of a neuron
two distinctive regions that receive excitatory synaptic inputs: the perforant path (PP) through the apical dendritic tuft (500-750 μm from soma) and the
Dendritic_spike
Protein-coding gene in humans
be required for long-term potentiation at the synapse between medial perforant path and dentate gyrus in murine hippocampal formation. Polymorphisms in
Dopamine_receptor_D5
American psychiatrist
Alzheimer's Disease patients have shown a loss of synapses from the perforant path, the connections between the entorhinal cortex and hippocampal formation
Christopher_H._van_Dyck
British scientist (1951–2026)
Errington, M. L.; Bliss, T. V. P. (1982). "Long-term potentiation of the perforant path in vivo is associated with increased glutamate release". Nature. 297
Annette_Dolphin
Concept in neuroscience
dentate area of the anaesthetized rabbit following stimulation of the perforant path". The Journal of Physiology. 232 (2): 331–356. doi:10.1113/jphysiol
Long-term potentiation induction
Long-term_potentiation_induction
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